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| 1 | Reproducibility of thrombus volume quantification in multicenter computed tomography pulmonary angiography studies显示文摘AIM To evaluate reproducibility of pulmonary embolism(PE) clot volume quantification using computed tomography pulmonary angiogram(CTPA) in a multicenter setting.METHODS This study was performed using anonymized data in conformance with HIPAA and IRB Regulations(March 2015-November 2016). Anonymized CTPA data was acquired from 23 scanners from 18 imaging centers using each site's standard PE protocol. Two independent analysts measured PE volumes using a semi-automated region-growing algorithm on an FDA-approved image analysis platform. Total thrombus volume(TTV) was calculated per patient as the primary endpoint. Secondary endpoints were individual thrombus volume(ITV), Qanadli score and modified Qanadli score per patient. Inter-and intra-observer reproducibility were assessed using intra-class correlation coefficient(ICC) and BlandAltman analysis. RESULTS Analyst 1 found 72 emboli in the 23 patients with a mean number of emboli of 3.13 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.0041-47.34 cm3(mean +/-SD, 5.93 +/-10.15 cm3). On the second read, analyst 1 found the same number and distribution of emboli with a range of volumes for read 2 from 0.0041 – 45.52 cm3(mean +/-SD, 5.42 +/-9.53 cm3). Analyst 2 found 73 emboli in the 23 patients with a mean number of emboli of 3.17 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.00459-46.29 cm3(mean +/-SD, 5.91 +/-10.06 cm3). Inter-and intraobserver variability measurements indicated excellent reproducibility of the semi-automated method for quantifying PE volume burden. ICC for all endpoints was greater than 0.95 for inter-and intra-observer analysis. Bland-Altman analysis indicated no significant biases.CONCLUSION Semi-automated region growing algorithm for quantifying PE is reproducible using data from multiple scanners and is a suitable method for image analysis in multicenter clinical trials. | Audrey E Kaufman Alison N Pruzan Ching Hsu Sarayu Ramachandran Adam Jacobi Indravadan Patel Lee Schwocho Michele F Mercuri Zahi A Fayad Venkatesh Mani | 2018 | World Journal of Radiology2018，10，10： | 3 |
| 2 | Reproducibility of the diagnosis of dysplasia in Barrett esophagus: A reaffirmation显示文摘 | Elizabeth Montgomery Mary P Bronner John R Goldblum Joel K Greenson Marian M Haber John Hart Laura W Lamps Gregory Y Lauwers Audrey J Lazenby David N Lewin Marie E Robert Alicia Y Toledano Yu Shyr Kay Washington | 2001 | Human Pathology2001，，4： | 3 |
| 3 | Effect of varying computed tomography acquisition and reconstruction parameters on semi-automated clot volume quantification显示文摘AIM To examine effects of computed tomography(CT)image acquisition/reconstruction parameters on clot volume quantification in vitro for research method validation purposes.METHODS This study was performed in conformance with HIPAA and IRB Regulations(March 2015-November 2016).A ten blood clot phantom was designed and scanned on a dual-energy CT scanner(SOMATOM Force,Siemens Healthcare Gm BH,Erlangen,Germany)with varying pitch,iterative reconstruction,energy level and slicethickness.A range of clot and tube sizes were used in an attempt to replicate in vivo emboli found within central and segmental branches of the pulmonary arteries in patients with pulmonary emboli.Clot volume was the measured parameter and was analyzed by a single image analyst using a semi-automated region growing algorithm implemented in the FDA-approved Siemens syngo.via image analysis platform.Mixed model analysis was performed on the data.RESULTS On the acquisition side,the continuous factor of energy showed no statistically significant effect on absolute clot volume quantification(P=0.9898).On the other hand,when considering the fixed factor of pitch,there were statistically significant differences in clot volume quantification(P<0.0001).On the reconstruction side,with the continuous factor of reconstruction slice thickness no statistically significant effect on absolute clot volume quantification was demonstrated(P=0.4500).Also on the reconstruction side,with the fixed factor of using iterative reconstructions there was also no statistically significant effect on absolute clot volume quantification(P=0.3011).In addition,there was excellent R^2 correlation between the scale-measured mass of the clots both with respect to the CT measured volumes and with respect to volumes measure by the water displacement method.CONCLUSION Aside from varying pitch,changing CT acquisition parameters and using iterative reconstructions had no significant impact on clot volume quantification with a semi-automated region growing algorithm. | Audrey E Kaufman Alison N Pruzan Ching Hsu Sarayu Ramachandran Adam Jacobi Zahi A Fayad Venkatesh Mani | 2018 | World Journal of Radiology2018，10，3： | 3 |
| 4 | High-Dose Split-Course Radiation Therapy for Anal Cancer: Outcome Analysis Regarding the Boost Strategy (CORS-03 Study)显示文摘 | Jean-Michel Hannoun-Levi Cécile Ortholan Michel Resbeut Eric Teissier Philippe Ronchin Didier Cowen Audrey Zaccariotto Karen Bénézery Eric Fran?ois Naji Salem Steve Ellis David Azria Jean-Pierre Gerard | 2011 | International Journal of Radiation Oncology Biology Physics2011，，3： | 1 |
| 5 | secondhand smoke levels in Scottish pubs: the effect of smoke-free legislation 显示文摘 | Scan S Karen S Audrey N | 2007 | Tob Control2007，16，： | 1 |
| 6 | Nuclear forms of parathyroid hormone-related peptide are translated from non-AUG start sites downstream from the initiator methionine显示文摘 | Bin He N Karaplis AC | 2001 | Endocrinology2001，142，2： | 1 |
| 7 | Deployment of Demand Response as a Real-Time Resource in Organized Markets显示文摘 | Zibelman Audrey Krapels Edward N | | 0，，21： | 1 |
| 8 | Sustainable systems theory:ecological and other aspects显示文摘 | CHRISTOPHER W PAWLOWSKI AUDREY L MAYER N THERESA HOAGLAND | 2005 | Journal of Cleaner Production2005，，13： | 1 |
| 9 | Dysplasia as a predictive marker for invasive carcinoma in Barrett esophagus: A follow-up study based on 138 cases from a diagnostic variability study显示文摘 | Elizabeth Montgomery John R Goldblum Joel K Greenson Marian M Haber Laura W Lamps Gregory Y Lauwers Audrey J Lazenby David N Lewin Marie E Robert Kay Washington Marianna L Zahurak John Hart | 2001 | Human Pathology2001，，： | 1 |
| 10 | Reproducibility of the diagnosis of dysplasia in Barrett esophagus: A reaffirmation显示文摘 | Elizabeth Montgomery Mary P Bronner John R Goldblum Joel K Greenson Marian M Haber John Hart Laura W Lamps Gregory Y Lauwers Audrey J Lazenby David N Lewin Marie E Robert Alicia Y Toledano Yu Shyr Kay Washington | 2001 | Human Pathology2001，，： | 1 |
| 11 | Informal and formal care : exploring the complementarity显示文摘 | N CHAPPELLA A BLCMDFORD NEENA C AUDREY B | 1991 | Aging and Society1991，11，3： | 1 |
| 12 | Liver single breath-hold dynamic subtraction CT with multi-detector row helical technology-feasibility stud显示文摘 | Audrey S Rendon N Carolyn L | 2002 | Radiology2002，222，1： | 1 |
| 13 | Reproducibility of the diagnosis of dysplasia in Barrett esophagus: A reaffirmation显示文摘 | Elizabeth Montgomery Mary P Bronner John R Goldblum Joel K Greenson Marian M Haber John Hart Laura W Lamps Gregory Y Lauwers Audrey J Lazenby David N Lewin Marie E Robert Alicia Y Toledano Yu Shyr Kay Washington | 2001 | Human Pathology2001，，4： | 1 |
| 14 | Ascorbic acid induced deg- radation of beta-glucan: Hydroxyl radicals as intermediates stud- ied by spin trapping and electron spin resonance spectroscopy 显示文摘 | Audrey M F Mogens L A Laura N | 2012 | Carbohydrate Polymers2012，87，3： | 1 |
| 15 | Changes in intestinal bifidobacteria levels are associated with the inflammatory response in magnesium-deficient mice显示文摘 | BARBARA D P AUDREY M N LOUISE D | 2010 | J Nutr2010，140，3： | 1 |
| 16 | Gene expression changes during asexual sporulation by the late blight agent Phytophthora infestans occur in discrete temporal stages显示文摘 | Howard S J Reena D N Audrey M V | 2009 | Molecular Genetics and Genomics2009，2，281： | 1 |
| 17 | Recombinant bacterial He-moglobin alters metabolism of Aspergillus niger 显示文摘 | Gerald H Audrey D Jens N | 2009 | Met- abolic Engineering2009，11，1： | 1 |
| 18 | Suppression of PPAR-attenuates insulin-stimulated glucose uptake by affecting both GLUT1 and GLUT4 in 3T3-L1 adipocytes显示文摘 | Wei L Audrey N Takeshi Y | 2007 | Am J Physiol Endocrinol Metab2007，293，1： | 1 |
| 19 | A- nalysis and synthesis of research on responsible environmental behavior: A meta-analysis显示文摘 | Jody M Hines Harold R Hungerford Audrey N Tomera | 1987 | The Journal of Environmental Education1987，18，2： | 1 |
| 20 | The spectrum of GI strongyloidiasis: an endoscopic-pathologic study显示文摘 | Bryan F Thompson Luc??a C Fry Christopher D Wells Mart??n Olmos David H Lee Audrey J Lazenby Klaus E M?nkemüller | 2004 | Gastrointestinal Endoscopy2004，，7： | 1 |
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