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| 1 | Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion显示文摘The recent outbreak of coronavirus disease(COVID-19)caused by SARS-CoV-2 infection in Wuhan,China has posed a serious threat to global public health.To develop specific anti-coronavirus therapeutics and prophylactics,the molecular mechanism that underlies viral infection must first be defined.Therefore,we herein established a SARS-CoV-2 spike(S)protein-mediated cell-cell fusion assay and found that SARS-CoV-2 showed a superior plasma membrane fusion capacity compared to that of SARS-CoV.We solved the X-ray crystal structure of six-helical bundle(6-HB)core of the HR1 and HR2 domains in the SARS-CoV-2 S protein S2 subunit revealing that several mutated amino acid residues in the HR1 domain may be associated with enhanced interactions with the HR2 domain.We previously developed a pan-coronavirus fusion inhibitor,EK1,which targeted the HR!domain and could inhibit infection by divergent human coronaviruses tested,including SARS-CoV and MERS-CoV.Here we generated a series of lipopeptides derived from EK1 and found that EK1C4 was the most potent fusion inhibitor against SARS-CoV-2 S protein-mediated membrane fusion and pseudovirus infection with IC50s of 1.3 and 15.8 nM,about 241-and 149-fold more potent than the original EK1 peptide,respectively.EK1C4 was also highly effective against membrane fusion and infection of other human coronavirus pseudoviruses tested,including SARS-CoV and MERS-CoV,as well as SARSr-CoVs,and potently inhibited the replication of 5 live human coronaviruses examined,including SARS-CoV-2.Intranasal application of EK1C4 before or after challenge with HCoV-OC43 protected mice from infection,suggesting that EK1C4 could be used for prevention and treatment of infection by the currently circulating SARS-CoV-2 and other emerging SARSr-CoVs. | Shuai Xia Meiqin Liu Chao Wang Wei Xu Qiaoshuai Lan Siliang Feng Feifei Qi Linlin Bao Lanying Du Shuwen Liu Chuan Qin Fei Sun Zhengli Shi Yun Zhu Shibo Jiang Lu Lu | 2020 | Cell Research2020，30，4： | 81 |
| 2 | The Genome Sequence Archive Family: Toward Explosive Data Growth and Diverse Data Types显示文摘The Genome Sequence Archive(GSA)is a data repository for archiving raw sequence data,which provides data storage and sharing services for worldwide scientific communities.Considering explosive data growth with diverse data types,here we present the GSA family by expanding into a set of resources for raw data archive with different purposes,namely,GSA(https://ngdc.cncb.ac.cn/gsa/),GSA for Human(GSA-Human,https://ngdc.cncb.ac.cn/gsa-human/),and Open Archive for Miscellaneous Data(OMIX,https://ngdc.cncb.ac.cn/omix/).Compared with the 2017 version,GSA has been significantly updated in data model,online functionalities,and web interfaces.GSA-Human,as a new partner of GSA,is a data repository specialized in human genetics-related data with controlled access and security.OMIX,as a critical complement to the two resources mentioned above,is an open archive for miscellaneous data.Together,all these resources form a family of resources dedicated to archiving explosive data with diverse types,accepting data submissions from all over the world,and providing free open access to all publicly available data in support of worldwide research activities. | Tingting Chen Xu Chen Sisi Zhang Junwei Zhu Bixia Tang Anke Wang Lili Dong Zhewen Zhang Caixia Yu Yanling Sun Lianjiang Chi Huanxin Chen Shuang Zhai Yubin Sun Li Lan Xin Zhang Jingfa Xiao Yiming Bao Yanqing Wang Zhang Zhang Wenming Zhao | 2021 | Genomics, Proteomics & Bioinformatics2021，19，4： | 38 |
| 3 | Somatosensory neuron types identified by high-coverage single-cell RNA-sequencing and functional heterogeneity显示文摘感觉神经原被不同发信号的网络和接受特征区分。因此,感觉神经原类型能被连接基于 transcriptome 的神经原与感觉显型打字定义。这里,我们分类老鼠的 somatosensory 神经原由高范围的单个房间的定序 RNA 的背面的根中心(DRG )(10 950 ±1 218 基因每神经原) 并且神经原基于尺寸的层次聚类。而且,对皮肤的刺激作出回应的单个 DRG 神经原被记录用一在里面 vivo 整个房间的补丁夹钳技术并且由神经原类型分类基因标记。小直径 DRG 神经原被分类进低阀值的 mechanoreceptor 的一种类型和 mechanoheat nociceptors (MHN ) 的五种类型。每 MHN 类型进一步被分成二种子类型。大 DRG 神经原被分成四种类型,包括表示联系 BAI1 的蛋白质 2-like 的 neurexophilin 1 快车 MHN 和机械 nociceptors (MN ) 1 (Baiap2l1 ) 。表示 trafficking 蛋白质粒子建筑群 3-like 和 Baiap2l1 显著的 MN 的 Mechanoreceptors 各被细分进二种子类型。这些结果为编目 somatosensory 神经原和他们的 transcriptome 数据库提供一个新系统。 | Chang-Lin Li Kai-Cheng Li Dan Wu Yan Chen Hao Luo Jing-Rong Zhao Sa-Shuang Wang Ming-Ming Sun Ying-Jin Lu Yan-Qing Zhong Xu-Ye Hu Rui Hou Bei-Bei Zhou Lan Bao Hua-Sheng Xiao Xu Zhang | 2016 | Cell Research2016，26，1： | 21 |
| 4 | Effects of Short-Term Forest Bathing on Human Health in a Broad-Leaved Evergreen Forest in Zhejiang Province,China显示文摘Objective To investigate the effects of short-term forest bathing on human health.Methods Twenty healthy male university students participated as subjects and were randomly divided into two groups of 10.One group was sent on a two-night trip to a broad-leaved evergreen forest,and the other was sent to a city area.Serum cytokine levels reflecting inflammatory and stress response,indicators reflecting oxidative stress,the distribution of leukocyte subsets,and plasma endothelin-1 (ET-1) concentrations were measured before and after the experiment to evaluate the positive health effects of forest environments.A profile of mood states (POMS) evaluation was used to assess changes in mood states.Results No significant differences in the baseline values of the indicators were observed between the two groups before the experiment.Subjects exposed to the forest environment showed reduced oxidative stress and pro-inflammatory level,as evidenced by decreased malondialdehyde,interleukin-6,and tumor necrosis factor α levels compared with the urban group.Serum cortisol levels were also lower than in the urban group.Notably,the concentration of plasma ET-1 was much lower in subjects exposed to the forest environment.The POMS evaluation showed that after exposure to the forest environment,subjects had lower scores in the negative subscales,and the score for vigor was increased.Conclusion Forest bathing is beneficial to human health,perhaps through preventive effects related to several pathological factors. | MAO Gen Xiang LAN Xiao Guang CAO Yong Bao CHEN Zhuo Mei HE Zhi Huat LV Yuan Dong WANG Ya Zhen HU Xi Lian WANG Guo Fu YAN Jing | 2012 | Biomedical and Environmental Sciences2012，25，3： | 20 |
| 5 | Calcium-binding ability of soy protein hydrolysates显示文摘This present study investigated the ability of various soy protein hydrolysates(SPHs)in binding calcium.It was demonstrated that the amount of Ca-bound depended greatly on the SPHs obtained using different proteases,which included:neutrase, flavourzyme,protease M and pepsin.The maximum level of Ca-bound(66.9 mg/g)occurred when protease M was used to hydrolyze soy protein.Peptide fragments exhibiting high Ca-binding capacity had molecular weights of either 14.4 or 8-9 kDa.The level of Ca-bound increased linearly with the increment of carboxyl content in SPHs,and further deamidation on SPHs from protease M improved Ca-binding of the hydrolysate. | Xiao Lan Bao Mei Song Jing Zhang Yang Chen Shun Tang Guo | 2007 | Chinese Chemical Letters2007，18，9： | 14 |
| 6 | Improving Plant Genome Editing with High-Fidelity xCas9 and Non-canonical PAM-Targeting Cas9-NG显示文摘Two recently engineered SpCas9 variants, namely xCas9 and Cas9-NG, show promising potential in improving targeting specificity and broadening the targeting range. In this study, we evaluated these Cas9 variants in the model and crop plant, rice. We first tested xCas9-3.7, the most effective xCas9 variant in mammalian cells, for targeted mutagenesis at 16 possible NGN PAM (protospacer adjacent motif) combinations in duplicates. xCas9 exhibited nearly equivalent editing efficiency to wild-type Cas9 (Cas9-WT) at most canonical NGG PAM sites tested, whereas it showed limited activity at non-canonical NGH (H = A, C, T) PAM sites. High editing efficiency of xCas9 at NGG PAMs was further demonstrated with C to T base editing by both rAPOBECI and PmCDAI cytidine deaminases. With mismatched sgRNAs, we found that xCas9 had improved targeting specificity over the Cas9-WT. Furthermore, we tested two Cas9-NG variants, Cas9-NGv1 and Cas9-NG, for targeting NGN PAMs. Both Cas9-NG variants showed higher editing efficiency at most non-canonical NG PAM sites tested, and enabled much more efficient editing than xCas9 at AT-rich PAM sites such as GAT, GAA, and CAA. Nevertheless, we found that Cas9-NG variants showed significant reduced activity at the canonical NGG PAM sites. In stable transgenic rice lines, we demonstrated that Cas9-NG had much higher editing efficiency than Cas9-NGv1 and xCas9 at NG PAM sites. To expand the base-editing scope, we developed an efficient C to T base-editing system by making fusion of Cas9-NG nickase (D10A version), PmCDAI, and UGI. Taken together, our work benchmarked xCas9 as a high-fidelity nuclease for targeting canonical NGG PAMs and Cas9-NG as a preferred variant for targeting relaxed PAMs for plant genome editing. | Zhaohui Zhong Simon Sretenovic Qiurong Ren Lijia Yang Yu Bao Caiyan Qi Mingzhu Yuan Yao He Shishi Liu Xiaopei Liu Jiaheng Wang Lan Huang Yan Wang Dibin Baby David Wang Tao Zhang Yiping Qi Yong Zhang | 2019 | Molecular Plant2019，12，7： | 13 |
| 7 | Target classification with low-resolution radar based on dispersion situations of eigenvalue spectra显示文摘Most low-resolution radar systems, especially ground surveillance radar systems, work at relatively low pulse repeat frequency (PRF) and with short time-on-target (TOT) (duration in scanning). Low PRF leads to Doppler ambiguity and short TOT results in low Doppler resolution, which poses a problem to target classification with low-resolution radar based on the jet engine modulation (JEM) characteristic of radar echo. From the pattern classification viewpoint, we propose a method of using dispersion situations of JEM eigenvalue spectra to categorize aeroplanes into three kinds, namely turbojet aircraft, prop aircraft and helicopter. We analyze the mathematical model of JEM echoes consisting of a series of line spectra and regard them as a sum of several series of harmonious waves. Classification features can be extracted based on the harmonious wave sum model. Some schemes for extracting features from echoes within or between pulses are proposed. Low-dimensional features are extracted to reduce computation burden. Our methods do not compensate for the fuselage echoes and are insensitive to the variation of fuselage Doppler. The feasibility of our methods is demonstrated by simulation experiment. | CHEN Feng, LIU HongWei, DU Lan & BAO Zheng National Laboratory of Radar Signal Processing, Xidian University, Xi’an 710071, China | 2010 | Science China(Information Sciences)2010，53，7： | 12 |
| 8 | Influence of up-regulation of Notch ligand DLL4 on biological behaviors of human gastric cancer cells显示文摘AIM: To investigate the potential roles of Delta-like ligand 4 (DLL4) on the biological behavior of gastric cancer cells and its molecular mechanisms. METHODS: A recombinant eukaryotic expression vector containing human DLL4 gene was constructed and transfected into the human gastric cancer cell line SGC7901. Clones with up-regulated DLL4 were selected and amplified. The effect of DLL4 up-regulation on gastric cancer cell growth was assessed using cell growth assay. The migration and invasion were assessed using a transwell migration assay and matrigel invasion assay. Matrix metalloproteinases were detected using the zymogram technique. Cells were implanted subcutaneously into male BALB/c nu/nu mice. Tumor volumes were then calculated and compared. DLL4 staining in the implanted tumor was performed using immunohistochemistry technique. RESULTS: Growth curves over a six-day time course showed significantly promoted cell proliferation of SGC7901 cells with up-regulated DLL4. DLL4 up-regulation in SGC7901 cells promoted the migration (205.4 ± 15.2 vs 22.3 ± 12.1, P < 0.05) and invasion (68.8 ± 5.3 vs 18.2 ± 6.0, P < 0.05) in vitro and tumorigenicity in vivo (2640.5 ± 923.6 mm 3 vs 1115.1 ± 223.8 mm 3 , P < 0.05). Furthermore, significantly increased mRNA level and increased secretion of matrix metalloproteinase-2 (MMP-2) proenzyme were observed in SGC7901 cells with up-regulated DLL4. However, increased MMP-9 mRNA level but decreased extracellular MMP-9 proenzyme level was observed. CONCLUSION: Our observations indicated a mechanism by which activation of DLL4-mediated Notch signaling promotes the expression and secretion of MMP-2 proenzyme and influences the progress of gastric cancer. | Guo-Gang Li Lan Li Chao Li Long-Yun Ye Xiao-Wen Li Da-Ren Liu Qi Bao Yi-Xiong Zheng Da-Peng Xiang Li Chen Jian Chen | 2013 | World Journal of Gastroenterology2013，19，28： | 12 |
| 9 | Radar automatic target recognition based on feature extraction for complex HRRP显示文摘Radar high-resolution range profile(HRRP) has received intensive attention from the radar automatic target recognition(RATR) community.Usually,since the initial phase of a complex HRRP is strongly sensitive to target position variation,which is referred to as the initial phase sensitivity in this paper,only the amplitude informa-tion in the complex HRRP,called the real HRRP in this paper,is used for RATR,whereas the phase information is discarded.However,the remaining phase infor-mation except for initial phases in the complex HRRP also contains valuable target discriminant information.This paper proposes a novel feature extraction method for the complex HRRP.The extracted complex feature vector,referred to as the complex feature vector with difference phases,contains the difference phase in-formation between range cells but no initial phase information in the complex HRRP.According to the scattering center model,the physical mechanism of the proposed complex feature vector is similar to that of the real HRRP,except for reserving some phase information independent of the initial phase in the complex HRRP.The recognition algorithms,frame-template establishment methods and preprocessing methods used in the real HRRP-based RATR can also be applied to the proposed complex feature vector-based RATR.Moreover,the components in the complex feature vector with difference phases approximate to follow Gaussian distribution,which make it simple to perform the statistical recognition by such complex feature vector.The recognition experiments based on measured data show that the pro-posed complex feature vector can obtain better recognition performance than the real HRRP if only the cell interval parameters are properly selected. | DU Lan LIU HongWei BAO Zheng ZHANG JunYing | 2008 | Science in China(Series F)2008，51，8： | 9 |
| 10 | Robust radar automatic target recognition algorithm based on HRRP signature显示文摘自动目标识别(ATR ) 是为现代雷达的重要功能。目标的高分辨率范围侧面(HRRP ) 包含目标结构签名,例如目标尺寸, scatterer 分发,等等,它是为 ATR 的有希望的签名。目标 HRRP 的统计建模是为 HRRP 统计识别的关键阶段,包括模型选择和参数评价。为统计识别算法,测试样品作为训练数据的跟随一样的分发模型,这通常被假定。因为收到的 HRRP 的 signal-to-noise 比率(SNR ) 是目标距离的功能,假设不能在实践被遇见。在这份报纸,我们在场为 HRRP 统计识别的一个柔韧的方法测试 HRRP 的 SNR 什么时候比训练的低,取样。噪音是散布的假定独立 Gaussian,当 HRRP 被概率的主要部件分析(PPCA ) 建模时模型。模仿的实验基于测量数据显示出建议方法的有效性。 | Hongwei LIU Feng CHEN Lan DU Zheng BAO | 2012 | Frontiers of Electrical and Electronic Engineering in China2012，7，1： | 8 |
| 11 | Reduction of follistatin-like 1 in primary afferent neurons contributes to neuropathic pain hypersensitivity显示文摘 | Kai-Cheng Li Feng Wang Yan-Qing Zhong Ying-Jin Lu Qiong Wang Fang-Xiong Zhang Hua-Sheng Xiao Lan Bao Xu Zhang | 2011 | Cell Research2011，21，4： | 8 |
| 12 | Separation and identification of moxifloxacin impurities in drug substance by high-performance liquid chromatography coupled with ultraviolet detection and Fourier transform ion cyclotron resonance mass spectrometry显示文摘在这份报纸,高效的液体层析结合了紫外察觉, Fourier 变换离子回旋加速器回声团 spectrometry (HPLCUV/FTICRMS ) 方法在 moxifloxacin (MOX ) 为杂质侧面的调查被描述药物质和化学参考书物质。十杂质被 HPLCUV 检测,当八杂质被使用与多重阶段的集体度谱的数据和破碎规则相结合的高精确的分子的团识别时。到我们的知识,另外,五杂质在 MOX 药物质第一次被成立。 | Cai Sheng Wu Zhi Xin Jia Bao Ming Ning Jin Lan Zhang Song Wu | 2012 | Chinese Chemical Letters2012，23，10： | 8 |
| 13 | Endosome-mediated retrograde axonal transport of P2X3 receptor signals in primary sensory neurons显示文摘Neurotrophins 和他们的受体采用发信号的内涵体播送后退信号。然而,机制后退发信号因为另外的 ligand/receptor 系统糟糕被理解。这里,我们报导 purinergic (P) 2X 3 受体的信号,一条门 ATP 的离子隧道, retrogradely 在背面的根中心(DRG ) 被搬运神经原轴突。我们发现了那 Rab5,小 GTPase,控制早 P2X 3 受体排序进内涵体,当 Rab7 调停时快后退 P2X 3 受体的运输。Intraplantar 注射和 axonal 申请进 α 的 microfluidic 房间;, β -methylene-ATP (α, β -MeATP), P2X 选择收缩筋,提高了 endocytosis 并且后退 P2X 3 受体的运输。α, β激活的 -MeATP-induced Ca 2+ 流入由蛋白质 kinase C 组成的一条小径,病毒的 oncogene 和细胞外的调整信号的蛋白质 kinase (英皇家空军之阶级最低之兵) ,它与 endocytic P2X 3 受体联系了到形成表明内涵体的老鼠肉瘤。类脂化合物椽子的混乱废除了 α, β -MeATP-induced 英皇家空军之阶级最低之兵 phosphorylation, endocytosis 并且后退 P2X 3 受体的运输。而且,有 α 的外部轴突的治疗;, β -MeATP 在 DRG 的房间身体增加了英皇家空军之阶级最低之兵和营地反应元素绑定蛋白质的激活水平神经原和提高的 neuronal 易兴奋性。也的缺陷在 vivo 的基于微导管的 axonal 运输或在 vitro 的 dynein 功能堵住了 α, β -MeATP-induced 后退信号。这些结果显示那 P2X 3 激活受体的信号在主要感觉神经原经由 retrogradely 搬运的内涵体被播送并且为门 ligand 的隧道提供新奇发信号机制。 | Xu-Qiao Chen Bin Wang Chengbiao Wu Jin Pan Bo Yuan Yuan-Yuan Su Xing-Yu Jiang Xu Zhang Lan Bao | 2012 | Cell Research2012，22，4： | 8 |
| 14 | Establishment and analysis of global gridded Tm-Ts relationship model显示文摘In ground-based GPS meteorology, Tm is a key parameter to calculate the conversion factor that can convert the zenith wet delay(ZWD) to precipitable water vapor(PWV). It is generally acknowledged that Tm is in an approximate linear relationship with surface temperature Ts, and the relationship presents regional variation. This paper employed sliding average method to calculate correlation coefficients and linear regression coefficients between Tm and Ts at every 2°× 2.5° grid point using Ts data from European Centre for Medium-Range Weather Forecasts(ECMWF) and Tm data from 'GGOS Atmosphere', yielding the grid and bilinear interpolation-based Tm Grid model. Tested by Tm and Ts grid data, Constellation Observation System of Meteorology, Ionosphere, and Climate(COSMIC) data and radiosonde data, the Tm Grid model shows a higher accuracy relative to the Bevis Tm-Ts relationship which is widely used nowadays. The Tm Grid model will be of certain practical value in high-precision PWV calculation. | Zeying Lan Bao Zhang Yichao Geng | 2016 | Geodesy and Geodynamics2016，7，2： | 7 |
| 15 | The flavonoid TL-2-8 induces cell death and immature mitophagy in breast cancer cells via abrogating the function of the AHA1/Hsp90 complex显示文摘flavonoid 橡黄素与很少副作用展出重要 anticancer 活动。在当前的学习,我们描绘了 TL-2-8,橡黄素衍生物,在 vitro 并且在 vivo 的一个新奇 anticancer 代理人。房间增长和生存能力用分别地数 Kit-8 和 CellTiter 蓝的试金的房间被估计。房间死亡用 PI 染色或 TUNEL 试金被检验。Mitophagy 被测量 autophagic 流动并且由共焦的成像决定。蛋白质表示被西方的弄污检验。我们发现 TL-2-8 有选择地禁止了增长并且减少各种各样的癌症房间的生存能力(在在 72 h 的 MDA-MB-231 , MDA-MB-468 和 MCF-7 乳癌房间的反增长 IC50 价值是 8.28 , 8.56 ,和 9.58 mol/L ,分别地),并且它对正常 MCF-10A 和 HEK-293 房间显示了仅仅细微的 cytotoxicity 。在 MDA-MB-231 和 MDA-MB-468 乳癌房间,没有导致 Hsp70, TL-2-8 治疗导致了多重 Hsp90 顾客蛋白质的降级。TL-2-8 (3, 6, 12 mol/L ) dose-dependently 禁止了 AHA1, Hsp90 ATPase 的使活跃之物,和减少的 Hsp90-AHA1 复杂形成的表达式,导致减少的 Hsp90 女伴函数和减少的像马球的 kinase 1 (PLK1 ) 发信号。因而,损害了 mitophagy 经由联系 lysosomal 的膜蛋白质 2 的 downregulation (LAMP2 ) 被导致。在里面 TL-2-8 的 vivo anticancer 效果在一个 MDA-MB-231 乳癌异种皮移植模型被评估,它与 TL-2-8 被对待(25, 50, 100 | Hui-juan LIU Xiao-xiao JIANG Yi-zhen GUO Fang-hui SUN Xin-hui KOU Yong BAO Zhu-qing ZHANG Zhao-hu LIN Ting-bo DING Lan JIANG Xin-sheng LEI Yong-hua YANG | 2017 | Acta Pharmacologica Sinica2017，38，10： | 7 |
| 16 | Dosage effect of multiple genes accounts for multisystem disorder of myotonic dystrophy type 1显示文摘Multisystem manifestations in myotonic dystrophy type 1(DM1)may be due to dosage reduction in multiple genes induced by aberrant expansion of CTG repeats in DMPK,including DMPK,its neighboring genes(SIX5 or DMWD)and downstream MBNLh However,direct evidence is lacking.Here,we develop a new strategy to generate mice carrying multigene heterozygous mutations to mimic dosage reduction in one step by injection of haploid embryonic stem cells with mutant Dmpk,Six5 and Mbnll into oocytes.The triple heterozygous mutant mice exhibit adult-onset DM1 phenotypes.With the additional mutation in Dmwd,the quadruple heterozygous mutant mice recapitulate many major manifestations in congenital DM1.Moreover,muscle stem cells in both models display reduced sternness,providing a unique model for screening small molecules for treatment of DM1.Our results suggest that the complex symptoms of DM1 result from the reduced dosage of multiple genes. | Qi Yin Hongye Wang Na Li Yifu Ding Zhenfei Xie Lifang Jin Yan Li Qiong Wang Xinyi Liu Liuqing Xu Qing Li Yongjian Ma Yanbo Cheng Kai Wang Cuiqing Zhong Qian Yu Wei Tang Wanjin Chen Wenjun Yang Fan Zhang Chen Ding Lan Bao Bin Zhou Ping Hu Jinsong Li | 2020 | Cell Research2020，30，2： | 7 |
| 17 | Effects of ethanol on the in situ synthesized Cu/SiO_2 catalyst:Texture,structure,and the catalytic performance in hydrogenation dimethyl oxalate to ethylene glycol显示文摘Cu/SiO2 催化剂被 tetraethyl orthosilicate (TEOS ) 的水解作用作为合作溶剂或 TEOS/H2O 用乙醇在一阶段溶液在 situ 综合二阶段溶液,由氨蒸发在 SiO2 上由铜的降水列在后面。在 dimethyl 盐的加氢,一个阶段水解作用准备的催化剂展出了更高的活动和乙烯乙二醇(例如) 在更低的温度的选择由于它的更大的赌注表面区域和多模式的毛孔分发比二的分阶段执行。在 488503 K,催化剂与水 / 乙醇(W/E ) 在一个阶段答案准备了 3:1 的体积比率例如展出了 9095% 选择,当催化剂由二个阶段准备了时,水解作用例如到达了 90% 仅仅在 498503 K 的选择。 | Shu Rong Wang Ling Jun Zhu Ying Ying Zhu Xiao Lan Ge Xin Bao Li | 2011 | Chinese Chemical Letters2011，22，3： | 6 |
| 18 | An adjustment method for active reflector of large high-frequency antennas considering gain and boresight显示文摘The design of the Qitai 110 m Radio Telescope(QTT) with large aperture and very high working frequency(115 GHz) was investigated in Xinjiang, China. The results lead to a main reflector with high surface precision and high pointing precision. In this paper, the properties of active surface adjustment in a deformed parabolic reflector antenna are analyzed. To assure the performance of large reflector antennas such as gain and boresight, which can be obtained by utilizing an electromechanical coupling model, and satisfy them simultaneously, research on active surface adjustment applied to a new parabolic reflector as target surface has been done. Based on the initial position of actuators and the relationship between adjustment points and target points, a novel mathematical model and a program thatdirectly calculates the movements of actuators have been developed for guiding the active surface adjustment of large reflector antennas. This adjustment method is applied to an 8 m reflector antenna,in which we only consider gravity deformation. The results show that this method is more efficient in adjusting the surface and improving the working performance. | Cong-Si Wang Lan Xiao Wei Wang Qian Xu Bin-Bin Xiang Jian-Feng Zhong Li Jiang Hong Bao Na Wang | 2017 | Research in Astronomy and Astrophysics2017，17，5： | 6 |
| 19 | Transport of receptors, receptor signaling complexes and ion channels via neuropeptide-secretory vesicles显示文摘大稠密核心的泡(LDCV ) 的导致刺激的 exocytosis 与血浆膜导致 neuropeptides 的分泌物和 LDCV 膜的熔化。然而,到 neuronal 膜的性质的 LDCV 的贡献仍然保持大部分不清楚。现在的学习发现 LDCV 与多重受体,隧道和发信号的分子被联系,建议那 neuronal 敏感被调停 LDCV 的机制调制。与 subcellular 部分的 immunoblotting 相结合的液体层析团 spectrometry 在从背面的针的绳索净化的 LDCV 膜识别了 298 蛋白质,包括表明分子,离子隧道和 trafficking 相关的蛋白质的 G-protein-coupled 受体, G 蛋白质和其它。词法试金显示出那 -opioid 受体 1 ( DOR1 ), 2 是的 2 肾上腺素能的受体( AR ), Gi2 ,电压门钙隧道 21 子单元和 P2X purinoceptor 在物质 P ( SP )局部性在小直径的背面的根中心神经原的积极 LDCV ,而 1 AR , Wnt 受体 frizzled 8 并且弄乱 1 在SP否定的 LDCV 是在场的。而且, DOR1/Gi2/G15/phospholipase C 2 建筑群与 LDCV 被联系。DOR1/Gi2 相互作用的封锁大部分废除了 Gi2 的 LDCV 本地化并且损害了 Gi2 的导致刺激的表面表示。因此, LDCV 担任表明建筑群的受体,离子隧道和 preassembled 受体的搬运人,启用一快速, neuronal 的活动依赖者调整敏感。 | Bo Zhao Hai-Bo Wang Ying-Jin Lu Jian-Wen Hu Lan Bao Xu Zhang | 2011 | Cell Research2011，21，5： | 6 |
| 20 | Simulation of groundwater table dynamics based on Feflow in the Minqin Basin,China显示文摘As groundwater table declination is an important factor resulting in degradation of eco-environment in the Minqin Basin,China,it is significant to investigate and understand the groundwater table dynamics in this area. According to the physical and geographical conditions of the Minqin Basin,a hydrogeological conceptual model and a mathematical model were established,and the mathematical model was figured out by using Finite Element subsurface Flow system(Feflow).Accurate hydrogeological parameters were acquired,and the spatio-temporal distribution dynamics of groundwater table for 1983–2001 were also simulated.The model performed well with a correlation coefficient of 0.977 and a mean error of 0.9768 m.The inflow and outflow of the groundwater system were predicted by time series analysis,and the groundwater table dynamics for 2011 were further acquired.Generally the groundwater table in the Minqin Basin would continue to decline.The groundwater table would decline during spring and summer irrigation,while it would rise during autumn-winter irrigation.The groundwater depression cones would expand with the increase of center depths.Therefore,regulatory measures should be taken to prevent the declination of groundwater table and improve the eco-environment of this area. | Lan MA XiaoMei WEI AnMing BAO ShiFei WANG | 2012 | Journal of Arid Land2012，4，2： | 5 |
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