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| 1 | Probiotics increase T regulatory cells and reduce severity of experimental colitis in mice显示文摘AIM:To investigate the effect of probiotics on regulating T regulatory cells and reducing the severity of experimental colitis in mice. METHODS:Forty C57/BL mice were randomly divided into four groups.Colitis was induced in the mice using 2,4,6-trinitrobenzene sulfonic acid(TNBS).After 10-d treatment with Bifico capsules(combined bifidobacterium,lactobacillus and enterococcus),body weight,colonic weight,colonic weight index,length of colon,and histological scores were evaluated.CD4+CD25+Foxp3+T cell in mesenteric lymph nodes were measured by flow cytometry,and cytokines in colonic tissue homogenateswere analyzed by a cytometric bead array. RESULTS:The colonic weight index and the colonic weight of colitis mice treated with Bifico were lower than that of TNBS-induced mice without treatment. However,colonic length and percent of body weight amplification were higher than in TNBS-induced mice without treatment.Compared with TNBS-induced mice without treatment,the level of CD4+CD25+Foxp3+T cells in mesenteric lymph nodes,the expression of interleukin(IL)-2,IL-4 and IL-10 in colonic tissues from colitis mice treated with Bifico were upregulated,and tumor necrosis factor-αand interferon-γwere downregulated. CONCLUSION:Probiotics effectively treat experimental colitis by increasing CD4+CD25+Foxp3+T cell and regulating the balance of Th1 and Th2 cytokines in the colonic mucosa. | Hai-Mei Zhao Xiao-Ying Huang Zhi-Qin Zuo Qi-Hong Pan Mei-Ying Ao Feng Zhou Hong-Ning Liu Zhi-Yong Liu Duan-Yong Liu | 2013 | World Journal of Gastroenterology2013，19，5： | 15 |
| 2 | Surface modification of small intestine submucosa in tissue engineering显示文摘With the development of tissue engineering,the required biomaterials need to have the ability to promote cell adhesion and proliferation in vitro and in vivo.Especially,surface modification of the scaffold material has a great influence on biocompatibility and functionality of materials.The small intestine submucosa(SIS)is an extracellular matrix isolated from the submucosal layer of porcine jejunum,which has good tissue mechanical properties and regenerative activity,and is suitable for cell adhesion,proliferation and differentiation.In recent years,SIS is widely used in different areas of tissue reconstruction,such as blood vessels,bone,cartilage,bladder and ureter,etc.This paper discusses the main methods for surface modification of SIS to improve and optimize the performance of SIS bioscaffolds,including functional group bonding,protein adsorption,mineral coating,topography and formatting modification and drug combination.In addition,the reasonable combination of these methods also offers great improvement on SIS surface modification.This article makes a shallow review of the surface modification of SIS and its application in tissue engineering. | Pan Zhao Xiang Li Qin Fang Fanglin Wang Qiang Ao Xiaohong Wang Xiaohong Tian Hao Tong Shuling Bai Jun Fan | 2020 | Regenerative Biomaterials2020，7，4： | 9 |
| 3 | Endoscopic decompression of the optic canal for traumatic optic neuropathy显示文摘 | Zhen-Hua He Zheng-Bo Lan Ao Xiong Guo-Kuo Hou Ya-Wen Pan Qiang Li Xin-Ding Zhang | 2016 | Chinese Journal of Traumatology2016，19，6： | 8 |
| 4 | Positron emission tomography/computerized tomography in the evaluation of primary non-Hodgkin's lymphoma of prostate显示文摘Primary malignant lymphoma of the prostate is exceedingly rare.Here we report a case of a 65-year-old man who presented with increased urinary frequency,urinary urgency,and urinary incontinence for two years.Benign prostatic hypertrophy was suspected at primary impression.Ultrasound revealed a hypoechoic lesion of the prostate.The total serum prostate-specific antigen was within normal range.Positron emission tomography/computerized tomography(PET/CT)showed a hypermetabolic prostatic lesion.Prostate biopsy was consistent with a non-germinal center diffuse large B cell lymphoma.There was complete remission of the prostatic lesion following six cycles of chemotherapy as shown on the second PET/CT imaging.18F-fluoro-deoxy glucose PET/CT is not only a complement to conventional imaging,but also plays a significant role in the diagnosis and evaluation of treatment response of prostatic lymphoma. | Bo Pan Jian-Kui Han Shi-Cun Wang Ao Xu | 2013 | World Journal of Gastroenterology2013，19，39： | 4 |
| 5 | Current research progress of photopolymerized hydrogels in tissue engineering显示文摘Owing to the special fo rmation of photopolymerized hydrogels,they can effectively control the formation of hydrogels in space and time.Moreover,the photopolymerized hydrogels have mild formation conditions and biocompatibility;therefore,they can be widely used in tissue engineering.With the development and application of manufacturing technology,photopolymerized hydrogels can be widely used in cell encapsulation,scaffold materials,and other tissue engineering fields through more elaborate manufacturing methods.This review covers the types of photoinitiators,manu facturing technologies for photopolymerized hydrogels as well as the materials used,and a summary of the applications of photopolymerized hydrogels in tissue engineering. | Ao Sun Xinye He Xiao Ji Danrong Hu Meng Pan Linghong Zhang Zhiyong Qian | 2021 | Chinese Chemical Letters2021，32，7： | 2 |
| 6 | Investigation of interactions between dendrimer-coated magnetite nanoparticles and bovine serum albumin显示文摘 | Pan B Gao F Ao L | 2005 | J Magn Magn Mater2005，293，： | 1 |
| 7 | End-to-End SelfAssembly and Colorimetric Characterization of Gold Nanorods and Nanospheres via Oligonudeotide Hybridization显示文摘 | PAN B F AO L M GAO F | 2005 | NanotechnoloRy2005，16，： | 1 |
| 8 | Controlled self-assembly of thiolterminated poly (amidoamine) dendrimer and gold nanoparticles 显示文摘 | Pan BF Gao F Ao LM | 2005 | Colloid Surface (A)2005，259，1： | 1 |
| 9 | Fluoroimmunoassay for antigen based on fluorescence quenching signal of gold nanoparticles显示文摘 | Ao L M Gao F Pan B F | 2006 | Analytical Chemistry2006，78，4： | 1 |
| 10 | Magnetostratigraphic age of the Xiantai Paleolithic site in the Nihewan Basin and implications for early human colonization of Northeast Asia显示文摘 | Chenglong Deng Qi Wei Rixiang Zhu Hongqiang Wang Rui Zhang Hong Ao Liao Chang Yongxin Pan | 2006 | Earth and Planetary Science Letters2006，，1： | 1 |
| 11 | Effects of different states of sheep fetal fibroblasts as donor cells on the early development in vitro of reconstructed sheep embryos显示文摘To investigate the effects of different states of donor cells on the development of reconstructed sheep embryos, we designed five treatments of donor cells, including cell passage, cell size, serum starvation, colchicine treatment and gene transfection. Results are as follows: (Ⅰ) Compared with 16-18 passage cells, the morula/blastocyst rate of 5-7 passage cells as donor nuclei was significantly higher (17.3% vs. 4.9%, P<0.05), suggesting the advantage of short-time cultured cells in supporting the development of reconstructed embryos. (Ⅱ) The morula/blastocyst rate of reconstructed embryos derived from medium cells (15-25μm) as donor nuclei was higher than that from large cells (25-33μm) and small cells (8-15μm)( 20.0% vs. 8.0%, 9.7%), indicating that reconstructed embryos from medium cells had a greater potentiality to develop into morula/blastocysts than those from small or large ones. (Ⅲ) The morula/blastocyst rate of reconstructed embryos from donor cells of SS (serum starvation) was lower than that from donor cells of NSS (non-serum starvation), but no significant difference was detected between SS and NSS(11.8% vs. 18.6%, P>0.05). (Ⅳ) Fetal fibroblasts treated with 0.05μmol/L colchicine exhibited a higher morula/blastocyst rate of reconstructed embryos than those treated with 0.10 μmol/L colchicine and untreated ones (27.5% vs. 12.1%, 17.1%), however, no significant difference among the three treatments was detected (P>0.05). (Ⅴ) The morula/blastocyst rate of reconstructed embryos from fetal fibroblasts transfected with GFP gene only was 3.1%, significantly lower than that from non-transgenic cells (3.1% vs. 20.4%, P<0.05). In conclusion, our results demonstrated that fetal fibroblasts of fewer passages, medium size could ensure a higher morula/blastocyst rate of reconstructed embryos. Serum starvation of donor cells might be unnecessary to the development of reconstructed embryos. Donor cells treated with 0.05μmol/L colchicine could facilitate the development of reconstructed embryos. Additionally, as cells transfected with GFP gene were used as donor nuclei, adverse effect on the development of reconstructed embryos was observed. Therefore, the developmental efficiency of reconstructed embryos could be improved if proper treatments to donor cells were used. | WANG Hai, AO Hong, PAN QiuZhen, LI RongQi, ZHAO MengBin, LI AN ZhengXing, LI Ning & WU ChangXin 11nstitute of Zoology, Chinese Academy of Sciences, Beijing 100080, China 2 Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100094, China 3 Northeast Agricultural University, Harbin 150030, China 4Beijing Glorious Land Agricultural Co., Ltd. Beijing 100049, China 5 College of Animal Science and Technology, China Agricultural University, Beijing 100094, China 6 State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing 100094, China | 2007 | Science China(Life Sciences)2007，50，2： | 1 |
| 12 | Simultaneous nanoparticle formation and encapsulation driven by hydrophobic interaction of casein-graft-dextran and jJ-carotene显示文摘 | PAN Xiaoyun Y AO Ping JIANG Ming | 2007 | Colloid Interface Science2007，315，2： | 1 |
| 13 | The behaviour pattern of scoliosis associated with osteoid osteoma or osteoblastoma of the spine显示文摘 | Ransford AO Pozo JL Hutton PAN | 1984 | J Bone Joint Surg1984，66，： | 1 |
| 14 | End-to-end selfassembly and eolorimetric characterization of gold nanorods and nanospheres via oligonucleotide hybridization显示文摘 | Pan B F Ao L M Gao F | | 0，，09： | 1 |
| 15 | Fluoroimmunoassay for antigen based on fluorescence quenching signal of gold nanoparticles 显示文摘 | Ao LM Gao F Pan BF | 2006 | Analytical Chem2006，78，4： | 1 |
| 16 | End-end self-assembly and colorimetric characterization of gold nanorod and nanosphere via oligonucleotide hybridization 显示文摘 | Pan BF Ao LM Gao F | 2005 | Nanotechnol2005，16，7： | 1 |
| 17 | Micellization of casein-graft-dextran copolymer prepared through maillard reaction显示文摘 | PAN Xiaoyun MU Minfang Y AO Ping | 2006 | Biopolymers2006，81，： | 1 |
| 18 | End-to-end self-assembly and colorimetric characterization of gold nanorods and nanospheres via oligonucleotide hybridization显示文摘 | Bifeng Pan Limei Ao FengGao Hongye Tian Rong He Daxiang Cui | 2005 | Nanotechnology2005，16，： | 1 |
| 19 | RNA-seq reveals hormone-regulated synthesis of non-cellulose polysaccharides associated with fiber strength in a single-chromosomal-fragmentsubstituted upland cotton line显示文摘Cotton fibers are the main raw materials of the textile industry.Exogenous superior fiber genes have been introduced into upland cotton to develop high-yield cultivars with excellent fiber quality.We used a single chromosomal segment on the chromosome A07 substitution line SL7,with high fiber strength,to investigate the molecular mechanism underlying its fiber quality.RNA-seq and KEGG analysis showed that 70 differentially expressed genes were enriched in plant hormone transduction pathways,including auxin,ethylene and abscisic acid,in fibers at 10 days post-anthesis(DPA).Among these,fiberdevelopment related transcription factors MYB and NAC,including Gh_A11G0981(MYB108),Gh_A03G0887(NAC029),and Gh_A08G1691(NAC021),were significantly upregulated in SL7,as were numerous cellulose synthase-like(CSL)genes involved in non-cellulose polysaccharide and cell wall synthesis.The hemicellulose content of SL7 was significantly higher than that of L22,an upland cotton cultivar.These results suggest that key genes in the introgressed chromosomal segment of SL7 regulate the expression of transcription-factor genes via hormone-transduction pathways,thereby inducing the expression of genes involved in secondary wall synthesis and ultimately improving fiber quality.This study has shed light on the molecular mechanism of fiber development and will contribute to the improvement of fiber quality of upland cotton by molecular breeding. | Zhangqiang Song Yu Chen Chuanyun Zhang Jingxia Zhang Xuehan Huo Yang Gao Ao Pan Zhaohai Du Juan Zhou Yanxiu Zhao Zhi Liu Furong Wang Jun Zhang | 2020 | The Crop Journal2020，8，2： | 1 |
| 20 | 显示文摘 | Pan B F Gao F Ao L M | 2005 | Colloids Surf A2005，259，： | 1 |
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