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| 1 | Experimental study of therapeutic efficacy of Baicalin in rats with severe acute pancreatitis显示文摘AIM: To observe the therapeutic efficacy of Baicalin in rats with severe acute pancreatitis (SAP) and explore its therapeutic mechanisms.METHODS: The SAP rat models were randomly divided into the model control group, Baicalin treatment group, octreotide treatment group and sham operation group. All groups were randomly subdivided into 3 h, 6 h and 12 h groups with 15 rats in each group. The survival, ascites volume and pathological changes of pancreas in all rats were observed at different time points after operation. The plasma amylase content and serum TNF-α, IL-6, malonaldehyde (MDA) and PLA2 contents were also determined. RESULTS: The survival was not obviously different between the treated groups, and was significantly higher in treated groups at 12 h compared to the model control group (P < 0.05, 15 vs 10). The ascites/body weight ratio at 3 h and 6 h was significantly lower in Baicalin treatment group compared to the model control group and octreotide treatment group (P < 0.05, 1.00 vs 2.02 and 1.43 and P < 0.001, 2.29 (1.21) vs 2.70 (0.80) and 2.08 (2.21), respectively). The contents of amylase, TNF-α, IL-6, MDA and PLA2 were significantly lower in the treated groups than in the model control group (P < 0.05, 4342 vs 5303, 5058 vs 6272 in amylase, P < 0.01, 21.90 vs 36.30, 23.80 vs 39.70, 36 vs 54.35 in MDA and 56.25 vs 76.10 in PlA2, or P < 0.001, 65.10 and 47.60 vs 92.15 in TNF-α, 3.03 vs 5.44, 2.88 vs 6.82, 2.83 vs 5.36 in IL-6, respectively). The pathological scores of pancreas in the treated groups were significantly lower than that in the model control group (P < 0.05, 9.00 vs 10.05, 6.00 vs 9.00, 8.00 vs 10.05), but no marked difference was found between the treated groups. CONCLUSION: The Baicalin injection has significant therapeutic effects on SAP rats, its effects are similar to those of octreotide. The Baicalin injection is also cheap and has a big application range, quite hopefully to be used in clinical treatment of SAP. | Xi-Ping Zhang Ling Zhang Jin-Xian He Rui-Ping Zhang Qi-Hui Cheng Yi-Feng Zhou Bei Lu | 2007 | World Journal of Gastroenterology2007，13，5： | 23 |
| 2 | Remimazolam benzenesulfonate anesthesia effectiveness in cardiac surgery patients under general anesthesia显示文摘BACKGROUND Sedation with propofol injections is associated with a risk of addiction,but remimazolam benzenesulfonate is a comparable anesthetic with a short elimination half-life and independence from cell P450 enzyme metabolism.Compared to remimazolam,remimazolam benzenesulfonate has a faster effect,is more quickly metabolized,produces inactive metabolites and has weak drug interactions.Thus,remimazolam benzenesulfonate has good effectiveness and safety for diagnostic and operational sedation.AIM To investigate the clinical value of remimazolam benzenesulfonate in cardiac surgery patients under general anesthesia.METHODS A total of 80 patients who underwent surgery in the Department of Cardiothoracic Surgery from August 2020 to April 2021 were included in the study.Using a random number table,patients were divided into two anesthesia induction groups of 40 patients each:remimazolam(0.3 mg/kg remimazolam benzenesulfonate)and propofol(1.5 mg/kg propofol).Hemodynamic parameters,inflammatory stress response indices,respiratory function indices,perioperative indices and adverse reactions in the two groups were monitored over time for comparison.RESULTS At pre-anesthesia induction,the remimazolam and propofol groups did not differ regarding heart rate,mean arterial pressure,cardiac index or volume per wave index.After endotracheal intubation and when the sternum was cut off,mean arterial pressure and volume per wave index were significantly higher in the remimazolam group than in the propofol group(P<0.05).After endotracheal intubation,the oxygenation index and the respiratory index did not differ between the groups.After endotracheal intubation and when the sternum was cut off,the oxygenation index values were significantly higher in the remimazolam group than in the propofol group(P<0.05).Serum interleukin-6 and tumor necrosis factor-αlevels 12 h after surgery were significantly higher than before surgery in both groups(P<0.05).The observation indices were re-examined 2 h after surgery,and the epinephrine,cortisol and blood glucose levels were significantly higher in the remimazolam group than in the propofol group(P<0.05).The recovery and extubation times were significantly lower in the remimazolam group than in the propofol group(P<0.05);there were significantly fewer adverse reactions in the remimazolam group(10.00%)than in the propofol group(30.00%;P<0.05).CONCLUSION Compared with propofol,remimazolam benzenesulfonate benefited cardiac surgery patients under general anesthesia by reducing hemodynamic fluctuations.Remimazolam benzenesulfonate influenced the surgical stress response and respiratory function,thereby reducing anesthesia-related adverse reactions. | Fang Tang Jian-Min Yi Hong-Yan Gong Zi-Yun Lu Jie Chen Bei Fang Chen Chen Zhi-Yi Liu | 2021 | World Journal of Clinical Cases2021，9，34： | 19 |
| 3 | Serum and ascites levels of macrophage migration inhibitory factor, TNF-α and IL-6 in patients with chronic virus hepatitis B and hepatitis cirrhosis显示文摘Objective: To study the potential role of macrophagemigration inhibitory factor (MIF), tumor necrosisfactor-α (TNF-α) and interleukin-6 (IL-6) in thedevelopment of chronic virus hepatitis B (CH) andhepatitis cirrhosis (HC).Methods: The serum concentrations of MIF, TNF-αand IL-6 in 18 patients with chronic virus hepatitis Band in 14 patients with hepatitis cirrhosis without as-citic fluid, and the serum and ascites cytokine con-centrations in 22 HC patients with ascitic fluid weredetected by enzyme linked immunity sorbed assay.Results: The cytokine concentrations of the patientswere significantly higher than those of the controls.The serum levels of MIF, TNF-α and IL-6 of the 22patients with ascitic fluid were higer than those of 14HC patients without ascites. In the 18 patients withCH, the serum cytokine concentrations were the low-est. The serum cytokine concentrations of the 22 HCpatients with ascites were significantly higher thanthose of the 14 HC patients without ascites (P<0. 01). Their serum cytokine concentrations were sig-nificantly higher than those in the 18 patients withCH (P<0. 01). The concentration of IL-6 in asciteswas the highest among all the groups. The serum le-vels of MIF, TNF-α and IL-6 are correlated with al-anine aminotransferase (ALT) in the patients withCH, but not in those with HC with or without asci-tes.Conclusions: These results indicated that MIF, TNF-α and IL-6 may participate in the pathologicalprocess of CH and cirrhosis, that IL-6 seems to playan important role in ascites formation, and that se-rum levels of MIF, TNF-α and IL-6 appear to reflectthe severity of tissue injury in HBV disease. | Wei Zhang Bei Yue Gui-Qiang Wang Shu-Lan Lu the Department of Infectious Dispeases, Ruijing Hospital, Shanghai Second Medical University, Shanghai 200025, China Department of Intectious Diseases, Second Affiliated Hospital, Harbin Medical University, Harbin 150086, China | 2002 | Hepatobiliary & Pancreatic Diseases International2002，1，4： | 18 |
| 4 | Elevated nocturnal and morning blood pressure in patients with obstructive sleep apnea syndrome显示文摘 | HE Quan-ying FENG Jing ZHANG Xilong LIANG Zong-an HUANG Shao-guang KANG Jian WANG Guang-fa ZHANG Li-qiang MA Li-jun WANG Bei LIN Qi-chang ZHANG Jin-nong LIU Hui-guo LUO Yuan-ming LIU Jian-hong WANG Shi XIAO Gao-hui LU Gan ZHANG Jin FENG Xue-wei CHEN Bao-yuan | 2012 | Chinese Medical Journal2012，，10： | 15 |
| 5 | Influence of dexamethasone on mesenteric lymph node of rats with severe acute pancreatitis显示文摘AIM: To study the influence and mechanisms of dexamethasone on mesenteric lymph node of rats with severe acute pancreatitis (SAP). METHODS: The SAP rats were assigned to model, treated or sham-operated groups. The mortality, pathological changes of mesenteric lymph nodes, expression levels of NF-kB, P-selectin, Bax, Bcl-2 and caspase-3 protein and changes in apoptotic indexes in lymph nodes were observed at 3, 6 and 12 h after operation. The blood levels of endotoxin, superoxide dismutase (SOD), malondialdehyde (MDA), and endothelin-1 (ET-1) in blood were determined. RESULTS: SOD content, expression of Bax protein and apoptotic index were significantly higher in the treated group than in the model group at different time points (P < 0.05 or P < 0.01). Other blood-detecting indexes and histopathological scores of mesenteric lymphnodes were lower in the treated than in the model group (P < 0.05, P < 0.01 or P < 0.01). NF-kB protein expression was negative in all groups. Comparing P-selectin and caspase-3 expression levels among all three groups, there was no marked difference between the model and treated group. CONCLUSION: Dexamethasone can protect mesen-teric lymph nodes. The mechanism may be by reducing the content of inflammatory mediators in the blood and inducing lymphocyte apoptosis. | Xi-Ping Zhang Hong-Miao Xu Yi-Yu Jiang Shuo Yu Yang Cai Bei Lu Qi Xie Tong-Fa Ju | 2008 | World Journal of Gastroenterology2008，14，22： | 14 |
| 6 | Differential regulations of blood pressure and perturbed metabolism by total ginsenosides and conventional antihypertensive agents in spontaneously hypertensive rats显示文摘 | Ji-ye AA Guang-ji WANG Hai-ping HAO Qing HUANG Yi-hong LU Bei YAN Wei-bin ZHA Lin-sheng LIU An KANG | 2010 | Acta Pharmacologica Sinica2010，31，8： | 14 |
| 7 | 宫颈脱落细胞人乳头瘤病毒(HPV)E6/E7 mRNA检测在HPV阳性女性筛查中的应用(英文)显示文摘目的:基于临床样本探讨宫颈脱落细胞HPV E6/E7mR NA检测能否作为HPV阳性女性的筛查手段。创新点:首次比较了宫颈脱落细胞HPV E6/E7 mR NA检测与宫颈脱落细胞学检测对于HPV阳性女性宫颈活检结果的预测价值。方法:所有入组的HPV阳性女性均进行宫颈脱落细胞学及HPV E6/E7 mR NA检测。比较两种方法对于宫颈活检结果的预测价值。结论:对于HPV阳性的女性,高级别鳞状上皮内病变(HSIL)HPV E6/E7 mR NA阳性率高于低级别鳞状上皮内病变(LSIL)及正常病例。HPV E6/E7mR NA与细胞学检测相比,HSIL及以上级别病变的检测敏感性(89.52%vs.86.67%,P=0.671)、特异性(48.96%vs.48.96%,P=1.000)、阳性预测值(39.00%vs.38.24%,P=1.000)及阴性预测值(92.76%vs.90.97%,P=0.678)均无显著差异。HPV E6/E7 mR NA检测或能成为HPV阳性女性的一种新的筛查手段。 | Ye-li YAO Qi-fang TIAN Bei CHENG Yi-fan CHENG Jing YE Wei-guo LU | 2017 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2017，18，3： | 14 |
| 8 | Microstructure and mechanical properties of FeCoNiCr high-entropy alloy strengthened by nano-Y_2O_3 dispersion显示文摘In this manuscript, the FeCrCoNi high entropy alloy strengthened by nano-Y_2 O_3 particles was synthesized via mechanical alloying and spark plasma sintering. Effects of Y_2 O_3 additions on the microstructure and mechanical properties were investigated.The oxide-dispersion-strengthened(ODS) high-entropy alloy bearing 5 wt% Y_2 O_3 was found to have a finer grain with respect to the single-phase face-centered cubic(FCC) alloy without oxides. Consequently, the yield strength increased from 654 to1754 MPa, and the fracture strength reached up to 2325 MPa while the plasticity decreased appreciably for the ODS high-entropy alloy. The synergic effects of grain size hardening and particle strengthening on mechanical properties of the ODS HEA were discussed. This finding indicates that the addition of nano-scaled oxides is an effective and feasible approach to designing HEAs with superior mechanical properties. | jia bei liu xiongjun wang hui wu yuan lu zhaoping | 2018 | Science China(Technological Sciences)2018，61，2： | 12 |
| 9 | Relationship of daytime blood pressure and severity of obstructive sleep apnea among Chinese: a multi-center investigation in China显示文摘背景流行病的研究显示出在妨碍的睡觉呼吸暂停(OSA ) 和高血压之间的一个独立、明确的协会。这研究试图在中国的大陆在中国人口定义在白天血压和 OSA 的严厉之间的协会。二十大学医院睡觉在中国的大陆集中的方法被中国医药协会(CMA ) 邀请参予这流行病的研究和 2297 个连续病人(年老的 18-85 年;1981 男性和 316 女性) 为在 2004 年 1 月之间的 OSA 的评估参考了这二十个睡觉中心, 2006 年 4 月有希望地被注册。夜的 polysomnography 在每个病人被执行,并且疾病严厉基于呼吸暂停呼吸过慢过浅索引(AHI ) 被估计。这些病人是进四个组的 classfied:non-apneic 控制(控制, n=257 ) 与 AHI 5 事件 / 小时;温和睡觉呼吸暂停(温和, n=402 ) 与 AHI > 5 和 15 个事件 / 小时;中等睡觉呼吸暂停(中等, n=460 ) 与 AHI > 15 和 30 个事件 / 小时和严重睡觉呼吸暂停(严重, n=1178 ) 与 AHI > 30 个事件 / 小时。白天血压大小在为得到平均价值参考睡觉中心的日子在办公室里在上午 10 点在每个病人在标准化条件下面被执行。所有病人被请求两个都在 assessing.Results 的日子前停止与血压有关的药三天收缩血压和心脏舒张的血压珍视的白天是显著地与 AHI 有关断然(r = 0.201 和 0.276 分别地;两 P 价值 < 0.001 ) 并且到天底夜的氧浸透否定地(r=-0.215 和 -0.277, 分别地;两 Pvalues < 0.001 ) ,它是 OSA 严厉的参数。在二个特殊设计吝啬的阴谋,收缩的白天和心脏舒张的血压的工具与增加 AHI 逐渐地增加了。在 61-65 的 AHI 以外,这个增加的趋势到达了结果显示出的 plateau.Conclusions 那 OSA 严厉与白天血压被联系直到 61-65 的 AHI,为早 OSA 管理提供证据,特别在有伴随物高血压的 OSA 病人。 | HE Quan-ying FENG Jing ZHANG Xi-long LIANG Zong-an HUANG Shao-guang KANG Jian WANG Guang-fa ZHANG Li-qiang MA Li-jun, WANG Bei, LIN Qi-chang, ZHANG Jing-nong, LIU Hui-guo, LUO Yuan-ming,LIU Jian-hong, WANG Shi, XIAO Gao-hui, LU Gan, ZHANG Jin, FENG Xue-wei and CHEN Bao-yuan MA Li-jun WANG Bei LIN Qi-chang ZHANG Jing-nong LIU Hui-guo LUO Yuan-ming LIU Jian-hong WANG Shi XIAO Gao-hui LU Gan ZHANG Jin FENG Xue-wei CHEN Bao-yuan | 2010 | Chinese Medical Journal2010，，1： | 9 |
| 10 | Tissue microarrays in pathological examination of apoptotic acinar cells induced by dexamethasone in the pancreas of rats with severe acute pancreatitis显示文摘BACKGROUND:The good therapeutic effects of large dose of dexamethasone on severe acute pancreatitis(SAP) patients have been proved.This study was designed to investigate the influence of dexamethasone on apoptosis of acinar cells in the pancreas of rats with SAP and the protein expression of the apoptosis-regulating genes Bax and Bcl-2. METHODS:Ninety Sprague-Dawley rats with SAP were randomly divided into a model group and a dexamethasone treated group(45 rats in each group),and another 45 rats formed the sham operation group.Survival rates were calculated and gross pathological changes in the pancreas of each group were observed under a light microscope 3,6 and 12 hours after operation.Tissue microarray technology was applied to prepare pancreatic tissue sections.The changes in Bax and Bcl-2 protein expression levels of pancreatic tissues from each group were assessed by immunohistochemical staining,and TUNEL staining was used to evaluate changes in apoptosis index. RESULTS:The model and treated groups did not differ in mortality at each time point.The pathological score for the pancreas in the treated group was significantly lower than that in the model group at 3 and 6 hours.The positive rates of Bax protein expression in the head and tail of the pancreas in the treated group at all time points were all markedly higher than those of the model group. The positive rate of Bcl-2 protein expression in the head of the pancreas in the treated group was significantly higher than that of the model group at 3 hours.TUNEL staining showed that the pancreas head and tail apoptosis indices of the treated group were markedly higher than those of the model group after 6 hours. CONCLUSIONS:Apoptosis may be a protective response to pancreatic cell injury.The mechanism of action of dexamethasone in treating SAP may be related to the apoptosis of acinar cells in the pancreas induced by apoptosis-regulating genes such as Bax and Bcl-2. The advantages of tissue microarrays in pathological examination of the pancreas include saving of time and energy,efficiency and highly representative. | Zhang, Xi-Ping Tian, Hua Lu, Bei Chen, Li Xu, Ru-Jun Wang, Ke-Yi Wang, Zhi-Wei Cheng, Qi-Hui Shen, Hai-Ping | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，5： | 7 |
| 11 | Toxic effects of chlortetracycline on maize growth,reactive oxygen species generation and the antioxidant response显示文摘The toxicity of chlortetracycline (CTC) on maize (Zea mays L.) growth and reactive oxygen species (ROS) generation was studied.The root and shoot lengths and fresh weights of maize seedlings were inhibited by CTC treatment (p < 0.05).Root length was more sensitive than other parameters with the EC 10 value of 0.064 mg/L.The spin trapping technique followed by electron paramagnetic resonance (EPR) analysis was used to quantify the ROS production.The ROS generated in maize roots after exposure to CTC was identified as hydroxyl radical (·OH).The EPR signal intensity correlated positively with the logarithm of CTC concentrations exposed (p < 0.05).The dynamic changes of malondialdehyde (MDA) contents and the antioxidative enzyme activities in maize roots were also determined.As compared to the control group,CTC was found to significantly increase MDA content.Treatment of maize roots with the ·OH scavenger sodium benzoate (SB) reduced the MDA content and enhanced the antioxidative enzyme activities.The results demonstrated the harmfulness of CTC at high dose to maize in the early developmental stage,and clarified that the inducement of ·OH is one of the mechanisms of CTC toxicity. | Bei Wen Yu Liu Peng Wang Tong WU Shuzhen Zhang Xiaoquan Shan Jingfen Lu | 2012 | Journal of Environmental Sciences2012，24，6： | 6 |
| 12 | Aerosol observation in Fengtai area,Beijing显示文摘Measurements of aerosol number concentration and particulate matter with diameter less than 10 m(PM10) mass concentrations of urban background aerosols were performed in Fengtai area,Beijing in 2006.Black carbon(BC) was collected simultaneously from the ground and analyzed to determine the particulate matter components.To satisfy the interest in continuous monitoring of temporal and spatial distribution of aerosols,the relationship between extinction coefficient(visibility) measured by lidar remote sensing and the aerosol number concentration measured from the ground was derived by using statistical method.Vertical particle number concentration profile within the planetary boundary layer could be inversed through the lidar data as well as the statistical relation. | Zengdong Liu Jianguo Liu Bei Wang Fan Lu Shuhua Huang Dexia Wu Daowen Hart | 2008 | Particuology2008，6，3： | 6 |
| 13 | An experimental study of a yielding support for roadways constructed in deep broken soft rock under high stress显示文摘A rationally designed support for deep roadways excavated in broken soft rock under high stress was investigated. The deformation and failure characteristics and the mechanism of ''yielding support'' was studied for anchor bolts and cables. The rail roadway of the 2-501 working face in the Liyazhuang Mine of the Huozhou coal area located in Shanxi province was used for field trials. The geological conditions used there were used during the design phase. The new ''highly resistant, yielding'' support system has a core of high strength, yielding bolts and anchor cables. The field tests show that this support system adapts well to the deformation and pressure in the deep broken soft rock. The support system effectively controls damage to the roadway and ensures the long term stability of the wall rock and safe production in the coal mine. This provides a remarkable economic and social benefit and has broad prospects for fur- ther application. | Lu Yinlong Wang Lianguo Zhang Bei | 2011 | Mining Science and Technology2011，21，6： | 6 |
| 14 | NMRCloudQ: a quantum cloud experience on a nuclear magnetic resonance quantum computer显示文摘Cloud-based quantum computing is anticipated to be the most useful and reachable form for public users to experience with the power of quantum. As initial attempts, IBM Q has launched influential cloud services on a superconducting quantum processor in 2016, but no other platforms has followed up yet. Here,we report our new cloud quantum computing service – NMRCloud Q(http://nmrcloudq.com/zh-hans/),where nuclear magnetic resonance, one of the pioneer platforms with mature techniques in experimental quantum computing, plays as the role of implementing computing tasks. Our service provides a comprehensive software environment preconfigured with a list of quantum information processing packages,and aims to be freely accessible to either amateurs that look forward to keeping pace with this quantum era or professionals that are interested in carrying out real quantum computing experiments in person. In our current version, four qubits are already usable with in average 99.10% single-qubit gate fidelity and 97.15% two-qubit fidelity via randomized benchmaking tests. Improved control precisions as well as a new seven-qubit processor are also in preparation and will be available later. | Tao Xin Shilin Huang Sirui Lu Keren Li Zhihuang Luo Zhangqi Yin Jun Li Dawei Lu Guilu Long Bei Zeng | 2018 | Science Bulletin2018，63，1： | 5 |
| 15 | Origin of strong solid solution strengthening in the CrCoNi-W medium entropy alloy显示文摘Solid solution strengthening is one of the most conventional strategies for optimizing alloys strength,while the corresponding mechanisms can be more complicated than we traditionally thought specifically as heterogeneity of microstructure is involved.In this work,by comparing the change of chemical distribution,dislocation behaviors and mechanical properties after doping equivalent amount of tungsten(W)atoms in CrCoNi alloy and pure Ni,respectively,it is found that the alloying element W in CrCoNi alloy resulted in much stronger strengthening effect due to the significant increase of heterogeneity in chemical distribution after doping trace amount of W.The large atomic scale concentration fluctuation of all elements in CrCoNi-3W causes dislocation motion via strong nanoscale segment detrapping and severe dislocation pile up which is not the case in Ni-3W.The results revealed the high sensitivity of elements distribution in multi-principle element alloys to composition and the significant consequent influence in tuning the mechanical properties,giving insight for complex alloy design. | Yujie Chen Yan Fang Xiaoqian Fu Yiping Lu Sijing Chen Hongbin Bei Qian Yu | 2021 | Journal of Materials Science & Technology2021，，14： | 5 |
| 16 | Expressing p20 hairpin RNA of Citrus tristeza virus confers Citrus aurantium with tolerance/resistance against stem pitting and seedling yellow CTV strains显示文摘The Citrus tristeza virus(CTV) uses 3 silencing suppressor genes, p20, p23 and p25, to resist the attacks from its Citrus hosts. Inactivating these genes is therefore obviously a potential defensive option in addition to the current control strategies including aphid management and the use of mild strain cross protection. In this study, we cloned partial DNA fragments from the three genes, and used them to construct vectors for expressing hairpin RNAs(hp RNAs). To facilitate the formation of hp RNAs, the constructs were introduced in a loop structure. Following transformation of sour orange(Citrus aurantium) with these constructs, 8 p20 hp RNA(hp20) and 1 p25 hp RNA(hp25) expressing lines were obtained. The 7 hp20 transgenic lines were further characterized. Their reactions to CTV were tested following inoculation with CT14 A and/or TR-L514, both of which are severe strains. Results showed that 3 lines(hp20-5, hp20-6 and hp20-8) were completely resistant to TR-L514 under greenhouse conditions for no detectable viral load was found in their leaves by PCR. However, they exhibited only partial suppression of TR-L514 under screen house conditions since the virus was detected in their leaves, though 2 months later compared to non-transgenic controls. Further tests showed that hp20-5 was tolerant also to CT14 A under screen house conditions. The growth of hp20-5 was much better than others including the controls that were concurrently challenged with CT14 A. These results showed that expressing p20 hp RNA was sufficient to c onfer sour orange with CTV resistance/tolerance. | CHENG Chun-zhen YANG Jia-wei YAN Hu-bin BEI Xue-jun ZHANG Yong-yan LU Zhi-ming ZHONG Guang-yan | 2015 | Journal of Integrative Agriculture2015，14，9： | 5 |
| 17 | Roadway failure and support in a coal seam underlying a previously mined coal seam显示文摘The influence of an upper,mined coal seam on the stability of rock surrounding a roadway in a lower coal seam is examined.The technical problems of roadway control are discussed based on the geological conditions existing in the Liyazhuang Mine No.2 coal seam.The stress distribution and floor failure in the lower works after mining the upper coal is studied through numerical simulations.The failure mechanism of the roof and walls of a roadway located in the lower coal seam is described.The predicted deformation and failure of the roadway for different distances between the two coal seams are used to design two ways of supporting the lower structure.One is a combined support consisting of anchors with a joist steel tent and a combined anchor truss.A field test of the design was performed to good effect.The results have significance for the design of supports for roadways located in similar conditions. | Lu Yinlong Wang Lianguo Zhang Bei | 2012 | International Journal of Mining Science and Technology2012，22，5： | 5 |
| 18 | Prognostic value of lymphovascular invasion in Bismuth-Corlette type Ⅳ hilar cholangiocarcinoma显示文摘AIM To assess the prognostic value of lymphovascular invasion(LVI)in Bismuth-Corlette typeⅣhilar cholangiocarcinoma(HC)patients. METHODS A retrospective analysis was performed on 142consecutively recruited typeⅣHC patients undergoing radical resection with at least 5 years of followup.Survival analysis was performed by the KaplanMeier method,and the association between the clinicopathologic variables and survival was evaluated by log-rank test.Multivariate analysis was adopted to identify the independent prognostic factors for overall survival(OS)and disease-free survival(DFS).Multiple logistic regression analysis was performed to determine the association between LVI and potential variables. RESULTS LVI was confirmed histopathologically in 29(20.4%)patients.Multivariate analysis showed that positive resection margin(HR=6.255,95%CI:3.485-11.229,P<0.001),N1 stage(HR=2.902,95%CI:1.132-7.439,P=0.027),tumor size>30 mm(HR=1.942,95%CI:1.176-3.209,P=0.010)and LVI positivity(HR=2.799,95%CI:1.588-4.935,P<0.001)were adverse prognostic factors for DFS.The independent risk factors for OS were positive resection margin(HR=6.776,95%CI:3.988-11.479,P<0.001),N1 stage(HR=2.827,95%CI:1.243-6.429,P=0.013),tumor size>30 mm(HR=1.739,95%CI:1.101-2.745,P=0.018)and LVI positivity(HR=2.908,95%CI:1.712-4.938,P<0.001).LVI was associated with N1 stage and tumor size>30 mm.Multiple logistic regression analysis indicated that N1 stage(HR=3.312,95%CI:1.338-8.198,P=0.026)and tumor size>30 mm(HR=3.258,95%CI:1.288-8.236,P=0.013)were associated with LVI. CONCLUSION LVI is associated with N1 stage and tumor size>30mm and adversely influences DFS and OS in typeⅣHC patients. | Bei Li Xian-Ze Xiong Yong Zhou Si-Jia Wu Zhen You Jiong Lu Nan-Sheng Cheng | 2017 | World Journal of Gastroenterology2017，23，36： | 5 |
| 19 | Synthesis of a highly hydrophobic cyclic decapeptide by solid-phase synthesis of linear peptide and cyclization in solution显示文摘A general method was described to synthesize a highly hydrophobic cyclic peptide,cyclo[LWLWLWLWLQ]where underlines indicate D-configuration of the amino acid,by a two-step solid-phase/solution synthesis strategy.The linear decapeptide was assembled by standard Boc chemistry on solid-phase and subsequently cyclized in solution with high efficiency and reproducibility. In subsequent purification by semi-preparative HPLC,50%(v/v) DMF/H_2O was employed as the solvent to overcome the difficulty of solubilizat... | Chen, Jian Zhang, Bei Xie, Cao Lu, Yi Wu, Wei | 2010 | Chinese Chemical Letters2010，21，4： | 5 |
| 20 | 人乳头瘤病毒16/18分型在细胞学轻度异常的低度宫颈病变中的预测价值(英文)显示文摘目的:评估人乳头瘤病毒(HPV)16/18分型在细胞学正常或轻度异常的低度宫颈病变中的预测价值,为临床分流决策提供依据。创新点:目前对于细胞学正常或轻度异常的低度宫颈病变患者缺乏有效分流策略。本研究首次探索HPV16/18分型对这部分患者疾病转归的预测价值。方法:新招募细胞学正常或轻度异常的低度宫颈病变患者,以6个月为间隔随访2年,采用Cox回归模型对入组HPV16/18分型结果与疾病转归进行关联分析。结论:对于HPV16/18阳性,细胞学轻度异常,且30岁及以上的低度宫颈病变患者,可以考虑比保守随访更积极的诊疗方案。 | Jing YE Bei CHENG Yi-fan CHENG Ye-li YAO Xing XIE Wei-guo LU Xiao-dong CHENG | 2017 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2017，18，3： | 5 |
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