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| 1 | Evaluation of the colorectal cancer risk conferred by rare UNC5C alleles显示文摘AIM:To evaluate the risk associated with variants of the UNC5C gene recently suspected to predispose to familial colorectal cancer(CRC).METHODS:We screened patients with familial CRC forms as well as patients with sporadic CRCs.In a first time,we analyzed exon 11 of the UNC5C gene in 120unrelated patients with suspected hereditary CRC,58patients with suspected Lynch-associated cancer or polyposis,and 132 index cases of Lynch syndrome families with a characterized mutation in a DNA mismatch repair(MMR).Next,1023 patients with sporadic CRC and1121 healthy individuals were screened for the variants identified in patients with familial cancer.RESULTS:Of 120 patients with familial CRC of unknown etiology,one carried the previously reported mis-sense mutation p.Arg603Cys(R603C)and another exhibited the unreported variant of unknown significance p.Thr617Ile(T617I).The p.Ala628Lys(A628K)mutation previously described as the main UNC5C risk variant for familial CRC was not detected in any cases of familial CRC of unknown etiology,but was present in a patient with familial gastric cancer and in two Lynch syndrome patients in co-occurrence with MMR mutations.A statistically non-significant increase in cancer risk was identified in familial CRC and/or other Lynchassociated cancers(1/178 patients vs 2/1121 healthy controls,OR=3.2,95%CI:0.29-35.05,P=0.348)and in sporadic CRCs(4/1023 patients vs 2/1121 healthy controls,OR=2.2,95%CI:0.40-12.02,P=0.364).CONCLUSION:We confirm that UNC5C mutations are very rare in familial and sporadic CRCs,but further investigations are needed to justify routine UNC5C testing for diagnostic purposes. | Sébastien Küry Céline Garrec Fabrice Airaud Flora Breheret Virginie Guibert Cécile Frenard Shuo Jiao Dominique Bonneau Pascaline Berthet Céline Bossard Olivier Ingster Estelle Cauchin Stéphane Bezieau | 2014 | World Journal of Gastroenterology2014，20，1： | 4 |
| 2 | The mismatch negativity to frequency deviant stimuli during natural sleep显示文摘 | Loewy DH Campbell KB Bastien C | 1996 | Clin Neurophysiol1996，98，： | 1 |
| 3 | Protective immune responses induced by the immunization of mice with a recombinant phage displaying an epitope of the human respiratory syncytial virus显示文摘 | BASTIEN N TRUDEL M SIMARD C | 1997 | Virology1997，234，1： | 1 |
| 4 | Effects of chronic insomnia and use of benzodiazepines on daytime performance in older adults显示文摘 | Vignola A Lamoureux C Bastien CH | 2000 | Gerontol B Psychol Sci Soc Sci2000，55，： | 1 |
| 5 | Effects of environment and progeny on biomass estimations of five hybrid poplar families grown at three contrasting sites across Europe 显示文摘 | Dillen S Marron N Bastien C | 2007 | Forest Ecology and Management2007，252，1： | 1 |
| 6 | Randomized clinical trial of supervised tapering and cognitive behavior therapy to facilitate benzodiazepine discontinuation in older adults with chronic insom- nia 显示文摘 | Morin CM Bastien C Guay B | 2004 | Am J Psychiatry2004，161，2： | 1 |
| 7 | Low iron stores:a risk factor for excessive hair loss in non-menopausal women显示文摘 | Deloche C Bastien P Chadoutaud S | 2007 | Eur J Dermatol2007，17，6： | 1 |
| 8 | The effect of the driv- ing activity on target detection as a function of the visibility level: Implications for road lighting 显示文摘 | Mayeur A Bremond R Bastien J M C | 2010 | Transportation Re- search Part F: Traffic Psychology and Behaviour2010，13，2： | 1 |
| 9 | Paradoxical(REM)sleep deprivation causes a large and rapidly reversible decrease in long-term potentiation,synaptic transmission,glutamate receptor protein levels,and ERK/MAPK activation in the dorsal hippocampus显示文摘 | Pascal Ravassard Bastien Pachoud Comte J C | | 0，，02： | 1 |
| 10 | Candida albicans and non-Candida albi- cans fungemia in an institutional hospital during a decade 显示文摘 | Parmeland L Gazon M Guerin C Argaud L Lehot JJ Bastien O Allaouchiche B Michallet M Picot S Bienvenu AL Study Group | 2013 | Med Mycol2013，51，1： | 1 |
| 11 | A lattice gas model for erosion and particles transport in a fluid 显示文摘 | BASTIEN C ALEXANDRE M ALEXANDRE D | 2000 | Computer Physics Communications2000，129，： | 1 |
| 12 | Nuclear retinoid receptors and the transcription of retinoid-target genes显示文摘 | Bastien J Rochette -Egly C | 2004 | Gene2004，328，： | 1 |
| 13 | QTL for yield in bioenergy Populus:identifying G× E interactions from growth at three contrasting sites 显示文摘 | Rae A M Pinel M P C Bastien C | 2008 | Tree Genetics and Genomes2008，4，： | 1 |
| 14 | Influence of soil properties and aging on the toxicity of copper on compost worm and barley显示文摘 | Daoust C M Bastien C Deschênes L | 2006 | Journal of Environmental Quality2006，35，： | 1 |
| 15 | Salt distribution in the Senegal middle valley:Analysis of a saline structure on planned irrigation schemes from N'Galenka creek显示文摘 | Laurent B Sébastien C Landing M | 2001 | Agricultural Water Management2001，46，： | 1 |
| 16 | Clay mineral assemblages in the northern South China Sea: implications for East Asian monsoon evolution over the past 2 million years显示文摘 | Zhifei Liu Alain Trentesaux Steven C Clemens Christophe Colin Pinxian Wang Baoqi Huang Sébastien Boulay | 2003 | Marine Geology2003，，1： | 1 |
| 17 | Protective immune responses induced by the immunization of mice with a recombinant bacteriophage displaying an epitope of the human respiratory syncytial virus显示文摘 | Bastien N Trudel M Simard C | 1997 | Virology1997，234，： | 1 |
| 18 | Protective immune responses induced by the immunization of mice with a recombinant bacteriophage displaying an epitope of the human respiratory syncytial virus显示文摘 | Bastien N TrudeI M Simard C | 1997 | Virology1997，234，1： | 1 |
| 19 | Comprehensive approach to opti-mize dryer plant-from drying energy saving to sheet stabilization显示文摘 | Deshanais J Bastien C Tsuzuno H | 2010 | Japan Tappi Journal2010，64，9： | 1 |
| 20 | Comparative study of converting enzyme inhibition and angiotensin Ⅱ receptor antagonism on survival from chronic heart failure in cardiomyopathic hamster 显示文摘 | Lambert C Bastien NR Legault | 1998 | ( Abstract )Eur Heart J1998，，： | 1 |
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