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| 1 | Management of nonalcoholic fatty liver disease:An evidence-based clinical practice review显示文摘AIM:To build a consensus among Chilean specialists on the appropriate management of patients with nonalcoholic fatty liver disease(NAFLD)in clinical practice.METHODS:NAFLD has now reached epidemic proportions worldwide.The optimal treatment for NAFLD has not been established due to a lack of evidence-based recommendations.An expert panel of members of the Chilean Gastroenterological Society and the Chilean Hepatology Association conducted a structured analysis of the current literature on NAFLD therapy.The quality of the evidence and the level of recommendations supporting each statement were assessed according to the recommendations of the United States Preventive Services Task Force.A modified three-round Delphi technique was used to reach a consensus among the experts.RESULTS:A group of thirteen experts was established.The survey included 17 open-ended questions that were distributed among the experts,who assessed the articles associated with each question.The levels of agreement achieved by the panel were 93.8%in the first round and 100%in the second and third rounds.The final recommendations support the indication of lifestyle changes,including diet and exercise,for all patients with NAFLD.Proven pharmacological therapies include only vitamin E and pioglitazone,which can be used in nondiabetic patients with biopsy-proven nonalcoholic steatohepatitis(the progressive form of NAFLD),although the long-term safety and efficacy of these therapies have not yet been established.CONCLUSION:Current NAFLD management is rapidly evolving,and new pathophysiology-based therapies are expected to be introduced in the near future.All NAFLD patients should be evaluated using a three-focused approach that considers the risks of liver disease,diabetes and cardiovascular events. | Juan P Arab Roberto Candia Rodrigo Zapata Cristián Mu?oz Juan P Arancibia Jaime Poniachik Alejandro Soza Francisco Fuster Javier Brahm Edgar Sanhueza Jorge Contreras M Carolina Cuellar Marco Arrese Arnoldo Riquelme | 2014 | World Journal of Gastroenterology2014，20，34： | 11 |
| 2 | Management of Helicobacter pylori infection in Latin America: A Delphi technique-based consensus显示文摘AIM: To optimize diagnosis and treatment guidelines for this geographic region, a panel of gastroenterologists, epidemiologists, and basic scientists carried out a structured evaluation of available literature.METHODS: Relevant questions were distributed among the experts, who generated draft statements for consideration by the entire panel. A modified three-round Delphi technique method was used to reach consensus. Critical input was also obtained from representatives of the concerned medical community. The quality of the evidence and level of recommendation supporting each statement was graded according to United States Preventive Services Task Force criteria.RESULTS: A group of ten experts was established. The survey included 15 open-ended questions that were distributed among the experts, who assessed the articles associated with each question. The levels of agreement achieved by the panel were 50% in the first round, 73.3% in the second round and 100% in the third round. Main consensus recommendations included:(1) when available, urea breath and stool antigen test(HpSA) should be used for non-invasive diagnosis;(2) detect and eradicate Helicobacter pylori(H. pylori) in all gastroscopy patients to decrease risk of peptic ulcer disease, prevent o retard progression in patients with preneoplastic lesions, and to prevent recurrence in patients treated for gastric cancer;(3) further investigate implementation issues and health outcomes of H. pylorieradication for primary prevention of gastric cancer in high-risk populations;(4) prescribe standard 14-d triple therapy or sequential therapy for first-line treatment;(5) routinely assess eradication success post-treatment in clinical settings; and(6) select second- and third-line therapies according to antibiotic susceptibility testing.CONCLUSION: These achievable steps toward better region-specific management can be expected to improve clinical health outcomes. | Antonio Rollan Juan Pablo Arab M Constanza Camargo Roberto Candia Paul Harris Catterina Ferreccio Charles S Rabkin Juan Cristóbal Gana Pablo Cortés Rolando Herrero Luisa Durán Apolinaria García Claudio Toledo Alberto Espino Nicole Lustig Alberto Sarfatis Catalina Figueroa Javier Torres Arnoldo Riquelme | 2014 | World Journal of Gastroenterology2014，20，31： | 2 |
| 3 | Beta-amyloid neurotoxicity in vitro:evidence of oxidative stress but not protection by antioxidants显示文摘 | PIKE C J RAMEZN ARAB N COTMAN C W | 1997 | J Neurochem1997，69，4： | 1 |
| 4 | Brucella prostatic abscess显示文摘 | Ben Arab N Maaloul I Bouhlel A | 2008 | Med Mal Infect2008，38，4： | 1 |
| 5 | Homogenization of a reaction-diffusion system modeling sulfate corrosion of concrete in locally periodic perforated domains显示文摘 | Fatima T Arab N Zemskov E P | 2011 | Journal of Engineering Mathematics2011，69，2： | 1 |
| 6 | Evidence-based systematic literaturereview of haemoglobin/hematocrit and all-cause mortality indialysis patients显示文摘 | Volkova N Arab L | 2006 | Am J Kidney Dis2006，4，1： | 1 |
| 7 | Are certain lifestyle habits associated with lower Alzheimer' s disease risk? 显示文摘 | Arab L Sabbagh M N | 2010 | J Alzheimers Dis2010，20，3： | 1 |
| 8 | Statistical modeling of strain-hardening exponent and grain size of Nb-microalloyed steels using a two-level factorial design of experiment 显示文摘 | ARAB N B M AYAZ M KHAKI D M | 2013 | Journal of Materials Engineering and Performance2013，22，11： | 1 |
| 9 | The effect of dryneedling on pain, pressure pain threshold and disability inpatients with a myofascial trigger point in the upper trapeziusmuscle显示文摘 | Ziaeifar M Arab AM Karimi N | 2014 | J Bodywork Move Ther2014，18，2： | 1 |
| 10 | Automatic speed control of an asymmetrical six-phase induction motor using emotional controller (BELBIC)显示文摘 | DARYABEIGI E ABJADI N R ARAB MARKADEH G R | 2014 | Journal of intelligent and Ktzzy systems2014，26，4： | 1 |
| 11 | 显示文摘 | Ohno N H arab T Matsunaga Y | 2000 | Materials Science in Semiconductor Processing2000，3，3： | 1 |
| 12 | Snapshot in surgery: in- traperitoneal encapsulated fat necrosis显示文摘 | Oh HB Arab N Teo L | 2015 | Clin Case Rep2015，3，2： | 1 |
| 13 | Unconventional approach for demineralization of deproteinized crustacean shells for chitin production 显示文摘 | Mahmoud N S Ghaly A E Arab F | 2007 | Am J Biochem Biotechnol2007，3，： | 1 |
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