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| 1 | Emerging role of caldesmon in cancer:A potential biomarker for colorectal cancer and other cancers显示文摘Colorectal cancer(CRC) is a devastating disease, mainly because of metastasis. As a result, there is a need to better understand the molecular basis of invasion and metastasis and to identify new biomarkers and therapeutic targets to aid in managing these tumors. The actin cytoskeleton and actin-binding proteins are known to play an important role in the process of cancer metastasis because they control and execute essential steps in cell motility and contractility as well as cell division. Caldesmon(CaD) is an actin-binding protein encoded by the CALD1 gene as multiple transcripts that mainly encode two protein isoforms: High-molecular-weight CaD, expressed in smooth muscle, and low-molecular weight CaD(l-CaD), expressed in nonsmooth muscle cells. According to our comprehensive review of the literature, CaD, particularly l-CaD, plays a key role in the development, metastasis, and resistance to chemoradiotherapy in colorectal, breast, and urinary bladder cancers and gliomas, among other malignancies. CaD is involved in many aspects of the carcinogenic hallmarks, including epithelial mesenchymal transition via transforming growth factor-beta signaling, angiogenesis, resistance to hormonal therapy, and immune evasion. Recent data show that CaD is expressed in tumor cells as well as in stromal cells, such as cancerassociated fibroblasts, where it modulates the tumor microenvironment to favor the tumor. Interestingly, CaD undergoes selective tumor-specific splicing, and the resulting isoforms are generally not expressed in normal tissues, making these transcripts ideal targets for drug design. In this review, we will analyze these features of CaD with a focus on CRC and show how the currently available data qualify CaD as a potential candidate for targeted therapy in addition to its role in the diagnosis and prognosis of cancer. | Alya R Alnuaimi Vidhya A Nair Lara J Bou Malhab Eman Abu-Gharbieh Anu Vinod Ranade Gianfranco Pintus Mohamad Hamad Hauke Busch Jutta Kirfel Rifat Hamoudi Wael M Abdel-Rahman | 2022 | World Journal of Gastrointestinal Oncology2022，14，9： | 2 |
| 2 | Conservatism and Auditor-Client Negotiations显示文摘 | Anue R Nalebuff B | | 0，，29： | 1 |
| 3 | Optimaization of culture for bacterial cellulose production from Gluconacetobacter hansenii UAC09显示文摘 | Mahadevaswamy U R Anu A | 2011 | Annals of Microbiology2011，，： | 1 |
| 4 | Agrobacterium mediated genetic transformation in Hevea brasiliensis for recombinant protein production显示文摘 | Kala R G Anu K S Manesh K | 2006 | Journal of plantation crops2006，34，3： | 1 |
| 5 | Distribution of Chlorinated Biphenyls in Mussels and sediments from Great Britain and the Irish Sea Coast显示文摘 | ANU T JANETTE R A DAVID D | 1996 | Marine Pollution Bulletin1996，32，2： | 1 |
| 6 | Autophagy inhibition and antimalarials promote cell death in gastrointestinal stromal tumor (GIST) 显示文摘 | Anu G Srirupa R Alexander J F | 2010 | Proc Natl Acad Sci2010，107，14： | 1 |
| 7 | Impact ofoptical modulation formats on SPM-limited fiber trans-mission in 10 and 40 Gb/s optimum dispersion-man-aged light wave systems 显示文摘 | Sheetal Anu Sharma Ajay K Kaler R S | 2010 | International Journal forLight and Electron Optics2010，121，3： | 1 |
| 8 | Fabrication of sucrose biosensor based on single mode planar optical waveguide using co-immobilized plant invertase and GOD 显示文摘 | Dipali S B Anu V Aiyer R C | 2007 | BiosensBioelectron2007，22，： | 1 |
| 9 | Ap-plying the Problem-Based Learning Approach to Teach Ele-mentary Circuit Analysis 显示文摘 | Luis R J Costa Mikko Honkala Anu Lehtovuori | 2007 | IEEE TRANSACTIONS ONEDUCATION2007，50，1： | 1 |
| 10 | A frequency domain approach to protein sequence similarity analysis and functional classification显示文摘 | Anu S R Tessamma T | 2011 | Signal and Image Processing2011，2，1： | 1 |
| 11 | Tailoring properties of polyaniline for simultaneous determination of a quaternary mixture of ascorbic acid,dopamine,uric acid,and tryptophan显示文摘 | ANU PRATHAP M SRIVASTAVA R | 2013 | Sens Actuators B:Chem2013，177，： | 1 |
| 12 | Critical factors in electronic grocery shopping显示文摘 | Anu R Kristiina T V | 2001 | International Review of Retail Distribution & Consumer Research2001，11，3： | 1 |
| 13 | Exposure to HIV- protease inhibitors selects for increased expression of P- glycoprotein (ABCB1) in Kaposi's sarcoma cells 显示文摘 | Lucia MB Anu R Handley M | 2011 | British Journal of Cancer2011，105，4： | 1 |
| 14 | Pharmacokinetics of ciprofloxacin in sheep following intravenous and subcutaneous administration显示文摘 | Anu R Amit K Ahmad A H | 2007 | Small Rumin Res2007，73，12： | 1 |
| 15 | Synthesis of nanoporous metal oxides through the self-assembly of phloroglucinol- formaldehyde resol and tri-block copolymer 显示文摘 | Anu Prathap M U Srivastava R | 2011 | J ColloidInterf Sci2011，358，2： | 1 |
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