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| 1 | 十五肽BPC157减弱慢性苯丙胺诱导的行为障碍(英文)显示文摘AIM: To investigate the effect of pentadecapeptide BPC 157 on chronic exposure to amphetamine in rats, particularly the changes commonly referred in chronic amphetamine studies as tolerance ( lesser grade of stereotyped behavior, without increased excitability) and reverse tolerance (ie, prominent stereotyped behavior and heightened startle response upon late amphetamine challenges). METHODS: After initial application (initial single dose-regimen), amphetamine (10 mg/kg, ip) was given once daily till d 5 ( continuous administration-regimen), and thereafter on d 8, 16, and 46 (intermittent administration regimen). For stereotyped behavior and heightened startle response the observation period was 120 min after amphetamine application, and each animal was observed for 10 s in 5 min intervals. Pentadecapeptide BPC 157 (10 μg/kg or 10 ng/kg, ip) or saline (5.0 mL/kg, ip) were given only at the beginning of the experiment, simultaneously with the initial dose of amphetamine. RESULTS: In relation to | Predrag SIKIRIC, Nikola JELOVAC, Andjelka JELOVAC-GJELDUM, Goran DODIG, Mario STARESINIC, Tornislav ANIC, Ivan ZORICIC, Davor RAK, Darko PEROVIC, Gorana ARALICA, Gojko BULJAT, Ingrid PRKACEV, Martina LOVRIC-BENCIC, Jadranka SEPAROVIC, Sven SEIWERTH, Rudolf RUCMAN, Marijan PETEK, Branko TURKOVIC, Tihomil ZIGER, AJenka BOBAN-BLAGAIC, Vlado BEDEKOVIC, Ante TONKIC, Slaven BABIC ( Department of Pharmacology, Medical Faculty University of Zagreb, Croatia) | 2002 | Acta Pharmacologica Sinica2002，23，5： | 2 |
| 2 | Celiac disease: From pathophysiology to treatment显示文摘Celiac disease, also known as 'celiac sprue', is a chronic inflammatory disorder of the small intestine, produced by the ingestion of dietary gluten products in susceptible people. It is a multifactorial disease, including genetic and environmental factors. Environmental trigger is represented by gluten while the genetic predisposition has been identified in the major histocompatibility complex region. Celiac disease is not a rare disorder like previously thought, with a global prevalence around 1%. The reason of its under-recognition is mainly referable to the fact that about half of affected people do not have the classic gastrointestinal symptoms, but they present nonspecific manifestations of nutritional deficiency or have no symptoms at all. Here we review the most recent data concerning epidemiology, pathogenesis, clinical presentation, available diagnostic tests and therapeutic management of celiac disease. | Ilaria Parzanese Dorina Qehajaj Federica Patrinicola Merica Aralica Maurizio Chiriva-Internati Sanja Stifter Luca Elli Fabio Grizzi | 2017 | World Journal of Gastrointestinal Pathophysiology2017，8，2： | 1 |
| 3 | miR-106a overexpressionand pRB downregulation in sporadic colorectal cancer显示文摘 | Catcla I T Aralica G Cacev T | 2013 | ExpMol Pathol2013，94，1： | 1 |
| 4 | BPC-157,一种胃十五肽的抗焦虑作用:休克探查/埋藏试验和明暗试验(英文)显示文摘AIM: To study anxiolytic effect of a gastric pentade-capeptide, BPC-157. METHODS: In shock probe/burying test, pentadecapeptide BPC-157 (10 μg/kg, 10ng/kg, ip), diazepam (0.075, 0.0375 mg/kg, ip),and an equivolume of saline (5 mL/kg, ip) were givenat 30 min prior test. In light/dark test, the same dosageof diazepam, BPC-157, and saline were given at 45 minPrior procedure. RESULTS: Shock probe/buryingtest: rats treated with either diazepam or pentadecapeptideBPC-157 were much less afraid after the shock: | Predrag SIKIRIC Nikola JELOVAC Andjelka JELOVAC-GJELDUM Goran DODIG Mario STARESINIC Tomislav ANIC Ivan ZORICIC Darko PEROVIC Gorana ARALICA Gojko BULJAT Ingrid PRKACIN Martina LOVRIC-BENCIC Jadranka SEPAROVIC Sven SEIWERTH Rudolf RUCMAN Marijan PETEK Branko TURKOVIC Tihomil ZIGER | 2001 | Acta Pharmacologica Sinica2001，22，3： | 1 |
| 5 | miR-106a overexpression and pRB downregulation in sporadic colorectal cancer显示文摘 | T. Catela Ivkovic G. Aralica T. Cacev B. Loncar S. Kapitanovic | 2013 | Experimental and Molecular Pathology2013，，： | 1 |
| 6 | Effect of unilateral ureteral obstruction and anti-angiotensin II treatment on renal tubule cell apoptosis andinterstitial fibrosis in rats显示文摘 | Radovi N Aralica G Ljubanovi D G | 2014 | Coll Antropol2014，38，2： | 1 |
| 7 | miR-106a overex-pression and pRB downregulation in sporadic colorectal cancer显示文摘 | Catela IT Aralica G Cacev T | | 0，，01： | 1 |
| 8 | miR-106a overex-pression and pRB downregulation in sporadic colorectal cancer显示文摘 | Catela IT Aralica G Cacev T | | 0，，01： | 1 |
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