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| 1 | In vitro antioxidant and in vivo antidiabetic potential of the methanol extract of Ficus glumosa Del (Moraceae) stem bark in alloxan-induced diabetic mice 显示文摘 | Madubunyi Ⅱ Onoja SO Asuzu IU | 2012 | Comp Clin Pathol2012，21，4： | 1 |
| 2 | Anti-ulcer activity of the ethanolic extract of Combretum dolichopetalum root显示文摘 | Asuzu IU Onu OU | | 0，，1： | 1 |
| 3 | Paralysis and lameness associated with aflatoxicosis in broilers 显示文摘 | Okoye J 0 A I U Asuzu and J C Gugnani | 1988 | Avian Path1988，，17： | 1 |
| 4 | Histological changes and antidiabetic activities of Icacina trichantha tuber extract in beta-cells of alloxan induced diabetic rats显示文摘Objective:To investigate the antidiabetic,hypolipidaemic activities and histopathological changes ofIcacina trichantha(I.trichantha)tuber extract in alloxan induced diabetic rats.Methods:In the present study,80%methanol extract of I.trichanthatuber was tested on alloxan induced diabetic rats.They were randomly grouped into control(distilled water and glibenclamide)and experimental(200,400 and 600 mg/kg body weight).Diabetes was induced by a single intraperitoneal injection of 160 mg/kg body weight of alloxan.Blood glucose levels weremeasured using blood glucose test strips with AccuCheck Advantage II glucometer at 1,3,6,and 24 h on the first day and 1 h after treatment on Day 7,14 and 21.Blood samples were collected and centrifuged to separate serum for estimation of lipid profile and other biochemical parameters.Histopathological changes in diabetic rats pancreas were also studied after extract treatment.Results:Daily oral administration ofI.trichanthatuber extract(200,400,and 600 mg/kg bodyweight)and glibenclamide(2 mg/kg)showed beneficial effects on blood glucose level(P<0.01)as well as improving liver,kidney functions and hyperlipidaemia due to diabetes.The extract had a favourable effect on the histopathological changes of the pancreas in alloxan induced diabetes.Conclusions:I.trichanthatuber extracts posses antidiabetic activities as well as improve liver and renal profile and total lipids levels.I.trichanthatuber extracts also have favourable effects to inhibit the histopathological changes of the pancreas in alloxan induced diabetes. | Onakpa Michael Monday Asuzu Isaac Uzoma | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，8： | 1 |
| 5 | Oleanolic acid, a bieactive component of the leaves of Ocimum gratissimum (Lamiaceae) 显示文摘 | Njoku CJ Zeng L Asuzu IU | 1997 | Int J Pharmacogn1997，35，： | 1 |
| 6 | The effects of combination of methanolic leaf extract of Azadirachta indica and diminazene diaceturate in the treatment of experimental Trypanosoma brucei brucei infection in rats显示文摘Objective:To investigate the effects of combination therapy of methanolic leaf extract of Azadirachta indica(A.indica) and diminazene diaceturate(DDA) in the treatment of experimental Trypanosoma brucei brucei(T.brucei brucei) infection in rats.Methods:Acute toxicity study of the drug and extract combinations were done.Selection of the best drug and extract combinations was carried out using fifty four rats of both sexes separated into 9 groups.Three dose combinations were derived from selection of the best drug and extract combinations used for the final study viz:7 mg/kg bw DDA plus 125 mg/kg bw extract(group B),3.5 mg/kg bw DDA plus 250 mg/kg bw extract(group C),and 1.8 mg/kg bw DDA plus 500 mg/kg bw extract(group D).The final study had in addition to the three groups derived from the dose response study,four other groups viz:uninfected untreated negative control(group F),infected and treated with 3 000 mg/kg bw extract alone(group E),infected and treated with 7 mg/kg bw DDA alone(group A),and infected untreated positive control(group G).The parameters assessed were onset of parasitaemia(OP), level of parasitaemia(LOP),clearance of parasites post treatment(COPPT),relapse infection period(RIP),post infection survival period(PIST).Results:There was no significant difference in OP between the groups(P<0.05).One day post treatment,the mean LOP of groups A,B,and C were found to be significantly lower than that of group D which in turn was lower than that of group E and G respectively.The mean LOP of group E was significantly lower than group G two days post treatment and this trend continued throughout the experimental period.Mean COPPT of group D was significantly longer than that of groups A,C and B.There was no significant difference in the mean COPPT among groups B,C and A.The mean RIP of group D was significantly shorter than group C,and that of group C was significantly shorter than that of group A.There was no relapse of infection in group B.The PIST of group E did not differ significantly from group G.Conclusions:This experiment stands to conclude that combination of 125 mg/kg bw extract and 7 mg/kg bw DDA is very effective in the treatment of trypanosomosis,caused by T. brucei.This combination therapy proved to be better than single therapy of DDA. | Omoja VU Anaga AO Obidike IR Ihedioha TE Umeakuana PU Mhomga LI Asuzu IU Anika SM | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，5： | 1 |
| 7 | The effect of pilot cognitive restructuring therapy intervention on depression in female cancerpatients显示文摘 | Asuzu CC Akin-Odanye EO | 2016 | Psychooncology2016，25，6： | 1 |
| 8 | TURN: A simple predictor of symptomatic intracerebral hemorrhage after IV thrombolysis显示文摘 | Asuzu D Nystr0m K Amin H | 2015 | Neurocrit Care2015，23，： | 1 |
| 9 | TURN score predicts 90-day outcome in acute ischemic stroke patients after IV thrombolysis显示文摘 | Asuzu D Nystr6m K Schindler J | 2015 | Neurocrit Care2015，23，： | 1 |
| 10 | Relationship between blood pressure and body mass index in lean populations显示文摘 | Kaufman J S Asuzu M C Mufunda J | 1997 | Hypertension1997，30，6： | 1 |
| 11 | The AnthelminticActivityofD-3-O-Methylchiroinositol Isolated from Piliostigma thonningii Stem Bark显示文摘 | ASUZU I U GRAY A I WATERMAN P G | 1999 | Fitoterapia1999，70，1： | 1 |
| 12 | Acute and chronic toxicity studies of Erythrina senegalensis DC stem bark extract in mice显示文摘 | S. C. Udem O. Obidoa I. U. Asuzu | 2010 | Comparative Clinical Pathology2010，，3： | 1 |
| 13 | 'Diarrhetic' type shellfish poisoning in Nigeria 显示文摘 | Igboeli OO Asuzu IU | 2010 | Bull Environ Contain Toxieol2010，84，1： | 1 |
| 14 | ‘Diarrhetic’ Type Shellfish Poisoning in Nigeria显示文摘 | Okechukwu O. Igboeli Isaac U. Asuzu | 2010 | Bulletin of Environmental Contamination and Toxicology2010，，1： | 1 |
| 15 | Determinants of goodoral hygiene among pregnant women in ibadan, South-WesternNigeria显示文摘 | Ifesanya J U Ifesanya A O Asuzu MC | 2010 | Ann lb Postgrad Med2010，8，2： | 1 |
| 16 | Effect of Gongronema latifolium on gastric emptying in healthy dogs显示文摘AIM:To investigate sonographically the effect of Gonogronema latifolium (G.latifolium) on gastric emptying of semi-solid meals in healthy dogs.METHODS:In a randomized,placebo-controlled experiment,twenty-five clinically healthy dogs were randomly allotted into five groups of five dogs in each group.The placebo group served as the control,and the low,moderate and high dose groups ingested the methanolic leaf extract of G.latifolium in capsules at 100 mg/kg,250 mg/kg and 500 mg/kg,respectively,while the prokinetic group ingested 0.5 mg/kg capsules of metoclopramide.After a 12-h fast,each group ingested its treatment capsules 30 min before the administration of a test meal.Measurements of gastric emptying and blood glucoselevels were obtained 30 min before and immediately after the ingestion of the test meal and thereafter every 15 min for 4 h.This was followed by further measurements every 30 min for another 2 h.RESULTS:The gastric emptying times of the placebo,low dose,moderate dose,high dose and prokinetic dose groups were 127.0 ± 8.2 min,135.5 ± 3.7 min,155.5 ± 3.9 min,198.0 ± 5.3 min and 59.0 ± 2.5 min,respectively.Gastric emptying times of the moderate and high dose groups were significantly slower than in the placebo control group (155.5 ± 3.9 min,198.0 ± 5.3 min vs 127.0 ± 8.2 min,P=0.000).No significant difference in gastric emptying between the low dose and placebo control groups was noted (135.5 ± 3.7 min vs 127.0 ± 8.2 min,P=0.072).Gastric emptying of the prokinetic group was significantly faster than that of the control group (59.0 ± 2.5 min vs 127.0 ± 8.2 min,P=0.000).The hypoglycaemic effect of G.latifolium and gastric emptying were inversely related (r=-0.95,P=0.000).CONCLUSION:G.latifolium delays gastric emptying and lowers postprandial blood glucose in healthy dogs.It reduces the postprandial blood glucose by delaying gastric emptying. | Sylvester O Ogbu Kenneth K Agwu Isaac U Asuzu | 2013 | World Journal of Gastroenterology2013，19，6： | 0 |
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