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| 1 | Radiofrequency ablation for treatment of hypersplenism: A feasible therapeutic option显示文摘We present a case of a patient with hypersplenism secondary to portal hypertension due to hepato-splenic schistosomiasis, which was accompanied by severe and refractory thrombocytopenia. We performed spleen ablation and measured the total spleen and ablated volumes with contrast-enhanced computed tomography and volumetry. No major complications occurred, thrombocytopenia was resolved, and platelet levels remained stable, which allowed for early treatment of the patient's underlying disease. Previous work has shown that splenic radiofrequency ablation is an attractive alternative treatment for hypersplenism induced by liver cirrhosis. We aimed to contribute to the currently sparse literature evaluating the role of radiofrequency ablation(RFA) in the management of hypersplenism. We conclude that splenic RFA appears to be a viable and promising option for the treatment of hypersplenism. | Guilherme Lopes P Martins Joao Paulo G Bernardes Marcello S Rovella Raphael G Andrade Publio Cesar C Viana Paulo Herman Giovanni Guido Cerri Marcos Roberto Menezes | 2015 | World Journal of Gastroenterology2015，21，20： | 17 |
| 2 | Role of immunosuppression and tumor differentiation in predicting recurrence after liver transplantation for hepatocellular carcinoma: A multicenter study of 412 patients显示文摘AIM: To assess pre-orthotopic liver transplantation (OLT) factors that could be evaluated pre-operatively or con- trolled post-operatively associated with hepatocellular carcinoma (HCC) recurrence and disease-free survival after liver transplantation (LT).METHODS: Four hundred and twelve patients trans- planted for HCC between 1988 and 1998 in 14 French centers, who survived the postoperative period were studied. Kaplan Meier estimates were calculated for 24 variables potentially associated with recurrence of HCC. Uni- and multivariate analyses were conducted to iden- tify independent predictors of recurrence. RESULTS: Overall 5-year disease-free survival was 57.1%. By univariate analysis, variables associated with disease-free survival were: presence of cirrhosis (P = 0.001), etiology of liver disease (P = 0.03), α fetoprotein level (< 200, 200 to 2000, or > 2000; P < 0.0001), γ-GT activity (N, N to 2N or > 2N; P = 0.02), the number of nodules (1, 2-3 or ≥ 4; P = 0.02), maximal diameter of the largest nodule (< 3 cm, 3 to 5 cm or > 5 cm; P < 0.0001), the sum of the diameter of the nodules (< 3 cm, 3 to 5 cm, 5 to 10 cm or >10 cm; P < 0.0001), bi- lobar location (P = 0.01), preoperative portal thrombosis (P < 0.0001), peri-operative treatment of the tumor (P = 0.002) and chemoembolization (P = 0.03), tumor differentiation (P = 0.01), initial type of calcineurin inhibitor (P = 0.003), the use of antilymphocyte antibodies (P = 0.02), rejection episodes (P = 0.003) and period of LT (P < 0.0001). By multivariate analysis, 6 variables were independently associated with HCC recurrence: maximal diameter of the largest nodule (P < 0.0001), time of LT (P < 0.0001), tumor differentiation (P < 0.0001), use of anti-lymphocyte antibody (ATG) or anti-CD3 antibody (OKT3) (P = 0.005), preoperative portal thrombosis (P = 0.06) and the number of nodules (P = 0.06). CONCLUSION: This study identif ies immunosuppression, through the use of ATG or OKT3, as a predictive factor of tumor recurrence, and confi rms the prognostic value of tumor differentiation. | Thomas Decaens Franoise Roudot-Thoraval Solange Bresson-Hadni Carole Meyer Jean Gugenheim Francois Durand Pierre-Henri Bernard Olivier Boillot Philippe Compagnon Yvon Calmus Jean Hardwigsen Christian Ducerf Georges Philippe Pageaux Sébastien Dharancy Olivier Chazouillères Daniel Cherqui Christophe Duvoux | 2006 | World Journal of Gastroenterology2006，12，45： | 10 |
| 3 | 表层土壤团聚体稳定性对径流及土壤侵蚀的影响显示文摘 | Bernard Barthès Eric Roose | 2002 | 中国水土保持2002，，7： | 8 |
| 4 | 肌电生物反馈在陈旧性颈脊髓损伤中的应用显示文摘目的 :观察EMG生物反馈治疗是否能够恢复和增强陈旧性颈脊髓 (C1—C6)损伤患者上肢各肌的自主肌电信号和肌力。方法 :1 39例非完全性颈脊髓 (C1—C6)损伤患者 ,病程均在 6个月以上、伴有不同程度的上肢功能障碍和肌力缺陷 ,且经其它康复方法治疗而无进一步功能恢复者。全部患者均接受 1个疗程、1 5次、每次 50min的治疗。分别记录治疗前后的中三角肌、肱二头肌、肱三头肌、腕伸肌、腕屈肌、指伸肌和指屈肌肌电信号和肌力测定分级数据 ,进行统计学分析。结果 :治疗后患者自主肌电信号和肌力均较治疗前有明显提高 (P <0 .0 0 1 )。结论 :EMG生物反馈是治疗非完全性、陈旧性颈脊髓 (C1—C6) | 赵文汝 Bernard S Brucker 王秀汝 刘金敬 | 2003 | 中国康复医学杂志2003，18，2： | 8 |
| 5 | Screening and Surveillance for the Early Detection of Colorectal Cancer and Adenomatous Polyps, 2008: A Joint Guideline From the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology显示文摘 | Bernard Levin David A. Lieberman Beth McFarland Kimberly S. Andrews Durado Brooks John Bond Chiranjeev Dash Francis M. Giardiello Seth Glick David Johnson C. Daniel Johnson Theodore R. Levin Perry J. Pickhardt Douglas K. Rex Robert A. Smith Alan Thorson S | 2008 | Gastroenterology2008，，5： | 8 |
| 6 | 操作性肌电生物反馈治疗慢性颈脊髓损伤的疗效观察显示文摘目的 观察操作性肌电生物反馈治疗是否能够增强慢性颈脊髓 (C1~ 6)损伤患者上肢各肌的自主肌电信号和肌力。方法 慢性非完全性颈脊髓 (C1~ 6)损伤患者 13 9例 ,为美国迈阿嘧大学医学院附属Jackson医学中心骨、康复科门诊患者 ,病程 >6个月 ,均有不同程度上肢功能障碍和肌力减低 ,而且均为经其它康复方法治疗而无进一步功能恢复者。全部患者均接受 15次 (1个疗程 )、每次 5 0min的治疗。分别记录治疗前、后三角肌中部、肱二头肌、肱三头肌、腕伸肌、腕屈肌、指伸肌和指屈肌的肌电信号和肌力测定分级数据 ,并进行比较和统计学分析。结果 治疗后患者自主肌电信号和肌力均较治疗前有明显提高 ,差异有显著性 (P <0 .0 1)。结论 操作性肌电生物反馈是治疗非完全性、慢性颈脊髓 (C1~ 6)损伤的有效方法。 | 赵文汝 Bernard S Brucker | 2003 | 中华物理医学与康复杂志2003，25，5： | 7 |
| 7 | Natural polyphenols effects on protein aggregates in Alzheimer's and Parkinson's prion-like diseases显示文摘Alzheimer's and Parkinson's diseases are the most common neurodegenerative diseases. They are characterized by protein aggregates and so can be considered as prion-like disease. The major components of these deposits are amyloid peptide and tau for Alzheimer's disease, α-synuclein and synphilin-1 for Parkinson's disease. Drugs currently proposed to treat these pathologies do not prevent neurodegenerative processes and are mainly symptomatic therapies. Molecules inducing inhibition of aggregation or disaggregation of these proteins could have beneficial effects, especially if they have other beneficial effects for these diseases. Thus, several natural polyphenols, which have antioxidative, anti-inflammatory and neuroprotective properties, have been largely studied, for their effects on protein aggregates found in these diseases, notably in vitro. In this article, we propose to review the significant papers concerning the role of polyphenols on aggregation and disaggregation of amyloid peptide, tau, α-synuclein, synphilin-1, suggesting that these compounds could be useful in the treatments in Alzheimer's and Parkinson's diseases. | aline freyssin guylène page bernard fauconneau agnès rioux bilan | 2018 | Neural Regeneration Research2018，13，6： | 3 |
| 8 | 伦理学与SARS:多伦多的教训显示文摘SARS的流行说明传染病在世界范围内流行是件多么容易的事,为了更好地应对下一次流行病,我们不仅要解决医学方面的问题,也同样需要解决伦理学方面的问题。 | Peter A Singer Solomon R Benatar Mark Bernstein Abdallah S Daar Bernard M Dickens Susan K MacRae Ross E G Upshur Linda Wright Randi Zlotnik Shaul 肖月 | 2004 | 英国医学杂志中文版2004，7，4： | 3 |
| 9 | 操作性肌电生物反馈治疗陈旧性颈脊髓损伤多疗程疗效观察显示文摘目的观察操作性EMG生物反馈多疗程连续治疗是否能够在前一疗程疗效的基础上,进一步恢复和增强陈旧性颈脊髓(C1—C6)损伤患者上肢各肌的自主肌电信号和肌力。方法39例非完全性颈脊髓(C1—C6)损伤患者,病程均在6个月以上、均有不同程度上肢功能障碍和肌力缺陷,而且均经其它康复方法治疗而无进一步功能恢复者。全部患者均接受每年1疗程,每疗程15次,每次50min,连续4个疗程的治疗。记录中三角肌、肱二头肌、肱三头肌、腕伸肌、腕屈肌、指伸肌和指屈肌治疗前后的肌电信号和肌力测定分级数据,进行比较。结果每疗程治疗后患者的自主肌电信号和肌力均较前一疗程治疗后的自主肌电信号和肌力有明显提高(P<0.01)。结论多疗程操作性EMG生物反馈治疗能够在前一疗程疗效的基础上,进一步提高陈旧性颈脊髓损伤患者上肢各肌的自主肌电信号和肌力。 | 赵文汝 Bernard S Brucker 杜巨豹 | 2004 | 中国康复医学杂志2004，19，7： | 3 |
| 10 | Patterns of genomic and phenomic diversity in wine and table grapes显示文摘Grapes are one of the most economically and culturally important crops worldwide,and they have been bred for both winemaking and fresh consumption.Here we evaluate patterns of diversity across 33 phenotypes collected over a 17-year period from 580 table and wine grape accessions that belong to one of the world’s largest grape gene banks,the grape germplasm collection of the United States Department of Agriculture.We find that phenological events throughout the growing season are correlated,and quantify the marked difference in size between table and wine grapes.By pairing publicly available historical phenotype data with genome-wide polymorphism data,we identify large effect loci controlling traits that have been targeted during domestication and breeding,including hermaphroditism,lighter skin pigmentation and muscat aroma.Breeding for larger berries in table grapes was traditionally concentrated in geographic regions where Islam predominates and alcohol was prohibited,whereas wine grapes retained the ancestral smaller size that is more desirable for winemaking in predominantly Christian regions.We uncover a novel locus with a suggestive association with berry size that harbors a signature of positive selection for larger berries.Our results suggest that religious rules concerning alcohol consumption have had a marked impact on patterns of phenomic and genomic diversity in grapes. | ZoëMigicovsky Jason Sawler Kyle M Gardner Mallikarjuna K Aradhya Bernard H Prins Heidi R Schwaninger Carlos D Bustamante Edward S Buckler Gan-Yuan Zhong Patrick J Brown Sean Myles | 2017 | Horticulture Research2017，4，1： | 3 |
| 11 | An α‐E‐catenin ( CTNNA1 ) mutation in hereditary diffuse gastric cancer显示文摘 | Ian J Majewski Irma Kluijt Annemieke Cats Thomas S Scerri Daphne Jong Roelof JC Kluin Samantha Hansford Frans BL Hogervorst Astrid J Bosma Ingrid Hofland Marcel Winter David Huntsman Jos Jonkers Melanie Bahlo René Bernards | 2013 | J. Pathol2013，，4： | 2 |
| 12 | Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence显示文摘 | Juan C. Acosta Ana O’Loghlen Ana Banito Maria V. Guijarro Arnaud Augert Selina Raguz Marzia Fumagalli Marco Da Costa Celia Brown Nikolay Popov Yoshihiro Takatsu Jonathan Melamed Fabrizio d’Adda di Fagagna David Bernard Eva Hernando Jesús Gil | 2008 | Cell2008，，6： | 2 |
| 13 | Natural stilbenes effects in animal models of Alzheimer’s disease显示文摘Alzheimer’s disease is one of the most frequent neurodegenerative diseases.This pathology is characterized by protein aggregates,mainly constituted by amyloid peptide and tau,leading to neuronal death and cognitive impairments.Drugs currently proposed to treat this pathology do not prevent neurodegenerative processes and are mainly symptomatic therapies.However,stilbenes presenting multiple pharmacological effects could be good potential therapeutic candidates.The aim of this review is to gather the more significant papers among the broad literature on this topic,concerning the beneficial effects of stilbenes (resveratrol derivatives) in animal models of Alzheimer’s disease.Indeed,numerous studies focus on cellular models,but an in vivo approach remains of primary importance since in animals (mice or rats,generally),bioavailability and metabolism are taken into account,which is not the case in in vitro studies.Furthermore,examination of memory ability is feasible in animal models,which strengthens the relevance of a compound with a view to future therapy in humans.This paper is addressed to any researcher who needs to study untested natural stilbenes or who wants to experiment the most effective natural stilbenes in largest animals or in humans.This review shows that resveratrol,the reference polyphenol,is largely studied and seems to have interesting properties on amyloid plaques,and cognitive impairment.However,some resveratrol derivatives such as gnetin C,trans-piceid,or astringin have never been tested on animals.Furthermore,pterostilbene is of particular interest,by its improvement of cognitive disorders and its neuroprotective role.It could be relevant to evaluate this molecule in clinical trials. | Aline Freyssin Guylène Page Bernard Fauconneau Agnès Rioux Bilan | 2020 | Neural Regeneration Research2020，15，5： | 2 |
| 14 | 操作性肌电生物反馈治疗陈旧性颈脊髓损伤零肌力肌肉的疗效分析显示文摘目的:观察操作性肌电生物反馈是否能够治疗陈旧性颈脊髓(C1—C5)损伤患者上肢零肌力肌肉的自主肌电信号和肌力。探讨临床检查的零肌力与零肌电信号间的差别,以及对该肌肉自主活动恢复的意义。方法:77例非完全性颈脊髓(C1—C5)损伤患者,均来自于美国迈阿嘧大学医学院附属Jackson医学中心骨、康复科门诊。其病程在6个月以上、有不同程度的上肢功能障碍,而且均经其它康复方法治疗而无进一步功能恢复者。77例中采用Lovett肌力评估的343块零肌力肌肉均接受1个疗程的治疗。分别记录治疗前后的零肌力中三角肌、肱二头肌、肱三头肌、腕伸肌、腕屈肌、指伸肌和指屈肌肌电信号和肌力测定分级数据。结果:治疗后患者的自主肌电信号和肌力均较治疗前有明显提高(P<0.01)。结论:EMG生物反馈治疗能够提高陈旧性颈脊髓(C1—C5)损伤患者上肢零肌力肌肉的自主肌电信号和肌力。临床评估的零肌力并不意味着该肌肉为零肌电信号,治疗后仍有功能恢复的可能。 | 赵文汝 Bernard S Bruckerx | 2004 | 中国康复医学杂志2004，19，9： | 2 |
| 15 | Oxidative stress promotes pathologic polyploidization in nonalcoholic fatty liver disease显示文摘 | Gentric Géraldine Maillet Vanessa Paradis Valérie Couton Dominique L’Hermitte Antoine Panasyuk Ganna Fromenty Bernard Celton-Morizur Séverine Desdouets Chantal | 2015 | Journal of Clinical Investigation2015，，： | 2 |
| 16 | Responses of Tree Species to Climate Warming at Different Spatial Scales显示文摘Tree species respond to climate change at multiple scales,such as species physiological response at fine scale and species distribution (quantified by percent area) at broader spatial scale.At a given spatial scale,species physiological response and distribution can be correlated positively or negatively.The consistency of such correlation relationships at different spatial scales determines whether species responses derived from local scales can be extrapo-lated to broader spatial scales.In this study,we used a coupled modeling approach that coupled a plot-level ecosystem process model (LINKAGES) with a spatially explicit landscape model (LANDIS).We investigated species physio-logical responses and distribution responses to climate warming at the local,zonal and landscape scales respectively,and examined how species physiological response and distribution correlated at each corresponding scale and whether the correlations were consistent among these scales.The results indicate that for zonal and warming-sensitive species,the correlations between species physiological response and distribution are consistent at these spatial scales,and therefore the research results of vegetation response to climate warming at the local scale can be extrapolated to the zonal and landscape scales.By contrast,for zonal and warming-insensitive species the correlations among different spatial scales are consistent at some spatial scales but at other scales.The results also suggest that the results of azonal species at the local scale near their distribution boundaries can not be extrapolated simply to broader scales due to stronger responses to climate warming in those boundary regions. | LIANG Yu HE Hong S LEWIS Bernard L | 2011 | Chinese Geographical Science2011，21，4： | 2 |
| 17 | Effect of tensile cracking on diffusivity of mortar: 3D numerical modeling显示文摘 | KAMALI-BERNARD S BERNARD F | 2009 | Computational Materials Science2009，47，： | 1 |
| 18 | Simulation of Agroforestry Systems With Sugarcane in Piracicaba,Brazil显示文摘 | PINTO L F G BERNARDES M S NOORDWIJK M V | 2005 | Agricultural Systems2005，86，3： | 1 |
| 19 | Creating new forms of 4x,6x and 6x primary triticale associating both complete R and D genomes显示文摘 | Bernard S Bernard M | 1987 | Theor Appl Genet1987，74，： | 1 |
| 20 | Managers and productive investment decisions:the impact of uncertainty and risk aversion显示文摘 | Bernard J Leroy S | 2004 | Journal of Small Business Management2004，42，1： | 1 |
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