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| 1 | Assessment of the correlation between serum prolidase and alpha-fetoprotein levels in patients with hepatocellular carcinoma显示文摘AIM: To determine the predictive value of increased prolidase activity that reflects increased collagen turnover in patients with hepatocellular carcinoma(HCC).METHODS: Sixty-eight patients with HCC(mean age of 69.1 ± 10.1), 31 cirrhosis patients(mean age of59.3 ± 6.3) and 33 healthy volunteers(mean age of51.4 ± 12.6) were enrolled in this study. Univariate and multivariate analysis were used to evaluate the association of serum α-fetoprotein(AFP) values with HCC clinicopathological features, such as tumor size,number and presence of vascular and macrovascular invasion. The patients with HCC were divided into groups according to tumor size, number and presence of vascular invasion(diameters; ≤ 3 cm, 3-5 cmand ≥ 5 cm, number; 1, 2 and ≥ 3, macrovascular invasion; yes/no). Barcelona-clinic liver cancer(BCLC)criteria were used to stage HCC patients. Serum samples for measurement of prolidase and alphafetoprotein levels were kept at-80 ℃ until use.Prolidase levels were measured spectrophotometrically and AFP concentrations were determined by a chemiluminescence immunometric commercial diagnostic assay.RESULTS: In patients with HCC, prolidase and AFP values were evaluated according to tumor size, number,presence of macrovascular invasion and BCLC staging classification. Prolidase values were significantly higher in patients with HCC compared with controls(P <0.001). Prolidase levels were significantly associated with tumor size and number(P < 0.001, P = 0.002,respectively). Prolidase levels also differed in patients in terms of BCLC staging classification(P < 0.001).Furthermore the prolidase levels in HCC patients showed a significant difference compared with patients with cirrhosis(P < 0.001). In HCC patients grouped according to tumor size, number and BCLC staging classification, AFP values differed separately(P = 0.032,P = 0.038, P = 0.015, respectively). In patients with HCC, there was a significant correlation(r = 0.616; P< 0.001) between prolidase and AFP values in terms of tumor size, number and BCLC staging classification,whereas the presence of macrovascular invasion did not show a positive association with serum prolidase and AFP levels.CONCLUSION: Considering the levels of both serum prolidase and AFP could contribute to the early diagnosing of hepatocellular carcinoma. | Sevil Uygun Ilikhan Muammer Bilici Hatice Sahin Ayse Semra Demir Akca Murat Can Ibrahim Ilker Oz Berrak Guven M Cagatay Buyukuysal Yucel Ustundag | 2015 | World Journal of Gastroenterology2015，21，22： | 8 |
| 2 | Phosphate adsorption in flocculation processes of aluminium sulphate and poly-aluminium-silicate-sulphate显示文摘 | Jean-Philippe Boisvert Thi Cong To Abderrazak Berrak Carmel Jolicoeur | 1997 | Water Research1997，，8： | 2 |
| 3 | The Role of Household and Business Credit in Banking Crises显示文摘 | Berrak Büyükkarabacak Neven T Valev | | 0，，34： | 1 |
| 4 | Determination of betaxolol in human aqueous humour by highperformance liquid chromatography with fluorescence detection显示文摘 | Berrak D Nursabah EB Ilgaz SY | 2002 | J Chromatogr B2002，772，： | 1 |
| 5 | Phosphate adsorption in flocculation processes of aluminium sulphate and poly-aluminium-silicate-sulphate显示文摘 | Boisvert JP To TC Berrak A | 1997 | WATER RESEARCH1997，31，8： | 1 |
| 6 | Malignancy-asso- ciated hemophagocytic lymphohistiocytosis in pediatric ca- ses: A multicenter study from Turkey 显示文摘 | Celkan T Berrak S Kazanci E | 2009 | Turk J Pedi- atr2009，51，3： | 1 |
| 7 | Long- term safety and efficacy of a once-daily niacin/lovastatin formulation for patients with dyslipidemia 显示文摘 | Kashyap ML McGovern ME BerraK | 2002 | Am J Cardiol2002，89，6： | 1 |
| 8 | Cardiac and pulmonary rehabilitation:Historical perspectives and future needs显示文摘 | Berrak | 1991 | J Cardiopulm Rehabil1991，11，： | 1 |
| 9 | Adenosine Protects Against Indomethacin-Induced Gastric Damage in Rats显示文摘 | Ayhan Bozkurt Meral Yuksel Goncagul Haklar Hizir Kurtel Berrak C. Yegen Inci Alican | 1998 | Digestive Diseases and Sciences1998，，6： | 1 |
| 10 | Nitrosourea efficacy in high-grade glioma: a survival gain analysis summarizing 504 cohorts with 24193 patients显示文摘 | Wolff JE1 Berrak S Koontz Webb SE | 2008 | J Neurooncol2008，88，1： | 1 |
| 11 | Phosphate adsorption in flocculation processes of aluminium sulphate and poly-aluminiumsilicate-sulphate显示文摘 | Boisvert J P To T C Berrak A | 1997 | Water Research1997，31，8： | 1 |
| 12 | Phosphate Adsorption in Flocculation Processes of Alu- minum Sulphate and Poly-aluminum-silicate-sulphate显示文摘 | Jean-Philippe Boisvert Thi Cong To Abderrazak Berrak | 1997 | Water Res1997，31，8： | 1 |
| 13 | Malignancy-associated hemophagocytic lymphohistiocytosis in pediatric cases : a muhicenter study from Turkey 显示文摘 | Celkan T Berrak S Kazanci E | 2009 | Turk J Pediatr2009，51，3： | 1 |
| 14 | Nitrosourea efficacy in high-grade glioma:a survival gain analysis summarizing 504 cohorts with 24193 patients显示文摘 | Wolff JE Berrak S Konntz Webb SE | 2008 | Neurooncol2008，88，： | 1 |
| 15 | Nitrosourea efficacy in high-grade glioma: a survival gain analysis summarizing 504 cohorts with 24193 patients显示文摘 | Johannes E. A. Wolff Su Berrak Susannah E. Koontz Webb Ming Zhang | 2008 | Journal of Neuro-Oncology2008，，1： | 1 |
| 16 | Melatonin Protects Against Oxidative Organ Injury in a Rat Model of Sepsis显示文摘 | G?ksel ?ener Hale Toklu Caner Kapucu Feriha Ercan G?zde Erkanl? Ayhan Ka?maz Metin Tilki Berrak ?. Ye?en | 2005 | Surgery Today2005，，1： | 1 |
| 17 | Clinical features and management of carboplatin-related hypersensitivity reactions in pediatric low-grade glioma 显示文摘 | Genc DB Canpolat C Berrak SG | 2012 | Support Care Cancer2012，20，2： | 1 |
| 18 | Phosphate adsorption in flocculation processes of aluminum sulphate and poly-aluminum-silicate-sulphate 显示文摘 | Boisvert J P To T C Berrak A | 1997 | Water Res1997，31，8： | 1 |
| 19 | Phosphate adsorption in flocculation processes of aluminium sulphate and poly - aluminium - silicate - sulphate 显示文摘 | BOISVERT J P TO T C BERRAK A | 1997 | Water Res1997，31，8： | 1 |
| 20 | Nitrosourea efficacy in high grade glioma: a survival gain analysis summarizing 504 cohorts with 24 193 patients显示文摘 | WOLFF J E A BERRAK S KOONTZ WEBB S E etal | 2008 | J Neurooneol2008，88，： | 1 |
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