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| 1 | A randomized controlled clinical trial on the treatment of Thymosin-a1 versus interferon-α in patients with hepatitis B显示文摘INTRODUCTIONChronic hepatitis B virus (HBV) infection is a serious problem because of its world wide distribution and possible adverse sequelae ,such as cirrhosis and hepatocellular carcinoma .The World Health Organization estimates that HBV has infected mord than 350 million people worldwide ,and up to 20% of them will become chromic carricrs and will be at significant risk for cirrhosis and HCC .The ultimate goal of the therapy for chronic hepatitis B is to prevent progression to cirrhosis and to prevent development of HCC. | Jing You Lin Zhuang Bao Zhang Tang Wei Bo Yang Su Ying Ding Wu Li Rong Xue Wu Hong Li Zhang Yan Mei Zhang Shao Ming Yan Lu Zhang ~1Department of Infectious Diseases,The First Affiliated Hospital of Kunming Medical College,Kunming 650032,Yunnan Province,China ~2Departrnent of Hepatology,Kunming Third Municipal People’s Hospital,Kunming 650041,Yunnan Province,China | 2001 | World Journal of Gastroenterology2001，7，3： | 48 |
| 2 | RECTANGLE: a bit-slice lightweight block cipher suitable for multiple platforms显示文摘In this paper, we propose a new lightweight block cipher named RECTANGLE. The main idea of the design of RECTANGLE is to allow lightweight and fast implementations using bit-slice techniques. RECTANGLE uses an SP-network. The substitution layer consists of 16 4 × 4 S-boxes in parallel. The permutation layer is composed of 3 rotations. As shown in this paper, RECTANGLE offers great performance in both hardware and software environment, which provides enough flexibility for different application scenario. The following are3 main advantages of RECTANGLE. First, RECTANGLE is extremely hardware-friendly. For the 80-bit key version, a one-cycle-per-round parallel implementation only needs 1600 gates for a throughput of 246 Kbits/s at100 k Hz clock and an energy efficiency of 3.0 p J/bit. Second, RECTANGLE achieves a very competitive software speed among the existing lightweight block ciphers due to its bit-slice style. Using 128-bit SSE instructions,a bit-slice implementation of RECTANGLE reaches an average encryption speed of about 3.9 cycles/byte for messages around 3000 bytes. Last but not least, we propose new design criteria for the RECTANGLE S-box.Due to our careful selection of the S-box and the asymmetric design of the permutation layer, RECTANGLE achieves a very good security-performance tradeoff. Our extensive and deep security analysis shows that the highest number of rounds that we can attack, is 18(out of 25). | ZHANG WenTao BAO ZhenZhen LIN DongDai Vincent RIJMEN YANG Bo Han Ingrid VERBAUWHEDE | 2015 | Science China Chemistry2015，58，12： | 22 |
| 3 | Advanced Space-based Solar Observatory(ASO-S):an overview显示文摘The Advanced Space-based Solar Observatory(ASO-S)is a mission proposed for the 25 th solar maximum by the Chinese solar community.The scientific objectives are to study the relationships between the solar magnetic field,solar flares and coronal mass ejections(CMEs).Three payloads are deployed:the Full-disk vector Magneto Graph(FMG),the Lyman-αSolar Telescope(LST)and the Hard X-ray Imager(HXI).ASO-S will perform the first simultaneous observations of the photospheric vector magnetic field,non-thermal imaging of solar flares,and the initiation and early propagation of CMEs on a single platform.ASO-S is scheduled to be launched into a 720 km Sun-synchronous orbit in 2022.This paper presents an overview of the mission till the end of Phase-B and the beginning of Phase-C. | Wei-Qun Gan Cheng Zhu Yuan-Yong Deng Hui Li Yang Su Hai-Ying Zhang Bo Chen Zhe Zhang Jian Wu Lei Deng Yu Huang Jian-Feng Yang Ji-Jun Cui Jin Chang Chi Wang Ji Wu Zeng-Shan Yin Wen Chen Cheng Fang Yi-Hua Yan Jun Lin Wei-Ming Xiong Bin Chen Hai-Chao Bao Cai-Xia Cao Yan-Ping Bai Tao Wang Bing-Long Chen Xin-Yu Li Ye Zhang Li Feng Jiang-Tao Su Ying Li Wei Chen You-Ping Li Ying-Na Su Hai-Yan Wu Mei Gu Lei Huang Xue-Jun Tang | 2019 | Research in Astronomy and Astrophysics2019，19，11： | 17 |
| 4 | Autophagic pathways as new targets for cancer drug development显示文摘Autophagy 是涉及长寿蛋白质的降级并且损坏了细胞器的一个 evolutionarily 保存的 lysosomal 自我消化过程。在最近的年里,增加证据显示 autophagy 与很多个病理学的过程被联系,包括癌症。在这评论,我们集中于在包含的 autophagosome 形成和小径被含有的 evolutionarily 保存的 autophagy 相关的基因(ATG ) 的最近的研究。我们讨论几个关键 autophagic 调停人(例如, Beclin-1, UVRAG, Bcl-2,类 III 并且我 PI3K, mTOR,和 p53 ) 在在癌症表明网络的 autophagic 起枢轴的作用。我们在癌症讨论 autophagy 的 Janus 角色并且加亮他们的关系到肿瘤抑制和肿瘤前进。我们也举作为 anticancer 策略指向 ATG 和几蛋白质 kinases 的一些例子,并且作为 antitumor 代理人讨论一些模块化 autophagy 代理人。在 autophagy 和癌症之间的关系的更好的理解将最终允许我们在癌症治疗学为药发现作为新目标利用 autophagic 小径。 | Bo LIU Yan CHENG Qian LIU Jin-ku BAO Jin-Ming YANG | 2010 | Acta Pharmacologica Sinica2010，31，9： | 15 |
| 5 | Synergetic strengthening mechanism of ultrasound combined with calcium fluoride towards vanadium extraction from low-grade vanadium-bearing shale显示文摘The effect and mechanism of ultrasound and CaF_(2) on vanadium leaching from vanadium-bearing shale were investigated systematically.In consideration of the enhancement for vanadium recovery,the combination of ultrasound and CaF_(2)(66.28%) exerts more evident effects than ultrasound(26.97%) and CaF_(2)(60.35%) alone,demonstrating the synergetic effect of ultrasound and CaF_(2).Kinetic analysis manifests that the product layer diffusion controls vanadium leaching in ultrasound system without CaF_(2),however product layer diffusion and interfacial reaction is the rate-controlling step for vanadium leaching in other three leaching systems.The combination of ultrasound and CaF_(2) notably decreases the activation energy(E_(a)) from 62.03 to 27.61 kJ/mol,nevertheless individual CaF_(2) only reduces the E_(a) to 50.70 kj/mol.X-ray diffraction and fourier transform infrared spectrometer analyses show that the decomposition degree of the vanadium-bearing mica structure is the most significant in ultrasound and CaF_(2) system,proving the highest release degree of vanadium.Specific surface area and pore distribution combined with scanning electron microscope analyses reveal that the action of ultrasound and CaF_(2) would provide higher specific surface area,more abundant pores structure and cracks for the particles,which further prompts the rapid diffusion of H^(+),F^(-)and HF,and achieves the conspicuous improvement of vanadium leaching recovery. | Bo Chen Shenxu Bao Yimin Zhang | 2021 | International Journal of Mining Science and Technology2021，31，6： | 14 |
| 6 | Efficient generation of transgenic chickens using the spermatogonial stem cells in vivo and ex vivo transfection显示文摘The highly efficient novel methods to produce transgenic chickens were established by directly in-jecting the recombinant plasmid containing green fluorescent protein (GFP) gene into the cock's testis termed as testis-medianted gene transfer (TMGT), and transplanting transfected spermatogonial stem cells (TTSSCs). For the TMGT approach,four dosages of pEGFP-N1 DNA/cationic polymer complex were injected intratesticularly. The results showed: (1) 48 h after the injection,the percentages of testis cells expressing GFP were 4.0%, 8.7%, 10.2% and 13.6% in the 50, 100, 150 and 200 μg/mL group, re-spectively. The difference from the four dosage groups was significant (P<0.05). On day 25 after the injection, a dosage-dependent and time-dependent increase in the number of transgenic sperm was observed. The percentages of gene expression reached the summit and became stable from day 70 to 160, being 12.7%, 12.8%, 15.9% and 19.1%, respectively. The difference from the four dosage groups was also significant (P<0.05). (2) 70 d after the injection, strong green fluorescent could be observed in the seminiferous tubules by whole-mount in-situ hybridization. (3) 70 d after the injection, the semen was collected and used to artificially inseminate wild-type females. The blastoderms of F1 and F2 transgenic chicken expressed GFP were 56.2% (254/452) and 53.2% (275/517), respectively. The detec-tion of polymerase chain reaction (PCR) of F1 and F2 transgenic chicken blood genomic DNA showed that 56.5% (3/23) of F1 and 52.9% (9/17) of F2 were positive. Southern blot showed GFP DNA was in-serted in their genomic DNAs. (4) Frozen whole mount tissue sections of F1 and F2 transgenic chicken liver, heart, kidney and muscle showed that the rates of green fluorescent positive were between 50.0% and 66.7%. (5) With the TTSSCs method, SSCs ex vivo transfected with GFP were transplanted into recipient roosters whose endogenic SSCs had been resoluted. The donor SSCs settled and GFP ex-pression became readily detectable in the frozen whole mount tissue sections of recepient testes. Moreover, sperms carrying GFP could be produced normally. The results of artificially inseminating wild-type females with these sperms showed 12.5% (8/64) of offspring embryo expressed GFP and 11.1% (2/18) hatched chicks were tested transgenic. Our data therefore suggest TMGT and TTSSCs are the feasible methods for the generation of transgenic chickens. | LI BiChun SUN GuoBo SUN HuaiChang XU Qi GAO Bo ZHOU GuanYue ZHAO WenMing WU XinSheng BAO WenBin YU Fei WANG KeHua CHEN GuoHong | 2008 | Science China(Life Sciences)2008，51，8： | 13 |
| 7 | Increase of TNFα-stimulated Osteoarthritic Chondrocytes Apoptosis and Decrease of Matrix Metalloproteinases 9 by NF-κB Inhibition显示文摘Objective To investigate the in vitro effect of caffeic acid phenethyl ester(CAPE),a NF-κB inhibitor,on the apoptosis of osteoarthritic(OA)chondrocytes and on the regulation of the gelatinases matrix metalloproteinase 2(MMP-2)and matrix metalloproteinase 9(MMP-9).Methods Annexin V-FITC/propidium iodide(PI)labeling and western blotting were used to observe and determine the apoptosis in TNFα-stimulated primary cultured osteoarthritic chondrocytes.Also,gelatin zymography was applied to examine MMP-2 and MMP-9 activities in supernatants.Results It was confirmed by both flow cytometry and western blotting that chondrocytes from OA patients have an apoptotic background.Use of CAPE in combination with 10 ng/mL of TNFα for 24 h facilitated the apoptosis.MMP-9 in the supernatant could be autoactivated(from proMMP-9 to active MMP-9),and the physiologic calcium concentration(2.5 mmol/L)could delay the autoactivation of MMP-9.The activities of MMP-2 and MMP-9 in the fresh supernatant increased significantly in response to stimulation by 10 ng/mL of TNFα for 24 h.The stimulatory effect of TNFα just on proMMP-9 was counteracted significantly by CAPE.Conclusion NF-κB could prevent chondrocytes apoptosis though its activation was attributed to the increase of proMMP-9 activity induced by TNFα(a pro-apoptotic factor).Therefore,therapeutic NF-κB inhibitor was a 'double-edged swords' to the apoptosis of chondrocytes and the secretion of MMP-9. | WANG Yan LI De Ling ZHANG Xin Bo DUAN Yuan Hui WU Zhi Hong HAO Dong Sheng CHEN Bao Sheng QIU Gui Xing | 2013 | Biomedical and Environmental Sciences2013，26，4： | 13 |
| 8 | Tree-ring-based May-July mean temperature history for Lüliang Mountains,China,since 1836显示文摘As a consequence of recent global warming and its social impact, regional climate change is attracting an increasing amount of attention from scientists. A May-July temperature proxy extending back to 1836 was developed from tree-ring width of Chinese pine (Pinus tabulaeformis Carr.) found in the middle Lüliang Mountains, northern China. Correlations with climatic data from six nearby meteorological stations range from -0.58 to -0.65, indicating a strong response of tree-ring index to May-July mean temperatures, which were subsequently reconstructed. The reconstruction captures 45% (F=38.474, P<0.001) of the regional variance in the instrumental data over the calibration period 1955-2003. Reconstructed warm and cold periods were verified by additional temperature reconstructions based on tree-ring data from northern China. In addition, the reconstruction was significantly corre-lated with May-July mean temperatures from 13 other meteorological stations in northern China, suggesting that our reconstruction is also representative of north-central China. The warming trend during the second half of the 20th century is seen in the reconstruction, but only the 1994-2002 mean temperature seems unprecedented over the whole reconstructed period. | CAI QiuFang LIU Yu BAO Guang LEI Ying SUN Bo | 2010 | Chinese Science Bulletin2010，55，26： | 12 |
| 9 | A cytotoxic compound from the leaves of Juglans mandshurica显示文摘From Juglans mandshurica leaves, a new quinone compound was isolated through bioassay-guided fractionation. The structure elucidation of the compound was established based on spectroscopic studies, notably of the 2D NMR spectra. The compound exhibited moderate cytotoxic activities against Hela, MCF-7, BGC823 and 3T3-L1cell lines with IC50 ranges from 7.5 to26.8 mmol/L. | Zhi Bo Li Yong Ming Bao Hong Bo Chen Jing Yun Wang Jie Han Hu Li Jia An | 2007 | Chinese Chemical Letters2007，18，7： | 11 |
| 10 | Progress in ceramic materials and structure design toward advanced thermal barrier coatings显示文摘Thermal barrier coatings(TBCs)can effectively protect the alloy substrate of hot components in aeroengines or land-based gas turbines by the thermal insulation and corrosion/erosion resistance of the ceramic top coat.However,the continuous pursuit of a higher operating temperature leads to degradation,delamination,and premature failure of the top coat.Both new ceramic materials and new coating structures must be developed to meet the demand for future advanced TBC systems.In this paper,the latest progress of some new ceramic materials is first reviewed.Then,a comprehensive spalling mechanism of the ceramic top coat is summarized to understand the dependence of lifetime on various factors such as oxidation scale growth,ceramic sintering,erosion,and calcium–magnesium–aluminium–silicate(CMAS)molten salt corrosion.Finally,new structural design methods for high-performance TBCs are discussed from the perspectives of lamellar,columnar,and nanostructure inclusions.The latest developments of ceramic top coat will be presented in terms of material selection,structural design,and failure mechanism,and the comprehensive guidance will be provided for the development of next-generation advanced TBCs with higher temperature resistance,better thermal insulation,and longer lifetime. | Zhi-Yuan WEI Guo-Hui MENG Lin CHEN Guang-Rong LI Mei-Jun LIU Wei-Xu ZHANG Li-Na ZHAO Qiang ZHANG Xiao-Dong ZHANG Chun-Lei WAN Zhi-Xue QU Lin CHEN Jing FENG Ling LIU Hui DONG Ze-Bin BAO Xiao-Feng ZHAO Xiao-Feng ZHANG Lei GUO Liang WANG Bo CHENG Wei-Wei ZHANG Peng-Yun XU Guan-Jun YANG Hong-Neng CAI Hong CUI You WANG Fu-Xing YE Zhuang MA Wei PAN Min LIU Ke-Song ZHOU Chang-Jiu LI | 2022 | Journal of Advanced Ceramics2022，11，7： | 9 |
| 11 | Defect-rich MoS2 nanowall catalyst for efficient hydrogen evolution reaction显示文摘为氢进化反应设计有效 electrocatalysts (她的) 由于对干净精力的迫切要求吸引了实质的注意在不久的将来面对精力危机和随后的环境问题。在她的催化剂的大变化之中,铝二硫化物(瞬间 2) 由于它的丰富,低价格,高效率,和明确的催化机制被认为是最著名的催化剂。在这研究,有可控制的厚度的设计缺点的瞬间 2 nanowall (NW ) 催化剂被制作并且展出一显著地提高了她的表演。得益于高度暴露的活跃的边地点和不平的表面由柔韧的 NW 结构伴随了,有优化厚度的充满缺点的瞬间 2 NW 催化剂显示出 85 mV 的 ultralow 发作过电位, 310.6 | Junfeng Xie Haichao Qu Jianping Xin Xinxia Zhang Guanwei Cui Xiaodong Zhang Jian Bao Bo Tang Yi Xie | 2017 | Nano Research2017，10，4： | 8 |
| 12 | Targeting autophagic pathways for cancer drug discovery显示文摘Autophagy , an evolutionarily conserved lysosomal degradation process , has drawn an increasing amount of attention in recent years for its role in a variety of human diseases, such as cancer. Notably, autophagy plays an important role in regulating several survival and death signaling pathways that determine cell fate in cancer. To date, substantial evidence has demonstrated that some key autophagic mediators, such as autophagy-related genes (ATGs), PI3K, mTOR, p53, and Beclin-1, may play crucial roles in modulating autophagic activity in cancer initiation and progression. Because autophagy-modulating agents such as rapamycin and chloroquine have already been used clinically to treat cancer, it is conceivable that targeting autophagic pathways may provide a new opportunity for discovery and development of more novel cancer therapeutics. With a deeper understanding of the regulatory mechanisms governing autophagy, we will have a better opportunity to facilitate the exploitation of autophagy as a target for therapeutic intervention in cancer. This review discusses the current status of targeting autophagic pathways as a potential cancer therapy. | Bo Liu Jin-Ku Bao Jin-Ming Yang Yan Cheng | 2013 | Chinese Journal of Cancer2013，32，3： | 8 |
| 13 | Association between Plasma Metal Levels and Diabetes Risk: a Case-control Study in China显示文摘Objective Many metals, some of which have been classified as environmental endocrine disruptors, are used extensively in everyday consumer products and are ubiquitous in our living environment. In the present study, we aimed to explore the associations between the prevalence risk of type 2 diabetes and plasma levels of 20 trace elements as well as those of heavy metals in a Han Chinese population. Methods We conducted a case-control study to investigate the associations between plasma concentrations of 20 metals and diabetes in Jiangsu province. A total of 122 newly diagnosed cases of type 2 diabetes and 429 matched controls were recruited from community physical examinations in Suzhou City of Jiangsu Province. Plasma metal levels were measured by inductively-coupled plasma mass spectrometry. Results After adjusting for confounders, plasma vanadium, chromium, manganese, copper, zinc, arsenic, selenium, strontium, palladium, cadmium, cesium, and barium were associated with diabetes risk(P < 0.05). The adjusted OR increased with increasing concentration of vanadium, manganese, copper, zinc, and cesium. Conclusion Many metals, including manganese, copper, zinc, arsenic, selenium, and cadmium in plasma, are associated with the morbidity of diabetes. Monitoring of environmental metal levels and further studies are urgently needed. | LI Xiu Ting YU Peng Fei GAO Yan GUO Wen Hui WANG Jun LIU Xin GU Ai Hua JI Gui Xiang DONG Qiu WANG Bo Shen CAO Ying ZHU Bao Li XIAO Hang | 2017 | Biomedical and Environmental Sciences2017，30，7： | 8 |
| 14 | Advances in statistical mechanics of rock masses and its engineering applications显示文摘To efficiently link the continuum mechanics for rocks with the structural statistics of rock masses,a theoretical and methodological system called the statistical mechanics of rock masses(SMRM)was developed in the past three decades.In SMRM,equivalent continuum models of stressestrain relationship,strength and failure probability for jointed rock masses were established,which were based on the geometric probability models characterising the rock mass structure.This follows the statistical physics,the continuum mechanics,the fracture mechanics and the weakest link hypothesis.A general constitutive model and complete stressestrain models under compressive and shear conditions were also developed as the derivatives of the SMRM theory.An SMRM calculation system was then developed to provide fast and precise solutions for parameter estimations of rock masses,such as full-direction rock quality designation(RQD),elastic modulus,Coulomb compressive strength,rock mass quality rating,and Poisson’s ratio and shear strength.The constitutive equations involved in SMRM were integrated into a FLAC3D based numerical module to apply for engineering rock masses.It is also capable of analysing the complete deformation of rock masses and active reinforcement of engineering rock masses.Examples of engineering applications of SMRM were presented,including a rock mass at QBT hydropower station in northwestern China,a dam slope of Zongo II hydropower station in D.R.Congo,an open-pit mine in Dexing,China,an underground powerhouse of Jinping I hydropower station in southwestern China,and a typical circular tunnel in Lanzhou-Chongqing railway,China.These applications verified the reliability of the SMRM and demonstrated its applicability to broad engineering issues associated with jointed rock masses. | Faquan Wu Jie Wu Han Bao Bo Li Zhigang Shan Deheng Kong | 2021 | Journal of Rock Mechanics and Geotechnical Engineering2021，13，1： | 8 |
| 15 | Endosome-mediated retrograde axonal transport of P2X3 receptor signals in primary sensory neurons显示文摘Neurotrophins 和他们的受体采用发信号的内涵体播送后退信号。然而,机制后退发信号因为另外的 ligand/receptor 系统糟糕被理解。这里,我们报导 purinergic (P) 2X 3 受体的信号,一条门 ATP 的离子隧道, retrogradely 在背面的根中心(DRG ) 被搬运神经原轴突。我们发现了那 Rab5,小 GTPase,控制早 P2X 3 受体排序进内涵体,当 Rab7 调停时快后退 P2X 3 受体的运输。Intraplantar 注射和 axonal 申请进 α 的 microfluidic 房间;, β -methylene-ATP (α, β -MeATP), P2X 选择收缩筋,提高了 endocytosis 并且后退 P2X 3 受体的运输。α, β激活的 -MeATP-induced Ca 2+ 流入由蛋白质 kinase C 组成的一条小径,病毒的 oncogene 和细胞外的调整信号的蛋白质 kinase (英皇家空军之阶级最低之兵) ,它与 endocytic P2X 3 受体联系了到形成表明内涵体的老鼠肉瘤。类脂化合物椽子的混乱废除了 α, β -MeATP-induced 英皇家空军之阶级最低之兵 phosphorylation, endocytosis 并且后退 P2X 3 受体的运输。而且,有 α 的外部轴突的治疗;, β -MeATP 在 DRG 的房间身体增加了英皇家空军之阶级最低之兵和营地反应元素绑定蛋白质的激活水平神经原和提高的 neuronal 易兴奋性。也的缺陷在 vivo 的基于微导管的 axonal 运输或在 vitro 的 dynein 功能堵住了 α, β -MeATP-induced 后退信号。这些结果显示那 P2X 3 激活受体的信号在主要感觉神经原经由 retrogradely 搬运的内涵体被播送并且为门 ligand 的隧道提供新奇发信号机制。 | Xu-Qiao Chen Bin Wang Chengbiao Wu Jin Pan Bo Yuan Yuan-Yuan Su Xing-Yu Jiang Xu Zhang Lan Bao | 2012 | Cell Research2012，22，4： | 8 |
| 16 | A cross-sectional survey on the prevalence of anxiety symptoms in Chinese patients with premature ventricular contractions without structural heart disease显示文摘 | LIANG Jin-jun HUANG He YANG Bo WAN Jun TANG Yan-hong BAO Ming-wei ZHAO Qin-yan wu Gang HUANG Cong-xin | 2012 | Chinese Medical Journal2012，，14： | 7 |
| 17 | Competitive virus and host RNAs: the interplay of a hidden virus and host interaction显示文摘在病毒感染期间,病毒的 RNA 和 mRNAs 在天生的免疫作为联系病原体的分子的模式(PAMP ) 为病毒的蛋白质合成并且可能作为蓝图工作。这里,在 microRNAs (miRNAs ) 和竞争内长的 RNA (ceRNAs ) 考虑最近的研究进步,我们作为海绵推测那病毒的 RNA 行为并且能扣押在内的内长的 miRNAs 感染了细胞,这样跨 regulating 稳定性和有分享的 miRNA 反应元素的宿主 mRNAs 的翻译效率。在病毒的 RNA 和主人 mRNAs 之间的这串音和这些相互的相互作用被称为竞争病毒并且主人 RNA (cvhRNAs ) 。我们进一步在肝炎 B 为 cvhRNAs 网络的存在提供最近的试验性的证据病毒(HBV ) ,以及 Herpesvirus saimiri (HVS ) , lysin 的鼠科的 cytomegalovirus (MCMV ) 和人的 cytomegalovirus (HCMV ) 感染。另外, cvhRNA 假设也预言可能在主人和另外的病毒之间跨规定例如丙肝病毒(HCV ) , HIV,流行性感冒病毒,人的乳头状瘤病毒(HPV ) 。因为在 miRNAs 和病毒的 RNA 之间的相互作用不可避免地也导致病毒的 RNA 功能的压抑,我们推测那个病毒可以演变采用 cvhRNA 网络或避免在主机以内为最佳的健康指向的 miRNA。CvhRNA 网络可以因此在病毒的复制,感染建立,和病毒的致病的规定起一个基本作用。 | Changfei Li Jun Hu Junli Hao Bao Zhao Bo Wu Lu Sun Shanxin Peng George F. Gao Songdong Meng | 2014 | Protein & Cell2014，5，5： | 6 |
| 18 | The FGOALS climate system model as a modeling tool for supporting climate sciences:An overview显示文摘Climate system models are useful tools for understanding the interactions among the components of the climate system and predicting/projecting future climate change. The development of climate models has been a central focus of the State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics, Institute of Atmospheric Physics, Chinese Academy of Sciences(LASG/IAP) since the establishment of the laboratory in 1985. In China, many pioneering component models and fully coupled models of the climate system have been developed by LASG/IAP. The fully coupled climate system developed in the recent decade is named FGOALS(Flexible Global Ocean-Atmosphere-Land System Model). In this paper, an application-oriented review of the LASG/IAP FGOALS model is presented. The improved model performances are demonstrated in the context of cloud-radiation processes, Asian monsoon, ENSO phenomena, Atlantic Meridional Overturning Circulation(AMOC) and sea ice. The FGOALS model has contributed to both CMIP5(Coupled Model Intercomparison Project-phase 5) and IPCC(Intergovernmental Panel on Climate Change) AR5(the Fifth Assessment Report). The release of FGOALS data has supported the publication of nearly 500 papers around the world. The results of FGOALS are cited ~106 times in the IPCC WG1(Working Group 1) AR5. In addition to the traditional long-term simulations and projections, near-term decadal climate prediction is a new set of CMIP experiment, progress of LAGS/IAP in the development of nearterm decadal prediction system is reviewed. The FGOALS model has supported many Chinese national-level research projects and contributed to the national climate change assessment report. The crucial role of FGOALS as a modeling tool for supporting climate sciences is highlighted by demonstrating the model's performances in the simulation of the evolution of Earth's climate from the past to the future. | TianJun Zhou Bin Wang YongQiang Yu YiMin Liu WeiPeng Zheng LiJuan Li Bo Wu PengFei Lin Zhun Guo WenMin Man Qing Bao AnMin Duan HaiLong Liu XiaoLong Chen Bian He JianDong Li LiWei Zou XiaoCong Wang LiXia Zhang Yong Sun WenXia Zhang | 2018 | Earth and Planetary Physics2018，2，4： | 6 |
| 19 | Endoscopic Approach to Remove Intra-extracranial Tumors in Various Skull Base Regions: 10-year Experience of a Single Center显示文摘 | Qiu-Hang Zhang Zhen-Lin Wang Hong-Chuan Guo Feng Kong Bo Yan Ming-Chu Li Ge Chen Jian-Tao Liang Yu-Hai Bao Feng Ling | 2017 | Chinese Medical Journal2017，，24： | 6 |
| 20 | The Lyman-alpha Solar Telescope (LST) for the ASO-S mission——Ⅰ. Scientific objectives and overview显示文摘As one of the payloads for the Advanced Space-based Solar Observatory(ASO-S)mission,the Lyman-alpha(Lyα)Solar Telescope(LST)is aimed at imaging the Sun and the inner corona up to 2.5 R⊙(mean solar radius)in both the Lyα(121.6 nm)and visible wavebands with high temporo-spatial resolution,mainly targeting solar flares,coronal mass ejections(CMEs)and filaments/prominences.LST observations allow us to trace solar eruptive phenomena from the disk center to the inner corona,to study the relationships between eruptive prominences/filaments,solar flares and CMEs,to explore the dynamical processes and evolution of solar eruptions,to diagnose solar winds,and to derive physical parameters of the solar atmosphere.LST is actually an instrument suite,which consists of a Solar Disk Imager(SDI),a Solar Corona Imager(SCI),a White-light Solar Telescope(WST)and two Guide Telescopes(GTs).This is the first paper in a series of LST-related papers.In this paper,we introduce the scientific objectives,present an overview of the LST payload and describe the planned observations.The detailed design and data along with potential diagnostics are described in the second(Paper II)and third(Paper III)papers,respectively,appearing in this issue. | Hui Li Bo Chen Li Feng Ying Li Yu Huang Jing-Wei Li Lei Lu Jian-Chao Xue Bei-Li Ying Jie Zhao Yu-Tong Yang Wei-Qun Gan Cheng Fang Ke-Fei Song Hong Wang Quan-Feng Guo Ling-Ping He Bo Zhu Cheng Zhu Lei Deng Hai-Chao Bao Cai-Xia Cao Zhong-Guang Yang | 2019 | Research in Astronomy and Astrophysics2019，19，11： | 6 |
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