|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 术中应用荧光素钠有利于胶质母细胞瘤浸润边缘的手术切除(英文)显示文摘Objective Extent of resection is an important prognostic factor in patients undergoing surgery for glioblastoma( GBM).Recent evidence suggests that intravenously administered fluorescein sodium associates with tumor tissue,facilitating safe maximal resection of GBM. In this study,the authors evaluate the safety and utility of intraoperative fluorescein guidance for the prediction of histopathological alteration both in the contrast-enhancing( CE) regions,where this relationship has been established,and into the nonCE( NCE),diffusely infiltrated margins. Methods Thirty-two patients received fluorescein sodium( 3 mg/kg) intravenously prior to resection. Fluorescence was intraoperatively visualized using a Zeiss Pentero surgical microscope equipped with a YELLOW 560 filter.Stereotactically localized biopsy specimens were acquired from CE and NCE regions based on preoperative MRI in conjunction with neuronavigation. The fluorescence intensity of these specimens was subjectively classified in real time with subsequent quantitative image analysis,histopathological evaluation of localized biopsy specimens,and radiological volumetric assessment of the extent of resection.Results Bright fluorescence was observed in all GBMs and localized to the CE regions and portions of the NCE margins of the tumors,thus serving as a visual guide during resection. Gross-total resection( GTR) was achieved in 84% of the patients with an average resected volume of 95%,and this rate was higher among patients for whom GTR was the surgical goal( GTR achieved in 93. 1% of patients,average resected volume of 99. 7%). Intraoperative fluorescein staining correlated with histopathological alteration in both CE and NCE regions,with positive predictive values by subjective fluorescence evaluation greater than 96% in NCE regions. Conclusions Intraoperative administration of fluorescein provides an easily visualized marker for glioma pathology in both CE and NCE regions of GBM. These findingssupport the use of fluorescein as a microsurgical adjunct for guiding GBM resection to facilitate safe maximal removal. | Neira JA Ung TH Sims J Malone HR Chow DS Samanamud JL Zanazzi GJ Guo X Bowden SG Zhao B Sheth SA McKhann GM 2nd Sisti MB Canoll P D'Amico RS Bruce JN | 2016 | 中华神经外科疾病研究杂志2016，15，5： | 2 |
| 2 | A review of malignant meningiomas: diagnosis, characteristics and treatment 显示文摘 | Hanft S Canoll P Bruce JN | 2010 | J Neurooncol2010，99，： | 1 |
| 3 | GGF/neuregulin induces a phenotypic reversion of oligodendrocytes 显示文摘 | Canoll P D Kraemer R Teng K K | 1999 | Mol Cell Neurosci1999，13，2： | 1 |
| 4 | GGF/neuregulin induces a phenotypic reversion of oligodendrocytes显示文摘 | Canoll P Kreamer R Teng K | 1999 | Mol Cell Neurosci1999，13，： | 1 |
| 5 | GGF/neuregulin is a neuronal signal that promotes the proliferation and sur,ival and inhibits the differentiation of oligodendrocyte progenitors显示文摘 | Canoll P Musachio J Hardy R | 1996 | Neuron1996，17，： | 1 |
| 6 | A review of malignant meningiomas: diagnosis, characteristics, and treatment显示文摘 | Hanft S Canoll P Bruce JN | 2010 | J Neurooncol2010，99，： | 1 |
| 7 | Selective destruction of glioblastoma cells by interference with the activity or expres?sion of ATF5显示文摘 | AngelastroJ M Canoll P D KuoJ | 2006 | Qncogene2006，25，6： | 1 |
| 8 | The cellular origin for ma- lignant glioma and prospects for clinical advancements显示文摘 | Zong H Verhaak RG Canoll P | 2012 | Expert Rev Mol Diagn2012，12，4： | 1 |
| 9 | Selective destruction of glioblastoma cells by interference with the activity or expression of ATF5显示文摘 | ANGELASTRO J M CANOLL P D KUO J | 2006 | Oncogene2006，25，6： | 1 |
| 10 | Optic nerveglioma: Case series with review of clinical,radiologic, molecular, and histopathologiccharacteristics显示文摘 | Glass LR Canoll P Lignelli A | 2014 | Ophthal Plast Reconstr Surg2014，30，5： | 1 |
| 11 | Selective destruction of glioblastoma cells by interference with the acti- vity or expression of ATF-5显示文摘 | ANGELASTRO J M CANOLL P D KUO J | 2006 | Oncogene2006，25，6： | 1 |
| 12 | Cell migration in the normal and pathological postnatal mammalian brain显示文摘 | Cayre M Canoll P Goldman JE | 2009 | Prog Neurobiol2009，88，1： | 1 |
| 13 | GGF/neuregulin is a neuronal signal that promotes the proliferation and survival and inhibits the differentiation of oligodendrocyte progenitors显示文摘 | Canoll P D Musacchio J M Hardy R | 1996 | Neuron1996，17，2： | 1 |
| 14 | GGF/neuregulin induces a phenotypic reversion of oligodendrocytes显示文摘 | Canoll P D Kreamer R Teng K | 1999 | Mol Cell Neurosci1999，13，3： | 1 |
| 15 | A review of malignant meningiomas diagnosis, characteristics and treatment 显示文摘 | Hanft S Canoll P Bruce IN | 2010 | Neurooncol2010，99，43： | 1 |
| 16 | The cellular origin for malignant glioma and prospects for clinical advancements显示文摘 | Zong H Verhaak RGW Canoll P | 2012 | Expert Rev Mol Diagn2012，12，： | 1 |
| 17 | The cellular origin for malignant glioma and prospects for clinical advancements显示文摘 | Zong H Verhaak RG Canoll P | 2012 | Expert Rev Mol Diagn2012，12，4： | 1 |
| 18 | Glial progenitors in adult white matter are driven to form malignant gliomas by platelet derived growth factor-expressing retroviruses显示文摘 | Assanah M Lochhead R Ogden A Bruce J Goldman J Canoll P | 2006 | J Neurosci2006，26，： | 1 |
| 19 | Expression of rat cathepsin S in phagocytic cells显示文摘 | Petanceska S Canoll P Lakshmi AD | 1996 | JBiol Chem1996，271，8： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员