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| 1 | Vitamin D receptor gene polymorphisms and hepatocellular carcinoma in alcoholic cirrhosis显示文摘AIM: To assess the relationship between vitamin D re-ceptor (VDR) gene polymorphisms and the presence of hepatocellular carcinoma (HCC). METHODS: Two-hundred forty patients who underwent liver transplantation were studied. The etiologies of liver disease were hepatitis C (100 patients), hepatitis B (37) and alcoholic liver disease (103). A group of 236 healthy subjects served as controls. HCC in the explanted liver was detected in 80 patients. The following single nucle-otide gene polymorphisms of the VDR were investigatedby polymerase chain reaction and restriction fragment length polymorphism: FokI C>T (F/f), BsmI A>G (B/b), ApaI T>G (A/a) and TaqI T>C (T/t) (BAT). RESULTS: The frequencies of genotypes in patients without and with HCC were for FokI F/F = 69, F/f = 73, f/f = 18 and F/F = 36, F/f = 36, f/f = 8; BsmI b/b = 45, B/b = 87, B/B = 28 and b/b = 33, B/b = 35, B/B = 12; for ApaI A/A = 53, A/a = 85, a/a = 22 and A/A = 27, A/a = 38, a/a = 15; for TaqI T/T = 44, T/t = 88, t/t = 28 and T/T = 32, T/t = 38, t/t = 10. Carriage of the b/b genotype of BsmI and the T/T genotype of TaqI was signif icantly associated with HCC (45/160 vs 33/80, P < 0.05 and 44/160 vs 32/80, P < 0.05, respectively). The absence of the A-T-C protective allele of BAT was signif i-cantly associated with the presence of HCC (46/80 vs 68/160, P < 0.05). A strong association was observed between carriage of the BAT A-T-C and G-T-T haplotypes and HCC only in alcoholic liver disease (7/46 vs 12/36 vs 11/21, P < 0.002, respectively).CONCLUSION: VDR genetic polymorphisms are sig-nificantly associated with the occurrence of HCC in patients with liver cirrhosis. This relationship is more specific for patients with an alcoholic etiology. | Edmondo Falleti Davide Bitetto Carlo Fabris Annarosa Cussigh Elisabetta Fontanini Ezio Fornasiere Elisa Fumolo Sara Bignulin Sara Cmet Rosalba Minisini Mario Pirisi Pierluigi Toniutto | 2010 | World Journal of Gastroenterology2010，16，24： | 14 |
| 2 | Comparison of de novo tumours after liver transplantation with incidence rates from Italian cancer registries显示文摘 | U. Baccarani P. Piselli D. Serraino G.L. Adani D. Lorenzin M. Gambato A. Buda G. Zanus A. Vitale A. De Paoli C. Cimaglia V. Bresadola P. Toniutto A. Risaliti U. Cillo F. Bresadola P. Burra | 2009 | Digestive and Liver Disease2009，，1： | 2 |
| 3 | Recipient Interleukin-28B Rs12979860 C/T Polymorphism and Acute Cellular Rejection After Liver Transplantation: Role of the Calcineurin Inhibitor Used显示文摘 | Davide Bitetto Carlo Fabris Edmondo Falleti Ezio Fornasiere Claudio Avellini Sara Cmet Annarosa Cussigh Elisabetta Fontanini Mario Pirisi Stefano Ginanni Corradini Manuela Merli Antonio Molinaro Pierluigi Toniutto | 2012 | Transplantation Journal2012，，10： | 2 |
| 4 | Antiviral treatment of hepatitis C 显示文摘 | Toniutto P Fabris C Pirisi M | 2006 | Expert Opin Pharmacother2006，7，15： | 1 |
| 5 | Usefulness of six non-proprietary indirect markers of liver fibrosis in patients with chronic hepatitis C 显示文摘 | Fabris C Smirne C Toniutto P | 2008 | Clin Chem Lab Med2008，46，2： | 1 |
| 6 | Apolipoprotein E geno- types modulate fibrosis progression in patients with chronic hepatitis C and persistently normal transaminases 显示文摘 | Fabris C Vandelli C Toniutto P | 2011 | J Gastroenterol Hep- atol2011，26，2： | 1 |
| 7 | Apolipoprotein E polymorphism influences orthotopic liver transplantation outcomes in patients with hepatitis C virus-induced liver cirrhosis显示文摘BACKGROUND Hepatitis C virus(HCV)infection is responsible for a chronic liver inflammation,which may cause end-stage liver disease and hepatocellular carcinoma.Apolipoprotein E(protein:ApoE,gene:APOE),a key player in cholesterol metabolism,is mainly synthesized in the liver and APOE polymorphisms may influence HCV-induced liver damage.AIM To determine whether APOE alleles affect outcomes in HCV-infected patients with liver cirrhosis following orthotopic liver transplantation(OLT).METHODS This was a cohort study in which 179 patients,both genders and aged 34-70 years,were included before or after(up to 10 years follow-up)OLT.Liver injury severity was assessed using different criteria,including METAVIR and models for endstage liver disease.APOE polymorphisms were analyzed by quantitative real-time polymerase chain reaction.RESULTS The APOE3 allele was the most common(67.3%).In inflammation severity of biopsies from 89 OLT explants and 2 patients in pre-transplant,the degree of severe inflammation(A3F4,0.0%)was significantly less frequent than in patients with minimal and moderate degree of inflammation(≤A2F4,16.2%)P=0.048,in patients carrying the APOE4 allele when compared to non-APOE4.In addition,a significant difference was also found(≤A2F4,64.4%vs A3F4,0.0%;P=0.043)and(A1F4,57.4%vs A3F4,0.0%;P=0.024)in APOE4 patients when compared to APOE3 carriers.The fibrosis degree of the liver graft in 8 of 91 patients and the lack of the E4 allele was associated with more moderate fibrosis(F2)(P=0.006).CONCLUSION Our results suggest that the E4 allele protects against progression of liver fibrosis and degree of inflammation in HCV-infected patients. | José Carlos Rodrigues Nascimento Lianna C Pereira Juliana Magalhães C Rêgo Ronaldo P Dias Paulo Goberlânio B Silva Silvio Alencar C Sobrinho Gustavo R Coelho Ivelise Regina C Brasil Edmilson F Oliveira-Filho James S Owen Pierluigi Toniutto Reinaldo B Oriá | 2021 | World Journal of Gastroenterology2021，27，11： | 1 |
| 8 | Evaluation of donor hepatic iron concentration as a factor of early fibrotic progression after liver transplantation 显示文摘 | Toniutto P Fabris C Bortolotti N | 2004 | J Hepatol2004，41，： | 1 |
| 9 | Risk factors for hepatocellular carcinoma recurrence after liver transplantation显示文摘Liver transplantation(LT)provides an excellent option for the long-term survival of patients with unresectable hepatocellular carcinoma(HCC)based on the Milan criteria.Despite careful selection of patients,HCC may still recur after LT,which represents the most important negative predictor of post-transplant survival.The growing demand for LT in HCC has led to the expansion of patient selection criteria,with a resultant increase in the risk of post-transplant HCC recurrence.Numerous tumor and host factors predict HCC recurrence.The morphological,histological,and serological characteristics of tumors in predicting HCC recurrence have been extensively studied.Furthermore,the type and duration of anticancer response before LT has also been considered a surrogate marker of tumor aggressiveness and is associated with the risk of recurrence.The demographic and clinical characteristics of recipients,as well as the type and duration of exposure to immunosuppressive therapy,represent the main host-related risk factors.Many studies have attempted to describe predictive models for the risk of HCC recurrence,considering evaluable parameters both before and after LT.Although many models have been proposed,relatively few have been externally validated on different patient populations.This paper aims to comprehensively summarize the available data on the predictive factors of HCC recurrence after LT,and to examine and discuss those that have been externally validated. | Pierluigi Toniutto Ezio Fornasiere Elisa Fumolo Davide Bitetto | 2020 | Hepatoma Research2020，6，8： | 1 |
| 10 | Antiviral treatment of hepatitis C 显示文摘 | TONIUTTO P FABRIS C PIRISI M | 2006 | Expert Opin Pharmacother2006，7，15： | 1 |
| 11 | Assessment of liver fibrosis progression in patients with chronic hepatitis C and normal alanine aminotransferase values:the role of AST to the platelet ratio index显示文摘 | Fabris C Smime C Toniutto P | 2006 | Clin Biochem2006，39，4： | 1 |
| 12 | Genetic polymorphism at the apolipoprotein E locus affects the outcome of chronic hepatitis B 显示文摘 | Toniutto P Fattovich G Fabris C | 2010 | JMedVirol2010，82，2： | 1 |
| 13 | Sex-related influence of angiotensin-converting enzyme polymorphisms on fibrosis progression due to recurrent hepatitis C after liver transplantation显示文摘 | Fabris C Toniutto P Bitetto D | 2007 | J Gastroenterol2007，42，7： | 1 |
| 14 | VEGF and VEGFR genotyping in the prediction of clinical outcome for HCC patients receiving sorafenib: The ALICE‐1 study显示文摘 | Mario Scartozzi Luca Faloppi Gianluca Svegliati Baroni Cristian Loretelli Fabio Piscaglia Massimo Iavarone Pierluigi Toniutto Giammarco Fava Samuele De Minicis Alessandra Mandolesi Maristella Bianconi Riccardo Giampieri Alessandro Granito Floriana Facchet | 2014 | Int. J. Cancer2014，，： | 1 |
| 15 | Antiviral treatment of hepatitis C显示文摘 | Toniutto P Fabris C Pirisi M | 2006 | Expert Opinion on Pharmacotherapy2006，7，15： | 1 |
| 16 | Evaluation of donor hepatie iron concentration as a factor of early fibrotic progression after liver transplantation显示文摘 | Fabris C Bortolotti N | 2004 | J Hepatol2004，41，2： | 1 |
| 17 | Assessment of liver fi- brosis progression in patients with chronic hepatitis C nor- mal alanine aminotransferase values:The role of AST to the platelet ratio index 显示文摘 | Fabris C Smime C Toniutto P | 2006 | Clin Biochem2006，39，： | 1 |
| 18 | Antiviral treatment of hepatitis C 显示文摘 | TONIUTTO P FABRIS C PIRISI M | 2006 | Expert Opin Pharmaeother2006，7，15： | 1 |
| 19 | Splenic artery syndrome (SAS) as a possible cause of late onset refractory ascites after liver transplantation: management with proximal splenic artery embolization显示文摘 | Riccardo Pravisani Umberto Baccarani Gianluigi Adani Dario Lorenzin Alessandro Vit Vittorio Cherchi Sergio Calandra Ilaria Rispoli Pierluigi Toniutto Massimo Sponza Andrea Risaliti | 2016 | Transplantation Proceedings2016，，： | 1 |
| 20 | Targeting the HGF-cMET Axis in Hepatocellular Carcinoma显示文摘 | Neeta K. Venepalli Laura Goff Pierluigi Toniutto | 2013 | International Journal of Hepatology2013，，： | 1 |
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