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| 1 | Regulation of mitochondrial function and endoplasmic reticulum stress by nitric oxide in pluripotent stem cells显示文摘Mitochondrial dysfunction and endoplasmic reticulum stress(ERS) are global processes that are interrelated and regulated by several stress factors. Nitric oxide(NO) is a multifunctional biomolecule with many varieties of physiological and pathological functions, such as the regulation of cytochrome c inhibition and activation of the immune response, ERS and DNA damage; these actions are dose-dependent. It has been reported that in embryonic stem cells, NO has a dual role, controlling differentiation, survival and pluripotency, but the molecular mechanisms by which it modulates these functions are not yet known. Low levels of NO maintain pluripotency and induce mitochondrial biogenesis. It is well established that NO disrupts the mitochondrial respiratory chain and causes changes in mitochondrial Ca^(2+) flux that induce ERS. Thus, at high concentrations, NO becomes a potential differentiation agent due to the relationship between ERS and the unfolded protein response in many differentiated cell lines. Nevertheless, many studies have demonstratedthe need for physiological levels of NO for a proper ERS response. In this review, we stress the importance of the relationships between NO levels, ERS and mitochondrial dysfunction that control stem cell fate as a new approach to possible cell therapy strategies. | Estefania Caballano-Infantes José Terron-Bautista Amparo Beltrán-Povea Gladys M Cahuana Bernat Soria Hajji Nabil Francisco J Bedoya Juan R Tejedo | 2017 | World Journal of Stem Cells2017，9，2： | 2 |
| 2 | Ribonuclease is partly responsible for the HIV-1 inhibitory effect activated by HLA alloantigen recognition 显示文摘 | Rugeles MT Trubey CM Bedoya VI | 2003 | AIDS2003，17，4： | 1 |
| 3 | Abiraterone acetate, a first in-class CYP17 inhibitor,establishes a new treatment paradigm in castra- tion-resistant prostate cancer显示文摘 | BEDOYA D J MITSIADES N | 2011 | Expert Rev Anticanc Ther2011，12，1： | 1 |
| 4 | An On-line water monitoring system using a smart ISFET array 显示文摘 | BERMEJO S BEDOYA G PARISI V | 2002 | Industrial Electronics Society IEEE2002，4，： | 1 |
| 5 | Genetic and biologic characteristics of Toxoplasma gondii isolates in free-range chickens from Colombia, South America显示文摘 | J.P. Dubey Jorge E. Gomez-Marin Angela Bedoya Fabiana Lora M.C.B. Vianna D. Hill O.C.H. Kwok S.K. Shen P.L. Marcet T. Lehmann | 2005 | Veterinary Parasitology2005，，1： | 1 |
| 6 | Genetic and biolog- ic characteristics of Toxoplasrna gondii isolates in free-range chickens from Colombia, South America显示文摘 | Dubey JP Gomez-Marin JE Bedoya A | 2005 | Vet Parasitol2005，134，12： | 1 |
| 7 | Abiraterone acetate, a first- in-class CYP17 inhibitor, establishes a new treatment paradigm in castration-resistant prostate cancer 显示文摘 | Bedoya D J Mitsiades N | 2012 | Expert Rev Anticanc Ther2012，12，1： | 1 |
| 8 | Thl7 cells in immunity and autoimmunity 显示文摘 | Bedoya SK Lam B Lau K | 2013 | Clin Dev Immunol2013，2013，98： | 1 |
| 9 | Role of nitric oxide in the maintenance of pluripotency and regulation of the hypoxia response in stem cells显示文摘Stem cell pluripotency and differentiation are global processes regulated by several pathways that have been studied intensively over recent years. Nitric oxide(NO) is an important molecule that affects gene expression at the level of transcription and translation and regulates cell survival and proliferation in diverse cell types. In embryonic stem cells NO has a dual role, controlling differentiation and survival, but the molecular mechanisms by which it modulates these functions are not completely defined. NO is a physiological regulator of cell respiration through the inhibition of cytochrome c oxidase. Many researchers have been examining the role that NO plays in other aspects of metabolism such as the cellular bioenergetics state, the hypoxia response and the relationship of these areas to stem cell stemness. | Amparo Beltran-Povea Estefania Caballano-Infantes Carmen Salguero-Aranda Franz Martín Bernat Soria Francisco J Bedoya Juan R Tejedo Gladys M Cahuana | 2015 | World Journal of Stem Cells2015，7，3： | 1 |
| 10 | Sr-Doped PbZr1-xTiO3Ceramics:Structural study and field-induced reorientation of ferroelectricdomains显示文摘 | Bedoya C Muller C H Baudour J L | 2000 | Materials Science and Engineering2000，75，： | 1 |
| 11 | A review of the diagnosis and management of impacted maxillary canines显示文摘 | Bedoya MM Park JH | 2009 | Am J Dent Assoc2009，140，12： | 1 |
| 12 | Humidity sensing witha luminescent Ru(II)complex and phase-sensitive detection显示文摘 | Bedoya M Díez M T Moreno-Bondi M C | 2006 | Sensors and Actuators B2006，113，： | 1 |
| 13 | Metal- organic chemical vapor deposition of ferroelectric SrBi2Ta2O9 films from a fluorine-containing precursor system显示文摘 | CONDORELLI G G FAVAZZA M BEDOYA C | 2006 | Chem Mater2006，18，4： | 1 |
| 14 | Hybrid method for calculating the maximum loading point using continuation load flow and nonlinear programming techniques显示文摘 | Manfred Bedrinana Duvier Bedoya Castro C A | 2007 | IEEE Trans on Trans on Power Systems2007，9，7： | 1 |
| 15 | Thl7 cells in immunity and au- toimmunity显示文摘 | BEDOYA S K LAM B LAU K | 2013 | Clin Dev Immunol2013，2013，98： | 1 |
| 16 | A review of the diagnosis and management of impacted maxillary canines显示文摘 | Bedoya MM Park JH | | 0，，12： | 1 |
| 17 | Genetic and biologic characteristics of Toxoplasma gondii isolates in free-range chickens from Colombia,South America显示文摘 | DUBEY JP GOMEZ-MARIN JE BEDOYA A | 2005 | Vet Parasitol2005，134，12： | 1 |
| 18 | Dexamethasone inhib- its apoptosis of human neutrophils induced by reactiveoxygen species显示文摘 | Ruiz LM Bedoya G Salazar J | 2002 | Inflammation2002，26，5： | 1 |
| 19 | SJ23B, a jatrophane diterpene activates classical PKCs and displays strong activity against HIV in vitro显示文摘 | Bedoya L M Mdrquez N Martinez N | 2009 | Bioehem Pharmaeol2009，77，： | 1 |
| 20 | Thl7 cells in immunity and auto- immunity显示文摘 | Bedoya SK Lain B Lau K | 2013 | Clin Dev lmmunol2013，2013，98： | 1 |
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