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| 1 | Role of mi RNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer显示文摘Alterations in epigenetic control of gene expression play an important role in many diseases, including gastric cancer. Many studies have identified a large number of upregulated oncogenic mi RNAs and downregulated tumour-suppressor mi RNAs in this type of cancer. In this review, we provide an overview of the role of mi RNAs, pointing to their potential to be useful as diagnostic and/or prognostic biomarkers in gastric cancer. Moreover, we discuss the influence of polymorphisms and epigenetic modifications on mi RNA activity. | Kelly Cristina da Silva Oliveira Taíssa Maíra Thomaz Araújo Camila Inagaki Albuquerque Gabriela Alcantara Barata Carolina Oliveira Gigek Mariana Ferreira Leal Fernanda Wisnieski Fernando Augusto Rodrigues Mello Junior André Salim Khayat Paulo Pimentel de Assumpcao Rommel Mário Rodriguez Burbano Marília Cardoso Smith Danielle Queiroz Calcagno | 2016 | World Journal of Gastroenterology2016，22，35： | 11 |
| 2 | Insights into gastric neuroendocrine tumors burden显示文摘Type 1 gastric neuroendocrine tumors(g NETs)are usually small lesions,restricted to mucosal and sub-mucosal layers of corpus and fundus,with low aggressive behavior,for the majority of cases.Nevertheless,some cases present aggressive behavior.The increasing incidence of g NETs brings together a new relevant problem:how to identify potentially aggressive type 1 g NETs.The challenging problem seems to be finding out signs or features able to predict potentially aggressive cases,allowing a tailored approach,since the involved societies dedicated to provide guidelines for management of these neoplasms apparently failed in producing staging systems able to accurately predict prognosis of these tumors.Additionally,it is also important to try to find out explanations for increasing incidence,as well as to identify potential targets aiming to reach better control of this neoplasia.Here,we discuss potential pathways implicated in aggressive behavior,as well as new strategies to improve clinical management of these tumors. | Taíssa Maíra Thomaz Araújo Williams Fernandes Barra André Salim Khayat Paulo Pimentel de Assumpcao | 2017 | Chinese Journal of Cancer Research2017，29，2： | 7 |
| 3 | Plasticity of repetitive DNA sequences within a bacterial ( type IV ) secretion system component 显示文摘 | Aras RA Fischer W Perez GI | 2003 | J Exp Med2003，198，： | 1 |
| 4 | The effects of Roux-en-Y limb length on gastric emptying and enterogastric reflux in rats显示文摘 | Dutra RA Araújo WM Andrade JI | | 0，，02： | 1 |
| 5 | Plasticity of repetitive DNA sequences within a bacterial (type Ⅳ) secretion system component显示文摘 | Aras RA Fischer W Perez-Perez GI | 2003 | J Exp Med2003，198，： | 1 |
| 6 | Single-session use of mineral trioxide aggregate as an apical barrier in a case of external root resorption 显示文摘 | Ara u jo RA Silveira CF Cunha RS | 2010 | J Oral Sci2010，52，2： | 1 |
| 7 | Effectiveness of rotary and hand files in gutta-percha and sealer removal using chloroform or chlorhexidine gel显示文摘 | Bueno CE Delboni MG de Araújo RA | 2006 | Braz Dent J2006，17，2： | 1 |
| 8 | Molecular typing and antifungal susceptibility of Trichophyton rubrum isolates from patients with onychomycosis pre-and post-treatment显示文摘 | de Assis Santos D de Carvalho Araújo RA Kohler LM | | 0，，05： | 1 |
| 9 | Helicobacter pylori and autoimmune diseases显示文摘 | Carolina Faria Raed Zakout Mascarenhas Araújo | 2012 | Biomedicine & Pharmacotherapy2012，，： | 1 |
| 10 | Evolutionary history of hrgA,which replaces the restriction gene hpyⅢR in the hpyⅢR locus of Helicobacter pylori显示文摘 | ANDO T ARAS RA KUSUGAMI K | 2003 | J Bacteriol2003，185，1： | 1 |
| 11 | Inhibitory effect of organic acids upon meat spoilage bacteria显示文摘 | Ouat ara B Simard RE Hol ey RA | | 0，，： | 1 |
| 12 | Trichophyton rubrum and Trichophyton interdigitale: genetic diversity among species and strains by random amplified polymorphic DNA method显示文摘 | Santos DA Araújo RA Hamdan JS | 2010 | Mycopathologia2010，169，4： | 1 |
| 13 | Identification of IL11RA and MELK amplification in gastric cancer by comprehensive genomic profiling of gastric cancer cell lines显示文摘AIM To identify common copy number alterations on gastric cancer cell lines.METHODS Four gastric cancer cell lines(ACP02, ACP03, AGP01 and PG100) underwent chromosomal comparative genome hybridization and array comparative genome hybridization. We also confirmed the results by fluorescence in situ hybridization analysis using the bacterial artificial chromosome clone and quantitative real time PCR analysis.RESULTS The amplification of 9p13.3 was detected in all cell lines by both methodologies. An increase in the copy number of 9p13.3 was also confirmed by fluorescence in situ hybridization analysis. Moreover, the interleukin 11 receptor alpha(IL11RA) and maternal embryonic leucine zipper kinase(MELK) genes, which are present in the 9p13.3 amplicon, revealed gains of the MELK gene in all the cell lines studied. Additionally, a gain in the copy number of IL11 RA and MELK was observed in 19.1%(13/68) and 55.9%(38/68) of primary gastric adenocarcinoma samples, respectively. CONCLUSION The characterization of a small gain region at 9p13.3 in gastric cancer cell lines and primary gastric adenocarcinoma samples has revealed MELK as a candidate target gene that is possibly related to the development of gastric cancer. | Danielle Queiroz Calcagno Sylvia Santomi Takeno Carolina Oliveira Gigek Mariana Ferreira Leal Fernanda Wisnieski Elizabeth Suchi Chen Taíssa Maíra Thomaz Araújo Eleonidas Moura Lima Maria Isabel Melaragno Samia Demachki Paulo Pimentel Assumpcao Rommel Rodriguez Burbano Marília Cardoso Smith | 2016 | World Journal of Gastroenterology2016，22，43： | 0 |
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