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| 1 | 术中应用荧光素钠有利于胶质母细胞瘤浸润边缘的手术切除(英文)显示文摘Objective Extent of resection is an important prognostic factor in patients undergoing surgery for glioblastoma( GBM).Recent evidence suggests that intravenously administered fluorescein sodium associates with tumor tissue,facilitating safe maximal resection of GBM. In this study,the authors evaluate the safety and utility of intraoperative fluorescein guidance for the prediction of histopathological alteration both in the contrast-enhancing( CE) regions,where this relationship has been established,and into the nonCE( NCE),diffusely infiltrated margins. Methods Thirty-two patients received fluorescein sodium( 3 mg/kg) intravenously prior to resection. Fluorescence was intraoperatively visualized using a Zeiss Pentero surgical microscope equipped with a YELLOW 560 filter.Stereotactically localized biopsy specimens were acquired from CE and NCE regions based on preoperative MRI in conjunction with neuronavigation. The fluorescence intensity of these specimens was subjectively classified in real time with subsequent quantitative image analysis,histopathological evaluation of localized biopsy specimens,and radiological volumetric assessment of the extent of resection.Results Bright fluorescence was observed in all GBMs and localized to the CE regions and portions of the NCE margins of the tumors,thus serving as a visual guide during resection. Gross-total resection( GTR) was achieved in 84% of the patients with an average resected volume of 95%,and this rate was higher among patients for whom GTR was the surgical goal( GTR achieved in 93. 1% of patients,average resected volume of 99. 7%). Intraoperative fluorescein staining correlated with histopathological alteration in both CE and NCE regions,with positive predictive values by subjective fluorescence evaluation greater than 96% in NCE regions. Conclusions Intraoperative administration of fluorescein provides an easily visualized marker for glioma pathology in both CE and NCE regions of GBM. These findingssupport the use of fluorescein as a microsurgical adjunct for guiding GBM resection to facilitate safe maximal removal. | Neira JA Ung TH Sims J Malone HR Chow DS Samanamud JL Zanazzi GJ Guo X Bowden SG Zhao B Sheth SA McKhann GM 2nd Sisti MB Canoll P D'Amico RS Bruce JN | 2016 | 中华神经外科疾病研究杂志2016，15，5： | 2 |
| 2 | Surgical strategies for treating patients with pineal region tumors 显示文摘 | Bruce Jn Ogden AT | 2004 | J Neurooncol2004，69，： | 1 |
| 3 | Treatment of meningioma: an update 显示文摘 | D'Ambrosio AL Bruce JN | 2003 | Curr Neurol Neurosci Rep2003，3，3： | 1 |
| 4 | Surgical management of pineal region tumors 显示文摘 | Bruce JN Stein BM | 1995 | Acta Neurochir ( Wien)1995，134，34： | 1 |
| 5 | A review of malignant meningiomas: diagnosis, characteristics and treatment 显示文摘 | Hanft S Canoll P Bruce JN | 2010 | J Neurooncol2010，99，： | 1 |
| 6 | Pineal tumors显示文摘 | Bruce JN Stein BM | 1990 | Neurosurg Clin North Am1990，1，： | 1 |
| 7 | Temozolomide (Temodar(R)) and capecitabine (Xeloda(R)) treatment of an aggressive corticotroph pituitary tumor显示文摘 | Thearle MS Freda PU Bruce JN | 2011 | Pituitary2011，14，4： | 1 |
| 8 | Human pineal physiology and functional significance of melatonin 显示文摘 | Macchi MM Bruce JN | 2004 | Front Neuroendocrinol2004，25，34： | 1 |
| 9 | A review of malignant meningiomas: diagnosis, characteristics, and treatment显示文摘 | Hanft S Canoll P Bruce JN | 2010 | J Neurooncol2010，99，： | 1 |
| 10 | Human pineal physiology and functional sig- nificance of melatonin 显示文摘 | Macchi MM Bruce JN | 2004 | Front Neuroendocrinol2004，25，34： | 1 |
| 11 | Vascular permeability induced by protein product of malignant brain tumors:inhibition by dexamethasone显示文摘 | Bruce JN Criscuolo GR M errrili MJ | 1987 | J Neuro surg1987，67，： | 1 |
| 12 | Features at diagnosis of 324 patients with acromegaly did not change from 1981 to 2006;Acromegaly remains under-recognized and under-diagnosed 显示文摘 | Reid TJ Post KD Bruce JN | 2009 | Clin Endocrinol (Oxf)2009，16，： | 1 |
| 13 | Surgical strategies for treating patients with pineal region tumors显示文摘 | Bruce JN Ogden AT | 2004 | J Neurooncol2004，69，13： | 1 |
| 14 | Surgical strategies for treating patientswith pineal region tumors显示文摘 | Bruce JN Ogden AT | 2004 | J Neurooncol2004，69，： | 1 |
| 15 | Surgical management of pineal region tumors显示文摘 | Bruce JN Stein BM | 1995 | Acta Neurochir (Wein)1995，134，34： | 1 |
| 16 | Treatment of meningioma:an update显示文摘 | D'Ambrosio AL Bruce JN | 2003 | Curr Neurol Neurosci Rep2003，3，3： | 1 |
| 17 | Human pineal physiology and functional significance of melatonin 显示文摘 | Macchi MM Bruce JN | 2004 | Front Neuroendocrinol2004，25，34： | 1 |
| 18 | Surgical management of craniopharyngiomas显示文摘 | Komotar RJ Roguski M Bruce JN | 2009 | J Neurooneol2009，92，3： | 1 |
| 19 | Surgical management of craniopharyngiomas 显示文摘 | Komotar RJ Roguski M Bruce JN | 2009 | J Neurooncol2009，92，3： | 1 |
| 20 | Surgical management of pineal region tumors 显示文摘 | Bruce JN Stein BM | 1995 | Acta Neurochir (Wien)1995，134，34： | 1 |
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