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| 1 | Appropriateness of systemic treatments in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors显示文摘AIM:To evaluate systemic treatment choices in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors(PNETs)and provide consensus treatment recommendations.METHODS:Systemic treatment options for pancreatic neuroendocrine tumors have expanded in recent years to include somatostatin analogs,angiogenesis inhibitors,inhibitors of mammalian target of rapamycinand cytotoxic agents.At this time,there is little data to guide treatment selection and sequence.We therefore assembled a panel of expert physicians to evaluate systemic treatment choices and provide consensus treatment recommendations.Treatment appropriateness ratings were collected using the RAND/UCLA modified Delphi process.After studying the literature,a multidisciplinary panel of 10 physicians assessed the appropriateness of various medical treatment scenarios on a 1-9 scale.Ratings were done both before and after an extended discussion of the evidence.Quantitative measurements of agreement were made and consensus statements developed from the second round ratings.RESULTS:Specialties represented were medical and surgical oncology,interventional radiology,and gastroenterology.Panelists had practiced for a mean of15.5 years(range:6-33).Among 202 rated scenarios,disagreement decreased from 13.2%(26 scenarios)before the face-to-face discussion of evidence to 1%(2)after.In the final ratings,46.5%(94 scenarios)were rated inappropriate,21.8%(44)were uncertain,and30.7%(62)were appropriate.Consensus statements from the scenarios included:(1)it is appropriate to use somatostatin analogs as first line therapy in patients with hormonally functional tumors and may be appropriate in patients who are asymptomatic;(2)it is appropriate to use everolimus,sunitinib,or cytotoxic chemotherapy therapy as first line therapy in patients with symptomatic or progressive tumors;and(3)beyond first line,these same agents can be used.In patients with uncontrolled secretory symptoms,octreotide LAR doses can be titrated up to 60 mg every4 wk or up to 40 mg every 3 or 4 wk.CONCLUSION:Using the Delphi process allowed physician experts to systematically obtain a consensus on the appropriateness of a variety of medical therapies in patients with PNETs. | Jonathan R Strosberg George A Fisher Al B Benson Lowell B Anthony Bulent Arslan John F Gibbs Edward Greeno Renuka V Iyer Michelle K Kim William J Maples Philip A Philip Edward M Wolin Dasha Cherepanov Michael S Broder | 2015 | World Journal of Gastroenterology2015，21，8： | 2 |
| 2 | Management of patie nts with atrial fibrillation显示文摘 | Benson DW Fuster V | 1996 | Circulation1996，93，6： | 1 |
| 3 | Direct trajectory optimization and eostate estimation via an orthogohal collocation method 显示文摘 | Benson D A Huntington G T Thorvaldsen T P Rao A V | 2006 | Journal of Guidance Control and Dynamics2006，29，6： | 1 |
| 4 | Water balance modeling of earthen final covers显示文摘 | KHIRE M V BENSON C H BOSSCHER P J | 1997 | Journal of Geoteehnieal and Geoenvironmental Engineering1997，123，8： | 1 |
| 5 | Climatic and hydrologic oscillations in the owens basin and adjacent sierra Nevada,California显示文摘 | Benson L V Burdett J W Kashgarian M | 1996 | Science1996，274，： | 1 |
| 6 | Particle size effect on strength,failure,and shock behavior in polytetrafluoroethylene-Al-W granular composite materials显示文摘 | Herbold E B Nesterenko V F Benson D J | 2008 | Journal of Applied Physics2008，104，10： | 1 |
| 7 | Vaginal versus abdominal reconstructive surgery for the treatment of pelvic support defects:A prospective randomized study显示文摘 | Lucente V McClellan E | 1998 | J Obstet Gynecol1998，72，： | 1 |
| 8 | Paleoclimatic implications of the high stand of Lake Lahontan derived from models of evaporation and lake level显示文摘 | Hostetler S W Benson L V | 1990 | Climate Dynamics1990，4，3： | 1 |
| 9 | The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘 | International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M | 2010 | Science2010，330，6010： | 1 |
| 10 | Direct Traj- ectory Optimization and Costate Estimation via an Or- thogonal Collocation Method 显示文摘 | BENSON A THORVALDSEN T RAO V | 2006 | Journal of Guidance Control and Dynamics2006，29，6： | 1 |
| 11 | Direct trajectory optimization and costae estimation via an orthogonal collocation method 显示文摘 | Benson A Thorvaldsen T Rao V | 2006 | Journal of Guidance Control and Dynamics2006，29，6： | 1 |
| 12 | Algorithm 902 :GPOPS,a MATLAB software for solving multiple-phaseoptimal control problems using the Gauss pseudospectralmethod显示文摘 | Rao A V Benson D A Darby C L | 2010 | ACM Transactions on Mathematical Software2010，37，2： | 1 |
| 13 | Sustained Kilowatt Lasing in a Free-Electron Laser with Same-Cell Energy Recovery显示文摘 | Neil G R Bohn C L Benson S V | 2000 | PHYSICAL REVIEW LETTERS2000，84，4： | 1 |
| 14 | A wide-angle alternating-direction implicit finite-difference beam propagation method显示文摘 | BEKKER V SEWELL P BENSON T M | | 0，，： | 1 |
| 15 | Sustained kilowatt lasing in a free-electron laser with same-cell energy recovery显示文摘 | Nell G R Bohn C L Benson S V | 2000 | Phys Rev Lett2000，84，4： | 1 |
| 16 | Acoustoelasticity显示文摘 | Benson R W Raelson V J | 1959 | Product Engineering1959，30，： | 1 |
| 17 | Testing Made-for-ELT Videos显示文摘 | Benson V | 1993 | The Language Teacher1993，21，9： | 1 |
| 18 | Management of patients with atrial fibrillation: a statement for healthcare professionals from the subcommittee on electrocardiography and electrophysiology, American Heart Association 显示文摘 | Prystowsky EN Benson DW Fuster V | 1996 | Circulation1996，93，6： | 1 |
| 19 | An Instrument for Measuring the Critical Factors of Quality Management 显示文摘 | Saraph J V Benson P G' Schroeder R G | 2007 | Decision Sciences2007，20，4： | 1 |
| 20 | Viscosity predictions of the slag composition of gasified coal, utilizing factsage equilibrium modelling显示文摘 | Dyk J C V Waanders F B Benson S A | 2009 | Fuel2009，88，1： | 1 |
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