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| 1 | Narrow line between benefit and harm: Additivity of hyperthermia to cisplatin cytotoxicity in different gastrointestinal cancer cells显示文摘AIM To investigate the response to hyperthermia and chemotherapy, analyzing apoptosis, cytotoxicity, and cisplatin concentration in different digestive system cancer cells.METHODS AGS(gastric cancer cell line), Caco-2(colon cancer cell line) and T3M4(pancreatic cancer cell line) were treated by cisplatin and different temperature setting(37 ℃ to 45 ℃) either in isolation, or in combination. Treatment lasted for one hour. 48 h after the treatment viability was evaluated by MTT, cell apoptosis by Annexin V-PE and 7 ADD flow cytometry. Intracellular cisplatin concentration was measured immediately after the treatment, using mass spectrometry. Isobologram analysis was performed to evaluate the mathematical combined effect of temperature and cisplatin.RESULTS AGS cells were the most sensitive to isolated application of hyperthermia. Hyperthermia, in addition to cisplatin treatment, did not provoke a synergistic effect at intervals from 37 ℃ to 41 ℃ in neither cancer cell line. However, a temperature of 43 ℃ enhanced cisplatin cytotoxicity for Caco-2 cells. Moreover, isobologram analysis revealed mathematical antagonistic effects of cisplatin and temperature combined treatment in AGS cells; variations between synergistic, additive, and antagonistic effects in Caco-2 cells; and additive and antagonistic effects in T3 M4 cells. Combined treatment enhanced initiation of cell apoptosis in AGS, Caco-2, and T3 M4 cells by 61%, 20%, and 19% respectively. The increase of intracellular cisplatin concentration was observed at 43 ℃ by 30%, 20%, and 18% in AGS, Caco-2, and T3 M4 cells, respectively.CONCLUSION In addition to cisplatin, hyperthermia up to 43 ℃ does not affect the viability of cancer cells in a synergistic manner. | Vaidotas Cesna Arturas Sukovas Aldona Jasukaitiene Rima Naginiene Giedrius Barauskas Zilvinas Dambrauskas Saulius Paskauskas Antanas Gulbinas | 2018 | World Journal of Gastroenterology2018，24，10： | 6 |
| 2 | Inhibition of the G9a/GLP histone methyltransferase complex modulates anxiety-related behavior in mice显示文摘Epigenetic 基因规定畸形包括精神分裂症和消沉在各种各样的 neuropsychiatric 混乱,以及在心情和焦虑的规定被含有。另外, epigenetic 机制涉及精神病学的药的行动。当前的 anxiolytic 药有新药的重要缺点,和开发被保证。二蛋白质, G9a (也作为 EHMT2 或 KMT1C 知道) 并且 GLP (象 G9a 一样蛋白质,也作为 EHMT1 或 KMT1D 知道) ,它甲醇化物离氨酸 9 histone H3 (H3K9 ) ,能正在答应 anxiolytic 目标。G9a 的出生后的基因大美人减少焦虑相关的行为,与由过去常对待焦虑(amitriptyline, imipramine 和 paroxetine ) 的一些药的 G9a 层次的减小一致。相反地,在有 GLP haplodeficiency 的老鼠有增加的像焦虑的行为。我们寻求了决定是否 G9a/GLP, UNC0642 和 A-366 的二个药理学禁止者,将有类似的效果到基因 G9a/GLP 不足。当予成年老鼠以时,我们发现有任何一个化合物的 G9a/GLP 抑制减少了像焦虑的行为,与在大脑的减少的 H3K9 methylation 一起。相反,到这些的暴露从胚胎的白天加重(E9.5 ) 9.5 增加了像焦虑的行为直到出生并且减少在成人生活的社会相互作用,当 H3K9 methylation 在在成年老鼠的大脑的正常层次时。这些调查结果增强 G9a/GLP 在大脑开发的不同阶段在像焦虑的行为上有不同效果的基因证据,并且建议指向这条 histone methyltransferase 小径能为开发新 anxiolytic 药是有用的。这些数据也建议在 utero 的抗抑郁剂暴露能在成人生活有否定效果,并且这些效果的进一步的调查被保证。 | Dong-yao WANG Joel KOSOWAN James SAMSOM Laura LEUNG Kai-lai ZHANG Ying-xiang LI Yan XIONG Jian JIN Arturas PETRONIS Gabriel OH Albert H C WONG | 2018 | Acta Pharmacologica Sinica2018，39，5： | 4 |
| 3 | Epigenomic Profiling Reveals DNA-Methylation Changes Associated with Major Psychosis显示文摘 | Jonathan Mill Thomas Tang Zachary Kaminsky Tarang Khare Simin Yazdanpanah Luigi Bouchard Peixin Jia Abbas Assadzadeh James Flanagan Axel Schumacher Sun-Chong Wang Arturas Petronis | 2008 | The American Journal of Human Genetics2008，，3： | 1 |
| 4 | Restrictions to carbon dioxide conductance and photosynthesis in spinach leaves recovering from salt stress显示文摘 | Delfine S Artura A Villani C M Loreto F | 1999 | Plant Physiology1999，119，3： | 1 |
| 5 | Comparison of urine and cer- vical samples for detecting human papillomavirus(HPV) with the Co- bas 4800 HPV test显示文摘 | Bemal S Palomares JC Artura A | 2014 | J Clin Virol2014，61，4： | 1 |
| 6 | Epigenetics and twins: three variations on the theme显示文摘 | Arturas Petronis | 2006 | Trends in Genetics2006，，7： | 1 |
| 7 | Epigenetics and complex disease:from etiology to new therapeutics 显示文摘 | CAROLYN P ARTURAS P | 2008 | Annu Rev Pharmacol Toxicol2008，48，： | 1 |
| 8 | Selection of low-e windows in retrofit of public buildings by ap- plying multiple criteria method COPRAS: A Lithuanian case 显示文摘 | Arturas Kaklauskas Edmundas Kazimieras Zavadskas SauliusRaslanas | 2006 | Energy and Building2006，38，5： | 1 |
| 9 | Low-temperature synthesis of lutetium gallium garnet (LGG) using sol-gel technique 显示文摘 | KATELNIKOVAS Arturas KAREIVA Aivaras | 2008 | Mater Lett2008，62，： | 1 |
| 10 | Evaluating the life cycle of a building:a multivariant and multiple criteria app-roach显示文摘 | Nerija B Audrius B Arturas K | 2008 | Omega2008，36，3： | 1 |
| 11 | The Influence Of Knowledge Management On The Competitive Ability Of Lithuanian Enterprises显示文摘 | Edmundas Jasinskas Biruta Svagzdiene Arturas Simana vicius | 2015 | Procedia- Social and Behavioral Sciences2015，，191： | 1 |
| 12 | Method and system for Multi-Attribute Market Value Assessment in analysis of construction and retrofit projects显示文摘 | Kanapeckiene Loreta Kaklauskas Arturas Zavadskas Ed- mundas Kazimieras Raslanas Saulius | 2011 | Expert Systems with Applications v 38 n 112011，2011，： | 1 |
| 13 | Comparison of eobas 4800 human papillomavirus test against acombina- tion of the amplacor human papillomavirus and the linear ar- raytests for detection of HPV types 16 and 18 in cervical samples显示文摘 | Martinez S B Palomares J C Artura A | 2012 | J Virol Methods2012，180，12： | 1 |
| 14 | Experimental Research of the Impact Response of E - Glass Epoxy and carbon epoxy systems 显示文摘 | ARTURAS N ANTANAS Z | 2010 | MA- TERIALS SCIENCE ( MEDZIAGOTYRA)2010，16，4： | 1 |
| 15 | Passive house model for quantitative and qualitative analyses and its intelligent system显示文摘 | Arturas K Jevgenija R Edmundas K Z | 2012 | Energy and Buildings2012，50，7： | 1 |
| 16 | Photo-luminescence in sol-gel-derived YAG: Ce phosphors 显示文摘 | ARTURAS K PRANCI K V PAULIUS P | 2007 | Journal of Crystal Growth2007，304，2： | 1 |
| 17 | AFM based polarization nanolithography on PZT sol-gel films显示文摘 | Valentinas S Arturas U Kestutis N et aI | 2006 | Microelectronic Engineering2006，83，： | 1 |
| 18 | Solid-state lighting: Toward superior illumination 显示文摘 | MICHAEL S S ARTURAS ZUKAUSKAS | 2005 | Proc IEEE2005，93，10： | 1 |
| 19 | Complex leak before break analysis demonstrated on RBMK-1500 austenitic piping 显示文摘 | Arturas Klimasauskas Sigitas Rimkevicius and Linas Nedzinskas | 2003 | International Journal of Pressure Vessels and Piping2003，80，： | 1 |
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