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| 1 | Uncommon N-Methoxyindolediketopiperazines from Acrostalagmus luteoalbus,a Marine Algal Isolate of Endophytic Fungus显示文摘Main observation and conclusion Four new N-methoxyindolediketopiperazines(acrozines D—G,1—4)and six known congeners(5—10)were purified from the organic extract of Acrostalagmus luteoalbus TK-43,which was a marine algal-derived fungus obtained from Codium fragile.Their structures were determined by interpretation of NMR and mass spectroscopic data.The structures of compounds 1,2,and 4 including their absolute configurations were confirmed by single-crystal X-ray diffraction,while the absolute configuration of compound 3 was elucidated by comparative analysis of ECD and TDDFT-ECD calculations.Compounds 1—4,with a unique methoxy substitution at N-2,were rarely discovered among indolediketopiperazine alkaloids.All these compounds were evaluated for antimicrobial activities against human-and aquatic-pathogenic bacteria and plant-related pathogenic fungi,with compounds 5 and 7 exhibiting potent activity against Edwardsiella icataluri(MIC=3 and 5μmol/L,respectively),while compound 9 displayed a broad spectrum of antibacterial activities.The four new compounds were further tested for anti-acetylcholinesterase(AChE)properties,and compound 3 exhibited inhibitory activity with IC_(50)value of 8.4μmol/L. | Jin Cao Xiao-Ming Li Xin Li Hong-Lei Li Belma Konuklugil Bin-Gui Wang | 2021 | Chinese Journal of Chemistry2021，39，10： | 5 |
| 2 | 海绵Axinella verrucosa中溴吡咯生物碱的研究显示文摘目的分离鉴定海绵Axinella verrucosa中的溴吡咯生物碱,并进行体外免疫活性评价。方法利用减压柱层析、Sephdex LH-20凝胶柱层析、半制备HPLC等色谱方法分离纯化,运用NMR、MS等波谱方法并结合文献鉴定化合物结构,采用体外脾淋巴细胞增殖实验评价化合物的免疫活性。结果分离得到5个溴吡咯生物碱,分别鉴定为hymenidin(1)、stevensine(2)、4-bromopyrrole-2-carboxylic acid(3)、4,5-dibromopyrrole-2-carboxylic acid(4)和3,5-dibromo-2-pyrrolecarboxylic acid(5)。化合物1能够增强ConA诱导的T淋巴细胞增殖,化合物2能够增强LPS诱导的B淋巴细胞增殖。结论化合物4为首次从该种中分到,5为首次从该属中鉴定。化合物1和2具有一定的增强免疫作用。 | 高尚 李海花 王道亮 Belma Konuklugil 刘红兵 | 2015 | 中国海洋药物2015，34，2： | 2 |
| 3 | 海鞘内生真菌焦曲霉Aspergillus ustus TK-5的化学成分研究显示文摘焦曲霉(Aspergillusustus)TK-5是分离自土耳其海域海鞘(Pyuramomus)新鲜组织中的一株内生真菌,利用正相与反相硅胶柱层析、葡聚糖凝胶Sephadex LH-20柱层析以及高效液相制备等色谱方法从其发酵产物中分离得到17个化合物,通过一维、二维核磁共振、质谱等技术鉴定了所有化合物的结构,分别为血苋烷型倍半萜类化合物strobilactone A(1), ustusolate E(2), ustusolate C(3), ustusolate D(4),11-hydroustusolate E(5), 11, 6’-hydroustusolate E(6),(2’E, 4’E, 6’E)-6-(1’-carboxyocta-2’, 4’, 6’-triene)-11,12-epoxy-9, 11-dihydroxydrim-7-ene(7), 12-hydroxy-6-epi-albrassitriol (8), ustusolate A (9), deoxyuvidin B(10)和二倍半萜类化合物6-epi-ophiobolinG(11),(6α)-21,21-O-dihydroophiobolinG(12),6-epi-ophiobolin K(13), ophiobolin P(14) ophiobolin H(15), ophiobolin Q(16)及ophiobolin R(17)。活性筛选表明化合物2、6、7、9、11和13对神经氨酸酶具有一定的抑制活性,其半数抑制浓度(IC50)分别为31.8、37.3、28.4、36.8、46.6和37.6μmol/L。 | 李莉 李晓明 李洪雷 Belma Konuklugil 李鑫 王斌贵 | 2018 | 海洋科学2018，42，5： | 2 |
| 4 | Kinetics of mitotic arrest and apoptosis in murine mammary and ovarian tumors treated with taxol显示文摘 | Luka Milas Nancy R. Hunter Belma Kurdoglu Kathryn A. Mason Raymond E. Meyn L. C. Stephens Lester J. Peters | 1995 | Cancer Chemotherapy and Pharmacology1995，，4： | 1 |
| 5 | A lowpower inductorless LNA with double enhancement in130 nm CMOS 显示文摘 | BELMAS F HAMEAU F FOURNIER J M | 2012 | IEEE J Sol Sta Circ2012，47，5： | 1 |
| 6 | A Confirmatory Report for the Close Interaction of Helicobacter pylori With Gastric Epithelial MUC5AC Expression显示文摘 | Belma Kocer Murat Ulas Yucel Ustundag Sibel Erdogan Melih Karabeyoglu Osman Yldrm Bülent Unal Omer Cengiz Atilla Soran | 2004 | Journal of Clinical Gastroenterology2004，，6： | 1 |
| 7 | Protective effect of two edible mushrooms against oxidative cell damage and their phenolic composition显示文摘 | Feyza Oke Belma Aslim | 2011 | Food Chemistry2011，，3： | 1 |
| 8 | Historic Environment and Cultural Sensitivity: Ottoman Neighborhood in Macedonia显示文摘 | Belma Alik Nevnihal Erdogan | 2016 | Journal of Civil Engineering and Architecture2016，10，2： | 1 |
| 9 | Cholesterol removal by some lactic acid bacteria that can be used as probiotic显示文摘 | Esra Tok Belma Aslim | 2010 | Microbiology and Immunology2010，，54： | 1 |
| 10 | A modeling study on milk lactose hydrolysis and β-galactosidase stability under sonication显示文摘 | NESLIHAN S DILEK K A BELMA O | 2006 | Process Biochemistry2006，41，： | 1 |
| 11 | Effect of drying conditions on rehydration kinetics of microwave dried spinach显示文摘 | Gokge Dadali Elcin Demirhan Belma Ozbek | 2008 | Food and Bioproducts Processing2008，86，4： | 1 |
| 12 | The acquisition of tense aspect in child second language English显示文摘 | Belma Haznedar | 2007 | Second Language Research2007，23，383： | 1 |
| 13 | A low power inductorless LNA with double gm enhancement in 130nm CMOS显示文摘 | BELMAS F HAMEAU F FOURNIER J M | 2012 | IEEE Journal of Solid-State Circuits2012，47，5： | 1 |
| 14 | Preheating sensitization of a TATB composition part three: sensitization for various stimuli, interpretation and conclusions显示文摘 | Belmas R Gautier L David C | 2005 | Pellants Explosives Pyrotechnics2005，30，2： | 1 |
| 15 | Color Change Kinetics of Spinach Undergoing Microwave Drying显示文摘 | Gokce Dadali Elcin Demirhan Belma Ozbek | 2007 | Drying Technology2007，，10： | 1 |
| 16 | Microbial production of tannase : An enzyme with potential use in food industry 显示文摘 | BELMA RFS R CONTRERAS-ESQUIVEL J C RODRfGUEZ-HERRERA R | 2004 | Food Science and Technology2004，37，8： | 1 |
| 17 | Evaluation of cytotoxicity and oxidative DNA damaging effects of di(2-ethylhexyl)-phthalate (DEHP) and mono(2-ethylhexyl)-phthalate (MEHP) on MA-10 Leydig cells and protection by selenium显示文摘 | Pinar Erkekoglu Walid Rachidi Ozge Gursoy Yuzugullu Belma Giray Alain Favier Mehmet Ozturk Filiz Hincal | 2010 | Toxicology and Applied Pharmacology2010，，1： | 1 |
| 18 | α-Amylase inactivation during rice starch hydrolysis显示文摘 | Dilek K(l)lic Apar Belma | | 0，，03： | 1 |
| 19 | Microwave heat treatment of spinach: drying kinetics and effective moisture diffusivity显示文摘 | Gke Dadalia El:in Demirhana Belma Ozbeka | 2007 | Drying Technology2007，，25： | 1 |
| 20 | Exopolysaccharide production by Lactobacillus delbruckii subsp, bulgaricus and Streptococcus thermophilus strains under different growth conditions 显示文摘 | Belma As|im Zebra Nur Yuksekdag Yavuz Beyatli and Nazime Mercan | 2005 | World J Microb Biot2005，21，： | 1 |
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