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| 1 | Prevalence and risk factors of nonalcoholic fatty liver disease in patients with inflammatory bowel diseases:A cross-sectional and longitudinal analysis显示文摘BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is common in the German population,with an even higher prevalence in inflammatory bowel disease patients.AIM To investigate the risk factors for NAFLD in inflammatory bowel disease patients.METHODS This monocentric retrospective study with a cross-sectional and a longitudinal part included 694 patients.Inclusion criteria were diagnosed inflammatory bowel disease,age≥18 years,availability of at least one abdominal ultrasound.Patients with infectious or suspected alcoholic fatty liver disease were excluded.NAFLD was defined by increased echogenicity at liver ultrasound.Demographic characteristics,disease activity and medications were analyzed as potential risk factors.Parameters influencing the course of NAFLD were identified by a generalized linear mixed model.RESULTS Forty-eight percent of Crohn’s disease(CD)patients and 44%of ulcerative colitis patients suffered from NAFLD.Its occurrence was associated with greater age,hypertension and body mass index(BMI)in both groups,and with higher disease activity and dyslipidemia in CD.2467 ultrasound results were included in the longitudinal analysis.Risk factors for NAFLD were age,BMI,higher disease activity,bowel resection(s),endoscopic activity and azathioprine use in CD;and BMI and endoscopic activity in ulcerative colitis.CONCLUSION NAFLD was highly prevalent in this cohort of German inflammatory bowel disease patients.Its risk increased mainly with rising age and BMI.This analysis provides a rationale for non-invasive liver screening in inflammatory bowel disease patients. | Peter Hoffmann Victoria Jung Rouven Behnisch Annika Gauss | 2020 | World Journal of Gastroenterology2020，26，46： | 8 |
| 2 | Monitoring dioxins and PCBs in eggs as sensitive indicators for environmental pollution and global contaminated sites and recommendations for reducing and controlling releases and exposure显示文摘This review compiles information on PCDD/F-and PCB-contaminated eggs from 20 years of global egg monitoring around emission sources in four continents conducted by the International Pollutants Elimination Network(IPEN)and Arnika as well as a compilation of data from scientific literature.IPEN monitored 127 pooled egg samples including samples from 113 chicken flocks at potential PCDD/F-and PCB-contaminated sites around priority sources listed in the Stockholm Convention(e.g.waste incinerators,metal industries,cement plants,and open burning).99(88%)of pooled egg samples were above the EU maximum limits for PCDD/Fs(2.5 pg PCDD/F-TEQ/g fat)or the sum of PCDD/Fs and dioxinlike PCBs(5 pg PCDD/F-PCB-TEQ/g fat).Children consuming such eggs exceed the tolerable weekly intake(TWI).This demonstrates that close to 90%of these areas were not safe for the production of free-range eggs.Sixteen out of the 113 egg samples(14%)were contaminated above 50 pg TEQ/g fat and exceeded the EU maximum limit more than 10 times.From the 26 pooled egg samples around incinerators 24(92%)exceeded the limit with a mean of 43.1 pg TEQ/g fat(2.6e234 pg TEQ/g).All 21 egg samples around metal industries(4.4e112.6 pg TEQ/g fat)were above limits with mean concentration of 26.0 pg TEQ/g fat.Also all 7 egg samples measured at e-waste recycling sites were above limits(mean 308 pg TEQ/g fat).In 58(51%)pooled egg samples the PCB-TEQ was above 5 pg TEQ/g fat exceeding the EU maximum limit with dioxin-like PCBs alone.This highlights the role of commercial PCBs for global contamination with dioxin-like compounds.It was discovered that around metal industries,shredder plants,open burning sites of e-waste and dump sites,a high share of contamination was caused by dl-PCBs.This clearly shows severe PCB release from the end-of-life management of PCB-containing equipment in developing countries.Also highly contaminated eggs were found at many sites where plastic was incinerated.The highest contaminated egg sample ever measured came from an e-waste site in Ghana and had 856 pg TEQ/g fat plus 300 pg TEQ from brominated dioxins(PBDD/Fs).Other extreme PCDD/F contaminations of eggs were found at a chlor-alkali site(514 pg TEQ/g fat),Agent Orange contaminated areas in Vietnam(490,249 and 246 pg TEQ/g fat)and e-waste sites(568 and 520 pg TEQ/g fat).Where DR CALUX®bioassay revealed higher TEQ compared to measured PCDD/F-PCB-TEQ in IPEN studies,polybrominated PBDD/F were also measured and detected up to 300 pg TEQ/g fat at e-waste sites.One positive outcome from the IPEN studies is that all 10 pooled supermarket eggs in developing countries were below regulatory limit.Policy recommendations are made including:a systematic assessment of areas around PCDD/Fs and PCBs sources;measures for reduction of exposures of populations;urgent control of emission sources including PCB equipment,the open burning of plastic,and the use of plastic as fuel in boilers/incinerators in developing countries without air pollution control.Furthermore,soil limits need to be re-assessed and lowered for free-range poultry. | Jindrich Petrlik Lee Bell Joe DiGangi Serge Molly Allo'o Allo'o Gilbert Kuepouo Griffins Ochieng Ochola Valeriya Grechko Nikola Jelinek Jitka Strakova Martin Skalsky Yuyun Ismawati Drwiega Jonathan N.Hogarh Eric Akortia Sam Adu-Kumi Akarapon Teebthaisong Maria Carcamo Bjorn Beeler Peter Behnisch Claudia Baitinger Christine Herold Roland Weber | 2022 | Emerging Contaminants2022，8，1： | 2 |
| 3 | Thermogravimetric investigations on the kinetics of thermal degradation of polyoxymethylene显示文摘 | Zimmermann H Behnisch J | 1982 | Thermochimica Acta1982，59，1： | 1 |
| 4 | Comparison between chemical(HRGC/HRMS) and biochemical analysis(Micro-EROD) from thermal processing samples( emission, residues) of municipal waste 显示文摘 | Behnisch P Hosce K Shiozaki K | 2000 | Organohalogen Compd2000，45，： | 1 |
| 5 | Mechanistic approach to the plasma polymerization of acrylic acid by a pulsed MW (ECR) plasma 显示文摘 | Behnisch J Mehdom F Zimmermann H | 1998 | Surface and Coatings Technology1998，98，13： | 1 |
| 6 | Effects of single polychlorinated biphenyls on the morphology of cultured rat tubuli seminiferi显示文摘 | Pflieger Bruss S Hanf V Behnisch P | 1999 | Andrologia1999，31，2： | 1 |
| 7 | Low-temperature thermal decomposition of dioxin-like compounds in fly ash: Combination of chemical analysis with in vitro bioassays 显示文摘 | Behnisch P A Hosoe K Shiozaki Ken | 2002 | Environmental Science and Technology2002，36，23： | 1 |
| 8 | Single cell analysis of activity-dependent cyclic AMP-responsive element-binding protein phosphorylation during long-lasting long-term potentiation in area CA1 of mature rat Hipp- ocampal-organotypic cultures显示文摘 | Leutgeb JK Frey JU Behnisch T | 2005 | Neuroscience2005，131，3： | 1 |
| 9 | Harmonised Quality Criteria for Chemical and Bioassays Analyses of PCDDs/PCDFs in Feed and Food,Part 1:General Considerations,GC/MS Methods显示文摘 | Malisch R Baumann B Behnisch | 2001 | Organohalogen Compounds2001，50，： | 1 |
| 10 | Anaemia, thrombocytopenia and coagulopathy due to occult diffuse infantile haemangiomatosis of spleen and pancreas显示文摘 | A. S. Schulz J. Urban P. Gessler W. Behnisch E. Kohne B. Heymer | 1999 | European Journal of Pediatrics1999，，5： | 1 |
| 11 | Surface radical analysis on plasma-treated polymers显示文摘 | WILKEN R HOLLANDER A BEHNISCH J | 1999 | Surf Coat Technol1999，，： | 1 |
| 12 | Tuning of photo-and electroluminescence of new soluble,PPV-analogous short-chain compounds with naphthalene moieties显示文摘 | Martinez-Ruiz P Behnisch B Schweikart K H | 2000 | Chem Eur J2000，6，8： | 1 |
| 13 | Screening of dioxin-like toxicity equivalents for various matrices with wildtype and recombinant rat hepatoma H4IIE cells显示文摘 | Behnisch P A Hosoe K Brouwer A | 2002 | Toxicological Sciences2002，69，1： | 1 |
| 14 | First-in-man use of polymer-free wdsartan-eluting stents in small coronary vessels : a comparison to polymer-free rapamycin (2%)-eluting stents 显示文摘 | Peters S Behnisch B Heilmann T | 2009 | J Renin Angiotensin Aldosterone Syst2009，10，2： | 1 |
| 15 | Bioanalytical screening methods for dioxins and dioxin-like compounds-a review of bioassay/biomarker technology显示文摘 | Behnisch P A Hosoe K Sakai S I | 2001 | Environment International2001，27，5： | 1 |
| 16 | Formation of hydrophobic layers on biologically degradable polymeric foils by plasma polymerization 显示文摘 | Behnisch J | 1998 | Surf Coat Techn1998，98，13： | 1 |
| 17 | Bioanalyticalscreening methods for dioxins and dioxin-like compounds-a review ofbioassay/biomarker technology显示文摘 | Peter A Behnisch Kazunori Hosoa Shin-ichi Sakai | 2001 | Environment International2001，27，5： | 1 |
| 18 | Bioanalytical screening methods for dioxins and dioxin-like compounds-a review of bioassay/biomarker technology 显示文摘 | Behnisch PA Hosoe K Kasai S | 2001 | Environment International2001，27，： | 1 |
| 19 | Low-temperature thermal decomposition of dioxin-like compounds in fly ash: combination of chemical analysis with in vitro bioassays (EROD and DR-CALUX)显示文摘 | Behnisch PA Hosoe K Shiozaki K | 2002 | Environ Sci Technol2002，36，： | 1 |
| 20 | Catechol-O-methyltransferase polymorphism influences outcome after isehemic stroke: a prospec- tive double-blind study 显示文摘 | Liepert J Heller A Behnisch G | 2013 | Neurerehabil Neural Repair2013，27，： | 1 |
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