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| 1 | Association of glypican-3 expression with growth signaling molecules in hepatocellular carcinoma显示文摘AIM:To clarify the association of glypican-3(GPC3)expression with Wnt and other growth signaling molecules in hepatocellular carcinoma(HCC). METHODS:Expression of GPC3,Wnt,matrix metalloproteinases(MMPs),sulfatase(SULF)1,SULF2,and other growth signaling molecules was analyzed in HCC cell lines and tissue samples by real-time reverse transcriptionpolymerase chain reaction,immunoblotting,and/or immunostaining.Expression of various genes in GPC3 siRNA-transfected HCC cells was analyzed. RESULTS:GPC3 was overexpressed in most HCCs at mRNA and protein levels and its serum levels weresignificantly higher in patients with HCC than in non- HCC subjects(P<0.05).Altered expressions of various MMPs and growth signaling molecules,some of which were correlated with GPC3 expression,were observed in HCCs.Down-regulation of GPC3 expression by siRNA in GPC3-overexpressing HCC cell lines resulted in a significant decrease in expressions of MMP2,MMP14,fibroblast growth factor receptor 1,insulin-like growth factor 1 receptor.GPC3 expression was significantly correlated with nuclear/cytoplasmic localization ofβ-catenin. CONCLUSION:These results suggest that GPC3,in conjunction with MMPs and growth signaling molecules, might play an important role in the progression of HCC. | Noriyuki Akutsu Hiroyuki Yamamoto Shigeru Sasaki Hiroaki Taniguchi Yoshiaki Arimura Kohzoh Imai Yasuhisa Shinomura | 2010 | World Journal of Gastroenterology2010，16，28： | 20 |
| 2 | Local recurrence is an important prognostic factor of hepatocellular carcinoma显示文摘AIM: To clarify the importance of complete treatment by PEIT.METHODS: A total of 140 previously untreated cases of HCC were enrolled in this study from 1988 to 2002. The inclusion criteria were: a solitary tumor less than 4 cm in diameter or multiple tumors, fewer than four in number and less than 3 cm in diameter, without extrahepatic metastasis or vessel invasion. As general principles for the treatment of HCC, the patients underwent transcatheter arterial chemoembolization (TACE) prior to PEIT. After the initial treatment of the patients,ultrasonography and computed tomography were performed, and measurement of serum levels of α-fetoprotein (AFP) was determined. When tumor recurrences were detected, PEIT and/or TACE were repeated whenever the hepatic functional reserve of the patient permitted. We then analyzed the variables that could influence prognosis, including tumor size and number, the serum levels of AFP, the parameters of hepatic function (albumin, bilirubin, ALT, hepaplastin test,platelet number, and indocyanine green retention at 15min [ICG-R15]), combined therapy with TACE, distant recurrence, and local recurrence.RESULTS: Univariate analysis identified the ICG test,serum levels of AFP and albumin, tumor size and number,and local recurrence, but not distant recurrence, as significant prognostic variables. In multivariate analysis using those five parameters, the ICG test, tumor size, tumor number,and local recurrence were identified as significant prognostic factors. In both univariate and multivariate analyses, the relative risk for the ICG test was the highest, followed by local recurrence.CONCLUSION: We found that local recurrence is an independent prognostic factor of HCC, indicating that achieving complete treatment for HCC on first treatment is important for improving the prognosis of patients with HCC. | Eiichirou Arimura Kazuhiro Kotoh Makoto Nakamuta Shusuke Morizono Munechika Enjoji Hajime Nawata | 2005 | World Journal of Gastroenterology2005，11，36： | 7 |
| 3 | Scattered and rapid intrahepatic recurrences after radio frequency ablation for hepatocellular carcinoma显示文摘AIM: To evaluate a series of patients with hepatocellular carcinoma (HCC) treated with several different protocols and devices.METHODS: We treated 138 patients [chronic hepatitis/liver cirrhosis (Child-Pugh A/B/C), 3/135 (107/25/3)]with two different devices and protocols: cool-tip needle [initial ablation at 60 W (standard method) (n=37)or at 40 W (modified method) (n = 28)] or; ablation with a LeVeen needle using a standard single-step, full expansion (single-step) method (n = 39) or a multi-step,incremental expansion (multi-step) method.RESULTS: Eleven patients experienced rapid and scattered recurrences 1 to 7 mo after the ablation. Nine patients were treated by the cool-tip original protocol (60 W) (9/37=24%) and the other two by the LeVeen single-step method (2/39=5%). The location of the recurrence was surrounding and limited to the site of ablation segment in three cases, and spread over one lobule or both lobules in the other eight cases. There was no recurrence in the patients treated with the modified cool-tip modified method (40 W) or the LeVeen multi-step method.CONCLUSION: There is a risk of rapid and scattered recurrence after RFA, especially when the standard cooltip procedure is used. Because such recurrence would worsen the prognosis, we recommend that modified protocols for the cool-tip and LeVeen needle methods should be used in clinical practice. | Kazuhiro Kotoh Munechika Enjoji Eiichirou Arimura Shusuke Morizono Motoyuki Kohjima Hironori Sakai Makoto Nakamuta | 2005 | World Journal of Gastroenterology2005，11，43： | 7 |
| 4 | Genetic and epigenetic characteristics of gastric cancers with JC virus T-antigen显示文摘AIM:To clarify the significance of JC virus(JCV)T-antigen (T-Ag)expression in human gastric cancer. METHODS:We investigated the relationship between T-Ag detected by immunohistochemistry and Epstein- Barr virus(EBV)infection,microsatellite instability (MSI),and genetic and epigenetic alterations in gastric cancers.Mutations in the p53,β-catenin,KRAS,BRAF, PIK3CA genes were analyzed by polymerase chain reaction(PCR)-single strand conformation polymorphism and DNA sequencing.Allelic losses were determined by PCR at 7 microsatellite loci.Aberrant DNA methylation was analyzed by MethyLight assay. RESULTS:JCV T-Ag protein expression was found in 49%of 90 gastric cancer tissues.T-Ag positivity was not correlated with clinicopathological characteristics. T-Ag expression was detected in a similar percentage of EBV positive cancers(4 of 9,44%)and EBV negativecancers(35 of 73,48%).T-Ag expression was detected in a significantly lower percentage of MSI-H cancers (14%)than in non MSI-H cancers(55%,P=0.005). T-Ag expression was detected in a significantly higher percentage of cancers with nuclear/cytoplasmic localization of catenin(15 of 21,71%)than in cancers without(42%,P=0.018).p53 mutations were detected in a significantly lower percentage of T-Ag positive cancers(32%)than in T-Ag negative cancers(57%,P= 0.018).T-Ag positive gastric cancers showed a significant increase in the allelic losses and aberrant methylation compared with T-Ag negative gastric cancers(P=0.008 and P=0.003). CONCLUSION:The results suggest that JCV T-Ag is involved in gastric carcinogenesis through multiple mechanisms of genetic and epigenetic alterations. | Satoshi Yamaoka Hiroyuki Yamamoto Katsuhiko Nosho Hiroaki Taniguchi Yasushi Adachi Shigeru Sasaki Yoshiaki Arimura Kohzoh Imai Yasuhisa Shinomura | 2009 | World Journal of Gastroenterology2009，15，44： | 3 |
| 5 | C-reactive protein induces high-mobility group box-1 protein release through activation of p38MAPK in macrophage RAW264.7 cells显示文摘 | Ko-ichi Kawahara Kamal Krishna Biswas Masako Unoshima Takashi Ito Kiyoshi Kikuchi Yoko Morimoto Masahiro Iwata Salunya Tancharoen Yoko Oyama Kazunori Takenouchi Yuko Nawa Noboru Arimura Meng Xiao Jie Binita Shrestha Naoki Miura Toshiaki Shimizu Kentaro Me | 2008 | Cardiovascular Pathology2008，，3： | 3 |
| 6 | Heparin bridge therapy and post-polypectomy bleeding显示文摘AIM To identify risk factors for post-polypectomy bleeding(PPB), focusing on antithrombotic agents. METHODS This was a case-control study based on medical records at a single center. PPB was defined as bleeding that occurred 6 h to 10 d after colonoscopic polypectomy and required endoscopic hemostasis. As risk factors for PPB, patient-related factors including anticoagulants, antiplatelets and heparin bridge therapy as well as polyp- and procedure-related factors were evaluated. All colonoscopic hot polypectomies, endoscopic mucosal resections and endoscopic submucosal dissections performed between January 2011 and December 2014 were reviewed. RESULTS PPB occurred in 29(3.7%) of 788 polypectomies performed during the study period. Antiplatelet or anticoagulant agents were prescribed for 210(26.6%)patients and were ceased before polypectomy except for aspirin and cilostazol in 19 cases. Bridging therapy using intravenous unfractionated heparin was adopted for 73 patients. The univariate analysis revealed that anticoagulants, heparin bridge, and anticoagulants plus heparin bridge were significantly associated with PPB(P < 0.0001) whereas antiplatelets and antiplatelets plus heparin were not. None of the other factors including age, gender, location, size, shape, number of resected polyps, prophylactic clipping and resection method were correlated with PPB. The multivariate analysis demonstrated that anticoagulants and anticoagulants plus heparin bridge therapy were significant risk factors for PPB(P < 0.0001). Of the 29 PPB cases, 4 required transfusions and none required surgery. A thromboembolic event occurred in a patient who took anticoagulant. CONCLUSION Patients taking anticoagulants have an increased risk of PPB, even if the anticoagulants are interrupted before polypectomy. Heparin-bridge therapy might be responsible for the increased PPB in patients taking anticoagulants. | Toshiyuki Kubo Kentaro Yamashita Kei Onodera Tomoya Iida Yoshiaki Arimura Masanori Nojima Hiroshi Nakase | 2016 | World Journal of Gastroenterology2016，22，45： | 2 |
| 7 | Performances of glaucoma operations with Kahook Dual Blade or iStent combined with phacoemulsification in Japanese open angle glaucoma patients显示文摘AIM:To compare surgical outcomes of phacoemulsification combined with glaucoma surgical techniques performed with either Kahook Dual Blade(KDB)or iStent for Japanese patients with either primary open angle glaucoma or exfoliation glaucoma.METHODS:We retrospectively evaluated the surgical outcomes of 129 eyes of 84 Japanese patients with glaucoma who underwent KDB or 44 eyes of 34 patients who underwent phacoemulsification with iStent procedures combined with cataract surgery.The primary outcome was surgical success or failure[with surgical failure being indicated by<20%reduction from preoperative intraocular pressure(IOP)or IOP>18 mm Hg as criterion A;IOP>14 mm Hg as criterion B on two consecutive study visits;or reoperation requirement].In addition,we assessed the number of postoperative glaucoma medications and the resulting complications.RESULTS:The probability of success was significantly higher in the KDB group than in the iStent group for criterion A(60.2%vs 46.4%,P=0.019).In the KDB group,the mean preoperative IOP of 19.8±7.3 mm Hg decreased significantly to 13.0±3.1 mm Hg(P<0.01),and the mean number of glaucoma medications at 2.5±1.4 decreased significantly to 1.6±1.6(P<0.01)12 mo postoperatively.In the iStent group,the mean preoperative IOP of 17.8±2.9 mm Hg significantly decreased to 14.3±2.3 mm Hg(P<0.01),and the mean number of glaucoma medications at 2.2±1.1 decreased significantly to 0.9±1.4(P<0.01)12 mo postoperatively.The overall IOP reduction percentage was higher in the KDB group(26.2%)than in the iStent group(19.0%)12 mo postoperatively(P=0.03).Hyphema occurred significantly more frequently in the KDB group(16.3%)than in the iStent group(2.3%,P=0.017).CONCLUSION:KDB and iStent procedures combined with cataract surgery both result in significant IOP and glaucoma medication reductions after the 12-month followup.The patients in the KDB group have a higher success rate for the target IOP of less than 18 mm Hg and a higher complication rate than those in the iStent group. | Kentaro Iwasaki Yoshihiro Takamura Yusuke Orii Shogo Arimura Masaru Inatani | 2020 | International Journal of Ophthalmology(English edition)2020，13，6： | 2 |
| 8 | Endoscopic submucosal dissection is superior to conventional endoscopic resection as a curative treatment for early squamous cell carcinoma of the esophagus (with video)显示文摘 | Hiroaki Takahashi Yoshiaki Arimura Hosokawa Masao Satoshi Okahara Tokuma Tanuma Junichi Kodaira Hidetoshi Kagaya Yuichi Shimizu Kaku Hokari Hiroyuki Tsukagoshi Yasuhisa Shinomura Masahiro Fujita | 2010 | Gastrointestinal Endoscopy2010，，2： | 2 |
| 9 | Sc(OTf)3- and TfOH-catalyzed baeyer-villiger oxidation of carbonyl compounds with m-chloroperbenzoic acid显示文摘 | Kotsuki H Arimura K Araki T | 1999 | Synlett1999，，4： | 2 |
| 10 | Isolation of a novel 38 residue-hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cells显示文摘 | Miyata A Arimura A Dahl R R | 1989 | Biochem Biophys Res Commun1989，164，1： | 1 |
| 11 | PACAP:the road to discovery显示文摘 | Arimura A | 2007 | Peptides2007，28，： | 1 |
| 12 | Myelin-associated gly- coprotein inhibits micretubule assembly by a Rho-kinase-dependent mechanism显示文摘 | Mimura F Yamagishi S Arimura N | 2006 | J Biol Chem2006，281，15： | 1 |
| 13 | Elevated plasma pmcoagulant and fibrinolytic markers in patients with chronic obstructive pulmonary disease显示文摘 | Ashitani J Mukae H Arimura Y | 2002 | Intern Med2002，41，： | 1 |
| 14 | Serum concentration of IL-5,GM-CSF and IL-3 and the production by lymphocytes in various eosinophi显示文摘 | Enodihara H Arimura H | 1995 | Am J Hematology1995，50，2： | 1 |
| 15 | Isolation ofa novel 38 residue-hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cells显示文摘 | Miyata A Arimura A Dahl RR | 1989 | Biochem Biophys Res Commun1989，164，1： | 1 |
| 16 | Production of L-lactic acid from corncob显示文摘 | Shigenobu Miura Tomohiro Arimura Noriaki Itoda | 2004 | Journal of Bioscience and Bioengineering2004，97，3： | 1 |
| 17 | Pituitary adenylate cyclase activating polypeptide (PACAP) and its receptors: neuroendocrine and endocrine interaction显示文摘 | Shioda S | 1995 | Front Neuroendocrinol1995，16，： | 1 |
| 18 | Rescue of photoreceptors from the damaging effects of constant light by midkine, a retinoic acid-responsive gene product 显示文摘 | Unoki K Ohba N Arimura H Muramatsu H Muramatsu T | 1994 | Invest Ophthalmol Vis Sci1994，35，12： | 1 |
| 19 | Nomenclature of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide显示文摘 | Harmar AJ Arimura A Gozes I | 1998 | Pharmacol Rev1998，50，2： | 1 |
| 20 | ! Pituitary adenylate cyclase activating polypeptide(PACAP)and its receptors:neuroendocrine and endocrine interaction显示文摘 | Arimura A Shioda S | 1995 | Front Neuroendocrinol1995，16，1： | 1 |
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