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| 1 | Association of human leukocyte antigen DQB1 and DRB1 alleles with chronic hepatitis B显示文摘AIM: To investigate the effect of human leukocyte antigen(HLA) DRB1 and DQB1 alleles on the inactive and advanced stages of chronic hepatitis B.METHODS: Patient records at a single institution's hepatology clinic were reviewed. Demographic data, laboratory results, endoscopy results, virological parameters, biopsy scores and treatment statuses were recorded. In total, 355 patients were eligible for thestudy, of whom 226(63.7%) were male. Overall, 82(23.1%) were hepatitis B early antigen(HBeAg) positive, 87(24.5%) had cirrhosis, and 66(18.6%) had inactive disease. The presence of DQB1 and DRB1 alleles was determined by polymerase chain reaction with sequence-specific primers. The distribution of the genotyped alleles among patients with cirrhosis and patients with chronic active hepatitis was analyzed.RESULTS: The most frequent HLA DQB1 allele was DQB1*03:01(48.2%), and the most frequent HLA DRB1 allele was DRB1*13/14(51.8%). DQB1*05:01 was more frequent in patients with active disease than in inactive patients(27% vs 9.1%; P = 0.002, Pc = 0.026). DRB1*07 was rare in patients with cirrhosis compared with non-cirrhotics(3.4% vs 16%; P = 0.002, Pc = 0.022). Older age(P < 0.001) and male gender(P = 0.008) were the other factors that affected the presence of cirrhosis. In a multivariate logistic regression analysis, DRB1*07 remained a significant negative predictor of cirrhosis(P = 0.015). A bioinformatics analysis revealed that a polymorphic amino acid sequence in DRB1*07 may alter interaction with the T-cell recognition site.CONCLUSION: This study demonstrates that HLA alleles may influence cirrhosis development and disease activity in Turkish chronic hepatitis B patients. | Levent Doganay Arta Fejzullahu Seyma Katrinli Feruze Yilmaz Enc Oguzhan Ozturk Yasar Colak Celal Ulasoglu Ilyas Tuncer Gizem Dinler Doganay | 2014 | World Journal of Gastroenterology2014，20，25： | 3 |
| 2 | Top of the basilar syndrome and Chagasdisease显示文摘 | Carod Arta! FJ Vargas AP Melo M | 2002 | Rev ''7eurol2002，351，： | 1 |
| 3 | Initial experience of 3 tesla appar-ent diffusion coefficient values in differentiating benign and malig-nant thyroid nodules显示文摘 | Ilica AT Artas H Ayan A | 2013 | J Magn Reson Imaging2013，37，： | 1 |
| 4 | Investigation of ultra-and nanofiltration for utilization of whey protein and lactose显示文摘 | Arta R Vatai G Bekassy-Molnar | 2005 | Journal of Food Engineering2005，67，： | 1 |
| 5 | Optical aberrations of the human cornea as a function of age显示文摘 | Guirao A RedondoM Arta lP | | 0，，： | 1 |
| 6 | Tyrosine kinase inhibitor usage, treatment outcome, and prognostic scores in CML: report from the population-based Swedish CML registry显示文摘 | Martin H?glund Fredrik Sandin Karin Hellstr?m Mats Bj?reman Magnus Bj?rkholm Mats Brune Arta Dreimane Marja Ekblom S?ren Lehmann Per Ljungman Claes Malm Berit Markev?rn Kristina Myhr-Eriksson Lotta Ohm Ulla Olsson-Str?mberg Anders Sj?lander Hans Wadenvik | 2013 | Blood2013，，： | 1 |
| 7 | Scrotal calculi显示文摘 | Artas H Orhan I | | 0，，12： | 1 |
| 8 | Does maintenance/consolidation chemotherapy have a role in the management of small cell lung cancer( SCLC ) ? A meta analysis of the published controlled trials显示文摘 | Bozcuk H Artae M Ozdogan M | 2005 | Cancer2005，104，12： | 1 |
| 9 | Initial experience of 3 tesla ap- parent diffusion coefficient values in differentiating benign and ma- lignant thyroid nodules显示文摘 | Ilica AT Artas H Ayan A | 2013 | J Magn Reson Imaging2013，37，5： | 1 |
| 10 | Investigation of ultra and nanofiltration for utilization of whey protein and lactose显示文摘 | Arta R Vatai G Bekassy-Molnar | 2005 | Journal of Food Engineering2005，67，： | 1 |
| 11 | A Phase I Dose Escala- tion Study of Hypofraetionated IMRT Field- in - Field Boost for Newly Diagnosed Glioblastoma Multiforme显示文摘 | Arta M Monjazeb Deandra Ayala | 2012 | International Jour- nal of Radiation Oncology- Biology - Physics2012，82，2： | 1 |
| 12 | Emg related anxiety and pain:a prospetive study显示文摘 | Schw arta M Benstead Ji | 1999 | Can Jneurd Sci(Canada)1999，26，4： | 1 |
| 13 | Investigating a correlation between the results of transcranial Doppler and the level of nerve growth factor in cerebrospinal fluid of hydrocephalic infants:clinical study显示文摘 | Erol FS Yakar H Artas H | 2009 | Pediatr Neurosurg2009，45，3： | 1 |
| 14 | Value of Glut-1 and Koc markere in the differential diagnosis of reactive mesothelial hyperplasia,malignant mesothelioma and pulmonary adenocarcinoma显示文摘 | Ucer O Dagli A F Kilicarslan A Artas G | 2013 | Turk Patoloji Dergt2013，29，2： | 1 |
| 15 | Scleroglucan compatibility with thickeners, alcohols and polyalcohols and downstream processing implications显示文摘 | Silvana C. Vi?arta Mariana M. Yossen Jorge R. Vega Lucía I.C. Figueroa Julia I. Fari?a | 2013 | Carbohydrate Polymers2013，，2： | 1 |
| 16 | Spontaneous rupture of uterus in midtrimester pregnancy due to increased uterine pressure with previous laparoscopic myomectomy显示文摘 | Kiseli M Artas H Armagan F | 2013 | Int J Fertil Steril2013，7，3： | 1 |
| 17 | Gene methylation of SFRP2, p16, DAPK1, HIC1 and MGMT and KRAS mutations in sporadic coloreclal cancer显示文摘 | Pehlivan S Artae M Sever T | 2010 | Cancer Genet Cytogenet2010，201，2： | 1 |
| 18 | Reverse convertible bonds analyzed显示文摘 | Szymanowska M arta Horst J T Veld C H | 2009 | The Journal of Futures Markets2009，29，10： | 1 |
| 19 | Human behavior and opportunities for parasite transmission in communities surrounding long‐tailed macaque populations in Bali, Indonesia显示文摘 | Kelly E. Lane‐deGraaf I.G.A. Arta Putra I. Nengah Wandia Aida Rompis Hope Hollocher Agustin Fuentes | 2014 | Am. J. Primatol2014，，： | 1 |
| 20 | Use of DNA markers for cereal line uniformity assessment显示文摘 | Dainis Ru?gis Ilze Gaile Ilze Veinberga Sanita Zute Vija Strazdi?a Māra Bleidere Arta Kronberga | 2012 | Proceedings of the Latvian Academy of Sciences Section B Natural Exact and Applied Sciences (-)2012，，1： | 1 |
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