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		题名	作者	年代	出处	被引量
	1	累及眼部的肌肉特异性受体酪氨酸激酶抗体(MuSK-Ab)表达阳性的重症肌无力显示文摘Background: Antibodies (Ab) against the acetylcholine receptor (AChR) are found in 80-90% of generalized myasthenia gravis (MG),but only in 50% of pure ocular MG. Furthermore,Ab against the muscle-specific receptor tyrosine kinase (MuSK) were detected in 38-54% of patients with AChR-Ab negative (“ seronegative” ) MG,but not in pure ocular MG. Methods: 2 case reports have been analysed: Two patients (42 years old and 61 years old) with primary ocular MG were studied. Both patients complained of fluctuating bilateral ptosis and double vision lasting for 2 to 3 months. Results: AChR-Ab were negative but MuSK-Ab were clearly positive. In spite of treatment with pyridistigmin and prednisolone,the symptoms in patient 1 generalized within 4 weeks causing dysphagia,limb muscle weakness and respiratory crisis. Symptoms immediately responded to plasmapheresis. Patient 2 clearly improved under treatment with pyridostigmine,methylprednisone,and azathioprine. There was no generalizationwithin a course of 12 months. Conclusions: Both cases clearly indicate that MuSKAb can be found in primary isolated ocular MG lasting for 2 to 3 months. In a primary ocular manifestation of MG the detection of MuSK might indicate the risk for subsequent generalization and might have implications for immunosuppressive therapy. Therefore,seronegative MG requires testing for MuSK-Ab.	Bau V. Hanisch F. Hain B. Zierz S. 宋虎平(译)	2006	世界核心医学期刊文摘(眼科学分册)2006，2，6：	0

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