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| 1 | Exosomes:key players in cancer and potential therapeutic strategy显示文摘Exosomes are extracellular vesicles secreted by most eukaryotic cells and participate in intercellular communication.The components of exosomes,including proteins,DNA,mRNA,microRNA,long noncoding RNA,circular RNA,etc.,which play a crucial role in regulating tumor growth,metastasis,and angiogenesis in the process of cancer development,and can be used as a prognostic marker and/or grading basis for tumor patients.Hereby,we mainly summarized as followed:the role of exosome contents in cancer,focusing on proteins and noncoding RNA;the interaction between exosomes and tumor microenvironment;the mechanisms that epithelial-mesenchymal transition,invasion and migration of tumor affected by exosomes;and tumor suppression strategies based on exosomes.Finally,the application potential of exosomes in clinical tumor diagnosis and therapy is prospected,which providing theoretical supports for using exosomes to serve precise tumor treatment in the clinic. | Jie Dai Yangzhou Su Suye Zhong Li Cong Bang Liu Junjun Yang Yongguang Tao Zuping He Chao Chen Yiqun Jiang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 8 |
| 2 | Semibatch Emulsifier-free Emulsion Copolymerization of Methyl Methacrylate and n-Butyl Acrylate in the Presence of 2-Hydroxyethyl Methacrylate显示文摘The sendbatch emulsifier-free emulsion copolymerization of methyl methacrylate (MMA) and n-butyl acrylate (BA) in the presence of 2-hydroxyethyl methacrylate (HEMA) initiated by K2S2O8 (PSP) was studied. The average palticle diameter increases with an increase of total solids content, HEMA content, PSP content, ionic strength of the system and monomer feed rate, and decreases with the monomer feed ratio from 3/1 (MMA/BA mole.) to 1/3. The stability of this reaction system is improyed by adding HEMA as nonionic comonomer. The high so1ids content (50%) latex with monodisperse particle can be obtained using this process. | Tian Ying GUO Mou Dao SONG Qing Ye ZHOU Bang Hua ZHANG Jian Biao MA Bing Lin HE (The State key Laboratory of Functional Polymer Materials for Adsorption and Separation,Institute of Polymer Chendstry, Nankai University, Tianin, 300071) | 1998 | Chinese Chemical Letters1998，9，7： | 4 |
| 3 | The MING proposal at SHINE:megahertz cavity enhanced X‑ray generation显示文摘The cavity-based X-ray free-electron laser(XFEL)has promise in producing fully coherent pulses with a bandwidth of a few meV and very stable intensity,whereas the currently existing self-amplified spontaneous emission(SASE)XFEL is capable of generating ultra-short pulses with chaotic spectra.In general,a cavity-based XFEL can provide a spectral brightness three orders of magnitude higher than that of the SASE mode,thereby opening a new door for cutting-edge scientific research.With the development of superconducting MHz repetition-rate XFEL facilities such as FLASH,European-XFEL,LCLS-II,and SHINE,practical cavity-based XFEL operations are becoming increasingly achievable.In this study,megahertz cavity enhanced X-ray generation(MING)is proposed based on China’s first hard XFEL facility-SHINE,which we refer to as MING@SHINE. | Nan‑Shun Huang Zi‑Peng Liu Bang‑Jie Deng Zi‑Han Zhu Shao‑Hua Li Tao Liu Zheng Qi Jia‑Wei Yan Wei Zhang Sheng‑Wang Xiang Yang‑Yang Lei Ya Zhu Yong‑Zhou He Qi‑Bing Yuan Fei Gao Rong‑Bing Deng Sen Sun Zhi‑Di Lei Zhi‑Qiang Jiang Meng‑Qi Duan Yuan Zhuan Xue‑Fang Huang Peng‑Cheng Dong Zhong‑Liang Li Shang‑Yu Si Lian Xue Si Chen Yong‑Fang Liu Ya‑Jun Tong Hai‑Xiao Deng Zhen‑Tang Zhao | 2023 | Nuclear Science and Techniques2023，34，1： | 2 |
| 4 | Spark ignition natural gas engines A review 显示文摘 | CHO H M HE Bang quan | 2007 | Energy Conversion and Management2007，48，6： | 1 |
| 5 | Simultaneous enhancement of coercivity and electric resistivity of Nd-Fe-B magnets by Pr-Tb-Al-Cu synergistic grain boundary diffusion toward high-temperature motor rotors显示文摘To high-power permanent magnetic motors,it is critical for Nd-Fe-B magnets to maintain the desirable coercivity at high-temperature operating conditions.To address this,two approaches have been proven effective:(1)enhancing the room temperature coercivity;(2)reducing the eddy current loss.However,these two items are difficult to be simultaneously achieved.Here,the grain boundary diffusion(GBD)of the Pr-Tb-Al-Cu-based source is applied to enhance the coercivity and electric resistivity at room temperature from 1101 kA m-1 and 2.13×10–6Ωm to 1917 kA m-1 and 2.60×10–6Ωm,and those at 120°C from 384 kA m-1 and 4.31×10–6Ωm to 783 kA m-1 and 4.86×10–6Ωm,respectively.Such optimization is ascribed to the improved formation depth of Tb-rich 2:14:1 shells with large magnetocrystalline anisotropy and the increased intergranular Pr-based oxides with high electric resistivity,induced by the coordination effects of Tb and Pr,as proven by the atomic-scale observations and the first principles calculations.It thus results in the simultaneously improved output power and energy efficiency of the motor because of the combination of magnetic thermal stability enhancement and eddy current loss reduction,as theoretically confirmed by electromagnetic simulation. | Jiayi He Jinwen Hu Bang Zhou Haoyang Jia Xiaolian Liu Zhenhua Zhang Lin Wen Lizhong Zhao Hongya Yu Xichun Zhong Xuefeng Zhang Zhongwu Liu | 2023 | Journal of Materials Science & Technology2023，，23： | 1 |
| 6 | Novel polymorphie re, on of the rpoβ gene containing mycobacterium species-speclfic sequences and its use in identification of mycobacteria 显示文摘 | Lee H Bang HE Bai GH | 2003 | Journal of Clinic Microbiology2003，41，5： | 1 |
| 7 | Studies on the Technology and Mechanism of Laser Photoinduced Alignment of Liquid Crystal显示文摘IntroductionTheanisotropyofliquidcrystalsmakesitpossibletobemadeintomanykindsofelec-tro-opticdevices.WhenthethicknessoftheLCc... | HE Yu e WANG Zhan qi and XIE Ming gui (Department of Chemistry, Sichuan University, Chengdu, 610064) CAI Bang wei and BI Guo jiang (Department of Opt Electronic & Science, Sichuan University, Chengdu, 610064) | 1998 | Chemical Research in Chinese Universities1998，14，4： | 1 |
| 8 | Nonlinear joint fractional transform correlator显示文摘 | ZHU Bang he LIU Shu-tian HAN Li | 2001 | Appl Opt2001，40，17： | 1 |
| 9 | A dynamic food-chain model and program for predicting the consequences of nuclear accident显示文摘AdynamicfoodchainmodelandprogramforpredictingtheconsequencesofnuclearacidentHuErbang,GaoZhanrong,ZhangHeyuan,WeiWeiqiang... | Hu Er bang, Gao Zhan rong, Zhang He yuan, Wei Wei qiang Institute of Environmental Science, CIRP, Taiyuan 030006, China | 1998 | Journal of Environmental Sciences1998，10，2： | 1 |
| 10 | Mutation in the embB locus among Korean clinical isolates of Mycobacterium tuberculosis resistant to ethambutol 显示文摘 | Lee HY Myoung HJ Bang HE | 2002 | Yonsei Med J2002，43，1： | 1 |
| 11 | Novel polymorphic region of the rpoBgene containing mycobacterium species-specific sequences and itsuse in identification of mycobacteria显示文摘 | LeeH Bang HE Bai GH | 2003 | J Clin Microbiol2003，41，5： | 1 |
| 12 | Novel polymorphic region of the rpoBgene containing Mycobacterium species-specific sequences and its use in identification of mycobacteria显示文摘 | Lee H Bang HE Bai GH | 2003 | Journal of clinical microbiology2003，41，5： | 1 |
| 13 | The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment 显示文摘 | He M Subramanian R Bangs F | 2014 | Nature Cell Biol2014，16，7： | 1 |
| 14 | Exclusive mutations related to isoniazid and ethionamide resistance among Mycobacterium tuberculosis isolates from Korea显示文摘 | Cho SN Bang HE | 2000 | Int J Tuberc Lung Dis2000，4，5： | 1 |
| 15 | The kinesin-4 pro- tein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment显示文摘 | He M Subramanian R Bangs F | 2014 | Nat Cell Biol2014，16，7： | 1 |
| 16 | OptiCal image encryption based on the multi-fractional fourier transform显示文摘 | ZHU Bang he LIU Shu-tian | 2000 | Opt Let2000，25，25： | 1 |
| 17 | Relationship between Alzheimer′s,Parkinson′s disease and Apolipoprotein E polymorphism in the Chinese显示文摘目的 :探讨阿尔茨海默病 (AD)、帕金森病 (PD)及帕金森病痴呆 (PDD)的发病机理和与载脂蛋白 E(Apo E)基因多态性的关系。方法 :对 AD组 (48例 )、PD组 (5 4例 )、PDD组 (43例 )和非痴呆对照组 (2 34例 )的 Apo E基因频率及基因型分布进行对照研究。结果 :非痴呆对照组 Apo Eε3基因频率最高 (0 .887) ,而 AD组 Apo Eε 4基因频率明显升高 (0 .2 19) ,显著高于非痴呆对照组 (0 .0 5 1) (P<0 .0 1)。 PD(0 .0 2 8)和 PDD(0 .0 79)组 Apo Eε 4基因频率与非痴呆对照组相比无显著差异 (P>0 .0 5 )。结论 :Apo Eε4是导致 AD发病的易感或危险基因之一 ,而与 PD和 PDD的发病无关 ,说明 AD和 PD。 | QIN Bin 1, ZENG Xiang yu 1, GUO Han bang 2, TANG Wei qing 2, XU Rong *, HE Jian xin ** , WANG Shu 2, XU Xian hao 1 (1. Dept.of Neurology,Beijing Hospital,Beijing 100730 China 2.Biochemistry Division,Institute of Gerontal Medicine) | 2001 | 白求恩医科大学学报2001，27，5： | 0 |
| 18 | Prognostic analysis of related factors of adverse reactions to immunotherapy in advanced gastric cancer and establishment of a nomogram model显示文摘BACKGROUND Immunotherapy for advanced gastric cancer has attracted widespread attention in recent years.However,the adverse reactions of immunotherapy and its relationship with patient prognosis still need further study.In order to determine the association between adverse reaction factors and prognosis,the aim of this study was to conduct a systematic prognostic analysis.By comprehensively evaluating the clinical data of patients with advanced gastric cancer treated by immunotherapy,a nomogram model will be established to predict the survival status of patients more accurately.AIM To explore the characteristics and predictors of immune-related adverse reactions(irAEs)in advanced gastric cancer patients receiving immunotherapy with programmed death protein-1(PD-1)inhibitors and to analyze the correlation between irAEs and patient prognosis.METHODS A total of 140 patients with advanced gastric cancer who were treated with PD-1 inhibitors in our hospital from June 2021 to October 2023 were selected.Patients were divided into the irAEs group and the non-irAEs group according to whether or not irAEs occurred.Clinical features,manifestations,and prognosis of irAEs in the two groups were collected and analyzed.A multivariate logistic regression model was used to analyze the related factors affecting the occurrence of irAEs,and the prediction model of irAEs was established.The receiver operating characteristic(ROC)curve was used to evaluate the ability of different indicators to predict irAEs.A Kaplan-Meier survival curve was used to analyze the correlation between irAEs and prognosis.The Cox proportional risk model was used to analyze the related factors affecting the prognosis of patients.RESULTS A total of 132 patients were followed up,of whom 63(47.7%)developed irAEs.We looked at the two groups’clinical features and found that the two groups were statistically different in age≥65 years,Ki-67 index,white blood cell count,neutrophil count,and regulatory T cell(Treg)count(all P<0.05).Multivariate logistic regression analysis showed that Treg count was a protective factor affecting irAEs occurrence(P=0.030).The ROC curve indicated that Treg+Ki-67+age(≥65 years)combined could predict irAEs well(area under the curve=0.753,95%confidence interval:0.623-0.848,P=0.001).Results of the Kaplan-Meier survival curve showed that progressionfree survival(PFS)was longer in the irAEs group than in the non-irAEs group(P=0.001).Cox proportional hazard regression analysis suggested that the occurrence of irAEs was an independent factor for PFS(P=0.006).CONCLUSION The number of Treg cells is a separate factor that affects irAEs in advanced gastric cancer patients receiving PD-1 inhibitor immunotherapy.irAEs can affect the patients’PFS and result in longer PFS.Treg+Ki-67+age(≥65 years old)combined can better predict the occurrence of adverse reactions. | Xu-Xu He Bang Du Tao Wu Hao Shen | 2024 | World Journal of Gastrointestinal Oncology2024，16，4： | 0 |
| 19 | Advances in nuclear detection and readout techniques显示文摘“A Craftsman Must Sharpen His Tools to Do His Job,”said Confucius.Nuclear detection and readout techniques are the foundation of particle physics,nuclear physics,and particle astrophysics to reveal the nature of the universe.Also,they are being increasingly used in other disciplines like nuclear power generation,life sciences,environmental sciences,medical sciences,etc.The article reviews the short history,recent development,and trend of nuclear detection and readout techniques,covering Semiconductor Detector,Gaseous Detector,Scintillation Detector,Cherenkov Detector,Transition Radiation Detector,and Readout Techniques.By explaining the principle and using examples,we hope to help the interested reader underst and this research field and bring exciting information to the community. | Rui He Xiao‑Yang Niu Yi Wang Hong‑Wei Liang Hong‑Bang Liu Ye Tian Hong‑Lin Zhang Chao‑Jie Zou Zhi‑Yi Liu Yun‑Long Zhang Hai‑Bo Yang Ju Huang Hong‑Kai Wang Wei‑Jia Han Bei Cao Gang Chen Cong Dai Li‑Min Duan Rui‑Rui Fan Fang‑Fa Fu Jian‑Hua Guo Dong Han Wei Jiang Xian‑Qin Li Xin Li Zhuo‑Dai Li Yu‑Tie Liang Shun Liao De‑Xu Lin Cheng‑Ming Liu Guo‑Rui Liu Jun‑Tao Liu Ze Long Meng‑Chen Niu Hao Qiu Hu Ran Xiang‑Ming Sun Bo‑Tan Wang Jia Wang Jin‑Xiang Wang Qi‑Lin Wang Yong‑Sheng Wang Xiao‑Chuan Xia Hao‑Qing Xie He‑Run Yang Hong Yin Hong Yuan Chun‑Hui Zhang Rui‑Guang Zhao Ran Zheng Cheng‑Xin Zhao | 2023 | Nuclear Science and Techniques2023，34，12： | 0 |
| 20 | Correlation between synaptic protein expression and synaptic reorganization in the hippocampal CA3 region in a rat model of post-traumatic epilepsy显示文摘Postsynaptic density protein-95 and synaptophysin participate in synaptic reorganization in the forebrain of epilepsy models.However,the time-effect relationship between dynamic synapsin expression in hippocampus and synaptic reorganization in the post-traumatic epilepsy model remains unclear.FeCl2 was injected into the hippocampal CA3 region of the right forebrain in rats to induce post-traumatic epilepsy.Postsynaptic density protein-95 and synaptophysin expression was detected using immunohistochemistry.Epileptiform discharge induced by FeCl2 injection was determined in rat forebrain neurons,revealing decreased postsynaptic density protein-95 expression at 24 hours and lowest levels at 7 days.Synaptophysin expression was markedly reduced at 24 hours,but increased at 7 days.Postsynaptic density protein-95 and synaptophysin expression was consistent with abnormal mossy fiber sprouting and synaptic reorganization following neuronal injury in the hippocampal CA3 region of FeCl2-induced epilepsy models. | Gaolian Zhang Jianmin Huang Bang Zhao Haineng Huang Yuanyang Deng HuadongHuang Qirong He Jianping Liang | 2010 | Neural Regeneration Research2010，5，15： | 0 |
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