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| 1 | Baseline effects of lysophosphatidylcholine and nerve growth factor in a rat model of sciatic nerve regeneration after crush injury显示文摘Schwann cells play a major role in helping heal injured nerves. They help clear debris, produce neurotrophins, upregulate neurotrophin receptors, and form bands of Büngner to guide the healing nerve. But nerves do not always produce enough neurotrophins and neurotrophin receptors to repair themselves. Nerve growth factor(NGF) is an important neurotrophin for promoting nerve healing and lysophosphatidylcholine(LPC) has been shown to stimulate NGF receptors(NGFR). This study tested the administration of a single intraneural injection of LPC(1 mg/mL for single LPC injection and 10 mg/mL for multiple LPC injections) at day 0 and one(day 7), two(days 5 and 7), or three(days 5, 7, and 9) injections of NGF(160 ng/mL for single injections and 80 ng/mL for multiple injections) to determine baseline effects on crush ed sciatic nerves in rats. The rats were randomly divided into four groups: control, crush, crush-NGF, and crush-LPC-NGF. The healing of the nerves was measured weekly by monitoring gait; electrophysiological parameters: compound muscle action potential(CMAP) amplitudes; and morphological parameters: total fascicle areas, myelinated fiber counts, fiber densities, fiber packing, and mean g-ratio values at weeks 3 and 6. The crush, crush-NGF, and crush-LPC-NGF groups statistically differed from the control group for all six weeks for the electrophysiological parameters but only differed from the control group at week 3 for the morphological parameters. The crush, crush-NGF, and crush-LPC-NGF groups did not differ from each other over the course of the study. Single injections of LPC and NGF one week apart or multiple treatments of NGF at 5, 7 and 9 days post-injury did not alter the healing rate of the sciatic nerves during weeks 1-6 of the study. These findings are important to define the baseline effects of NGF and LPC injections, as part of a larger effort to determine the minimal dose regimen of NGF to regenerate peripheral nerves. | Ryan L.Wood Keaton S.Karlinsey Austin D.Thompson Mark N.Rigby Greggory D.Boatright William G.Pitt Beverly L.Roeder Scott C.Steffensen Alonzo D.Cook | 2018 | Neural Regeneration Research2018，13，5： | 5 |
| 2 | International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of Lung Adenocarcinoma显示文摘 | William D. Travis Elisabeth Brambilla Masayuki Noguchi Andrew G. Nicholson Kim R. Geisinger Yasushi Yatabe David G. Beer Charles A. Powell Gregory J. Riely Paul E. Van Schil Kavita Garg John H. M. Austin Hisao Asamura Valerie W. Rusch Fred R. Hirsch Giorg | 2011 | Journal of Thoracic Oncology2011，，2： | 4 |
| 3 | Deconvolution of adaptive optics retinal images显示文摘 | Julian C Christou Austin Roorda David R Williams | 2004 | J Opt Soc Am A2004，21，8： | 1 |
| 4 | International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of Lung Adenocarcinoma显示文摘 | William D. Travis Elisabeth Brambilla Masayuki Noguchi Andrew G. Nicholson Kim R. Geisinger Yasushi Yatabe David G. Beer Charles A. Powell Gregory J. Riely Paul E. Van Schil Kavita Garg John H. M. Austin Hisao Asamura Valerie W. Rusch Fred R. Hirsch Giorg | 2011 | Journal of Thoracic Oncology2011，，2： | 1 |
| 5 | Randomised controlled trial of cardiac rehabilitation in elderly patients with heart failure显示文摘 | Austin J Williams R Ross L | 2005 | Eur J Heart Fail2005，7，3： | 1 |
| 6 | Ontologies显示文摘 | William S Austin T | 1999 | IEEE Intelligent Systems1999，，12： | 1 |
| 7 | Ontologies 显示文摘 | William S Austin T | 1999 | IEEE Intelligent1999，，： | 1 |
| 8 | Randomised controlled trial of cardiac rehabilitation in elderly patients with heart failure 显示文摘 | Austin J Williams R Ross L | 2005 | Eur J Heart Fail2005，7，： | 1 |
| 9 | Distribution of CYP17αpolymorphism and selected physiochemical factors of uterine leiomyoma in Barbados显示文摘 | Alleyne AT Austin S Williams A | 2014 | Meta Gene2014，9，2： | 1 |
| 10 | The Emergence and Transformation of Disputes:Naming,Blaming,Claiming显示文摘 | Felstiner William L.F Richard L.Abel Austin Sarat | | 0，，： | 1 |
| 11 | Randomised controlled trial of cardiac rehabilitation in elderly patients with heart failure显示文摘 | Austin J Williams R Ross L | 2005 | European J Heart Failure2005，7，： | 1 |
| 12 | Neurodegeneration in Mice Resulting From Loss of Functional Selenoprotein P or Its Receptor Apolipoprotein E Receptor 2显示文摘 | William M. Valentine Ty W. Abel Kristina E. Hill Lori M. Austin Raymond F. Burk | 2008 | Journal of Neuropathology and Experimental Neurology2008，，1： | 1 |
| 13 | China’s Urban Revolution:Understanding Chinese Eco-Cities显示文摘Bloomsbury Academic By 2025,China will have built 15 new'super cities'each with 25 million inhabitants.It will also have created 250'eco-cities'which will be clean,green,car-free,peoplefriendly and hi-tech urban centers.The urban environmental turnaround experiment may provide valuable experience for cities worldwide.Austin Williams,a correspondent of the Architectural Review to China,explores the progress and challenges | Austin Williams David Ogula Kathryn Erskine Charly Palmer | 2017 | ChinAfrica2017，9，11： | 1 |
| 14 | International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of Lung Adenocarcinoma显示文摘 | William D. Travis Elisabeth Brambilla Masayuki Noguchi Andrew G. Nicholson Kim R. Geisinger Yasushi Yatabe David G. Beer Charles A. Powell Gregory J. Riely Paul E. Van Schil Kavita Garg John H. M. Austin Hisao Asamura Valerie W. Rusch Fred R. Hirsch Giorg | 2011 | Journal of Thoracic Oncology2011，，2： | 1 |
| 15 | Ontologies 显示文摘 | William S Austin T | 1999 | IEEE Intelligent Systems1999，14，12： | 1 |
| 16 | Oligoadenylate synthetase/protein kinase R pathways and alphabeta TCR+ T cells are required for adenovirus vector: IFN-gamma inhibition of herpes simplex virus-1 in cornea 显示文摘 | Austin BA Halford WP Williams BR | 2007 | J Immunol2007，178，8： | 1 |
| 17 | Ontologies 显示文摘 | WilliamS Austin T | 1999 | IEEE Intelligent Systems1999，，12： | 1 |
| 18 | Ontologies显示文摘 | William S Austin T | 1999 | IEEE Intelligent Sytems1999，，12： | 1 |
| 19 | Bacteremia, Acute Physiology and Chronic Health Evaluation II and Modified End Stage Liver Disease are independent predictors of mortality in critically ill nontransplanted patients with acute on chronic liver failure显示文摘 | Constantine J. Karvellas Fred Pink Mark McPhail Mark Austin Georg Auzinger William Bernal Elizabeth Sizer Demetrios J. Kutsogiannis Ian Eltringham Julia A. Wendon | 2010 | Critical Care Medicine2010，，1： | 1 |
| 20 | Ontologies 显示文摘 | WILLIAM S AUSTIN T | 1999 | IEEE Intelligent Systems1999，，： | 1 |
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