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您的检索式：作者名="Baichun Hu"
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| 1 | Emerging role of graphene oxide as sorbent for pesticides adsorption:Experimental observations analyzed by molecular modeling显示文摘The accumulation of pesticide residues in the environment due to their persistence and stability is causing increasing health concern.Indeed,researchers have rekindled their interest in eliminating pesticides from the environment by a range of biological and chemical approaches.In particular,graphene oxide(GO)has drawn great attention because it impressively enhances adsorption of pesticides in aqueous solutions,which provides promising environmental applications on water purification to remove pesticide residuals.However,although multiple studies have highlighted the adsorption of environmental contaminants by GO,the underlining molecular mechanisms remain limited.Consequently,we further delved into the knowledge regarding their adsorption molecular mechanism that is of both practical and theoretical importance.It was revealed that theπ-πstacking and van der Waals interactions accounted for the major adsorption interactions between GO and its removing pesticides through integrating both density functional theory(DFT)calculation,fully atomistic molecular dynamics(MD)simulation,and binding free energy calculation.These findings not only bridged the theoretical gap of the adsorption mechanisms of GO,but also provided a venue for visualizing the adsorption process,which were essential for guiding its future adsorption applications. | Hanxun Wang Baichun Hu Zisen Gao Fengjiao Zhang Jian Wang | 2021 | Journal of Materials Science & Technology2021，，4： | 2 |
| 2 | CUL4B facilitates HBV replication by promoting HBx stabilization显示文摘Objective:Hepatitis B virus(HBV)infection is a major public health problem worldwide.However,the regulatory mechanisms underlying HBV replication remain unclear.Cullin 4 B-RING ubiquitin E3 ligase(CRL4 B)is involved in regulating diverse physiological and pathophysiological processes.In our study,we aimed to explain the role of CUL4 B in HBV infection.Methods:Cul4 b transgenic mice or conditional knockout mice,as well as liver cell lines with CUL4 B overexpression or knockdown,were used to assess the role of CUL4 B in HBV replication.Immunoprecipitation assays and immunofluorescence staining were performed to study the interaction between CUL4 B and HBx.Cycloheximide chase assays and in vivo ubiquitination assays were performed to evaluate the half-life and the ubiquitination status of HBx.Results:The hydrodynamics-based hepatitis B model in Cul4 b transgenic or conditional knockout mice indicated that CUL4 B promoted HBV replication(P<0.05).Moreover,the overexpression or knockdown system in human liver cell lines validated that CUL4 B increased HBV replication in an HBx-dependent manner.Importantly,immunoprecipitation assays and immunofluorescence staining showed an interaction between CUL4 B and HBx.Furthermore,CUL4 B upregulated HBx protein levels by inhibiting HBx ubiquitination and proteasomal degradation(P<0.05).Finally,a positive correlation between CUL4 B expression and HBV pg RNA level was observed in liver tissues from HBV-positive patients and HBV transgenic mice.Conclusions:CUL4 B enhances HBV replication by interacting with HBx and disrupting its ubiquitin-dependent proteasomal degradation.CUL4 B may therefore be a potential target for anti-HBV therapy. | Haixia Shan Bo Wang Xiaodong Zhang Hui Song Xi Li Yongxin Zou Baichun Jiang Huili Hu Hao Dou Changshun Shao Lifen Gao Chunhong Ma Xiaoyun Yang Xiaohong Liang Yaoqin Gong | 2022 | Cancer Biology & Medicine2022，19，1： | 2 |
| 3 | Theoretical study on behaviors of 1s^22s-1s^2np transition for Co^(24+) ion in the whole energy region显示文摘Non-relativistic energies of 1s22s and 1s2np (n≤9) states for Co24+ ion are calculated by using the full-core plus correlation method. Our results of 1s22s and 1s22p states agree well with the high-precision results of Yan et al. Based on calculating the first-order corrections to the energy from relativistic and mass-polarization effects,we estimate the higher-order relativistic contribution and QED correc-tion to the energy under a hydrogenic approximation. The transition energies,wavelengths and oscil-lator strengths for the 1s22s-1s2np (n≤9) transitions of this ion are calculated. The results agree with the experimental data available in literature satisfactorily. By combining with quantum defect theory,our theoretical predictions on the energy and oscillator strength of this ion are extrapolated to the whole energy region including continuous states. | WANG ZhiWen,TONG BaiChun,HU MuHong,GUO Yang & LI Ye College of Physics and Electronic Technology,Liaoning Normal University,Dalian 116029,China | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，12： | 0 |
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