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| 1 | Arterial-phase contrast-enhanced ultrasonography for evaluating anti-angiogenesis treatment: A pilot study显示文摘AIM:To verify whether arterial-phase contrast-enhanced ultrasonography(CEUS) of tumor parenchymal tissue is useful for evaluation of anti-angiogenesis agents.METHODS:Rabbits with liver tumor were subjected to CEUS,and images of the nodular maximal diameter in vascular phase were recorded.Image analysis was performed to plot the time intensity curve(TIC) at the tumor parenchyma,which set the diameter of the region of interest of intensity measurement.The TIC was calculated to obtain the time to peak intensity(TPI) and the magnitude of PI.Rabbits were randomly assigned to a treatment group with sorafenib and a control group.Two weeks later,the same ultrasound examination was repeated followed by pathological testing to assess the effect of sorafenib on the liver tumor.RESULTS:In four rabbits in the treatment group,the rate of change of tumor size was decreased comparedwith that of the control(the rate 2.3 vs 7.9,P = 0.02).The TPI of the treatment group elongated significantly(the rate 3.1 vs 1.1,P = 0.07 for SonoVue,2.0 vs 0.88,P = 0.09 for Sonazoid).The magnitude of PI showed no significant changes.In pathological examination,capillary diameters in the treatment group were significantly smaller than those in the control group(26.4 vs 42.8 μm,P = 0.013).CONCLUSION:Analysis of the TIC in the arterial phase of tumor tissue could evaluate the efficacy of antiangiogenesis drug treatment in liver tumor. | Keiko Yoshida Tomihiko Hirokawa Fuminori Moriyasu Masahiko Yamada Yasuharu Imai | 2011 | World Journal of Gastroenterology2011，17，8： | 7 |
| 2 | Laparoscopic and endoscopic cooperative surgery for duodenal tumor resection显示文摘 | Fumitoshi Hirokawa Michihiro Hayashi Yoshiharu Miyamoto Mitsuhiro Asakuma Tetsunosuke Shimizu Koji Komeda Yoshihiro Inoue Eiji Umegaki Kazuhisa Uchiyama | 2014 | Endoscopy2014，，： | 3 |
| 3 | Peritoneovenous shunt for intractable ascites due to hepatic lymphorrhea after hepatectomy显示文摘A peritoneovenous shunt has become one of the most effi cient procedures for intractable ascites due to liver cirrhosis.A case of intractable ascites due to hepatic lymphorrhea after hepatectomy for hepatocellular carcinoma that was successfully treated by the placement of a peritoneovenous shunt is presented.A 72-year-old Japanese man underwent partial resection of the liver for hepatocellular carcinoma associated with hepatitis C viral infection.After hepatectomy,a considerable amount of ascites ranging from 800-4600 mL per day persisted despite conservative therapy,including numerous infusions of albumin and plasma protein fraction and administration of diuretics.Since the patient's general condition deteriorated,based on the diagnosis of intractable hepatic lymphorrhea,a subcutaneous peritoneovenous shunt was inserted.The patient's postoperative course was uneventful and the ascites decreased rapidly,with serum total protein and albumin levels and hepatic function improving accordingly.For intractable ascites due to hepatic lymphorrhea after hepatectomy,we recommend the placement of a peritoneovenous shunt as a procedure that can provide immediate effectiveness without increased surgical risk. | Yoshihiro Inoue Michihiro Hayashi Fumitoshi Hirokawa Atsushi Takeshita Nobuhiko Tanigawa | 2011 | World Journal of Gastrointestinal Surgery2011，3，1： | 3 |
| 4 | Ion chromatography for determination of nitrite and nitrate in seawater using monolithic ODS columns显示文摘 | Kazuaki Ito Yohichi Takayama Nobuyuki Makabe Ryo Mitsui Takeshi Hirokawa | 2005 | Journal of Chromatography A2005，，1： | 2 |
| 5 | Plasma miR-208 as a Biomarker of Myocardial Injury显示文摘 | Ji Xu Takahashi Rie Hiura Yumiko Hirokawa Go Fukushima Yasue Iwai Naoharu | 2009 | Clinical Chemistry2009，，： | 2 |
| 6 | Micritubule bundling by tau proteins in vivo:Analysis of functional domains显示文摘 | KANAl Y CHEN J HIROKAWA W | 1992 | EMBO J1992，11，： | 1 |
| 7 | Ion chromatography for determination of nitrite and nitrate in seawater using monolithic ODS columns 显示文摘 | Kazuaki It o Yohichi Takayama Nobuyuki Makabe Ryo Mitsui Takeshi Hirokawa | 2005 | Journal of Chromatography A2005，，1083： | 1 |
| 8 | Intracellular movement of Fodrin显示文摘 | Cheney R Hirokawa N Levine J | 1983 | Cell Motil1983，3，： | 1 |
| 9 | Spontaneous regression of focal nodular hyperplasia of the liver显示文摘 | Ohmoto K Honda T Hirokawa W | 2003 | J Gastroenterol2003，7，： | 1 |
| 10 | Excitation of an untilted narrow-wall slot in a rectangular waveguide by using etched strips on a dielectric plate显示文摘 | HIROKAWA J KIDAL P S | 1997 | IEEE Trans Antenna Propagat1997，45，6： | 1 |
| 11 | Kinesin and dynein superfamily proteins and the mechanism of organelle transport显示文摘 | Hirokawa N | 1998 | Science1998，279，： | 1 |
| 12 | Long-term response and outcome following immunosuppressive therapy in thymoma-associated pure rod cell aplasia: a nationwide cohort study in Japan by the PRCA collaborative study group 显示文摘 | Hirokawa M Sawada K Fujishima N | 2008 | Haematologiea2008，93，1： | 1 |
| 13 | Acquired pure red cell aplasia:updated review of treatment显示文摘 | Sawada K Fujishima N Hirokawa M | 2008 | Br J Haematol2008，142，4： | 1 |
| 14 | A soft dual-port trocar for endoscopic subcutaneous surgery显示文摘 | M. Hirokawa K. Oda A. Yamamoto S. Sasaguri | 2001 | Surgical Endoscopy2001，，5： | 1 |
| 15 | Three-dimensional deformation and stress distribution in an analytical/computational model of the anterior cruciate ligament显示文摘 | Hirokawa S Tsuruno R | | 0，，09： | 1 |
| 16 | Plasma miR-124 as a biomarker for cerebral infarction显示文摘 | Weng HC Shen CS Gou Hirokawa | | 0，，02： | 1 |
| 17 | The Influence ofSiberian Forest Fires on Carbon Monoxide Concentrationsat Happo,Japan 显示文摘 | Kato S Pochanart P Hirokawa J | 2002 | Atmospheric Environment2002，36，2： | 1 |
| 18 | A novel method us- ing the VIO soft-coagulation system for liver resection 显示文摘 | Hirokawa F Hayashi M Miyamoto Y | 2011 | Sur- gery2011，149，3： | 1 |
| 19 | Novel and potent human and rat/33-adrenergic receptor agonists containing substituted 3- indolylalkylamines显示文摘 | Harada H Hirokawa Y Suzuki K | 2003 | Bioorg Med Chem Lett2003，13，7： | 1 |
| 20 | KIFI B beta-and KIF1A- mediated axonal transport of presynaptic regulator Rab3 occurs in a GTP-dependent manner through DENN/MADD 显示文摘 | Niwa S Tanaka Y Hirokawa N | 2008 | Nat Cell B iol2008，10，11： | 1 |
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