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| 1 | New genes emerging for colorectal cancer predisposition显示文摘Colorectal cancer(CRC)is one of the most frequent neoplasms and an important cause of mortality in the developed world.This cancer is caused by both genetic and environmental factors although 35%of the variation in CRC susceptibility involves inherited genetic differences.Mendelian syndromes account for about5%of the total burden of CRC,with Lynch syndrome and familial adenomatous polyposis the most common forms.Excluding hereditary forms,there is an important fraction of CRC cases that present familial aggregation for the disease with an unknown germline genetic cause.CRC can be also considered as a complex disease taking into account the common diseasecommom variant hypothesis with a polygenic model of inheritance where the genetic components of common complex diseases correspond mostly to variants of low/moderate effect.So far,30 common,low-penetrance susceptibility variants have been identified for CRC.Recently,new sequencing technologies including exomeand whole-genome sequencing have permitted to add a new approach to facilitate the identification of new genes responsible for human disease predisposition.By using whole-genome sequencing,germline mutations in the POLE and POLD1 genes have been found to be responsible for a new form of CRC genetic predisposition called polymerase proofreading-associated polyposis. | Clara Esteban-Jurado Pilar Garre Maria Vila Juan José Lozano Anna Pristoupilova Sergi Beltrán Anna Abulí Jenifer Muoz Francesc Balaguer Teresa Ocaa Antoni Castells Josep M Piqué Angel Carracedo Clara Ruiz-Ponte Xavier Bessa Montserrat Andreu Luis Bujanda Trinidad Caldés Sergi Castellví-Bel | 2014 | World Journal of Gastroenterology2014，20，8： | 3 |
| 2 | Review on thermal energy storage with phase change: materials, heat transfer analysis and applications显示文摘 | Belén Zalba José M a Mar??n Luisa F. Cabeza Harald Mehling | 2002 | Applied Thermal Engineering2002，，3： | 3 |
| 3 | Emergence of novel strains of avian infectious bronchitis virus in Sweden显示文摘 | Shahid Hussain Abro Lena H.M. Renstr?m Karin Ullman Mats Isaksson Siamak Zohari Désirée S. Jansson Sándor Belák Claudia Baule | 2011 | Veterinary Microbiology (-)2011，，2： | 2 |
| 4 | Risk factors for antenatal depression: A review显示文摘Depression is the most prevalent mental disorder in pregnancy, and yet it is lessstudied than postpartum depression despite the consequences it may have onboth the pregnant woman and her offspring. Therefore, it would be important toknow which risk factors may favour the appearance of antenatal depression inorder to carry out appropriate prevention interventions. The aim of the presentreview was to identify the main risk factors of antenatal depression. We searchedin databases PubMed and PsycINFO for articles published about the factorsassociated with antenatal depression from January 2010 through December 2020.The literature review identified three main groups of antenatal depression riskfactors: sociodemographic, obstetric, and psychological. First, among thesociodemographic variables, the low level of studies and the economic incomeclearly stood out from the rest. Then, not having planned the pregnancy was themain obstetric variable, and finally, the main psychological risk factors werehaving a history of psychological disorders and/or depression as well aspresenting anxiety, stress, and/or low social support during pregnancy. Thisreview shows that the antenatal depression is affected by multiple factors. Mostcan be identified at the beginning of the pregnancy, and some are risk factorspotentially modifiable through appropriate interventions, such as psychologicalfactors. For this reason, it is important to carry out a good screening for depressionduring pregnancy and consequently, be able to prevent its appearance ortreat it if necessary. | M Carmen Míguez M Belén Vázquez | 2021 | World Journal of Psychiatry2021，11，7： | 2 |
| 5 | Involvement of serum retinoids and Leiden mutation in patients with esophageal, gastric, liver, pancreatic, and colorectal cancers in Hungary显示文摘AIM: To analyze the serum levels of retinoids and Leiden mutation in patients with esophageal, gastric, liver,pancreatic, and colorectal cancers.METHODS: The changes in serum levels of retinoids (vitamin A, α- and β-carotene, α- and β-cryptoxanthin,zeaxanthin, lutein) and Leiden mutation were measured by high liquid performance chromatography (HPLC)and polymerase chain reaction (PCR) in 107 patients (70 males/37 females) with esophageal (0/8), gastric (16/5), liver (8/7), pancreatic (6/4), and colorectal (30/21including 9 patients suffering from in situ colon cancer)cancer. Fifty-seven healthy subjects (in matched groups)for controls of serum retinoids and 600 healthy blood donors for Leiden mutation were used.RESULTS: The serum levels of vitamin A and zeaxanthin were decreased significantly in all groups of patients with gastrointestinal (GI) tumors except for vitamin A in patients with pancreatic cancer. No changes were obtained in the serum levels of α- and β-carotene,α- and β-cryptoxanthin, zeaxanthin, lutein in patients with GI cancer. The prevalence of Leiden mutation significantly increased in all groups of patients with GI cancer.CONCLUSION: Retinoids (as environmental factors)are decreased significantly with increased prevalence of Leiden mutation (as a genetic factor) in patients before the clinical manifestation of histologically different (planocellular and hepatocellular carcinoma, and adenocarcinoma) GI cancer. | Gyula Mózsik Gy(o|¨)rgy Rumi András D(o|¨)m(o|¨)t(o|¨)r Mária Figler Beáta Gasztonyi El(?)d Papp Alajos Pár Gabriella Pár József Belágyi Zoltán Matus Béla Melegh | 2005 | World Journal of Gastroenterology2005，11，48： | 2 |
| 6 | The effect of phototherapy on renal blood flow velocity in preterm infants显示文摘 | Benders M Van Bel F Van de Bor M | 1998 | Biol Neonate1998，73，4： | 1 |
| 7 | A Set of methods in transportation network synthesis and analysis 显示文摘 | DUBOIS D BEL G LIBRE M | 1979 | Journal of Operational Research Society1979，30，9： | 1 |
| 8 | Outcome de-terminants of pterional surgery for tuberculum sellaemeningiomas显示文摘 | Pamir MN Ozduman K Bel irgen M et a1 | 2005 | Acta Neurochir(Wien)2005，147，： | 1 |
| 9 | Highresolution distributed temperature sensing with the multiphoto-timing technique 显示文摘 | H o bel M Richa J Wtithrich M | 1995 | Applied Optics1995，34，16： | 1 |
| 10 | Changes in cerebral hemodynamics and oxygenation in the first 24 hours after birth asphyxia显示文摘 | Val Bel F Dorrepal CA Benders M J | 1993 | Pediatrics1993，92，3： | 1 |
| 11 | Detection of a novel porcine boca-like virus in the background of porcine circovirus type 2 induced postweaning multisystemic wasting syndrome显示文摘 | Anne-Lie Blomstr?m Sandor Belák Caroline Fossum John McKillen Gordon Allan Per Wallgren Mikael Berg | 2009 | Virus Research2009，，1： | 1 |
| 12 | Micro-computed tomography study of the abnormal osseous extensions of sella turcica显示文摘 | Skrzat J Kozerska M Wróbel A | 2014 | Folia Morphol2014，73，1： | 1 |
| 13 | The contribution of the mitochondrial COI/tRNA(Ser(UCN))gene mutations to non-syndromic and aminoglycoside-induced hearing loss in Polish patients显示文摘 | RYDZANICZ M CYWIN′SKA K WRBEL M | 2011 | Mol Genet Metab2011，104，： | 1 |
| 14 | PML induces a novel caspase-indepen-dent death process显示文摘 | Quignon F De Bels F Koken M | 1998 | Nat Genet1998，20，3： | 1 |
| 15 | Arget margins for random geometrical treatment uncertainties in conformal radiotherapy 显示文摘 | Bel A van Herk M Lebesque JV | 1996 | Med Phys1996，56，9： | 1 |
| 16 | N-terminal probrain natriuretic peptide(NT-proBNP)in the emergency diagnosis and in hospital monitoring of patients with dyspnoea and ventricular dysfunction显示文摘 | Bayés-Genis A Santaló-Bel M Zapico-Mu(n)iz E | | 0，，03： | 1 |
| 17 | A set of methods in transportation network synthesis and analysis 显示文摘 | DUBOIS D BEL G LLIBRE M | 1979 | Journal of the Operational Research Society1979，30，9： | 1 |
| 18 | Noise Performance of Chaotic Communication Systems显示文摘 | Bel A Schwarz W Gotz M | 2000 | IEEE Trans on Circuits and systems2000，47，12： | 1 |
| 19 | Transcatheter aortic valve implantation in very elderly patients: immediate results and medium term follow-up显示文摘ObjectiveTo 评估立即的 transcatheter 在有严重、征兆的大动脉的狭窄的很老的病人的大动脉的阀门培植(TAVI ) 结果和中期的后续(作为).MethodsThis multicenter,观察、未来的学习在三所医院里被执行。我们包括了连续很老(>85 年) 病人与作为严重由 TAVI 对待。主要端点是在包括的二 years.ResultsThe 研究从任何原因评估死亡率有一个平均数的 160 个连续病人 87 ± 变老;2.1 年(从 85 ~ 94 年的范围) 和 18.8%± 的吝啬的逻辑 EuroSCORE;11.2% 与 57 (35.6%) 病人得分 ≥20% 。程序的成功率是 97.5% ,与 25 (15.6%) 与主要流血经历尖锐复杂并发症的病人(最经常) 。全球死亡率在住院期间是 8.8%(n = 14 ) 并且 30 天的死亡率是 10%(n = 16 ) 。中部在时期上面列在后面是 252.24 ±232.17 天。在后续时期期间, 28 (17.5%) 病人们死了(他们中的 17 个由于心脏的原因) 。估计的二年全面、心脏的幸存率使用 Kaplan-Meier 方法分别地是 71% 和 86.4% 。比例的危险回归给看了的考克斯可变 EuroSCORE ≥20 是与全面 mortality.ConclusionsTAVI 联系的唯一的变量在很老的病人的一张选择人口安全、有效。我们的调查结果支持在病人的这个复杂的组的这个新过程的采纳。 | Isaac Pascual Antonio J Mu oz-García Diego López-Otero Pablo Avanzas Manuel F Jimenez-Navarro Belén Cid-Alvarez Raquel del Valle Juan H Alonso-Briales Raimundo Ocaranza-Sanchez José M Hemández Ramiro Trillo-Nouche César Morís | 2015 | Journal of Geriatric Cardiology2015，12，4： | 1 |
| 20 | Detection of a novel porcine boca-like virus in the background of porcine circovirus type 2 induced postweaning multisystemic wasting syndrome显示文摘 | Blomstr(o)m A L Belák S Fossum C | 2009 | Virus Res2009，146，12： | 1 |
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