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| 1 | Efficacy of sequential treatment of HCT116 colon cancer monolayers and xenografts with docetaxel,flavopiridol,and 5-fluorouracil显示文摘瞄准:有 docetaxel, flavopiridol,或 5 氟尿嘧啶(5-FU ) 的稳固的肿瘤的临床的治疗经常遇到不受欢迎的副作用和药抵抗。在 modulating chemosensitivity 并且更好与 docetaxel, flavopiridol,或 5-FU 评估联合治疗的潜在的角色的目的理解他们怎么可能临床上被使用的这研究。方法:HCT116 结肠癌房间在几不同行政时间表在试管内与 docetaxel, flavopiridol,和 5-FU 被对待,顺序或同时。房间幸存被 MTT 试金测量。caspase-3 的活动被 caspase-3 试金决定,软琼脂殖民地试金被用来在软琼脂测试 HCT116 房间的菌落形成。我们也建立了异种皮移植模型扩大在试管内观察到一个在活体内系统。结果:当人的结肠癌 HCT116 房间为 flavopiridol 为另一 24 h 为 24 h 和 5-FU 跟随的 1 h 与 docetaxel 被对待时,最大的细胞毒性被发现。这顺序的联合治疗不仅与另外的联合治疗相比更强烈禁止肿瘤细胞生长而且显著地在软琼脂减少菌落形成并且扩充 HCT116 细胞的 apoptosis。docetaxel 定序以后由 flavopiridol 跟随了 1 h,以后在异种皮移植模型由 5-FU 跟随了 24 h,也导致了推迟的肿瘤生长和更高的幸存率。结论:当把 docetaxel 与 flavopiridol 和 5-FU 相结合时,这些结果强调一张行政时间表的重要性,提供对它在临床的试用的发展的基本原理解释。 | Jun GUO An-wu ZHOU Yu-cai FW Udit N VERMA Debu TRIPATHY Eugene P FRENKEL Carlos R BECERRA | 2006 | Acta Pharmacologica Sinica2006，27，10： | 4 |
| 2 | Four-quadrant sensorless brushless ECM Drive 显示文摘 | Becerra R C | 1991 | IEEE Applied Power Electron Conf and Exp1991，87，8： | 1 |
| 3 | Effects of leaf litter and precipitation on germination and seedling survival in Beilschmiedia miersii 显示文摘 | Becerra P I Celis-Diez J L Bustamente R O | 2004 | Applied Vegetation Science2004，7，： | 1 |
| 4 | Four-wave mixing in the diamond configuration in an atomic vapor显示文摘 | Willis R T Becerra F E Orozco L A | 2009 | Phys Rev A2009，79，03： | 1 |
| 5 | Trustworthiness,risk,and the transfer of tacit and explicit knowledge between alliance partners显示文摘 | Becerra M Lunnan R Huemer L | 2008 | Journal of Management Studies2008，45，4： | 1 |
| 6 | Cultured differential evolution for constrained optimization显示文摘 | Becerra R L Coello C A C | 2006 | Computation Methods in Applied Mechanics and Engineering2006，195，33343536： | 1 |
| 7 | Organizational knowledgemanagement: A contingency perspective 显示文摘 | Becerra -Fernandez I Sabherwal R | 2001 | Journal ofManagement Information Systems2001，18，1： | 1 |
| 8 | A genetic map of Prunus based on an interspecific cross between peach and almond显示文摘 | FOOLAD M R ARULSEKAR S BECERRA V BLISS F A | 1995 | Tbeor Appl Genet1995，91，： | 1 |
| 9 | Interlocks and Firm Performance:The Role of Uncertainty in the Directorate Interlock-performance Relationship显示文摘 | Martin G Gzübüyük R Becerra M | 2015 | Strategic Management Journal2015，36，2： | 1 |
| 10 | Efficient evolutionary optimization through the use of a cultural algorithm显示文摘 | COELLO C A BECERRA R I | 2004 | Engineering Optimization2004，36，2： | 1 |
| 11 | A Cultural Algorithm for Constrained Optimization显示文摘 | Coello C A Becerra R L | 2002 | Computerscience2002，2313，： | 1 |
| 12 | Using classifiers as heuristics to describe local structure in active shape models with small training sets显示文摘 | TEDIN R BECERRA J A DURO R J | 2013 | Pattern Recognition Letters2013，34，14： | 1 |
| 13 | Trustworthiness, Risk, and the Transfer of Tacit and Explicit Knowledge Between Alliance Partners显示文摘 | BECERRA M LUNNAN R HUEMER L | 2008 | Journal of Management Studies2008，45，2： | 1 |
| 14 | Trustworthi- ness, risk, and the transfer of tacit and explicit knowledge between alliance partners 显示文摘 | BECERRA M LUNNAN R HUEMER L | 2008 | Journal of Management Studies2008，45，4： | 1 |
| 15 | Trustworthiness, risks, and the transfer of tacit and explicit knowledge be- tween alliance partners 显示文摘 | Becerra M Lunnan R Huemer L | 2008 | Journal of Management Studies2008，45，4： | 1 |
| 16 | A phase Ⅱ study of 5-Fu and LV plus open label Rofecoxib in patients with metastatic colorectal cancer 显示文摘 | Becerra CR Frenkel EP Gaynor R | 2002 | Proc Am Soc Clin Oncol2002，21，10： | 1 |
| 17 | High-speed torque control of brushless permanent magnet motors显示文摘 | BECERRA R | 1988 | IEEE Trans on Industrial Electronics1988，35，3： | 1 |
| 18 | Organizational knowledge management: A contingency perspective显示文摘 | Becerra - fernandez I Sabherwal R | 2001 | Journal of Management Information Systems2001，18，1： | 1 |
| 19 | Trustworthiness, Risk, and the Transfer of Tacit and Explicit Knowledge Between Alliance Partners 显示文摘 | Becerra M Lunnan R Huemer L | 2008 | Journal o f Management Studies2008，45，4： | 1 |
| 20 | Perceptions of Benevolence and the Design of Agency Contracts: CEO-TMT Relationships in Family Firm显示文摘 | Cruz C Gomez-Mejia L R Becerra M | 2010 | A- cademy of Management Journal2010，53，1： | 1 |
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