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| 1 | Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner显示文摘遇到 hypoxic 应力的房间由 downregulating 保存资源和精力蛋白质合成。这里我们 demonstratethat 在这回答的一机制是最高的 mRNAs 的翻译压抑编码 translationalapparatus 的部件。规定的这个模式包含 TSC 和 Rheb,当 Rheb 的 TSC1 或 TSC2 或 overexpression 的大美人在剥夺氧的房间救了最高的 mRNA 翻译。导致压力的翻译 repressionof 这些 mRNAs 密切与 4E-BP 的 hypophosphorylated 状态相关,一个翻译抑压者。然而, seriesof 4E-BP loss-of-function 和 gain-of-function 实验在氧或生长因素剥夺下面反驳在 phosphorylation statusof 4E-BP 和最高的 mRNAs 的翻译压抑之间的一种 cause-and-effect 关系。而且,血缺氧的 repressiveeffect 类似于由 Torin 1,而是更多 pronouncedthan 猛禽或 rictor 大美人由 mTOR 活动的有效抑制到达了那。同样,猛禽或 rictor 的缺乏它温和地 downregulated TOPmRNAs 的基础翻译效率,没能压制最高的 mRNAs 的调停氧的翻译激活。最后, TIA-1 和 TIAR co 击倒,二 RNA 有约束力的蛋白质以前在氨基的酸饥饿的房间在最高的 mRNAs 的翻译压抑含有, failedto 在另外的压力条件下面减轻最高的 mRNA 翻译。因此,近似翻译管理者 ofTOP mRNAs 的性质留下逃犯。 | Rachel Miloslavski Elad Cohen Adam Avraham Yifat I luz Zvi Hayouka Judith Kasir Rajini Mudhasani Stephen N. Jones Nadine Cybulski Markus A. Ruegg Ola Larsson Valentina Gandin Arjuna Rajakumar Ivan Topisirovic Oded Meyuhas | 2014 | Journal of Molecular Cell Biology2014，8，3： | 3 |
| 2 | Influence of non‐alcoholic fatty liver disease on the development of diabetes mellitus显示文摘 | Anuradhani Kasturiratne Sanjaya Weerasinghe Anuradha S Dassanayake Shaman Rajindrajith Arjuna P Silva Norihiro Kato A Rajitha Wickremasinghe H Janaka Silva | 2012 | J Gastroenterol Hepatol2012，，1： | 2 |
| 3 | Trafficking of osteonectin by retinal pigmentepithelial cells: Evidence for basolateral secre- tion显示文摘 | Arjuna R Paraoan L Nelson G | 2007 | The Interntional Journl of Biochemistry &Cell Biology2007，39，1： | 1 |
| 4 | Genetic associations of inflammatory bowel disease in a South Asian population显示文摘AIM To estimate prevalence and phenotypic associations of selected inflammatory bowel disease(IBD)-associated genetic variants among Sri Lankan patients. METHODS A case study of histologically confirmed ulcerative colitis(UC) or Crohn's disease(CD) patients with ≥ 1 year disease duration, who were compared to unrelated, gender-matched, healthy individuals as controls, was conducted at four major centers in Sri Lanka. Phenotypic data of the cases were obtained and all participants were genotyped for 16 selected genetic variants: IL12 B :rs1045431, IL23 R :rs11805303, ARPC2 :rs12612347, IRGM :rs13361189, IL26/IL22 :rs1558744, CDH1 :rs1728785, IL10 :rs3024505, FCGR2 A :rs3737240, PTGER4 :rs4613763, IL17 REL/PIM3 :rs5771069, HNF4 a :rs6017342, STAT3 :rs744166, SMURF1 :rs7809799, LAMB1 :rs886774, HLA-DRB5, DQA1, DRB1, DRA :rs9268853, MST1, UBA7, and APEH :rs9822268. The genotypes of all variants were in Hardy-Weinberg Equilibrium(P > 10^(-3)). To account for multiple hypothesis testing, P-values < 0.003 were considered significant.RESULTS A total of 415 patients and 465 controls were recruited. Out of the single nucleotide polymorphisms(SNPs) tested, the majority were not associated with IBD in Sri Lankans. Significant positive associations were noted between rs886774(LAMB1-gene) and UC(odds ratio(OR) = 1.42, P = 0.001). UC patients with rs886774 had mild disease(OR = 1.66, P < 0.001) and remained in remission(OR = 1.48, P < 0.001). A positive association was noted between rs10045431(IL 12 B gene) and upper gastrointestinal involvement in CD(OR = 4.76, P = 0.002). CONCLUSION This confirms the heterogeneity of allelic mutations in South Asians compared to Caucasians. Most SNPs and disease associations reported here have not been described in South Asians. | Madunil Anuk Niriella Isurujith Kongala Liyanage Senerath Kuleesha Kodisinghe Arjuna Priyadarsin De Silva Nimna Rajapakshe Sunali D Nanayakkara Dunya Luke Thilakshi Silva Metthananda Nawarathne Ranjith K Peiris Udaya P Kalubovila Sujeewa R Kumarasena Vajira Harshadeva Weerabaddana Dissanayake Rohan W Jayasekara Hithanadura Janaka de Silva | 2018 | World Journal of Clinical Cases2018，6，15： | 1 |
| 5 | Role of zirconium and impurities in grain refinement ofaluminium with Al-Ti-B显示文摘 | Arjuna Rao A Murty B S | 1997 | Materials Science and Technology1997，，13： | 1 |
| 6 | RoadBoundary detection and tracking using ladar sensing显示文摘 | Wijesoma W S Kodagoda K R S Balasuriya Arjuna P | 2004 | IEEE Transactions on Robotics and Automation2004，20，3： | 1 |
| 7 | Usage of complementary and alternative medicine among patients with chronic kidney disease on maintenance hemodialysis 显示文摘 | ARJUNA RAO A S PHANEENDRA D PAVANI CHD | 2016 | J Pharm Bioallied Sci2016，8，1： | 1 |
| 8 | Influence of chromium and impurities on the grain-refining behavior of aluminum显示文摘 | ARJUNA RAO A MURTY B CHAKRABORTY M | | 0，，： | 1 |
| 9 | Role of zirconium and impurities in grain refinement of aluminium with Al-Ti-B显示文摘 | ARJUNA RAO A MURTY B S CHAKRABORTY M | | 0，，09： | 1 |
| 10 | Road boundary Detection and tracking using ladar sensing显示文摘 | WIJESOMAW W S KODAGODA K R S ARJUNA P B | 2004 | IEEE Trans on Robotics and Automation2004，20，3： | 1 |
| 11 | Hypoxia induces myocyte-dependent COX-2 regulation in endothelial cells:role of VEGF显示文摘 | Wu GF Arjuna PM Wu JP | 2003 | Am J Physiol Heart Circ Physiol2003，285，： | 1 |
| 12 | Roadboundary detection and tracking using ladar sensing 显示文摘 | Wijesoma W S Kodagoda K R S Balasuriya Arjuna P | 2004 | IEEE Transactions on Robotics and Automation2004，20，3： | 1 |
| 13 | 2D space–time wave-digital multi-fan filter banks for signals consisting of multiple plane waves显示文摘 | Nilanka Rajapaksha Arjuna Madanayake Leonard T. Bruton | 2014 | Multidimensional Systems and Signal Processing2014，，1： | 1 |
| 14 | Effect of hot rolling on the g rain refining efficiency of Al-Ti and Al-Ti-B master alloys显示文摘 | PRASAD K V S ARJUNA R A DUTTA R S | 1994 | Ⅱ FTrans1994，，4： | 1 |
| 15 | A novel 5.8<ce:hsp sp='0.25'/>GHz quasi-lumped element resonator antenna显示文摘 | Mohd F. Ain Seyi S. Olokede Yazeed M. Qasaymeh Arjuna Marzuki Julie J. Mohammed Srimala Sreekantan Sabar D. Hutagalung Zainal A. Ahmad Mohd Z. Abdulla | 2013 | AEUE - International Journal of Electronics and Communications2013，，7： | 1 |
| 16 | Robotic Partial Nephrectomy with Superselective Versus Main Artery Clamping: A Retrospective Comparison显示文摘 | Mihir M. Desai Andre Luis de Castro Abreu Scott Leslie Jei Cai Eric Yi-Hsiu Huang Pierre-Marie Lewandowski Dennis Lee Arjuna Dharmaraja Andre K. Berger Alvin Goh Osamu Ukimura Monish Aron Inderbir S. Gill | 2014 | European Urology2014，，： | 1 |
| 17 | Autonomous Adaptive EnvironmentalAssessment and Feature Tracking viaAutono-mous Underwater Vehicles显示文摘 | Stephanie Petillo Arjuna Bala suriya Henrik Schmidt | 2010 | OCEANS2010，，： | 1 |
| 18 | Influence of chromium and impurities on the grain- refining behavior of aluminum显示文摘 | A. Arjuna Rao B. S. Murty M. Chakraborty | 1996 | Metallurgical and Materials Transactions A1996，，3： | 1 |
| 19 | Vision Based Data Fusion for Autonomous Vehicles Target Tracking Using Interacting Multiple Dynamic Models显示文摘 | Zhen Jia Arjuna Balasuriya | 2008 | Computer Vision and Image Understanding2008，109，1： | 1 |
| 20 | Vision based data fusion for autonomous vehicles target tracking using interacting multiple dynamic models显示文摘 | JIA Zhen BALASURIYA Arjuna CHALLA Subhash | 2008 | Computer Vision and Image Understanding2008，109，1： | 1 |
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