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| 1 | Bimanual motor skill learning and robotic assistance for chronic hemiparetic stroke: a randomized controlled trial显示文摘Using robotic devices might improve recovery post-stroke, but the optimal way to apply robotic assistance has yet to be determined. The current study aimed to investigate whether training under the robotic active-assisted mode improves bimanual motor skill learning(biMSkL) more than training under the active mode in stroke patients. Twenty-six healthy individuals(HI) and 23 chronic hemiparetic stroke patients with a detectable lesion on MRI or CT scan, who demonstrated motor deficits in the upper limb, were randomly allocated to two parallel groups. The protocol included a two-day training on a new bimanual cooperative task, LIFT-THE-TRAY, under either the active or activeassisted modes(where assistance decreased in a pre-determined stepwise fashion) with the bimanual version of the REAplan? robotic device. The hypothesis was that the active-assisted mode would result in greater biMSkL than the active mode. The biMSkL was quantified by a speed-accuracy trade-off(SAT) before(T1) and immediately after(T2) training on days 1 and 2(T3 and T4). The change in SAT after 2 days of training(T4/T1) indicated that both HI and stroke patients learned and retained the bimanual cooperative task. After 2 days of training, the active-assisted mode did not improve biMSkL more than the active mode(T4/T1) in HI nor stroke patients. Whereas HI generalized the learned bimanual skill to different execution speeds in both the active and active-assisted subgroups, the stroke patients generalized the learned skill only in the active subgroup. Taken together, the active-assisted mode, applied in a pre-determined stepwise decreasing fashion, did not improve biMSkL more than the active mode in HI and stroke subjects. Stroke subjects might benefit more from robotic assistance when applied 'as-needed.' This study was approved by the local ethical committee(Comité d'éthique médicale, CHU UCL Namur, MontGodinne, Yvoir, Belgium;Internal number: 54/2010, Eudra CT number: NUB B039201317382) on July 14, 2016 and was registered with ClinicalTrials.gov(Identifier: NCT03974750) on June 5, 2019. | Maral Yeganeh Doost Benoît Herman Adrien Denis Julien Sapin Daniel Galinski Audrey Riga Patrice Laloux Benoît Bihin Yves Vandermeeren | 2021 | Neural Regeneration Research2021，16，8： | 3 |
| 2 | Bovine immunoglobulin protein isolates for the nutritional management of enteropathy显示文摘The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction of the intestinal microbiota, diet, gut barrier function, and mucosal immune response. Disruptions in one or more of these factors can lead to intestinal disorders or enteropathies which are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Enteropathy is frequently associated with human immunodeficiency virus(HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, and irritable bowel syndrome(IBS), where pathologic changes in the intestinal tract lead to abdominal discomfort, bloating, abnormal bowel function(e.g., diarrhea, urgency, constipation and malabsorption). Unfortunately, effective therapies for the management ofenteropathy and restoring intestinal health are still not available. An accumulating body of preclinical studies has demonstrated that oral administration of plasmaor serum-derived protein concentrates containing high levels of immunoglobulins can improve weight, normalize gut barrier function, and reduce the severity of enteropathy in animal models. Recent studies in humans, using serum-derived bovine immunoglobulin/protein isolate, demonstrate that such protein preparations are safe and improve symptoms, nutritional status, and various biomarkers associated with enteropathy. Benefits have been shown in patients with HIV infection or diarrhea-predominant IBS. This review summarizes preclinical and clinical studies with plasma/serum protein concentrates and describes the effects on host nutrition, intestinal function, and markers of intestinal inflammation. It supports the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy. | Bryon W Petschow Anthony T Blikslager Eric M Weaver Joy M Campbell Javier Polo Audrey L Shaw Bruce P Burnett Gerald L Klein J Marc Rhoads | 2014 | World Journal of Gastroenterology2014，20，33： | 2 |
| 3 | Identification of stable normalization genes for quantitative real-time PCR in porcine articular cartilage显示文摘Background: Expression levels for genes of interest must be normalized with an appropriate reference, or housekeeping gene, to make accurate comparisons of quantitative real-time PCR results. The purpose of this study was to identify the most stable housekeeping genes in porcine articular cartilage subjected to a mechanical injury from a panel of 10 candidate genes. Results: Ten candidate housekeeping genes were evaluated in three different treatment groups of mechanically impacted porcine articular cartilage. The genes evaluated were: beta actin, beta-2-microglobulin, glyceraldehyde-3-phosphate dehydrogenase, hydroxymethylbilane synthase, hypoxanthine phosphoribosyl transferase, peptidylprolyl isomerase A (cyclophilin A), ribosomal protein L4, succinate dehydrogenase flavoprotein subunit A, TATA box binding protein, and tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein-zeta polypeptide. The stability of the genes was measured using geNorm, BestKeeper, and NormFinder software. The four most stable genes measured via geNorm were (most to least stable) succinate dehydrogenase flavoprotein, subunit A, peptidylprolyl isomerase A, glyceraldehyde-3-phosphate dehydrogenase, beta actin; the four most stable genes measured via BestKeeper were glyceraldehyde-3-phosphate dehydrogenase, peptidylprolyl isomerase A, beta actin, succinate dehydrogenase flavoprotein, subunit A; and the four most stable genes measured via NormFinder were peptidylprolyl isomerase A, succinate dehydrogenase flavoprotein, subunit A, glyceraldehyde-3-phosphate dehydrogenase, beta actin. Conclusions: BestKeeper, geNorm, and NormFinder all generated similar results for the most stable genes in porcine articular cartilage. The use of these appropriate reference genes will facilitate accurate gene expression studies of porcine articular cartilage and suggest appropriate housekeeping genes for articular cartilage studies in other species. | Ryan S McCulloch Melissa S Ashwell Audrey T O'Nan Peter L Mente | 2012 | Journal of Animal Science and Biotechnology2012，3，4： | 2 |
| 4 | Synthesis of 5-substituted-1H-indol- 2-yl-1H-quinolin-2-ones: a novel class of KDR kinase inhibitors显示文摘 | JEFFREY T K AUDREY W QU Chuan-xing | 2005 | J Org Chem2005，70，7： | 1 |
| 5 | Distribution of heavy metals in near-shore sediments of the swan river estuary,western Australia显示文摘 | ANDERSON W R ALISTAIR E R AUDREY T B | 2000 | Water Air and Soil Pollution2000，124，： | 1 |
| 6 | Genomic expression programs in the response of yeast ceils to environmental changes显示文摘 | AUDREY P G PAUL T S CAMILLA M K | | 0，，12： | 1 |
| 7 | Myxopyronin: a punch in the jaws of bacterial RNA polymerase显示文摘 | Audrey T Maxime G Konstantin B | 2009 | Future Microbiology2009，4，2： | 1 |
| 8 | Synthesis of imidazoliumand pyridinium-based ionic liquids and application of 1-al- kyl-3-methylimidazolium salts as pre-catalysts for the ben- zoin condensation using solvent-free and microwave activa- tion显示文摘 | Audrey A Bruce P Giang V T | 2010 | Tetrahedron2010，66，6： | 1 |
| 9 | First report of Spring viremia of carp virus (SVCV) in wild common carp in North America显示文摘 | Audrey L D Craig R Kathy T K | 2004 | J Aquatic Animal Health2004，16，： | 1 |
| 10 | Sound absorption in metallic foams显示文摘 | Lu T J Audrey H Ashby M F | 1999 | Journal of Applied Physics1999，85，11： | 1 |
| 11 | Sound absorbption in metallic foams 显示文摘 | Lu T J Audrey Hess Ashby M F | 1999 | Joumal of Applied Physics1999，85，1： | 1 |
| 12 | Sound absorption in me- tallic foams显示文摘 | LU T J AUDREY H Ashby M F | 1999 | J Appl Phys1999，85，11： | 1 |
| 13 | Mechanism of isehemic in- farct in spontaneous cervical artery dissection 显示文摘 | Audrey M Olivier N Emmanuel T | 2012 | Stroke2012，5，43： | 1 |
| 14 | Babesia boris The development of an expression oligonucleotide microarray 显示文摘 | Audrey O T L David L T Terry F M | 2007 | Experimental Parasitol2007，117，： | 1 |
| 15 | Intermittent hypoxia is an angiogenic inducer for endothelial cells: role of HIF-1 显示文摘 | Se?bastien T Audrey R Olivier F etal | 2009 | Angiogenesis2009，12，1： | 1 |
| 16 | Requirements-oriented methodology for evaluating ontologies 显示文摘 | JONATHAN Y JAMES A T AUDREY T | 2009 | Information Systems2009，34，8： | 1 |
| 17 | Sound Absorption in Metallic Foams 显示文摘 | Lu T J Hess Audrey Ashby M F | 1999 | Journal of Applied Physics1999，85，17： | 1 |
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