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| 1 | 术中应用荧光素钠有利于胶质母细胞瘤浸润边缘的手术切除(英文)显示文摘Objective Extent of resection is an important prognostic factor in patients undergoing surgery for glioblastoma( GBM).Recent evidence suggests that intravenously administered fluorescein sodium associates with tumor tissue,facilitating safe maximal resection of GBM. In this study,the authors evaluate the safety and utility of intraoperative fluorescein guidance for the prediction of histopathological alteration both in the contrast-enhancing( CE) regions,where this relationship has been established,and into the nonCE( NCE),diffusely infiltrated margins. Methods Thirty-two patients received fluorescein sodium( 3 mg/kg) intravenously prior to resection. Fluorescence was intraoperatively visualized using a Zeiss Pentero surgical microscope equipped with a YELLOW 560 filter.Stereotactically localized biopsy specimens were acquired from CE and NCE regions based on preoperative MRI in conjunction with neuronavigation. The fluorescence intensity of these specimens was subjectively classified in real time with subsequent quantitative image analysis,histopathological evaluation of localized biopsy specimens,and radiological volumetric assessment of the extent of resection.Results Bright fluorescence was observed in all GBMs and localized to the CE regions and portions of the NCE margins of the tumors,thus serving as a visual guide during resection. Gross-total resection( GTR) was achieved in 84% of the patients with an average resected volume of 95%,and this rate was higher among patients for whom GTR was the surgical goal( GTR achieved in 93. 1% of patients,average resected volume of 99. 7%). Intraoperative fluorescein staining correlated with histopathological alteration in both CE and NCE regions,with positive predictive values by subjective fluorescence evaluation greater than 96% in NCE regions. Conclusions Intraoperative administration of fluorescein provides an easily visualized marker for glioma pathology in both CE and NCE regions of GBM. These findingssupport the use of fluorescein as a microsurgical adjunct for guiding GBM resection to facilitate safe maximal removal. | Neira JA Ung TH Sims J Malone HR Chow DS Samanamud JL Zanazzi GJ Guo X Bowden SG Zhao B Sheth SA McKhann GM 2nd Sisti MB Canoll P D'Amico RS Bruce JN | 2016 | 中华神经外科疾病研究杂志2016，15，5： | 2 |
| 2 | Capripoxviruses: an e- merging worldwide threat to sheep, goats and cattle显示文摘 | Babiuk S Bowden T R Boyle D B | 2008 | Transbound Emerg Dis2008，55，7： | 1 |
| 3 | Sodium dodecyl Sulfate-polyacrylamide gel electrophoresis and immunoblotling analysis of smooth-lipopolysaccharide heterogeneity among Brucella biovars related to A and M specificities显示文摘 | Garin-Bastuji B Bowden G A dubray G | 1990 | J Clin Microbiol1990，28，10： | 1 |
| 4 | Calcium anidotrihydroborate:a hydrogen storage material显示文摘 | Diyabalanage H V K Shrestha R P Semelsberger TA Scott B L Bowden M E Davis B L Burrell A K | | 0，，47： | 1 |
| 5 | Studying muhisite binary and ternary protein interactions by global analysis of isothermal titration calorimetry data in SEDPHAT: application to adaptor protein complexes in cell signaling 显示文摘 | Houtman JC Brown PH Bowden B | 2007 | Protein Sci2007，16，1： | 1 |
| 6 | Persistence of cccDNA during the natural history of chronic hepatitis B and decline during adefovir dipivoxil therapy显示文摘 | Werle-Lapostolle B Bowden S Locarnini S | | 0，，07： | 1 |
| 7 | Persistence of cccDNA during the natural history of chronic hepatitis B and decline during adefovir dipivoxil therapy 显示文摘 | Werle-Lapostolle B Bowden S Loearnini S | 2004 | Gastroenterology2004，126，7： | 1 |
| 8 | Persistence of cccDNA during the natural history of' chronic hepatitis B and declene during adefovir dipivoxil therapy 显示文摘 | Werle- Lapostolle B Bowden S Locarnini S | 2004 | Gastroenterology2004，126，7： | 1 |
| 9 | Gaseous nitrogen emissions from undisturbed terrestrial ecosystems: an assessment of their impacts on local and global nitrogen budgets显示文摘 | BOWDEN W B | 1986 | Biogeochemistry1986，2，： | 1 |
| 10 | Persistence of cccDNA during the natural history of chronic hepatitis B and decline during adefovir dipivoxil therapy显示文摘 | Werle-Lapostolle B Bowden S Locarnini S | | 0，，07： | 1 |
| 11 | Persistence of cccDNA during the natural history of chronic hepatitis B and decline during adefovir dipivoxil therapy显示文摘 | Werle-Lapostolle B Bowden S Locarnini S | 2004 | Gastroenterology2004，126，7： | 1 |
| 12 | Zeolites 显示文摘 | Tapp N J Milestone N B Bowden M E | 1990 | 10:1051990，10，： | 1 |
| 13 | Capripoxviruses:an emerging worldwide threat to sheep,goats and cattle显示文摘 | BABIUK S BOWDEN T R BOYLE D B | 2008 | Transbound Emerg Dis2008，55，7： | 1 |
| 14 | The biogeochemistry of nitrogen in freshwater wetlands 显示文摘 | | 1987 | Biogeochemistry1987，4，： | 1 |
| 15 | Garmna-interferon in aplastic anemia:inability to detect significant levels in sera or demonstrate hematopoietic suppressing activity 显示文摘 | Torok-Storb B Johnson GG Bowden R | 1987 | Blood1987，69，2： | 1 |
| 16 | A new brominated diphenyl ether from the marine sponge Dysidea herbacea 显示文摘 | BOWDEN B F TOWERZEY L JUNK P C | 2000 | Australian Journal of Chemistry2000，53，4： | 1 |
| 17 | Petrogenetic Interpretation of Granitiod Rock Series Using Muhicationic Parameters显示文摘 | Batchlor R B Bowden P | 1985 | Chemical Geology1985，48，： | 1 |
| 18 | Concurrent verbalizations, pedagogical conditions, and reactivity: Two CALL studies 显示文摘 | Sanz C Lin H-J Lado B Bowden H W & Stafford C A | 2009 | Language Learning2009，，1： | 1 |
| 19 | Multicenter evaluation of the elecsys hepatitis B surface antigen quantitative assay显示文摘 | Zacher B J Moriconi F Bowden S | 2011 | Clin Vaccine Immunol2011，18，1： | 1 |
| 20 | Sodium dodeeyl sulfate-polyacrylamide gel eleetrophoresis and immunoblotting analysis of smooth-lipopolysaeeharide heterogeneity among Brucella biovars related to A and M specifieities显示文摘 | Bastuji B G R Bowden A Dubray G | 1990 | J Clin Microbiol1990，28，10： | 1 |
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