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| 1 | Identifying therapeutic targets in gastric cancer: the current status and future direction显示文摘胃的癌症是世界范围的癌症相关的死亡的第三个领先的原因。我们胃的癌症生物学的基本理解落伍于许多另外的癌症类型的。为胃的癌症的当前的标准治疗选择没变化最后 20 年了。因此,有迫切需要建立新奇策略治疗这致命的癌症。有在电流型逻辑和胃肠的 stromal 肿瘤的 Gleevec 的成功的临床的试用为癌症的指向的治疗建立了一个例子。在这评论,我们将在分类总结主要进步,胃的癌症的治疗学的选择。我们将也在胃的癌症为药电阻讨论分子的机制。另外,我们将试图在胃的癌症生物学和药目标建议潜在的未来方向。 | Beiqin Yu Jingwu Xie | 2016 | Acta Biochimica et Biophysica Sinica2016，48，1： | 11 |
| 2 | The role of GLI2-ABCG2 signaling axis for 5Fu resistance in gastric cancer显示文摘Gastric cancer is a leading cause of cancer-related mortality worldwide, and options to treat gastric cancer are limited. Fluorouracil(5Fu)-based chemotherapy is frequently used as a neoadjuvant or an adjuvant agent for gastric cancer therapy. Most patients with advanced gastric cancer eventually succumb to the disease despite the fact that some patients respond initially to chemotherapy. Thus, identifying molecular mechanisms responsible for chemotherapy resistance will help design novel strategies to treat gastric cancer. In this study, we discovered that residual cancer cells following 5Fu treatment have elevated expression of hedgehog(Hg) target genes GLI1 and GLI2, suggestive of Hh signaling activation. Hh signaling, a pathway essential for embryonic development, is an important regulator for putative cancer stem cells/residual cancer cells. We found that high GLI1/GLI2 expression is associated with some features of putative cancer stem cells, such as increased side population. We demonstrated that GLI2 knockdown sensitized gastric cancer cells to 5Fu treatment, decreased ABCG2 expression, and reduced side population. Elevated GLI2 expression is also associated with an increase in tumor sphere size, another marker for putative cancer stem cells. We believe that GLI2 regulates putative cancer stem cells through direct regulation of ABCG2. ABCG2 can rescue the GL12 shRNA effects in 5Fu response, tumor sphere formation and side population changes, suggesting that ABCG2 is an important mediator for GLI2-associated 5Fu resistance. The relevance of our studies to gastric cancer patient care is reflected by our discovery that high GLI1/GLI2/ABCG2 expression is associated with a high incidence of cancer relapse in two cohorts of gastric cancer patients who underwent chemotherapy(containing 5Fu). Taken together,we have identified a molecular mechanism by which gastric cancer cells gain 5Fu resistance. | Beiqin Yu Dongsheng Gu Xiaoli Zhang Bingya Liu Jingwu Xie | 2017 | Journal of Genetics and Genomics2017，44，8： | 9 |
| 3 | Down-regulated miR-625 suppresses invasion and metastasis of gastric cancer by targeting ILK显示文摘 | Ming Wang Chenglong Li Hui Nie Xin Lv Ying Qu Beiqin Yu Liping Su Jianfang Li Xuehua Chen Jingfang Ju Yingyan Yu Min Yan Qinlong Gu Zhenggang Zhu Bingya Liu | 2012 | FEBS Letters2012，，16： | 1 |
| 4 | Hepatocyte growth factor activates tumor stromal fibroblasts to promote tumorigenesis in gastric cancer显示文摘 | Xiongyan Wu Xuehua Chen Quan Zhou Pu Li Beiqin Yu Jianfang Li Ying Qu Jun Yan Yingyan Yu Min Yan Zhenggang Zhu Bingya Liu Liping Su | 2013 | Cancer Letters2013，，1： | 1 |
| 5 | miR-126 functions as a tumour suppressor in human gastric cancer显示文摘 | Runhua Feng Xuehua Chen Yingyan Yu Liping Su Beiqin Yu Jianfang Li Qu Cai Min Yan Bingya Liu Zhenggang Zhu | 2010 | Cancer Letters2010，，1： | 1 |
| 6 | miR-126 functions as a tumour suppressor in human gastric cancer显示文摘 | Runhua Feng Xuehua Chen Yingyan Yu Liping Su Beiqin Yu Jianfang Li Qu Cai Min Yan Bingya Liu Zhenggang Zhu | 2010 | Cancer Letters2010，，1： | 1 |
| 7 | Down-regulated miR-625 suppresses invasion and metastasis of gastric cancer by targeting ILK显示文摘 | Ming Wang Chenglong Li Hui Nie Xin Lv Ying Qu Beiqin Yu Liping Su Jianfang Li Xuehua Chen Jingfang Ju Yingyan Yu Min Yan Qinlong Gu Zhenggang Zhu Bingya Liu | 2012 | FEBS Letters2012，，16： | 1 |
| 8 | MiR-199a-3p promotes gastric cancer progression by targeting ZHX1显示文摘 | Zhenqiang Wang Xingjie Ma Qiang Cai Xinjing Wang Beiqin Yu Qu Cai Bingya liu Zhenggang Zhu Chen Li | 2014 | FEBS Letters2014，，： | 1 |
| 9 | Hypermethylated DNA as potential biomarkers for gastric cancer diagnosis显示文摘 | Yanan Zheng Lu Chen Jianfang Li Beiqin Yu Liping Su Xuehua Chen Yingyan Yu Min Yan Bingya Liu Zhenggang Zhu | 2011 | Clinical Biochemistry2011，，17： | 1 |
| 10 | Regulation of pancreatic cancer metastasis through the Gli2-YAP1 axis via regulation of anoikis显示文摘Pancreatic cancer,mostly pancreatic ductal adenocarcinoma(PDAC),is often metastatic upon the initial diagnosis,and has a high mortality rate.However,the primary and the matched metastatic cancers often share the same driver gene mutations.1,2 Gene expression comparison between primary and metastatic PDAC tissues revealed high expression of Gli2 and YAP1 in the metastatic PDAC.Gli2 is an important player in non-canonical hedgehog signaling,and YAP1 is an essential cell polarity gene.In this study,we investigated the effects of Gli2 and YAP1 on pancreatic cancer cell function in 3D culture and in mouse models.We further determined the relationship between Gli2 and YAP1.These studies further our understanding of pancreatic cancer metastasis. | Beiqin Yu Dongsheng Gu Xiaoli Zhang Bingya Liu Jingwu Xie | 2022 | Genes & Diseases2022，9，6： | 0 |
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