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| 1 | Nutritional therapy for hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is the most frequent primary liver cancer and presents together with cirrhosis in most cases.In addition to commonly recognized risk factors for HCC development,such as hepatitis B virus/hepatitis C virus infection,age and alcohol/tobacco consumption,there are nutritional risk factors also related to HCC development including high intake of saturated fats derived from red meat,type of cooking(generation of heterocyclic amines)and contamination of foods with aflatoxins.On the contrary,protective nutritional factors include diets rich in fiber,fruits and vegetables,n-3 polyunsaturated fatty acids and coffee.While the patient is being evaluated for staging and treatment of HCC,special attention should be paid to nutritional support,including proper nutritional assessment and therapy by a multidisciplinary team.It must be considered that these patients usually develop HCC on top of long-lasting cirrhosis,and therefore they could present with severe malnutrition.Cirrhosisrelated complications should be properly addressed and considered for nutritional care.In addition to traditional methods,functional testing,phase angle and computed tomography scan derived skeletal muscle index-L3 are among the most useful tools for nutritional assessment.Nutritional therapy should be centered on providing enough energy and protein to manage the increased requirements of both cirrhosis and cancer.Supplementation with branched-chain amino acids is also recommended as it improves response to treatment,nutritional status and survival,and finally physical exercise must be encouraged and adapted to individual needs. | Astrid Ruiz-Margáin Berenice M Román-Calleja Paulina Moreno-Guillén JoséA González-Regueiro DeyaniraKúsulas-Delint Alejandro Campos-Murguía Nayelli C Flores-García Ricardo Ulises Macías-Rodríguez | 2021 | World Journal of Gastrointestinal Oncology2021，13，10： | 4 |
| 2 | Spatial and temporal variations insoil respiration in relation to stand structure and soil parame-ters in an unmanaged beech forest显示文摘 | Astrid R B S Buchmann N | 2005 | Tree Physiology2005，25，11： | 1 |
| 3 | School Journeys and Leisure Activities in Rural and Urban Adolescents in Norway 显示文摘 | ASTRID N SJOLIE FORD THUEN | 2002 | Health Promotion Int2002，17，1： | 1 |
| 4 | Patial and temporal variations in soil respiration in relation to stand structure and soil parameters in an unmanaged beech forest 显示文摘 | Astrid R B S Buehmann N | 2005 | Tree Physiology2005，25，： | 1 |
| 5 | Muhiple flat warts asso- ciated with idiopathic CD4-positive T lymphocytopenia 显示文摘 | Louise AF Astrid N Henrik P | 2008 | Journal of the American Academy of Dermatology2008，58，2： | 1 |
| 6 | Allergens from fish and egg显示文摘 | Poulsen L K Hansen T K Astrid N | 2001 | Allergy2001，56，： | 1 |
| 7 | The effect of taxonomic resolution on the assessment of ecological water quality classes 显示文摘 | Astrid S K Rebi C N | 2004 | Hydrobiolngia2004，516，： | 1 |
| 8 | Bovine mastitis caused by a Mycoplasma species显示文摘 | HAL E H H H EMBOLD T C F PL ASTRID GE W N | 1962 | Cornell Veterinarian1962，，52： | 1 |
| 9 | Coupled effects of solution chemistry and hydrodynamics on the mobility and transport of quantum dot nanomaterials in the vadose zone显示文摘 | Burcu Uyusur Christophe J.G. Darnault Preston T. Snee Emre Kok?n Astrid R. Jacobson Robert R. Wells | 2010 | Journal of Contaminant Hydrology2010，，3： | 1 |
| 10 | Reversible kallmann syndrome, delayed puberty, and isolated anosmia occurring in a single family with a mutation in the fibroblast growth factor receptor 1 gene显示文摘 | Pitteloud N Acierno JS Jr Astrid U | 2005 | J Clin Endocrinol Metab2005，90，3： | 1 |
| 11 | GNRHR mutations in a woman with idiopathic hypogonadotropic hypogonadism highlight the differential sensitivity of luteinizing hormone and follicle-stimulating hormone to gonadotropin-releasing hormone显示文摘 | Meysing N Astrid U Kanasaki J | 2004 | J Clin Endocrinol Metab2004，89，7： | 1 |
| 12 | 眼科保健工作中如何应对新冠肺炎显示文摘新型冠状病毒(也称严重急性呼吸综合征冠状病毒2号,SARS-CoV-2)目前已致数百万人感染,其中许多患者病重难治。这一突发的危机超出了医疗系统的应对能力,甚至很多卫生保健工作者都因此丧生。为了控制新冠肺炎的传播,世界各国都采取了不同的政策,例如:·鼓励勤洗手,在公共场所佩戴口罩及保持至少1-2米的社交距离。 | Victor Hu Fatima Kyari N Venkatesh Prajna Astrid Leck Simon Arunga Esmael Habtamu Elmien Wolvaardt Heiko Philippin 刘超凡(译) | 2022 | 实用防盲技术2022，17，3： | 0 |
| 13 | Prognostic performance of an index based on lactic dehydrogenase and transaminases for patients with liver steatosis and COVID-19显示文摘BACKGROUND Metabolic associated fatty liver disease(MAFLD)is associated with complications and mortality in patients with coronavirus disease 2019(COVID-19).However,there are no prognostic scores aimed to evaluate the risk of severe disease specifically in patients with MAFLD,despite its high prevalence.Lactate dehydrogenase,aspartate aminotransferase and alanine aminotransferase have been used as markers of liver damage.Therefore,we propose an index based on lactate dehydrogenase,aspartate aminotransferase and alanine aminotransferase for the prediction of complications and mortality in patients with MAFLD and COVID-19.AIM To evaluate the prognostic performance of an index based on lactate dehydrogenase and transaminases(aspartate aminotransferase/alanine aminotransferase)in patients with COVID-19 and MAFLD[liver fibrosis and nutrition(LNF)-COVID-19 index].METHODS In this retrospective cohort study,two cohorts from two different tertiary centers were included.The first was the derivation cohort to obtain the score cutoffs,and the second was the validation cohort.We included hospitalized patients with severe COVID-19 and MAFLD.Liver steatosis was evaluated by computed tomography scan.Area under the receiver operating characteristic(ROC)curve analysis and survival analysis were used.RESULTS In the derivation cohort,44.6%had MAFLD;ROC curve analysis yielded a LFN-COVID-19 index>1.67 as the best cutoff,with a sensitivity of 78%,specificity of 63%,negative predictive value of 91%and an area under the ROC curve of 0.77.In the multivariate analysis,the LFN-COVID-19 index>1.67 was independently associated with the development of acute kidney injury(odds ratio:1.8,95%confidence interval:1.3-2.5,P<0.001),orotracheal intubation(odds ratio:1.9,95%confidence interval:1.4-2.4,P<0.001),and death(odds ratio:2.86,95%confidence interval:1.6-4.5,P<0.001)in both cohorts.CONCLUSION LFN-COVID-19 index has a good performance to predict prognosis in patients with MAFLD and COVID-19,which could be useful for the MAFLD population. | Ricardo Ulises Macías-Rodríguez Alberto Adrián Solís-Ortega Victoria J Ornelas-Arroyo Astrid Ruiz-Margáin Maria Sarai González-Huezo Nestor A Urdiales-Morán Berenice M Román-Calleja Juan M Mayorquín-Aguilar JoséA González-Regueiro Alejandro Campos-Murguía Israel Vicente Toledo-Coronado Mónica Chapa-Ibargüengoitia Bernardo Valencia-Peña Carlos Fernando Martínez-Cabrera Nayelli C Flores-García | 2022 | World Journal of Gastroenterology2022，28，37： | 0 |
| 14 | Clinical perspectives,assessment,and mechanisms of metabolicassociated fatty liver disease in patients with COVID-19显示文摘Metabolic diseases are highly prevalent worldwide and have been associated with adverse clinical outcomes,including mortality,in patients developing coronavirus disease(COVID-19).Because of the close relationship between metabolic diseases such as type 2 diabetes mellitus and obesity and the presence of metabolicassociated fatty liver disease(MAFLD),a high number of cases of patients affected by both MAFLD and COVID-19 would be expected,especially in highrisk populations.Some studies have shown an increased risk of adverse clinical outcomes,viral shedding,and deep vein thrombosis,especially in patients with MAFLD-related liver fibrosis.The predisposition to poor outcomes and severe acute respiratory syndrome coronavirus 2 infection in patients with MAFLD could be secondary to mechanisms common to both,including preexisting systemic chronic inflammation,endothelial dysfunction,and involvement of the renin-angiotensin system.Because of the increased risk of adverse outcomes,MAFLD should be screened in all patients admitted for COVID-19.Available computed tomography scans could be of help,assessment of liver fibrosis is also recommended,favoring noninvasive methods to limit the exposure of healthcare workers.Liver involvement in this population ranges from abnormalities in liver chemistry to hepatic steatosis in postmortem biopsies.Finally,preventive measures should be strongly advocated in patients already known to have MAFLD,including the use of telemedicine and vaccination in addition to general measures. | Alejandro Campos-Murguía Berenice M Román-Calleja JoséA González-Regueiro Ivonne Hurtado-Díaz-de-León Alberto Adrián Solís-Ortega Nayelli C Flores-García Ignacio García-Juárez Astrid Ruiz-Margáin Ricardo Ulises Macías-Rodríguez | 2021 | World Journal of Gastroenterology2021，27，33： | 0 |
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