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| 1 | Diagnostic and prognostic potential of tissue and circulating long non-coding RNAs in colorectal tumors显示文摘Long non-coding RNAs(lncRNAs)are members of the non-protein coding RNA family longer than 200 nucleotides.They participate in the regulation of gene and protein expression influencing apoptosis,cell proliferation and immune responses,thereby playing a critical role in the development and progression of various cancers,including colorectal cancer(CRC).As CRC is one of the most frequently diagnosed malignancies worldwide with high mortality,its screening and early detection are crucial,so the identification of disease-specific biomarkers is necessary.LncRNAs are promising candidates as they are involved in carcinogenesis,and certain lncRNAs(e.g.,CCAT1,CRNDE,CRCAL1-4)show altered expression in adenomas,making them potential early diagnostic markers.In addition to being useful as tissue-specific markers,analysis of circulating lncRNAs(e.g.,CCAT1,CCAT2,BLACAT1,CRNDE,NEAT1,UCA1)in peripheral blood offers the possibility to establish minimally invasive,liquid biopsy-based diagnostic tests.This review article aims to describe the origin,structure,and functions of lncRNAs and to discuss their contribution to CRC development.Moreover,our purpose is to summarise lncRNAs showing altered expression levels during tumor formation in both colon tissue and plasma/serum samples and to demonstrate their clinical implications as diagnostic or prognostic biomarkers for CRC. | Orsolya Galamb Barbara K Barták Alexandra Kalmár Zsófia B Nagy Krisztina A Szigeti Zsolt Tulassay Peter Igaz Béla Molnár | 2019 | World Journal of Gastroenterology2019，25，34： | 18 |
| 2 | Aging related methylation influences the gene expression of key control genes in colorectal cancer and adenoma显示文摘AIM To analyze colorectal carcinogenesis and age-related DNA methylation alterations of gene sequences associated with epigenetic clock CpG sites. METHODS In silico DNA methylation analysis of 353 epigenetic clock Cp G sites published by Steve Horvath was performed using methylation array data for a set of 123 colonic tissue samples [64 colorectal cancer(CRC), 42 adenoma, 17 normal; GEO accession number: GSE48684]. Among the differentially methylated agerelated genes, secreted frizzled related protein 1(SFRP1) promoter methylation was further investigated in colonic tissue from 8 healthy adults, 19 normal children, 20 adenoma and 8 CRC patients using bisulfite-specific PCR followed by methylation-specific high resolution melting(MS-HRM) analysis. m RNA expression of age-related 'epigenetic clock' genes was studied using Affymetrix HGU133 Plus2.0 whole transcriptome data of 153 colonic biopsy samples(49 healthy adult, 49 adenoma, 49 CRC, 6 healthy children)(GEO accession numbers: GSE37364, GSE10714, GSE4183, GSE37267). Whole promoter methylation analysis of genes showing inverse DNA methylationgene expression data was performed on 30 colonic samples using methyl capture sequencing.RESULTS Fifty-seven age-related Cp G sites including hypermethylated PPP1R16 B, SFRP1, SYNE1 and hypomethylated MGP, PIPOX were differentially methylated between CRC and normal tissues(P < 0.05, ?β≥ 10%). In the adenoma vs normal comparison, 70 CpG sites differed significantly, including hypermethylated DKK3, SDC2, SFRP1, SYNE1 and hypomethylated CEMIP, SPATA18(P < 0.05, ?β≥ 10%). In MS-HRM analysis, the SFRP1 promoter region was significantly hypermethylated in CRC(55.0% ± 8.4 %) and adenoma tissue samples(49.9% ± 18.1%) compared to normal adult(5.2% ± 2.7%) and young(2.2% ± 0.7%) colonic tissue(P < 0.0001). DNA methylation of SFRP1 promoter was slightly, but significantly increased in healthy adults compared to normal young samples(P < 0.02). This correlated with significantly increased SFRP1 m RNA levels in children compared to normal adult samples(P < 0.05). In CRC tissue the mR NA expression of 117 agerelated genes were changed, while in adenoma samples 102 genes showed differential expression compared with normal colonic tissue(P < 0.05, logF C > 0.5). The change of expression for several genes including SYNE1, CLEC3 B, LTBP3 and SFRP1, followed the same pattern in aging and carcinogenesis, though not for all genes(e.g., MGP). CONCLUSION Several age-related DNA methylation alterations can be observed during CRC development and progression affecting the m RNA expression of certain CRC- and adenoma-related key control genes. | Orsolya Galamb Alexandra Kalmár Barbara Kinga Barták árpád V Patai Katalin Leiszter Bálint Péterfia Barnabás Wichmann Gábor Valcz Gábor Veres Zsolt Tulassay Béla Molnár | 2016 | World Journal of Gastroenterology2016，22，47： | 7 |
| 3 | 利用位置测量的单点和两点差分跟踪起始算法的比较研究(英文)显示文摘我们考虑初始化当时,与将近经常的速度移动的一个目标的追踪的过滤器的问题位置 -- 仅仅(1D,2D, or3D ) 大小是可得到的。Kalman 过滤器为如此的一个问题是最佳的,这被知道,如果它正确地被初始化。我们比较一单个点并且著名二点的差别轨道初始化算法。我们经分解表演如果过程噪音接近零,过去常初始化速度变化的一个目标的最大的速度接近无穷,那么,单个点的算法归结为二点的差别算法。我们出现的现在的数字结果单个点的算法在均方差意义比二点的差别算法更好一致地表现。我们也介绍支持这一般来说是真的 conjecture 的分析结果。 | MALLICK Mahendra LA SCALA Barbara | 2008 | 自动化学报2008，34，3： | 2 |
| 4 | Angiostatin inhibits endothelial MMP-2 and MMP-14 expression: A hypoxia specific mechanism of action显示文摘 | Aneta Radziwon-Balicka Corey Ramer Cesar Moncada de la Rosa Barbara Zielnik-Drabik Paul Jurasz | 2012 | Vascular Pharmacology2012，，： | 2 |
| 5 | Viral Pathogens and ImmunityMutations Affecting the UL21 Gene Contribute to Avirulence of Pseudorabies Virus Vaccine Strain Bartha显示文摘 | Barbara G. Klupp Béla Lomniczi Nico Visser Walter Fuchs Thomas C. Mettenleiter | 1995 | Virology1995，，2： | 1 |
| 6 | Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 3 trial显示文摘 | Marcia S Brose Christopher M Nutting Barbara Jarzab Rossella Elisei Salvatore Siena Lars Bastholt Christelle de la Fouchardiere Furio Pacini Ralf Paschke Young Kee Shong Steven I Sherman Johannes W A Smit John Chung Christian Kappeler Carol Pe?a István Mo | 2014 | The Lancet2014，，： | 1 |
| 7 | Glycoconjugate and oligosaccharide mimetics by chemoselective ligation显示文摘 | FRANCESCO PERI LAURA CIPOLLA BARBARA LA FERLA | 2003 | C R Chimie2003，6，： | 1 |
| 8 | Method of evaluating effects of antibiotics on bacterial biofilm 显示文摘 | Barbara La TP Doris T Barbara AD | 1987 | Antimicrob Agents chemother1987，10，： | 1 |
| 9 | Identification of a Novel Gene on Chromosome 7q11.2 Interrupted by a Translocation Breakpoint in a Pair of Autistic Twins显示文摘 | Razia Sultana Chang-En Yu Jun Yu Jeffery Munson Donghui Chen Wenhui Hua Annette Estes Fanny Cortes Flora de la Barra Dongmei Yu Syed T. Haider Barbara J. Trask Eric D. Green Wendy H. Raskind Christine M. Disteche Ellen Wijsman Geraldine Dawson Daniel R. S | 2002 | Genomics2002，，： | 1 |
| 10 | Psychologic intervention im- proves survival for breast cancer patients显示文摘 | Barbara LA Hae CY William BF | 2008 | Cancer2008，113，12： | 1 |
| 11 | Associations of spink-1 (N345) and PRSS-1 (N29I AND R122H) gene mutations and chronic pancreatitis in Italy显示文摘 | Martina Cavestro Luca Frulloni F. Fontana La Ribeiro E. Cerati Barbara Calore Barbara Ferri Elena Coato Francesco Di Mario Giorgio Cavallini | 2003 | Gastroenterology2003，，4： | 1 |
| 12 | Histologic Transformation of Benign Endometriosis to Early Epithelial Ovarian Cancer显示文摘 | Ricardo Sainz de la Cuesta John H. Eichhorn Laurel W. Rice Arlan F. Fuller Jr Najmosama Nikrui Barbara A. Goff | 1996 | Gynecologic Oncology1996，，2： | 1 |
| 13 | Preparation of spherical aggregates of taro starch granules显示文摘 | Rosalia A Gonzalez–Soto Barbara de la Vega Francisco J García–Suarez | 2011 | LWT–Food Science and Technology2011，，20： | 1 |
| 14 | Choosing a track association method显示文摘 | Barbara F La Scala Alfonso Farina | 2002 | Information Fusion2002，2，2： | 1 |
| 15 | Psychological, behavioral and immune changes after a psychological intervention: A clinical trial显示文摘 | Barbara LA William B | 2004 | J Clin Onco2004，22，17： | 1 |
| 16 | Effect of chestnut extract and chestnut fiber on viability of potential probiotic Lactobacillus strains under gastrointestinal tract conditions显示文摘 | Giuseppe Blaiotta Barbara La Gatta Marika Di Capua Aldo Di Luccia Raffaele Coppola Maria Aponte | 2013 | Food Microbiology2013，，2： | 1 |
| 17 | Functionalization of liposomes with ApoE-derived peptides at different density affects cellular uptake and drug transport across a blood-brain barrier model显示文摘 | Francesca Re Ilaria Cambianica Cristiano Zona Silvia Sesana Maria Gregori Roberta Rigolio Barbara La Ferla Francesco Nicotra Gianluigi Forloni Alfredo Cagnotto Mario Salmona Massimo Masserini Giulio Sancini | 2011 | Nanomedicine: Nanotechnology Biology and Medicine2011，，5： | 1 |
| 18 | Oxidative damage and genotoxicity biomarkers in transfused and untransfused thalassemic subjects显示文摘 | Elisa Ferro Giuseppa Visalli Rosa Civa Maria Angela La Rosa Gaetano Randazzo Papa Barbara Baluce Domenico Giuseppe D’Ascola Basilia Piraino Carmelo Salpietro Angela Di Pietro | 2012 | Free Radical Biology and Medicine2012，，10： | 1 |
| 19 | A porous puckered V_(2)O_(5) polymorph as new high performance cathode material for aqueous rechargeable zinc batteries显示文摘Aqueous rechargeable zinc batteries are getting increasing attention for large-scale energy storage owing to their advantages in terms of cost,environmental friendliness and safety.Here,the layered puckeredγ’-V_(2)O_(5) polymorph with a porous morphology is firstly introduced as cathode for an aqueous zinc battery system in a binary Zn^(2+)/Li^(+)electrolyte.The Zn‖γ’-V_(2)O_(5) cell delivers high capacities of 240 and190 mAh g^(-1) at current densities of 29 and 147 mA g^(-1),respectively,and remarkable cycling stability in the 1.6 V-0.7 V voltage window(97%retention after 100 cycles at 0.15 A g^(-1)).The detailed structural evolution during first discharge-charge and subsequent cycling is investigated using X-ray diffraction and Raman spectroscopy.We demonstrate a reaction mechanism based on a selective Li insertion in the1.6 V-1.0 V voltage range.It involves a reversible exchange of 0.8 Li^(+)in γ’-V_(2)O_(5) and the same structural response as the one reported in lithiated organic electrolyte.However,in the extended 1.6 V-0.7 V voltage range,this work puts forward a concomitant and gradual phase transformation from γ’-V_(2)O_(5) to zinc pyrovanadate Zn_(3)V_(2)O_(7)(OH)2.2 H_(2)O(ZVO)during cycling.Such mechanism involving the in-situ formation of ZVO,known as an efficient Zn and Li intercalation material,explains the high electrochemical performance here reported for the Zn‖γ’-V_(2)O_(5) cell.This work highlights the peculiar layered-puckeredγ’-V_(2)O_(5) polymorph outperforms the conventionalα-V_(2)O_(5) with a huge improvement of capacity of 240 mAh g^(-1)vs 80 mAh g^(-1) in the same electrolyte and voltage window. | Dauren Batyrbekuly Barbara Laïk Jean-Pierre Pereira-Ramos Zhumabay Bakenov Rita Baddour-Hadjean | 2021 | Journal of Energy Chemistry2021，30，10： | 1 |
| 20 | Choosing a track association method显示文摘 | BARBARA F LA SCALA ALFONSO FARINA | 2002 | Information Fusion2002，3，： | 1 |
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