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| 1 | 多药耐药鲍氏不动杆菌耐药性与转座子及插入序列遗传标记研究显示文摘目的探讨多耐药鲍氏不动杆菌耐药性与转座子、插入序列等遗传原件之间的关系。方法 K-B法进行药物敏感试验,PCR进行转座子、插入序列遗传标记检测,并测序。结果临床分离的鲍氏不动杆菌对12种常见抗菌药物耐药率分别为头孢噻肟78.9%、头孢他啶63.1%、头孢吡肟78.9%、头孢西丁100.0%、亚胺培南73.7%、美罗培南73.7%、氨苄西林/舒巴坦78.9%、阿莫西林/克拉维酸78.9%、阿米卡星52.6%、庆大霉素57.8%、环丙沙星78.9%、四环素78.9%;转座子tnp513和插入序列遗传标记ISaba1、IS26检出率分别为47.4%、78.9%、47.4%。结论多药耐药鲍氏不动杆菌的耐药性与转座子和插入序列遗传标记有一定的关系。 | 苏兆亮 糜祖煌 孙光明 陈建国 郑东 刘嫣方 Sandoghchian Siamak 许化溪 | 2010 | 中华医院感染学杂志2010，20，20： | 113 |
| 2 | 多药耐药肺炎克雷伯菌β-内酰胺酶基因及膜孔蛋白基因研究显示文摘目的探讨多耐药肺炎克雷伯菌(MDR-KPN)β-内酰胺酶基因存在状况及其膜孔蛋白编码基因ompK36在其耐药中的作用。方法应用PCR检测20种β-内酰胺酶基因及膜孔蛋白编码基因ompK36,并用MEGA4.1对ompK36进行分子进化分析。结果 15株MDR-KPN共检出TEM、SHV、CTX-M-1群、LAP、KPC、DHA等6种β-内酰胺酶基因,阳性率分别为66.7%、60.0%、6.7%、13.3%、13.3%、20.0%;而膜孔蛋白编码基因ompK36均检测到,经测序比对均存在突变。结论 15株MDR-KPN耐β-内酰胺类药物至少与产β-内酰胺酶和同时伴有膜孔蛋白ompK36突变相关。 | 苏兆亮 糜祖煌 孙光明 陈建国 郑东 刘嫣方 Sandoghchian Siamak 许化溪 | 2010 | 中华医院感染学杂志2010，20，22： | 33 |
| 3 | Interleukin-33 drives hepatic fibrosis through activation of hepatic stellate cells显示文摘Liver fibrosis is a consequence of chronic liver disease,causing morbidity and mortality.Interleukin-33(IL-33)is a critical mediator of inflammation,which may be involved in the development of liver fibrosis.Here,we investigated the role of IL-33 in human patients and experimental bile-duct ligation(BDL)-induced fibrosis in mice.We report increased hepatic IL-33 expression in the murine BDL model of fibrosis and in surgical samples obtained from patients with liver fibrosis.Liver injury,inflammatory cell infiltration and fibrosis were reduced in the absence of the IL-33/ST2 receptor,and the activation of hepatic stellate cells(HSCs)was decreased in ST2-deficient mice.Recombinant IL-33 activated HSCs isolated from C57BL/6 mice,leading to the expression of IL-6,TGF-β,α-SMA and collagen,which was abrogated in the absence of ST2 or by pharmacological inhibition of MAPK signaling.Finally,administration of recombinant IL-33 significantly increased hepatic inflammation in sham-operated BL6 mice but did not enhance BDL-induced hepatic inflammation and fibrosis.In conclusion,BDL-induced liver inflammation and fibrosis are dependent on ST2 signaling in HSCs,and therefore,the IL-33/ST2 pathway may be a potential therapeutic target in human patients with chronic hepatitis and liver fibrosis. | Zhongming Tan Qianghui Liu Runqiu Jiang Long Lv Siamak S Shoto Isabelle Maillet Valerie Quesniaux Junwei Tang Wenjie Zhang Beicheng Sun Bernhard Ryffel | 2018 | Cellular & Molecular Immunology2018，15，4： | 24 |
| 4 | Banana Fusarium Wilt(Fusarium oxysporum f. sp. cubense)Control and Resistance, in the Context of Developing Wilt-resistant Bananas Within Sustainable Production Systems显示文摘Banana(Musa spp.) is seriously threatened by the soil-borne fungus Fusarium oxysporum f. sp. cubense(Foc), also known as Panama disease.Attempts to control Fusarium wilt with fungicides damage soil health and have limited efficiency due to pathogenic variability. Elucidating the mechanism of infection and molecular basis of host defense through banana genome sequencing, genome editing and proteomic profile analysis will help formulate strategies to develop resistant cultivars. This will include research to better understand the functions of Fusarium wilt-resistance proteins. Transgenic approaches and protoplast fusion could be employed as tools for transferring resistance genes from wild relatives to commercial banana varieties, and may serve as a new strategy in solving the problems faced by banana breeding programmes.Evaluation of banana germplasm for resistance to Fusarium wilt using in vitro mutation and selection, along with somaclonal variation and somatic hybridization, could improve banana breeding efficiency for resistance against Foc. Plant hormones could also play an important role in regulating plant growth and defense by mediating developmental processes and signaling networks involved in banana responses to Foc. A complementary approach for managing Fusarium wilt, such as exclusion, surveillance and biological control as important components of integrated disease management programs must be considered to prevent and contain contagion. This includes studies on banana plant-microbe interactions, embracing both plant growth promoting rhizobacteria(PGPR) to induce Foc resistance, and exploring Foc-derived elicitors for inducing defense-related enzymes in bananas. The role of Silicon and crop and livestock integration must also be included in the Fusarium control toolbox. The current review also gathers knowledge of the biotechnological approaches along with biological control of Fusarium wilt of banana that will provide researchers insights and criteria to develop future studies. | SIAMAK Shirani Bidabadi ZHENG Sijun | 2018 | Horticultural Plant Journal2018，4，5： | 16 |
| 5 | Effect of Silicon on Growth and Development of Strawberry under Water Deficit Conditions显示文摘Water stress is a major factor that limits agricultural crop production. Silicon(Si) is generally considered as a beneficial element for the growth of higher plants, especially for those grown under stressful environment. This study was conducted to examine the effects of Si on growth and development of strawberry(Fragaria × ananassa ‘Camarosa') under water stress conditions. A factorial experiment, in a completely randomized design, was used to investigate the effects of three irrigation levels and four Si treatments consisting of 0, 5, 10, and 15 mmol·L^(-1) potassium silicate(K_2 SiO_3). The results showed that an increase in the levels of water stress caused a decrease in most of the quantitative characteristics such as specific leaf area, chlorophyll fluorescence, net photosynthesis rate, and stomata conductance; addition of Si significantly increased most of the mentioned factors; water stress increased electrolyte leakage, proline, and water use efficiency(WUE); Si treatment significantly decreased transpiration rate and improved chlorophyll content and WUE. Water stress stimulated mineral nutrient absorption whereas Si application decreased it under water stress. In conclusion, it was found that in most of the investigated factors, 10 mmol·L^(-1) potassium silicate had the best effect on growth and development of strawberry. Besides, Si application had beneficial effects on strawberry plants and the addition of it could alleviate water stress. | DEHGHANIPOODEH Safoora GHOBADI Cyrus BANINASAB Bahram GHEYSARI Mahdi SHIRANIBIDABADI Siamak | 2018 | Horticultural Plant Journal2018，4，6： | 9 |
| 6 | Ⅱ型胶原诱导的小鼠关节炎模型IL-25表达水平的变化及意义显示文摘目的以Ⅱ型胶原诱导的DBA/1小鼠关节炎模型为研究对象,动态观察其IL-25的表达水平,探讨IL-25与关节炎发生发展的关系及其可能的机制,为寻找新的类风湿性关节炎免疫干预新途径积累实验数据。方法采用RT-PCR法扩增目的基因,构建mIL-25标准质粒,QRT-PCR检测模型鼠脾脏及其关节病变局部IL-25的表达水平;应用ELISA技术检测模型鼠血清和脾细胞培养上清IL-25蛋白的含量。结果在Ⅱ型胶原诱导的小鼠关节炎的发病过程中,模型鼠脾细胞和关节滑膜组织IL-25的mRNA表达水平、均呈持续上升趋势,与对照小鼠相比差异显著(P<0.05)。这种IL-25蛋白和转录水平的表达,随着关节炎症程度的增加而升高。此外,模型鼠脾细胞对ConA的刺激表现出强IL-25表达性应答。结论 IL-25的表达水平与Ⅱ型胶原诱导的关节炎的发生发展密切相关。 | 王楷文 周成林 王胜军 赵银霞 杨恒 郑东 薛渊 Sandoghchian Siamak 仝佳 苏兆亮 邵启祥 许化溪 | 2010 | 免疫学杂志2010，26，7： | 9 |
| 7 | CFD-DEM simulation of the hole cleaning process in a deviated well drilling: The effects of particle shape显示文摘 | Siamak Akhshik Mehdi Behzad Majid Rajabi | 2016 | Particuology2016，14，2： | 8 |
| 8 | A new model to predict roadheader performance using rock mass properties显示文摘 | Yazdani-Chamzini ABDOLREZA SIAMAK Haji Yakhchali | 2013 | Journal of Coal Science & Engineering(China)2013，19，1： | 7 |
| 9 | Toll-like receptors are potential therapeutic targets in rheumatoid arthritis显示文摘Toll-like receptors (TLRs) are found on the membranes of pattern recognition receptors and not only play important roles in activating immune responses but are also involved in the pathogenesis of inflammatory disease, injury and cancer. Furthermore, TLRs are also able to recognize endogenous alarmins released by damaged tissue and necrosis and/or apoptotic cells and are present in numerous autoimmune diseases. Therefore, the release of endogenous TLR ligands plays an important role in initiating and driving inflammatory diseases. Increasing data suggest a role for TLR signaling in rheumatoid arthritis, which is an autoimmune disease. Although their involvement is not comprehensively understood, the TLRs signaling transducers may provide potential therapeutic targets. | Siamak Sandoghchian Shotorbani | 2011 | World Journal of Biological Chemistry2011，2，7： | 4 |
| 10 | Studying thin film damping in a micro-beam resonator based on non-classical theories显示文摘In this paper, a mathematical model is presented for studying thin film damping of the surrounding fluid in an in-plane oscillating micro-beam resonator. The proposed model for this study is made up of a clamped-clamped micro-beam bound between two fixed layers. The microgap between the micro-beam and fixed layers is filled with air. As classical theories are not properly capable of predicting the size dependence behaviors of the micro-beam,and also behavior of micro-scale fluid media, hence in the presented model, equation of motion governing longitudinal displacement of the micro-beam has been extracted based on non-local elasticity theory. Furthermore, the fluid field has been modeled based on micro-polar theory. These coupled equations have been simplified using Newton-Laplace and continuity equations. After transforming to non-dimensional form and linearizing, the equations have been discretized and solved simultaneously using a Galerkin-based reduced order model. Considering slip boundary conditions and applying a complex frequency approach, the equivalent damping ratio and quality factor of the micro-beam resonator have been obtained. The obtained values for the quality factor have been compared to those based on classical theories. We have shown that applying non-classical theories underestimate the values of the quality factor obtained based on classical theo-ries. The effects of geometrical parameters of the micro-beam and micro-scale fluid field on the quality factor of the resonator have also been investigated. | Mina Ghanbari Siamak Hossainpour Ghader Rezazadeh | 2016 | Acta Mechanica Sinica2016，32，3： | 3 |
| 11 | 自体血清滴眼液对屈光性角膜切削术后角膜上皮愈合的影响(英文)显示文摘目的:研究自体血清滴眼液对屈光性角膜切削术(PRK)后角膜上皮愈合的影响。方法:本研究共纳入20例40眼近视及近视散光患者,其中男性9例,女性11例。每例患者随机选取一眼作为研究组应用20%含自体血清的人工泪液,另一眼为对照组应用常规人工泪液。PRK术中,40眼均于角膜表面居中放置直径8 mm的酒精储槽, 20%的酒精作用20s。术后每天观察直到角膜上皮愈合后,分别于1mo,6mo,12mo进行随访。上皮愈合时间为主要观察指标,并记录裸眼视力(UCVA),显然验光和混浊度。结果:两组间术前小瞳检影结果无明显差异。术后1d,2d,3d,研究组平均疼痛评分均显著低于对照组(P<0.05)。术后1d,3d,研究组的平均水平和垂直上皮缺损低于对照组(P<0.05)。研究组上皮完全愈合的平均时间比对照组短约0.7d(3.15±0.366d vs 3.85±0.587d,P=0.00)。结论:研究表明,应用自体血清滴眼液,通过加速角膜上皮愈合和减轻疼痛,从而缩短视力恢复时间,降低屈光性角膜切削术术后不适、混浊度和感染风险。 | Ali Mostafaei Behzad Fallahi Motlagh Nazli Taheri Siamak Nejatbakhsh | 2019 | 国际眼科杂志2019，19，4： | 3 |
| 12 | Azithromycin in one week quadruple therapy for H pylori eradication in Iran显示文摘瞄准:调查根除率,耐心的依从和 1-wk 的 toler 能力基于 Azithromycin 的四倍的治疗对 2-wk 常规治疗。方法: 129 个 H pylori积极的病人的一个总数被使随机化到任何一个 omeprazole 20 mg ,铋潜水艇柠檬酸盐 240 mg , azithromycin 250 mg ,和灭滴灵 500 mg ,为 1-wk ( B-OAzM )两次每日的所有或 omeprazole 20 mg ,铋潜水艇柠檬酸盐 240 mg , amoxicillin 1 g ,并且灭滴灵 500 mg 为 2-wk (B操作维护管理)两次每日的所有。H pylori 感染被组织学和快速的 urease 在入口定义,感染的痊愈被否定的脲呼吸测试决定。结果:B-OAzM 和 B 操作维护管理生产的 H pylori 根除率基于一个意愿分别地是 74.1% 和 70.4% 对待分析,并且 78.1% 对 75.7% 分别地基于每协议分析。,差的依从的发生更低不显著地那么,比为 B 操作维护管理(3.5% 对 4.3%) 在病人使随机化到 B-OAzM,但是难耐在二个组(35% 对 33.3%) 是类似的。结论:基于的四倍的政体完成的 1-wk azithromycin 比得上标准 2-wk 的 H pylori 根除率四倍的治疗,并且与可比较的耐心的依从和复杂并发症被联系。 | Shahrokh Mousavi Jafar Toussy Siamak Yaghmaie Mehrdad Zahmatkesh | 2006 | World Journal of Gastroenterology2006，12，28： | 3 |
| 13 | 磁感应或磁共振,哪个更适合于无线充电?显示文摘磁感应与磁共振是目前最主要的两种无线充电技术,本文分析各种技术的优缺点。本文网络版地址:http://www.eepw.com.cn/article/145521. | Siamak Bastami | 2013 | 电子产品世界2013，20，6： | 3 |
| 14 | Hospital readmissions in decompensated cirrhotics: Factors pointing toward a prevention strategy显示文摘AIM To reduce readmissions and improve patient outcomes in cirrhotic patients through better understanding of readmission predictors.METHODS We performed a single-center retrospective study of patients admitted with decompensated cirrhosis from January 1, 2011 to December 31, 2013(n = 222). Primary outcomes were time to first readmission and 30-d readmission rate due to complications of cirrhosis. Clinical and demographic data were collected to help describe predictors of readmission, along with care coordination measures such as post-discharge status and outpatient follow-up. Univariate and multivariateanalyses were performed to describe variables associated with readmission.RESULTS One hundred thirty-two patients(59.4%) were readmitted at least once during the study period. Median time to first and second readmissions were 54 and 93 d, respectively. Thirty and 90-d readmission rates were 20.7 and 30.1 percent, respectively. Predictors of 30-d readmission included education level, hepatic encephalopathy at index, ALT more than upper normal limit and Medicare coverage. There were no statistically significant differences in readmission rates when stratified by discharge disposition, outpatient follow-up provider or time to first outpatient visit.CONCLUSION Readmissions are challenging aspect of care for cirrhotic patients and risk continues beyond 30 d. More initiatives are needed to develop enhanced, longitudinal post-discharge systems. | Siamak M Seraj Emily J Campbell Sarah K Argyropoulos Kara Wegermann Raymond T Chung James M Richter | 2017 | World Journal of Gastroenterology2017，23，37： | 3 |
| 15 | Protective Effects of Vitamin E on Diabetes-induced Oxidative Stress Status and Homocysteine in the Rat Heart显示文摘 | Mojtaba Beyramzadeh Mohammad Hassan Khadem Ansari Kaveh Azimzadeh Siamak Salami | 2017 | Journal of Pharmacy and Pharmacology2017，5，10： | 2 |
| 16 | Emergence of novel strains of avian infectious bronchitis virus in Sweden显示文摘 | Shahid Hussain Abro Lena H.M. Renstr?m Karin Ullman Mats Isaksson Siamak Zohari Désirée S. Jansson Sándor Belák Claudia Baule | 2011 | Veterinary Microbiology (-)2011，，2： | 2 |
| 17 | Randomized Trial of Intravitreal Bevacizumab Alone or Combined with Triamcinolone versus Macular Photocoagulation in Diabetic Macular Edema显示文摘 | Masoud Soheilian Alireza Ramezani Arash Obudi Bijan Bijanzadeh Masoud Salehipour Mehdi Yaseri Hamid Ahmadieh Mohammad H. Dehghan Mohsen Azarmina Siamak Moradian Gholam A. Peyman | 2009 | Ophthalmology2009，，6： | 2 |
| 18 | Simulation of proppant transport at intersection of hydraulic fracture and natural fracture of wellbores using CFD-DEM显示文摘Proppants transport is an advanced technique to improve the hydraulic fracture phenomenon,in order to promote the versatility of gas/oil reservoirs.A numerical simulation of proppants transport at both hydraulic fracture(HF)and natural fracture(NF)intersection is performed to provide a better understand-ing of key factors which cause,or contribute to proppants transport in HF-NF intersection.Computational fluid dynamics(CFD)in association with discrete element method(DEM)is used to model the complex interactions between proppant particles,host fluid medium and fractured walls.The effect of non-spherical geometry of particles is considered in this model,using the multi-sphere method.All interaction forces between fluid flow and particles are considered in the computational model.Moreover,the inter-actions of particle-particle and particle-wall are taken into account via Hertz-Mindlin model.The results of the CFD-DEM simulations are compared to the experimental data.It is found that the CFD-DEM sim-ulation is capable of predicting proppant transport and deposition quality at intersections which are in agreement with experimental data.The results indicate that the HF-NF intersection type,fluid velocity and NF aperture affect the quality of blockage occurrence,presenting a new index,called the blockage coefficient which indicates the severity of the blockage. | Siamak Akhshik Majid Rajabi | 2022 | Particuology2022，20，4： | 2 |
| 19 | Influence of various surface treated silica nanoparticles on the electrochemical properties of SiOJpolyurethane nanocoatings 显示文摘 | Fatemeh Dolatzadeh Siamak Moradian Mohammad Mehdi Jalili | 2011 | Corrosion Science2011，53，12： | 1 |
| 20 | Prediction of flow stress at hot working condition显示文摘 | Siamak Serajzadeh Ali Karimi Taheri | 2002 | Mechanics Research Communications2002，，： | 1 |
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