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| 1 | Effect of short-term high-dose atorvastatin on systemic inflammatory response and myocardial ischemic injury in patients with unstable angina pectoris undergoing percutaneous coronary intervention显示文摘 | Sun Fei Yin Zhao Shi Quanxing Zhao Bei Wang Shouli | 2014 | Chinese Medical Journal2014，，21： | 27 |
| 2 | Aortic Artery and Cardiac Valve Calcification are Associated with Mortality in Chinese Hemodialysis Patients: A 3.5 Years Follow-up显示文摘 | Xiao-Nong Chen Zi-Jin Chen Xiao-Bo Ma Bei Ding Hua-Wei Ling Zhong-Wei Shi Nan Chen | 2015 | Chinese Medical Journal2015，，20： | 20 |
| 3 | Successful endoscopic sclerotherapy for bleeding gastric varices with combined cyanoacrylate and aethoxysklerol显示文摘Two patients with liver cirrhosis and portal hyper-tension related to hepatitis infection were admitted to Shanghai Ruijin Hospital due to recurrent melena and hematemesis. Isolated gastric varices were observed in the gastric fundus during the retroflexion of gastroscope. We carried out endoscopic sclerotherapy successfully for bleeding gastric varices with combined cyanoacrylate and aethoxysklerol, which disappeared dramatically several months after two courses of sclerotherapy for each patient. No complication and clinical signs of gastrointestinal re-bleeding were observed during the 6-mo endoscopic follow-up. CT portal angiography (CTPA) has been widely used in the assessment of variceal treatment and improves the results of endoscopic injection therapy. | Bei Shi Wei Wu Hui Zhu Yun-Lin Wu | 2008 | World Journal of Gastroenterology2008，14，22： | 18 |
| 4 | Elevated nocturnal and morning blood pressure in patients with obstructive sleep apnea syndrome显示文摘 | HE Quan-ying FENG Jing ZHANG Xilong LIANG Zong-an HUANG Shao-guang KANG Jian WANG Guang-fa ZHANG Li-qiang MA Li-jun WANG Bei LIN Qi-chang ZHANG Jin-nong LIU Hui-guo LUO Yuan-ming LIU Jian-hong WANG Shi XIAO Gao-hui LU Gan ZHANG Jin FENG Xue-wei CHEN Bao-yuan | 2012 | Chinese Medical Journal2012，，10： | 15 |
| 5 | Respective and interactive effects of doubled CO2 and O3 concentration on membrane lipid peroxidation and antioxidative ability of soybean显示文摘Effects of doubled CO2 and O3 concentration on Soybean were studied in open-top chambers (OTC). Under doubled CO2 concentration, grain yield and biomass increased, the SOD activity, vitamin C (Vc) and carotenoid (Car) content also increased; Superoxide (O2-.) generating rate decreased, relative conductivity and malondialdehyde (MDA) content significantly declined.But under doubled O3 concentration, the SOD activity, Vc and Car contents declined, resulting in imbalance of activated-oxygen production, enhanced O2-. generating rate and accelerated process of lipid peroxidation and increase in MDA content and ion leakage of leaves. The final result was decreased grain yield and plant biomass. Interactive effects of doubled CO2 and O3 concentrations on soybean were mostly counteractive. However, the beneficial effects of concentration-doubled CO2 are more than compensate the negative effects imposed by doubled O3, and the latter in its turn partly counteracted the positive effects of the former. | ZHAO Tianhong, SHI Yi, HUANG Guohong, WANG Yan & SUN Bei Key Laboratory of Terrestrial Ecological Process, Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China Shenyang Agricultural University, Shenyang 110161, China | 2005 | Science China(Life Sciences)2005，48，z1： | 14 |
| 6 | CD59 Silencing via Retrovirus-Mediated RNA Interference Enhanced Complement-Mediated Cell Damage in Ovary Cancer显示文摘CD59,belonging to membrane complement regulatory proteins(mCRPs) ,inhibits the cytolytic activity of complement and is over-expressed in solid cancers,including ovary cancer. The aim of the present study was to construct recombinant retrovirus encoding shRNA targeted human CD59 and infect A2780 cells in order to investigate the relationship between decreased CD59 expression and tumorigenesis of ovary cancer. siCD59 and siCD59-C were successfully constructed and identified by PCR,restriction endonuclease analyses and DNA sequencing,respectively. The siCD59 was able to efficiently infect A2780 cells,which was confirmed by Western blotting. When incubated with fresh normal human serum(8%,v/v) for 1 h at 37°C,the cell viability was decreased and cell damage was increased in siCD59 infected A2780 cells compared to siCD59-C infected cells. This led to the activation of caspase-3. The apoptosis in siCD59 infected cells was shown with hypercondensed nuclei using Hoechst staining. Meanwhile,the weight of ovary tumor graft in nude mice was significantly decreased in siCD59 group compared to that of siCD59-C group. And the expression of CD59 protein in tumor tissue in siCD59 group was significantly decreased. These results suggested that CD59 silencing in ovary cancer cells via retrovirusmediated RNAi can enhance complement-mediated cell damage,inhibiting growth of ovary cancer. CD59 might be a potential target for gene therapy in ovary cancer. | Xuexiang Shi Bei Zhang Jinlin Zang Guoying Wang Meihua Gao | 2009 | Cellular & Molecular Immunology2009，6，1： | 12 |
| 7 | A Novel Phenylpropanoid-substituted Catechin Glycoside and a New Dihydrochalcone from Sarcandra glabra显示文摘A novel phenylpropanoid-substituted catechin glycoside glabraoside A 1 and a newdihydrochalcone 3′-(7″-allylphenyl)-2′,4′,4″-trihydroxy-6′-methoxydihydrochalcone 2 wereisolated from the herbs of Sarcandra glabra. Their structures were elucidated on the basis ofspectroscopic analyses and chiroptical methods. | Yuan LI Dong Ming ZHANG Shi Shah YU Jian Bei LI Yong Ming LUO | 2006 | Chinese Chemical Letters2006，17，2： | 11 |
| 8 | Relationship of daytime blood pressure and severity of obstructive sleep apnea among Chinese: a multi-center investigation in China显示文摘背景流行病的研究显示出在妨碍的睡觉呼吸暂停(OSA ) 和高血压之间的一个独立、明确的协会。这研究试图在中国的大陆在中国人口定义在白天血压和 OSA 的严厉之间的协会。二十大学医院睡觉在中国的大陆集中的方法被中国医药协会(CMA ) 邀请参予这流行病的研究和 2297 个连续病人(年老的 18-85 年;1981 男性和 316 女性) 为在 2004 年 1 月之间的 OSA 的评估参考了这二十个睡觉中心, 2006 年 4 月有希望地被注册。夜的 polysomnography 在每个病人被执行,并且疾病严厉基于呼吸暂停呼吸过慢过浅索引(AHI ) 被估计。这些病人是进四个组的 classfied:non-apneic 控制(控制, n=257 ) 与 AHI 5 事件 / 小时;温和睡觉呼吸暂停(温和, n=402 ) 与 AHI > 5 和 15 个事件 / 小时;中等睡觉呼吸暂停(中等, n=460 ) 与 AHI > 15 和 30 个事件 / 小时和严重睡觉呼吸暂停(严重, n=1178 ) 与 AHI > 30 个事件 / 小时。白天血压大小在为得到平均价值参考睡觉中心的日子在办公室里在上午 10 点在每个病人在标准化条件下面被执行。所有病人被请求两个都在 assessing.Results 的日子前停止与血压有关的药三天收缩血压和心脏舒张的血压珍视的白天是显著地与 AHI 有关断然(r = 0.201 和 0.276 分别地;两 P 价值 < 0.001 ) 并且到天底夜的氧浸透否定地(r=-0.215 和 -0.277, 分别地;两 Pvalues < 0.001 ) ,它是 OSA 严厉的参数。在二个特殊设计吝啬的阴谋,收缩的白天和心脏舒张的血压的工具与增加 AHI 逐渐地增加了。在 61-65 的 AHI 以外,这个增加的趋势到达了结果显示出的 plateau.Conclusions 那 OSA 严厉与白天血压被联系直到 61-65 的 AHI,为早 OSA 管理提供证据,特别在有伴随物高血压的 OSA 病人。 | HE Quan-ying FENG Jing ZHANG Xi-long LIANG Zong-an HUANG Shao-guang KANG Jian WANG Guang-fa ZHANG Li-qiang MA Li-jun, WANG Bei, LIN Qi-chang, ZHANG Jing-nong, LIU Hui-guo, LUO Yuan-ming,LIU Jian-hong, WANG Shi, XIAO Gao-hui, LU Gan, ZHANG Jin, FENG Xue-wei and CHEN Bao-yuan MA Li-jun WANG Bei LIN Qi-chang ZHANG Jing-nong LIU Hui-guo LUO Yuan-ming LIU Jian-hong WANG Shi XIAO Gao-hui LU Gan ZHANG Jin FENG Xue-wei CHEN Bao-yuan | 2010 | Chinese Medical Journal2010，，1： | 9 |
| 9 | Alpl prevents bone ageing sensitivity by specifically regulating senescence and differentiation in mesenchymal stem cells显示文摘Mutations in the liver/bone/kidney alkaline phosphatase(Alpl) gene cause hypophosphatasia(HPP) and early-onset bone dysplasia,suggesting that this gene is a key factor in human bone development. However, how and where Alpl acts in bone ageing is largely unknown. Here, we determined that ablation of Alpl induces prototypical premature bone ageing characteristics, including bone mass loss and marrow fat gain coupled with elevated expression of p16^(INK4A)(p16) and p53 due to senescence and impaired differentiation in mesenchymal stem cells(MSCs). Mechanistically, Alpl deficiency in MSCs enhances ATP release and reduces ATP hydrolysis. Then, the excessive extracellular ATP is, in turn, internalized by MSCs and causes an elevation in the intracellular ATP level, which consequently inactivates the AMPKα pathway and contributes to the cell fate switch of MSCs. Reactivating AMPKα by metformin treatment successfully prevents premature bone ageing in Alpl+/-mice by improving the function of endogenous MSCs.These results identify a previously unknown role of Alpl in the regulation of ATP-mediated AMPKα alterations that maintain MSC stemness and prevent bone ageing and show that metformin offers a potential therapeutic option. | Wenjia Liu Liqiang Zhang Kun Xuan Chenghu Hu Shiyu Liu Li Liao Bei Li Fang Jin Songtao Shi Yan Jin | 2018 | Bone Research2018，6，4： | 9 |
| 10 | An investigation of cellular distribution of manganese in hyperaccumlator plant Phytolacca acinosa Roxb. using SRXRF analysis显示文摘Phytolacca acinosa Roxb. (P. acinosa) is a recently discovered mangane se hyperaccumulator plant from southern China. It is a good candidate for phytor emediation of manganese(Mn) polluted soil for its high biomass and fast growth. Knowledge of the tissue localization and identification of heavy metals can prov ide essential information on metal toxicity and bioaccumulation mechanisms. Sync hrotron radiation X-ray fluorescence spectroscopy (SRXRF) microprobe was used in this study to investigate the cellular distributions of Mn and other elements i n root, stem, leaf, petiole and midrib of P. acinosa. The highest Mn content was found in the vascular tissues of root, stem, petiole and midrib. Cortex in root played a key role in Mn absorption and Mn was limited in the vascular bundle du ring the process of transportation in stem. Moreover, Mn content in leaf epiderm is was higher than that in mesophyll, which suggested that the sequestration of Mn in leaf epidermis might be one of the detoxification mechanisms of P. acinosa . The significance of other elemental (such as P, S, K, Ca, Fe, Zn and Cu) distr ibution patterns and the correlation with Mn were also discussed. | XU Xiang-hua SHI Ji-yan CHEN Ying-xu XUE Sheng-guo WU Bei HUANG Yu-ying | 2006 | Journal of Environmental Sciences2006，18，4： | 9 |
| 11 | Effects of nicorandil on myocardial infarct size in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention:study design and protocol for the randomized controlled trial显示文摘Previous studies have shown that nicorandil has a protective effect on cardiomyocytes.However,there is no study to investigate whether perioperative intravenous nicorandil can further reduce the myocardial infarct size in patients with ST-segment elevation myocardial infarction(STEMI)compared to the current standard of percutaneous coronary intervention(PCI)regimen.The CHANGE(China-Administration of Nicorandil Group)study is a multicenter,prospective,randomized,double-blind and parallel-controlled clinical study of STEMI patients undergoing primary PCI in China,aiming to evaluate the efficacy and safety of intravenous nicorandil in ameliorating the myocardial infarct size in STEMI patients undergoing primary PCI and provide evidence-based support for myocardial protection strategies of STEMI patients. | Xiao-Si JIANG Li-Chao TIAN Zi-Chao JIANG Yu-Ting ZOU Ping LI Xin-Chun YANG Xi SU Jin-Wen TIAN Bei SHI Zong-Zhuang LI Yong-Jun LI Ren-Qiang YANG Geng QIAN Yun-Dai CHEN | 2020 | Journal of Geriatric Cardiology2020，17，8： | 7 |
| 12 | Chevrier's Field Mouse(Apodemus chevrieri) and Père David's Vole(Eothenomys melanogaster) in China Carry Orthohepeviruses that form Two Putative Novel Genotypes Within the Species Orthohepevirus C显示文摘Hepatitis E virus(HEV)is the prototype of the family Hepeviridae and the causative agent of common acute viral hepatitis.Genetically diverse HEV-related viruses have been detected in a variety of mammals and some of them may have zoonotic potential.In this study,we tested 278 specimens collected from seven wild small mammal species in Yunnan province,China,for the presence and prevalence of orthohepevirus by broad-spectrum reverse transcription(RT)-PCR.HEV-related sequences were detected in two rodent species,including Chevrier’s field mouse(Apodemus chevrieri,family Muridae)and Père David’s vole(Eothenomys melanogaster,family Cricetidae),with the infection rates of 29.20%(59/202)and 7.27%(4/55),respectively.Further four representative full-length genomes were generated:two each from Chevrier’s field mouse(named Rd HEVAc14 and Rd HEVAc86)and Père David’s vole(Rd HEVEm40 and Rd HEVEm67).Phylogenetic analyses and pairwise distance comparisons of whole genome sequences and amino acid sequences of the gene coding regions showed that orthohepeviruses identified in Chinese Chevrier’s field mouse and Père David’s vole belonged to the species Orthohepevirus C but were highly divergent from the two assigned genotypes:HEV-C1 derived from rat and shrew,and HEV-C2 derived from ferret and possibly mink.Quantitative real-time RT-PCR demonstrated that these newly discovered orthohepeviruses had hepatic tropism.In summary,our work discovered two putative novel genotypes orthohepeviruses preliminarily named HEVC3 and HEV-C4 within the species Orthohepevirus C,which expands our understanding of orthohepevirus infection in the order Rodentia and gives new insights into the origin,evolution,and host range of orthohepevirus. | Bo Wang Wen Li Ji-Hua Zhou Bei Li Wei Zhang Wei-Hong Yang Hong Pan Li-Xia Wang Thomas Bock Zheng-Li Shi Yun-Zhi Zhang Xing-Lou Yang | 2018 | Virologica Sinica2018，33，1： | 6 |
| 13 | Targeting MAPK pathways by naringenin modulates microglia M1 / M2 polarization in lipopolysaccharide-stimulated cultures显示文摘OBJECTIVE Neuroinflammation is considered to be an important and inevitable pathological process associated with all types of damages to the central nervous system.The hallmark of neuroinflammation is the microglia activation.In response to different micro-environmental disturbances,microglia could polarize into either an M1 pro-inflammatory phenotype,exacerbating neurotoxicity,or an M2 anti-inflammatory phenotype,exerting neuroprotection.Therefore,shifting the polarization of microglia toward the M2 phenotype could possess a more viable strategy for the neuroinflammatory disorders treatment.Naringenin(NAR) is natural y a grapefruit flavonoid and possesses various kinds of pharmacological activities,such as anti-inflammatory and neuroprotective activities.In the present study,we aimed to investigate the potential effects of NAR on microglial M1/M2 polarization and further reveal the underlying mechanisms of actions.METHODS BV-2 cells were pretreated with NAR(100 μmol·L^(-1)) for 1 h and then incubated with LPS(1 mg·L^(-1)) for 24 h.The effects of NAR on LPS-induced microglia activation,microglial M1/M2 polarization and MAPK pathways were detected.In addition,BV-2 cells were incubated with or without anisomycin(ANI,a selective agonist of JNK) to evaluate the role of JNK on microglia activation and microglia M1/M2 polarization.RESULTS First,NAR inhibited LPS-induced microglial activation.Then,NAR shifted the M1 pro-inflammatory microglia phenotype to the M2 anti-inflammatory M2 microglia state as demonstrated by the decreased expression of M1 markers,ie,inducible tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β)and the elevated expression of M2 markers(ie,arginase 1,IL-4 and IL-10).In addition,the effects of NAR on microglial polarization was dependent on MAPK signaling,particularly JNK inactivation,as evidenced by the fact that the selective activator of JNK abolished NAR-promoted M2 polarization and further NAR-inhibited microglial activation.CONCLUSION NAR promotes microglia M1/M2 polarization,thus conferring anti-neuroinflammatory effects via the inhibition of MAPK signaling activation.These findings might provide new alternative avenues for neuroinflammation-related disorders treatment. | ZHANG Bei WEI Yi-zheng WANG Guo-qing LI Dai-di SHI Jing-shan ZHANG Feng | 2018 | 中国药理学与毒理学杂志2018，32，9： | 5 |
| 14 | Different cell death modes of pancreatic acinar cells on macrophage activation in rats显示文摘背景尖锐胰腺炎的致病复杂、大部分不清楚。这研究的目的是在胰腺的 acinar 房间,房间内容的版本和我们的实验包括了的 macrophagas.Methods 的煽动性的反应探索在房间死亡的模式之间的关系四个组:组织 A (控制组) ,组织 B (由 caerulein 的 AR42J 房间 overstimulated ) ,组织 C (与 lipopolysaccharide 和 caerulein 对待的 AR42J 房间) ,并且组织 D (与 octreotide 和 caerulein 对待的 AR42J 房间) 。Apoptosis 和 oncosis,和淀粉酶的版本并且喂奶从 AR42J 房间的脱氢酶(LDH ) 被检测。老鼠巨噬细胞被 AR42J 的文化媒介的 1 ml supematant cells.Finally 刺激, NF-B 激活和由巨噬细胞的 IL-1 分泌物是在当 apoptctic 房间减少了时,增加的组 C 的 detected.Results Oncotlc 房间(P < 0.05 ) ;在组 D 的房间有反的反应。淀粉酶和 LDH 的版本随着 oncosis 的出现直接变化了。抄写因素 NF-B 被激活, TNF-1 和 IL-1 的分泌物比在组 B 在组 C 是显著地更高的(P < 0.05 ) ;在组 D,这些行动比在组 B 显著地低(P < 0.05 ) 。这个趋势与在淀粉酶的变化一致,在那里的 LDH production.Conclusion 是在胰腺的 acinar 房间死亡,房间内容的版本和巨噬细胞的煽动性的反应的模式之间的一种靠近的关系。 | LIANG Tao LIU Tie-fu XUE Dong-bo SUN Bei SHI Li-jun | 2008 | Chinese Medical Journal2008，，19： | 5 |
| 15 | Mapping theme trends and knowledge structures for human neural stem cells:a quantitative and co-word biclustering analysis for the 2013-2018 period显示文摘Neural stem cells,which are capable of multi-potential differentiation and self-renewal,have recently been shown to have clinical potential for repairing central nervous system tissue damage.However,the theme trends and knowledge structures for human neural stem cells have not yet been studied bibliometrically.In this study,we retrieved 2742 articles from the PubMed database from 2013 to 2018 using 'Neural Stem Cells' as the retrieval word.Co-word analysis was conducted to statistically quantify the characteristics and popular themes of human neural stem cell-related studies.Bibliographic data matrices were generated with the Bibliographic Item Co-Occurrence Matrix Builder.We identified 78 high-frequency Medical Subject Heading(MeSH)terms.A visual matrix was built with the repeated bisection method in gCLUTO software.A social network analysis network was generated with Ucinet 6.0 software and GraphPad Prism 5 software.The analyses demonstrated that in the 6-year period,hot topics were clustered into five categories.As suggested by the constructed strategic diagram,studies related to cytology and physiology were well-developed,whereas those related to neural stem cell applications,tissue engineering,metabolism and cell signaling,and neural stem cell pathology and virology remained immature.Neural stem cell therapy for stroke and Parkinson’s disease,the genetics of microRNAs and brain neoplasms,as well as neuroprotective agents,Zika virus,Notch receptor,neural crest and embryonic stem cells were identified as emerging hot spots.These undeveloped themes and popular topics are potential points of focus for new studies on human neural stem cells. | Wen-Juan Wei Bei Shi Xin Guan Jing-Yun Ma Ya-Chen Wang Jing Liu | 2019 | Neural Regeneration Research2019，14，10： | 5 |
| 16 | Comparison study of slag corrosion resistance of MgO–MgAl_(2)O_(4),MgO–CaO and MgO–C refractories under electromagnetic field显示文摘To illuminate the corrosion behavior of MgO-based refractories under electromagnetic field(EMF),herein,the slag corrosion and penetration resistance of MgO–MgAl_(2)O_(4),MgO–CaO,and MgO–C refractories were investigated using the rotary immersion slag resistance test at 1873 K for 1 h.The results showed that the order of the good slag resistance of as-tested refractories was MgO–C>MgO–CaO>MgO–MgAl_(2)O_(4).The EMF accelerated the corrosion and penetration of slag to the refractories,which caused the molten slag to be easier into the refractories by natural convection and Marangoni effect.In addition,the MgO–C refractories did not show an overwhelming advantage in slag resistance because EMF impeded the formation of the dense protection layer.Consequently,in view of the present results,the MgO–C refractories are still the most promising slag line material for refining furnace among MgO–MgAl_(2)O_(4),MgO–CaO,and MgO–C refractories. | Xin‑ming Ren Bei‑yue Ma Shi‑ming Li Hong‑xia Li Guo‑qi Liu Wen‑gang Yang Fan Qian Shi‑xian Zhao Jing‑kun Yu | 2021 | Journal of Iron and Steel Research(International)2021，28，1： | 4 |
| 17 | Ionomycin ameliorates hypophosphatasia via rescuing alkaline phosphatase deficiency-mediated L-type Ca^(2+) channel internalization in mesenchymal stem cells显示文摘The loss-of-function mutations in the ALPL result in hypophosphatasia(HPP), an inborn metabolic disorder that causes skeletal mineralization defects. In adults, the main clinical features are early loss of primary or secondary teeth, osteoporosis, bone pain,chondrocalcinosis, and fractures. However, guidelines for the treatment of adults with HPP are not available. Here, we show that ALPL deficiency caused a reduction in intracellular Ca2+ influx, resulting in an osteoporotic phenotype due to downregulated osteogenic differentiation and upregulated adipogenic differentiation in both human and mouse bone marrow mesenchymal stem cells(BMSCs). Increasing the intracellular level of calcium in BMSCs by ionomycin treatment rescued the osteoporotic phenotype in alpl+/- mice and BMSC-specific(Prrx1-alpl-/-) conditional alpl knockout mice. Mechanistically, ALPL was found to be required for the maintenance of intracellular Ca2+ influx, which it achieves by regulating L-type Ca2+ channel trafficking via binding to the α2δsubunits to regulate the internalization of the L-type Ca2+ channel. Decreased Ca2+ flux inactivates the Akt/GSK3β/β-catenin signaling pathway, which regulates lineage differentiation of BMSCs. This study identifies a previously unknown role of the ectoenzyme ALPL in the maintenance of calcium channel trafficking to regulate stem cell lineage differentiation and bone homeostasis. Accelerating Ca2+ flux through L-type Ca2+ channels by ionomycin treatment may be a promising therapeutic approach for adult patients with HPP. | Bei Li Xiaoning He Zhiwei Dong Kun Xuan Wei Sun Li Gao Shiyu Liu Wenjia Liu Chenghu Hu Yimin Zhao Songtao Shi Yan Jin | 2020 | Bone Research2020，8，2： | 4 |
| 18 | Coexistence of multiple coronaviruses in several bat colonies in an abandoned mineshaft显示文摘Since the 2002–2003 severe acute respiratory syndrome(SARS) outbreak prompted a search for the natural reservoir of the SARS coronavirus, numerous alpha- and betacoronaviruses have been discovered in bats around the world. Bats are likely the natural reservoir of alpha- and betacoronaviruses, and due to the rich diversity and global distribution of bats, the number of bat coronaviruses will likely increase. We conducted a surveillance of coronaviruses in bats in an abandoned mineshaft in Mojiang County, Yunnan Province, China, from 2012–2013. Six bat species were frequently detected in the cave: Rhinolophus sinicus, Rhinolophus affinis, Hipposideros pomona, Miniopterus schreibersii, Miniopterus fuliginosus, and Miniopterus fuscus. By sequencing PCR products of the coronavirus RNA-dependent RNA polymerase gene(Rd Rp), we found a high frequency of infection by a diverse group of coronaviruses in different bat species in the mineshaft. Sequenced partial Rd Rp fragments had 80%–99% nucleic acid sequence identity with well-characterized Alphacoronavirus species, including Bt CoV HKU2, Bt CoV HKU8, and Bt CoV1,and unassigned species Bt CoV HKU7 and Bt CoV HKU10. Additionally, the surveillance identified two unclassified betacoronaviruses, one new strain of SARS-like coronavirus, and one potentially new betacoronavirus species. Furthermore, coronavirus co-infection was detected in all six bat species, a phenomenon that fosters recombination and promotes the emergence of novel virus strains. Our findings highlight the importance of bats as natural reservoirs of coronaviruses and the potentially zoonotic source of viral pathogens. | Xing-Yi Ge Ning Wang Wei Zhang Ben Hu Bei Li Yun-Zhi Zhang Ji-Hua Zhou Chu-Ming Luo Xing-Lou Yang Li-Jun Wu Bo Wang Yun Zhang Zong-Xiao Li Zheng-Li Shi | 2016 | Virologica Sinica2016，31，1： | 4 |
| 19 | The cross-correlation of signals and spatial impression in surround sound reproduction显示文摘恰好,在喂信号和由左被创造的听觉的空间印象(ASI ) 的跨关联的系数之间的关系离开了在 5.1 隧道包围并且恰好包围扬声器包围健全系统被 psychoacoustic 实验调查。结果为由左右或左右的前面复制显示出那包围扬声器对,听觉的来源宽度(ASW ) 能被控制喂信号到某程度的 crosscorrelation 系数拓宽。在 ASW 和跨关联的系数之间的量的关系频率依赖者。为由一双侧面的扬声器复制,然而, ASW 不能被控制喂信号的跨关联的系数改变。为由前面复制并且仅仅用中央频率同时并且为粉红色的噪音和八音度噪音包围扬声器对 1kHz,听众包封(LEV ) 的一种强壮的感觉能被控制适当地喂信号的 crosscorrelation 系数获得。为有在 2 kHz 和 4 kHz 的中央频率的八音度乐队噪音,然而, LEV 不能被控制喂信号的 crosscorrelation 系数获得。在之间没有唯一的关系的进一步理论的计算和大小表演内部听觉跨关联(IACC ) 并且在 5.1 条隧道的 ASW 包围健全复制,它可能由于 IACC 的算法计算。进一步试验性的确认被需要为评估 ASI 调查 IACC 的适用性。现在的结果将对有用实际包围记录的健全编程和评估。 | SHI Bei XIE Bosun | 2010 | Chinese Journal of Acoustics2010，29，3： | 4 |
| 20 | Detection and characterization of three zoonotic viruses in wild rodents and shrews from Shenzhen city,China显示文摘Diverse species of rodents and shrews, which are abundant worldwide, harbor a variety of viruses;some of these are closely related to human viruses and possess zoonotic potential. Previously studies have demonstrated that the mammarenavirus and hantavirus carried by rodents or shrews could cause diseases in human population. To determine the distribution of zoonotic viruses in Shenzhen city, the major city in southern China with a high population density, we analyzed 225 rodents(Rattus norvegicus and Rattus flavipectus) and 196 shrews(Suncus murinus) from urban and rural districts for the presence of mammarenavirus, hantavirus, and hepatitis E virus(HEV) by RT-PCR targeting the conserved regions. The infection rates for mammarenavirus, hantaviruses,and HEV in rodents and shrews were 3.56%, 6.89%, and 1.66%, respectively. Partial genome fragment analysis indicated that mammarenavirus and hantavirus strains had more than 90% and 99% nucleic acid identity with Cardamones virus and Seoul virus, respectively, which cause diseases in humans. Although the present HEV strains identified are typically found worldwide,phylogenetic analysis demonstrated a divergence of 16%. To our knowledge, the present work is the first report of the prevalence of mammarenavirus, hantaviruses, and rat HEV strains in rodents and shrews from Shenzhen city, China. Our findings highlight the zoonotic potential of rodent-and shrew-borne mammarenavirus and hantavirus, and the biodiversity of rat HEV isolates in Shenzhen city. The present work suggests that utilization of good hygiene habits is important to minimize the risk of zoonosis. | Bo Wang Chun-Lin Cai Bei Li Wei Zhang Yan Zhu Wei-Hong Chen Fei Zhuo Zheng-Li Shi Xing-Lou Yang | 2017 | Virologica Sinica2017，32，4： | 4 |
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