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| 1 | Removal of diminutive colorectal polyps: A prospective randomized clinical trial between cold snare polypectomy and hot forceps biopsy显示文摘AIM To compare the efficacy and safety of cold snare polypectomy(CSP) and hot forceps biopsy(HFB) for diminutive colorectal polyps.METHODS This prospective, randomized single-center clinical trial included consecutive patients ≥ 20 years of age with diminutive colorectal polyps 3-5 mm from December 2014 to October 2015. The primary outcome measures were en-bloc resection(endoscopic evaluation) and complete resection rates(pathological evaluation). The secondary outcome measures were the immediate bleeding or immediate perforation rate after polypectomy, delayed bleeding or delayed perforation rate after polypectomy, use of clipping for bleeding or perforation, and polyp retrieval rate. Prophylactic clipping after polyp removal wasn't routinely performed.RESULTS Two hundred eight patients were randomized into the CSP(102), HFB(106) and 283 polyps were evaluated(CSP: 148, HFB: 135). The en-bloc resection rate was significantly higher with CSP than with HFB [99.3%(147/148) vs 80.0%(108/135), P < 0.0001]. The complete resection rate was significantly higher with CSP than with HFB [80.4%(119/148) vs 47.4%(64/135), P < 0.0001]. The immediate bleeding rate was similar between the groups [8.6%(13/148) vs 8.1%(11/135), P = 1.000], and endoscopic hemostasis with hemoclips was successful in all cases. No cases of perforation or delayed bleeding occurred. The rate of severe tissue injury to the pathological specimen was higher HFB than CSP [52.6%(71/135) vs 1.3%(2/148), P < 0.0001]. Polyp retrieval failure was encountered CSP(7), HFB(2).CONCLUSION CSP is more effective than HFB for resecting diminutive polyps. Further long-term follow-up study is required. | Yoriaki Komeda Hiroshi Kashida Toshiharu Sakurai George Tribonias Kazuki Okamoto Masashi Kono Mitsunari Yamada Teppei Adachi Hiromasa Mine Tomoyuki Nagai Yutaka Asakuma Satoru Hagiwara Shigenaga Matsui Tomohiro Watanabe Masayuki Kitano Takaaki Chikugo Yasutaka Chiba Masatoshi Kudo | 2017 | World Journal of Gastroenterology2017，23，2： | 20 |
| 2 | Efficacy of treatment with rebamipide for endoscopic submucosal dissection-induced ulcers显示文摘AIM:To prospectively compare the healing rates of endoscopic submucosal dissection(ESD)-induced ulcers treated with either a proton-pump inhibitor(PPI)or rebamipide.METHODS:We examined 90 patients with early gastric cancer who had undergone ESD.All patients were administered an intravenous infusion of the PPI lansoprazole(20 mg)every 12 h for 2 d,followed by oral administration of lansoprazole(30 mg/d,5 d).After7-d treatment,the patients were randomly assigned to 2 groups and received either lansoprazole(30 mg/d orally,n=45;PPI group)or rebamipide(300 mg orally,three times a day;n=45;rebamipide group).At 4and 8 wk after ESD,the ulcer outcomes in the 2 groups were compared.RESULTS:No significant differences were noted in patient age,underlying disease,tumor location,Helicobacter pylori infection rate,or ESD-induced ulcersize between the 2 groups.At both 4 and 8 wk,the healing rates of ESD-induced ulcers were similar in the PPI-treated and the rebamipide-treated patients(4 wk:PPI,27.2%;rebamipide,33.3%;P=0.5341;8 wk:PPI,90.9%;rebamipide,93.3%;P=0.6710).At 8 wk,the rates of granulation lesions following ulcer healing were significantly higher in the PPI-treated group(13.6%)than in the rebamipide-treated group(0.0%;P=0.0103).Ulcer-related symptoms were similar in the2 treatment groups at 8 wk.The medication cost of 8-wk treatment with the PPI was 10945 yen vs 4889 yen for rebamipide.No ulcer bleeding or complications due to the drugs were observed in either treatment group.CONCLUSION:The healing rate of ESD-induced ulcers was similar with rebamipide or PPI treatment;however,rebamipide treatment is more cost-effective and prevents granulation lesions following ulcer healing. | Masaki Takayama Shigenaga Matsui Masanori Kawasaki Yutaka Asakuma Toshiharu Sakurai Hiroshi Kashida Masatoshi Kudo | 2013 | World Journal of Gastroenterology2013，19，34： | 15 |
| 3 | NOTES:The question for minimal resection and sentinel node in early gastric cancer显示文摘Surgical therapy for gastric cancer involves both removal of the cancer lesion and complete lymph node dissection.Natural orifice transluminal endoscopic surgery(NOTES) is considered to represent the next revolution in surgery.Many surgeons and endoscopists believe that NOTES may be a superior alternative for early gastric cancer treatment.Sentinel node(SN) navigation surgery for gastric cancer:Single institution results of SN mapping for early gastric cancer are increasingly being considered acceptable.Furthermore,a major large-scale clinical trial of SN mapping for gastric cancer has recently been completed by The Japan Society of SN Navigation Surgery study group.They reported false negative rate of 7.0 while the sensitivity of metastasis detection based on SN status was 93.Combination of SN biopsy and NOTES:This concept was first described by Cahill et al who proved the feasibility of lymphatic mapping and SN biopsy by NOTES.Lymphatic channel filling was immediately observable via the intraperitoneal optics.Partial resection of the stomach by hybrid NOTES:Several centers have already reported gastrectomy assisted by NOTES using the transvaginal route.However,the main problem of full-thickness resection of gastric wall remains endoscopic gastric closure.Establishing an endoscopic suturing method would be an important step toward expanding potential indications.NOTES is met with both enthusiasm and skepticism but will gain its own place as human creativity eventually provides solutions to its technical limitations.In the near future,NOTES can evolve the capacity to complement the existing armamentarium for gastric cancer surgery. | Mitsuhiro Asakuma Ronan A Cahill Sang-Woong Lee Eiji Nomura Nobuhiko Tanigawa | 2010 | World Journal of Gastrointestinal Surgery2010，2，6： | 3 |
| 4 | Laparoscopic and endoscopic cooperative surgery for duodenal tumor resection显示文摘 | Fumitoshi Hirokawa Michihiro Hayashi Yoshiharu Miyamoto Mitsuhiro Asakuma Tetsunosuke Shimizu Koji Komeda Yoshihiro Inoue Eiji Umegaki Kazuhisa Uchiyama | 2014 | Endoscopy2014，，： | 3 |
| 5 | Adrenalectomy using natural orifice translumenal endoscopic surgery (NOTES): A transvaginal retroperitoneal approach显示文摘 | Silvana Perretta Pierre Allemann Mitsuhiro Asakuma Bernard Dallemagne Jacques Marescaux | 2009 | Surgical Endoscopy2009，，6： | 3 |
| 6 | NOTES retroperitoneal transvaginal distal pancreatectomy显示文摘 | Pierre Allemann Silvana Perretta Mitsuhiro Asakuma Bernard Dallemagne Didier Mutter Jacques Marescaux | 2009 | Surgical Endoscopy2009，，4： | 3 |
| 7 | Thermal Analysis of Resin Composites with Ellipsoidal Filler Considering Thermal Boundary Resistance显示文摘The effective thermal conductivity of composites with ellipsoidal fillers is analyzed by using a homogenization method that is able to represent the microstructure precisely.In this study,various parameters such as the volume fraction,shape,and distribution of the filler are quantitatively estimated to understand the mechanisms of heat transfer in the composite.First,thermal boundary resistance between resin and filler is important for obtaining composites with higher thermal conductivity.Second,the anisotropy of the effective thermal conductivity arises from contact between filler in the case of ellipsoidal filler and produces lower thermal resistance.Finally,the filler network and thermal resistance are essential for the heat transfer in composites because the path of thermal conduction is improved by contact between neighboring filler particles. | Yusuke Asakuma Tsuyoshi Yamamoto | 2016 | Journal of Thermal Science2016，25，5： | 2 |
| 8 | Gastric lymphatic mapping for sentinel node biopsy by natural orifice transluminal endoscopic surgery (NOTES)显示文摘 | R. A. Cahill M. Asakuma S. Perretta B. Dallemagne J. Marescaux | 2009 | Surgical Endoscopy2009，，5： | 2 |
| 9 | A Study of Growth Mechanism of KDP and ADP Crystals by Means of Quantum Chemistry显示文摘 | Asakuma Y Li Q Ang H M | 2008 | Applied Surface Science2008，254，： | 1 |
| 10 | Selective Akt inactivation and tumor necrosis factor-related apoptosis-inducing ligand sensitization of renal cancer cells by low concentrations of paclitaxel显示文摘 | Asakuma J Sumitomo M Asano | 2003 | Cancer Res2003，63，6： | 1 |
| 11 | A Study of Growth Mechanism of KDP and ADP Crystals by Means of Quantum Chemistry 显示文摘 | Asakuma Y Li Q Ang H M | 2008 | Applied Suq'ace Science2008，254，： | 1 |
| 12 | Adrena- lectomy using natural orifice translumenal endoscopic surgery (NOTES): a transvaginal retroperitoneal ap- proach显示文摘 | Perretta S Allemann P Asakuma M | 2009 | Surg Endosc2009，23，： | 1 |
| 13 | Theoretical study of transesterification of triglycerides to biodiesel fuel显示文摘 | Asakuma Y Maeda K Kuramochi H | 2009 | Fuel2009，88，5： | 1 |
| 14 | Quantum Estimation of Impurity Effect for KDP Crystal Growth 显示文摘 | Asakuma Y Jee L Nishimura M | 2008 | Journal of Molecular Structure2008，851，： | 1 |
| 15 | Joystick interfaces are not suitable for robotized endoscope applied to NOTES 显示文摘 | Allemann P Ott L Asakuma M | 2009 | Surgical Innovation2009，16，2： | 1 |
| 16 | Challenges and lessons learned from NOTES cholecystectomy initial experience:a stepwise approach from the laboratory to clinical application显示文摘 | ASAKUMA M PERRETTA S ALLEMANN P | 2009 | J Hepatobiliary Pancreat Surg2009，16，3： | 1 |
| 17 | Impact of Caveolin-1 expression on clinicopathological parameters in renal cell carcinoma 显示文摘 | Horiguchi A Asano T Asakuma J | 2004 | J Urol2004，172，2： | 1 |
| 18 | Increased serum leptin levels and over expression of leptin receptors are associated with the invasion and progression of renal cell carcinoma显示文摘 | Horiguchi A Sumitomo M Asakuma J | 2006 | J Urol2006，176，41： | 1 |
| 19 | Impact of caveolin-1expression on clinicopathological parameters in renal cell carcinoma显示文摘 | Horiguchi A Asano T Asakuma J | 2004 | J Urol2004，172，2： | 1 |
| 20 | Ultraviolet-laser-induced crystallization of sol-gel derived inorganic oxide films显示文摘 | FUKUI T AIZAWA M | 2000 | Journal of Sol-Gel Science and Technology2000，19，： | 1 |
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