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| 1 | 累及眼部的肌肉特异性受体酪氨酸激酶抗体(MuSK-Ab)表达阳性的重症肌无力显示文摘Background: Antibodies (Ab) against the acetylcholine receptor (AChR) are found in 80-90% of generalized myasthenia gravis (MG),but only in 50% of pure ocular MG. Furthermore,Ab against the muscle-specific receptor tyrosine kinase (MuSK) were detected in 38-54% of patients with AChR-Ab negative (“ seronegative” ) MG,but not in pure ocular MG. Methods: 2 case reports have been analysed: Two patients (42 years old and 61 years old) with primary ocular MG were studied. Both patients complained of fluctuating bilateral ptosis and double vision lasting for 2 to 3 months. Results: AChR-Ab were negative but MuSK-Ab were clearly positive. In spite of treatment with pyridistigmin and prednisolone,the symptoms in patient 1 generalized within 4 weeks causing dysphagia,limb muscle weakness and respiratory crisis. Symptoms immediately responded to plasmapheresis. Patient 2 clearly improved under treatment with pyridostigmine,methylprednisone,and azathioprine. There was no generalizationwithin a course of 12 months. Conclusions: Both cases clearly indicate that MuSKAb can be found in primary isolated ocular MG lasting for 2 to 3 months. In a primary ocular manifestation of MG the detection of MuSK might indicate the risk for subsequent generalization and might have implications for immunosuppressive therapy. Therefore,seronegative MG requires testing for MuSK-Ab. | Bau V. Hanisch F. Hain B. Zierz S. 宋虎平(译) | 2006 | 世界核心医学期刊文摘(眼科学分册)2006，2，6： | 0 |
| 2 | 孤立的双侧盲作为短暂缺血发作的唯一表现显示文摘Purpose:To explain the rare phenomenon of acute transient bilateral blindness without additional ophthalmological or neurological symptoms and signs.Methods:Six patients with isolated bilateral visual loss lasting 1-15 mins and occurring simultaneously in both eyes were evaluated.Clinical observation,neuroimaging(CT,MRI,MR-angiography),extra-and transcranial Doppler and vascular risk factors assessment were performed.Results:Cortical blindness due to bilateral occipital lobe transient ischaemic attacks(TIAs)was established as the most likely cause of acute transient visual loss in all patients.Conclusion:We suggest that in cases of transient bilateral blindness with sudden onset,appearing simultaneously in both visual fields,a bilateral ischaemia of the visual cortex should be suspected even if other neurological symptoms are lacking.Patients should be managed in the same way as patients with vertebrobasilar TIAs. | Krasnianski M. Bau V. Neudecker S. 宋虎平(译) | 2006 | 世界核心医学期刊文摘(眼科学分册)2006，2，9： | 0 |
| 3 | 自体同侧旋转式穿透性角膜移植术:一种预防Peter异常症中严重不可逆弱视的早期手术方法(德) | Grü nauer- Kloevekorn C. Bau V. Weidlich R. Duncker G. 韩静 | 2005 | 世界核心医学期刊文摘(眼科学分册)2005，0，7： | 0 |
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