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| 1 | Resective surgery for liver tumor: a multivariate analysis of causes and risk factors linked to postoperative complications显示文摘BACKGROUND: In spite of accurate selection of patients eligible for resection, and although advances in surgical techniques and perioperative management have greatly contributed to reducing the rate of perioperative deaths, stress must be placed on reducing the postoperative complication rates reported to be still as high as 50%. This study was designed to analyze the causes and foreseeable risk factors linked to postoperative morbidity on the grounds of data derived from a single-center surgical population. METHODS: From September 1989 to March 2005, 287 consecutive patients, affected either with HCC or liver metastasis, had liver resection at our department. Among the HCC series we recorded 98 patients (73.2%) in Child- Pugh class A, 32 (23.8%) in class B and 4 in class C (3%). In 104 colorectal metastases, 71% were due to colon cancer, 25% rectal, 3% sigmoid, and 1% anorectal. In 49 non-colorectal metastases, 22.4% were derived from breast cancer, 63.2% gastrointestinal tumors (excluding colon) and 14.4% other cancers. We performed 80 wedge resections, 77 bisegmentectomies and/or left lobectomies, 74 segmentectomies, 22 major hepatectomies, 20 left hepatectomies, and 14 trisegmentectomies. RESULTS: The in-hospital mortality rate in this series was 4.5%, and the morbidity rate was 47.7%, because of pleural effusion (30%), hepatic abscess (25%), hepatic insufficiency (19%), ascites (10%), hemoperitoneum (10%), or biliary fistula (6%). The variables associated with the technical aspects of the surgical procedure thatwere responsible for the complications were: a Pringle maneuver length more than 20 minutes (P=0.001); the type of liver resection procedure, including major hepatectomy (P=0.02), left hepatectomy (P=0.04), trisegmentectomy (P=0.04), bisegmentectomy and/or left lobectomy (P=0,04); and a blood transfusion of more than 600 ml (P=0.04). CONCLUSION: The evaluation of causes and foreseeable risk factors linked to postoperative morbidity during the planning of surgical treatment should play the same role as other factors weighed in the selection of patients eligible for liver resection. | Enrico Benzoni Dario Lorenzin Umberto Baccarani Gian Luigi Adani Alessandro Favero Alessandro Cojutti Fabrizio Bresadola Alessandro Uzzau | 2006 | Hepatobiliary & Pancreatic Diseases International2006，5，4： | 17 |
| 2 | Combined approach for spontaneous rupture of hepatocellular carcinoma显示文摘Ruptured hepatocellular carcinoma is a rare,emergency occurrence in western countries with high mortality risk.A number of hypotheses have been formulated in order to explain the precise mechanism that leads to hepatocellular carcinoma(HCC) rupture:sub-capsular location,dimensions,portal hypertension,tumour necrosis,local increase of venous pressure due to the outflow reduction caused by neoplastic invasion,and the presence of a previous vascular injury which might predispose to HCC rupture.There is still a debate in the literature concerning the best approach in cases of HCC rupture.Surgery is the first option for treatment of acute abdominal bleeding.However the advent of endovascular treatments widens the range of possible therapies for acute bleeding control and subsequent ablation purposes.We report a case of hemoperitoneum from spontaneous rupture of undiagnosed HCC,that was treated successfully by emergency surgical resection followed by transarterial chemo-embolizationfor local recurrence. | Anna Rossetto Gian Luigi Adani Andrea Risaliti Umberto Baccarani Vittorio Bresadola Dario Lorenzin Giovanni Terrosu | 2010 | World Journal of Hepatology2010，2，1： | 10 |
| 3 | European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013显示文摘 | Michele Baccarani Michael W. Deininger Gianantonio Rosti Andreas Hochhaus Simona Soverini Jane F. Apperley Francisco Cervantes Richard E. Clark Jorge E. Cortes Fran?ois Guilhot Henrik Hjorth-Hansen Timothy P. Hughes Hagop M. Kantarjian Dong-Wook Kim Richa | 2013 | Blood2013，，6： | 3 |
| 4 | Impact of new treatment options for hepatitis c virus infection in liver transplantation显示文摘Liver transplant candidates and recipients with hepatitis C virus(HCV)-related liver disease greatly benefit from an effective antiviral therapy. The achievement of a sustained virological response before transplantation can prevent the recurrence of post-transplant HCV disease that occurs universally and correlates with enhanced progression to graft cirrhosis. Previous standard-of-care regimens(e.g.,pegylated-interferon plus ribavirin with or without first generation protease inhibitors,boceprevir and telaprevir) displayed suboptimal results and poor tolerance in liver transplant recipients. A new class of potent direct-acting antiviral agents(DAA) characterized by all-oral regimens with minimal side effects has been approved and included in the recent guidelines for the treatment of liver transplant recipients with recurrent HCV disease. Association of sofosbuvir with ribavirin and/or ledipasvir is recommended in liver transplant recipients and patients with decompensated cirrhosis. Other regimens include simeprevir,daclatasvir,and combination of other DAA. Possible interactions should be monitored,especially in coinfected human immunodeficiency virus/HCV patients receiving antiretrovirals. | Elda Righi Angela Londero Alessia Carnelutti Umberto Baccarani Matteo Bassetti | 2015 | World Journal of Gastroenterology2015，21，38： | 3 |
| 5 | Comparison of de novo tumours after liver transplantation with incidence rates from Italian cancer registries显示文摘 | U. Baccarani P. Piselli D. Serraino G.L. Adani D. Lorenzin M. Gambato A. Buda G. Zanus A. Vitale A. De Paoli C. Cimaglia V. Bresadola P. Toniutto A. Risaliti U. Cillo F. Bresadola P. Burra | 2009 | Digestive and Liver Disease2009，，1： | 2 |
| 6 | Non-erosive and uncomplicated erosive reflux diseases:Difference in physiopathological and symptom pattern显示文摘AIM:To investigate differences in the physiopathological findings(manometry and pH monitoring) and symptoms between cases of non-erosive reflux disease(NERD) and erosive reflux disease(ERD) found positive at 24 h pH monitoring. METHODS:For a total of 670 patients who underwent 24 h pH monitoring,esophageal manometry and upper endoscopy were retrospectively evaluated,assessing the reflux symptoms,manometric characteristics of the lower esophageal sphincter(LES) and esophageal body and the presence or absence of esophagitis and hiatal hernia. Typical and atypical symptoms were also evaluated. For inclusion in the study,patients had to have NERD or ERD and be found positive on pH monitoring(NERD+) . Patients with Gastroesophageal reflux disease(GERD) complicated by stenosis,ulcers or Barrett's esophagus were ruled out. RESULTS:214 patients were involved in the study,i.e. 107 cases of NERD+ and 107 of ERD. There were no significant gender-or age-related differences between the two groups. The ERD group had more cases of hiatal hernia(P = 0.02) and more acid reflux,both in terms of number of reflux episodes(P = 0.01) and as a percentage of the total time with a pH < 4(P = 0.00) ,when upright(P = 0.007) and supine(P = 0.00) . The NERD+ cases had more reflux episodes while upright(P = 0.02) and the ERD cases while supine(P = 0.01) . The LES pressure was higher in cases of NERD+(P = 0.03) while the amplitude and duration of their esophageal peristaltic waves tended to be better than in the ERD group(P >0.05) . The NERD+ patients presented more often with atypical symptoms(P = 0.01) . CONCLUSION:The NERD+ patients' fewer reflux episodes and the fact that they occurred mainly while in the upright position(unlike the cases of ERD) may be two factors that do not favor the onset of esophagitis. The frequently atypical symptoms seen in patients with NERD+ need to be accurately evaluated for therapeutic purposes because patients with GERD and atypical symptoms generally respond only partially to medical and surgical treatments. | Vittorio Bresadola Gian Luigi Adani Francesco Londero Cosimo Alex Leo Vittorio Cherchi Dario Lorenzin Anna Rossetto Gianmatteo Vit Umberto Baccarani Giovanni Terrosu Dino De Anna | 2011 | World Journal of Gastrointestinal Pathophysiology2011，2，3： | 2 |
| 7 | Dasatinib induces notable hematologic and cytogenetic responses in chronic phase chronic myeloid leukemia after failure of imatinib therapy显示文摘 | Hochhaus A Kantarjian H M Baccarani M | 2007 | BIood2007，109，6： | 1 |
| 8 | A compact double-gate MOSFET model comprising quantum-mechanical and nonstatic effects显示文摘 | Baccarani G Reggiani S | 1999 | IEEE Trans Electron Devices1999，46，： | 1 |
| 9 | Dasatinib induces notable hematologic and cytogenetic responses in chronic-phase chronic myeloid leukemia after failure of ima- tinib therapy 显示文摘 | HOCHHAUS A KANTARJIAN HM BACCARANI M | 2007 | Blood2007，109，6： | 1 |
| 10 | Targeted therapy and the T315I mutation in Philadelphia-positive leukemias显示文摘 | Soverini S Iacobucci I Baccarani M | 2007 | Haematologic2007，92，4： | 1 |
| 11 | Immunochemical identification of abnormal constituents in the dermis of pseudoxanthoma elasticum patients显示文摘 | Baccarani CM Vineenzi D Cicchetti F | 1994 | Eur J Histochem1994，38，2： | 1 |
| 12 | The EUTOS prognostic score:review and validation in 1288 patients with CML treated frontline with imatinib 显示文摘 | Hoffmann VS Baccarani M Lindoerfer D | 2013 | Leukemia2013，27，10： | 1 |
| 13 | A New Method for the Cytofluorometric Analysis of Mitochondrial Membrane Potential Using tbe J - Aggregate Forming Lipophilic Cation 5,5 ', 6,6'- Tetrachloro - 1,1,3,3 ' - tetraethylbenzimid- azolcarbo - cyanine lodide (JC - 1 ) 显示文摘 | Cossarizza A Baccarani - Contri M Kalashnikova G | 1993 | Biochem Biophys Res Commun1993，197，1： | 1 |
| 14 | Dexamethason eplus rituximab yields higher sustained response rates than dexamethasone monotherapy in adults with primary immune thrombocytopenia显示文摘 | ZAJA F BACCARANI M MAZZA P | 2010 | Blood2010，115，： | 1 |
| 15 | Chronic myeloid leukaemia显示文摘 | Hehlmann R Hochhaus A Baccarani M | 2007 | Lancet2007，370，： | 1 |
| 16 | Rhabdomyolysis due to Lamivudine administration in a liver transplant recipient显示文摘 | Adani GL Baccarani U Risaliti A | | 0，，03： | 1 |
| 17 | Dexamethasone plus rit uximab yields higher sustained response rates than dexam ethasone monotherapy in adults with primary immune throm bocytopenia显示文摘 | Zaja F Baccarani M Mazza P | 2010 | Blood2010，115，14： | 1 |
| 18 | Chronic myeloid leukaemia显示文摘 | Rüdiger Hehlmann Andreas Hochhaus Michele Baccarani | 2007 | 2007 (9584)2007，，9584： | 1 |
| 19 | European Leukemia- Net recommendations for the management of chronic myeloid leukemia:2013 显示文摘 | Baccarani M Deininger MW Rosti G | 2013 | Blood2013，122，6： | 1 |
| 20 | Polyacrylamide hydro- gel injectionin the management of human immunodeficiency virus- related facial lipoatrophy : a 2-year clinical experience 显示文摘 | de Santis G Jacob V Baccarani A | 2008 | Plast Reconstr Surg2008，121，2： | 1 |
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