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| 1 | Role of endoglin and VEGF family expression in colorectal cancer prognosis and anti-angiogenic therapies显示文摘Colorectal cancer(CRC)is one of the cancer models and most of the carcinogenic steps are presently well understood.Therefore,successful preventive measures are currently used in medical practice.However,CRC is still an important public health problem as it is the third most common cancer and the fourth most frequent cause of cancer death worldwide.Nowadays,pathologic stage is a unique and well-recognized prognostic indicator,however,more accurate indicators of the biologic behavior of CRC are expected to improve the specificity of medical treatment.Angiogenesis plays an important role in the growth and progression of cancer but its role as a prognostic factor is still controversial.Probably the most important clinical implication of tumor angiogenesis is the development of anti-angiogenic therapy.The goal of this review is to critically evaluate the role of angiogenic markers,assessed by either endoglin-related microvessel density or expression of vascular endothelial growth factor family members in the CRC setting and discuss the role of these angiogenic markers in antiangiogenic therapies. | Sandra F Martins Rui M Reis Antonio Mesquita Rodrigues Fátima Baltazar Adhemar Longatto Filho | 2011 | World Journal of Clinical Oncology2011，2，6： | 9 |
| 2 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 3 | Oxidation of Medium-chain acyl-CoA Esters by Extracts of Aspergillus niger: En- zymology and Characterization of Intermediates by HPLC 显示文摘 | BALTAZAR M F DICKINSON F M RATLEDGE C | 1999 | Micro- biology1999，145，1： | 1 |
| 4 | Study of interracial stiffness ratio of a rough surface in contact using a spring model 显示文摘 | GONZALEZ-VALADEZ M BALTAZAR A DW- YER-JOYCE R S | 2010 | Wear2010，26，34： | 1 |
| 5 | Maize pollen lon- gevity and distance isolation requirements for effective pollen control显示文摘 | Luna S Figueroa V J Baltazar M B | 2001 | Crop Science2001，41，： | 1 |
| 6 | Study of interfacial stiffness ratio of a rough in contact using a spring model 显示文摘 | Valadez G M Baltazar A Joyce D R S | 2010 | Wear2010，268，34： | 1 |
| 7 | IFN-γimpairs Trichophyton rubrum proliferation in a murine model of dermatophytosis through the production of IL-1βand reactive oxygen species显示文摘 | Baltazar Lde M Santos PC Paula TP | 2014 | Med Mycol2014，52，3： | 1 |
| 8 | Adaptation to flooding in upland and lowland ecotypes of Cyperus rotundus, a troublesome sedge weed of rice: tuber morphology and carbohydrate metabolism显示文摘 | Pena-Fronteras J T ViUalobos M C Baltazar A M | 2009 | Annals of Botany2009，103，2： | 1 |
| 9 | Antiaorta antibodies and Takayasu arteritis显示文摘 | Baltazares M Mendoza F D6bague J | 1998 | Int J Cardiol1998，66，： | 1 |
| 10 | Study of interfacial stiffness ratio of a rough surface in contact using a spring model显示文摘 | GONZALEZ-VALADEZ M BALTAZAR A DWYER- JOYCE R S | 2010 | Wear2010，268，34： | 1 |
| 11 | Combined effect of superplasticizer, silica fume and temperature in the performance of natural hydraulic lime grouts 显示文摘 | Baltazar L G Henriques F M A Jome F | 2014 | Construction and Building Materials2014，50，： | 1 |
| 12 | Transport inefficiency in branched out mesoscopic networks: An analog of the Braess paradox 显示文摘 | Pala M Baltazar S Huant S | 2012 | Physical ReviewLetters2012，108，07： | 1 |
| 13 | Study of interfacial stiffness ratio of a rough surface in contact using a spring model显示文摘 | Gonzalez-Valadez M Baltazar A Dwyer-Joyce R S | 2010 | Wear2010，268，34： | 1 |
| 14 | HLA class Ⅱ haplotypes in Mexican systemic lupus erythematosus patients显示文摘 | Cortes L Baltazar L Lopez-Cardona M | 2004 | Hum Immunol2004，65，12： | 1 |
| 15 | Study of Interfacial Stiffness Ratio of a Rough Surface in Contact Using a Spring Model 显示文摘 | Gonzalez- Valadez M Baltazar A Dwyer- Joyce R S | 2010 | Wear2010，268，34： | 1 |
| 16 | Adap- tation to flooding in upland and lowland ecotypes of Cyperus rotun- dus, a troublesome sedge weed of rice : tuber morphology and car- bohydrate metabolism 显示文摘 | Pe na-Fronteras J T Villaiobos M C Baltazar A M | 2009 | Annals of Botany2009，103，2： | 1 |
| 17 | Study of inter- facial stiffness ratio of a rough surface in contact using a spring model显示文摘 | M Gonzalez-Valadez A Baltazar R S Dwyer-Joyee | 2010 | Wear2010，，268： | 1 |
| 18 | Weed management in rice显示文摘 | BALTAZAR A M DE DATTA S K | 1992 | Weed Abstr1992，41，： | 1 |
| 19 | A new approach for calculating zone-2 setting of distance relays and its use in an adaptive protection system显示文摘 | SIDHU T S BALTAZAR D S PALOMINO R M | | 0，，01： | 1 |
| 20 | Maize pollen longevity and distance isolation requirements for effective pollen control显示文摘 | Luna V S Figueroa J M Baltazar B M | 2001 | Crop Sci2001，41，： | 1 |
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