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| 1 | Ameliorative effects of bombesin and neurotensin on trinitrobenzene sulphonic acid-induced colitis,oxidative damage and apoptosis in rats显示文摘AIM:To investigate the effects of bombesin (BBS) and neurotensin (NTS) on apoptosis and colitis in an ulcerative colitis model. METHODS:In this study, a total of 50 rats were divided equally into 5 groups. In the control group, no colitis induction or drug administration was performed. Colitis was induced in all other groups. Following the induction of colitis, BBS, NTS or both were applied to three groups of rats. The remaining group (colitis group) received no treatment. On the 11th d after induction of colitis and drug treatment, blood samples were collected for TNF-α and IL-6 level studies. Malondialdehyde (MDA), carbonyl, myeloperoxidase (MPO) and caspase-3 activities, as well as histopathological findings, evaluated in colonic tissues. RESULTS:According to the macroscopic and microscopic findings, the study groups treated with BBS, NTS and BBS + NTS showed significantly lower damage and inflammation compared with the colitis group (macroscopic score, 2.1 ± 0.87, 3.7 ± 0.94 and 2.1 ± 0.87 vs 7.3 ± 0.94;microscopic score, 2.0 ± 0.66, 3.3 ± 0.82 and 1.8 ± 0.63 vs 5.2 ± 0.78, P < 0.01). TNF-α and IL-6 levels were increased significantly in all groups compared with the control group. These increases were significantly smaller in the BBS, NTS and BBS + NTS groups compared with the colitis group (TNF-α levels, 169.69 ± 53.56, 245.86 ± 64.85 and 175.54 ± 42.19 vs 556.44 ± 49.82;IL-6 levels, 443.30 ± 53.99, 612.80 ± 70.39 and 396.80 ± 78.43 vs 1505.90 ± 222.23, P < 0.05). The colonic MPO and MDA levels were significantly lower in control, BBS, NTS and BBS + NTS groups than in the colitis group (MPO levels, 24.36 ± 8.10, 40.51 ± 8.67 and 25.83 ± 6.43 vs 161.47 ± 38.24;MDA levels, 4.70 ± 1.41, 6.55 ± 1.12 and 4.51 ± 0.54 vs 15.60 ± 1.88, P < 0.05). Carbonyl content and caspase-3 levels were higher in the colitis and NTS groups than in control, BBS and BBS + NTS groups (carbonyl levels, 553.99 ± 59.58 and 336.26 ± 35.72 vs 209.76 ± 30.92, 219.76 ± 25.77 and 220.34 ± 36.95;caspase-3 levels, 451.70 ± 68.27 and 216.20 ± 28.17 vs 28.60 ± 6.46, 170.50 ± 32.37 and 166.50 ± 30.95, P < 0.05). CONCLUSION:The results of this study suggest BBS and NTS, through their anti-inflammatory actions, support the maintenance of colonic integrity and merit consideration as potential agents for ameliorating colonic inflammation. | Alper Akcan Sebahattin Muhtaroglu Hulya Akgun Hizir Akyildiz Can Kucuk Erdogan Sozuer Alper Yurci Namik Yilmaz | 2008 | World Journal of Gastroenterology2008，14，8： | 14 |
| 2 | Integrated model for earthquake risk assessment using neural network and analytic hierarchy process:Aceh province,Indonesia显示文摘Catastrophic natural hazards,such as earthquake,pose serious threats to properties and human lives in urban areas.Therefore,earthquake risk assessment(ERA)is indispensable in disaster management.ERA is an integration of the extent of probability and vulnerability of assets.This study develops an integrated model by using the artificial neural network–analytic hierarchy process(ANN–AHP)model for constructing the ERA map.The aim of the study is to quantify urban population risk that may be caused by impending earthquakes.The model is applied to the city of Banda Aceh in Indonesia,a seismically active zone of Aceh province frequently affected by devastating earthquakes.ANN is used for probability mapping,whereas AHP is used to assess urban vulnerability after the hazard map is created with the aid of earthquake intensity variation thematic layering.The risk map is subsequently created by combining the probability,hazard,and vulnerability maps.Then,the risk levels of various zones are obtained.The validation process reveals that the proposed model can map the earthquake probability based on historical events with an accuracy of 84%.Furthermore,results show that the central and southeastern regions of the city have moderate to very high risk classifications,whereas the other parts of the city fall under low to very low earthquake risk classifications.The findings of this research are useful for government agencies and decision makers,particularly in estimating risk dimensions in urban areas and for the future studies to project the preparedness strategies for Banda Aceh. | Ratiranjan Jena Biswajeet Pradhan Ghassan Beydoun Nizamuddin Ardiansyah Hizir Sofyan Muzailin Affan | 2020 | Geoscience Frontiers2020，11，2： | 5 |
| 3 | Melatonin reduces bacterial translocation and apoptosis in trinitrobenzene sulphonic acid-induced colitis of rats显示文摘AIM: To investigate the effects of exogenous melatonin on bacterial translocation and apoptosis in a rat ulcerati-ve colitis model. METHODS: Rats were randomly assigned to three groups: groupⅠ: control, group Ⅱ: experimental colitis, group Ⅲ: colitis plus melatonin treatment. On d 11 after colitis, plasma tumor necrosis factor-α, portal blood endotoxin levels, colon tissue myeloperoxidase and caspase-3 activity were measured. Bacterial translocation was quantified by blood, lymph node, liver and spleen culture. RESULTS: We observed a significantly reduced inciden-ce of bacterial translocation to the liver, spleen, mesen-teric lymph nodes, portal and systemic blood in animals treated with melatonin. Treatment with melatonin signifi-cantly decreased the caspase-3 activity in colonic tissues compared to that in trinitrobenzene sulphonic acid-trea-ted rats (16.11 ± 2.46 vs 32.97 ± 3.91, P < 0.01). CONCLUSION: Melatonin has a protective effect on ba-cterial translocation and apoptosis. | Alper Akcan Can Kucuk Erdogan Sozuer Duygu Esel Hizir Akyildiz Hulya Akgun Sabahattin Muhtaroglu Yucel Aritas | 2008 | World Journal of Gastroenterology2008，14，6： | 5 |
| 4 | Predisposing factors and surgical outcome of complicated liver hydatid cysts显示文摘AIM: To evaluate the predisposing factors for peritoneal perforation and intrabiliary rupture and the effects of these complications on surgical outcome in liver hydatid disease.METHODS: A total of 372 patients with liver hydatid cysts who had undergone surgical treatment were evaluated retrospectively. Twenty eight patients with peritoneal perforation, 93 patients with spontaneous intrabiliary perforation, and 251 patients with noncomplicated hydatid cysts were treated in our clinics.RESULTS: When the predisposing factors for complications were evaluated, younger age, superf icial position, and larger cyst dimensions (P < 0.05; range, 0.0010.017) increased peritoneal perforation rates. It was shown that older age increased cyst dimensions, and presence of multiple and bilobar cysts increased intrabiliary rupture rates (P < 0.05; range, 0.0010.028). Partial pericystectomy and drainage was the most frequent surgical procedure in all groups (71.6%). The incidence of postoperative complications in the peritoneal perforated group, in the intrabiliary ruptured group, and in the noncomplicated group was 25%, 16.1% and 5.5%, respectively. When compared, complication rates were significantly different (P = 0.002). When length of hospital stay was compared, there was no signif icant difference between the groups (P > 0.05). The overall recurrence rate was 3.8% (14 patients), but there was not any statistical difference among the patient groups (P = 0.13). The early postoperative mortality rate was 1.1%. CONCLUSION: In peritoneally perforated and intrabiliary ruptured cases, the most important steps are irrigation of the peritoneal cavity and clearance of the cystic material from the biliary tree. | Alper Akcan Erdogan Sozuer Hizir Akyildiz Zeki Yilmaz Ahmet Ozturk Altay Atalay | 2010 | World Journal of Gastroenterology2010，16，24： | 4 |
| 5 | Coastal erosion in eastern black sea region, Turkey显示文摘 | Omer Yuksek Hizir Onsoy Alin R B | 1995 | Coastal Engineering1995，，26： | 1 |
| 6 | Feasibility of single-stage resection and primary anastomosis in patients with acute noncomplicated sigmoid volvulus显示文摘 | Alper Akcan Hizir Akyildiz Tarik Artis Namik Yilmaz Erdogan Sozuer | 2007 | The American Journal of Surgery2007，，4： | 1 |
| 7 | Adenosine Protects Against Indomethacin-Induced Gastric Damage in Rats显示文摘 | Ayhan Bozkurt Meral Yuksel Goncagul Haklar Hizir Kurtel Berrak C. Yegen Inci Alican | 1998 | Digestive Diseases and Sciences1998，，6： | 1 |
| 8 | Laparoscopic radiofrequency thermal ablation of neuroendocrine hepatic metastases: Long-term follow-up显示文摘 | Hizir Yakup Akyildiz Jamie Mitchell Mira Milas Allan Siperstein Eren Berber | 2010 | Surgery2010，，6： | 1 |
| 9 | Identification of discrete- time bilinear systems through equivalent linear models显示文摘 | Hizir N B Phan M Q Betti R | 2012 | Nonlinear Dynamics2012，69，4： | 1 |
| 10 | Multimodality treatment of neuroendocrine liver metastases显示文摘 | Koray Karabulut Hizir Yakup Akyildiz Craig Lance Federico Aucejo Gordon McLennan Orhan Agcaoglu Allan Siperstein Eren Berber | 2011 | Surgery2011，，2： | 1 |
| 11 | Feasibility of single-stage resection and primary anastomosis in patients with acute noncomplicated sigmoid volvulus显示文摘 | Alper Akcan Hizir Akyildiz Tarik Artis Namik Yilmaz Erdogan Sozuer | 2007 | The American Journal of Surgery2007，，4： | 1 |
| 12 | Cold restraint stress-induced gastric mucosal dysfunction role of nitric oxide显示文摘 | Tamer Coskun MD Berrak C. Ye?en MD Inci Alican MD PhD ?nder Peker MD Dr. Hizir Kurtel MD | 1996 | Digestive Diseases and Sciences1996，，5： | 1 |
| 13 | Characterization of interfacial morphology in polymer electrolyte fuel cells:Micro-porous layer and catalyst layer surfaces显示文摘 | HIZIR F E URAL S O KUMBUR E C et a/ | 2010 | Journal of Power Sourc es2010，195，： | 1 |
| 14 | Granulomatous lobular- mastitis: a complex diagnostic and therapeutic problem 显示文摘 | Alper A Hizir A Mehmet A | 2006 | Word J Surg2006，30，8： | 1 |
| 15 | Obtaining,structure,microstructure and dielectric characteristics of ceramics and thin films of ferro-piezoelectric materials based on the PZT system显示文摘This paper presents the results of studies of the structure,microstructure,dependences of the piezoelectric properties on the electric field(dielectric hysteresis loops,reversible nonlinearity,deformation characteristics)and dielectric properties of the ceramic material PCR-13(based on the PZT system)in the temperature range 300-900K and frequencies of an alternating electric field(25÷2·10^(6))Hz.The character of the obtained dependences made it possible to attribute PCR-13 to ferro-hard materials.Using the HF cathodic sputtering method,PCR-13 thin films were fabricated on Si(001)substrates.It is shown that they are polycrystalline textured,while in comparison with bulk material,the film contains tensile stresses of the unit cell in the plane of the substrate and compresses in the perpendicular direction with the valueε_(33)=-0.018.The capacitance-voltage characteristics of the Al/PCR-13/Si/Al heterostructure were studied.The reasons for the revealed patterns are discussed. | Inna Andryushina Anatoliy Pavlenko Sergey Zinchenko Konstantin Andryushin Lidiya Shilkina Ekaterina Glazunova Alexandr Nagaenko Daniil Stryukov Hizir Sadykov Larisa Reznichenko | 2020 | Journal of Advanced Dielectrics2020，10，1： | 0 |
| 16 | The influence of thermodynamic history and external influences on the electrophysical properties of ferropiezoceramic materials based on a multicomponent system PZT-PMN-PZN+SiO_(2)显示文摘This paper presents the results of a comprehensive study of the industrially produced ferro-piezoelectric ceramic material based on the PbZrO_(3)-PbTiO_(3)-PbMn_(1/3)Nb_(2/3)O_(3)-PbZn_(1/3)Nb_(2/3)O_(3)+SiO_(2)system.Studies have confirmed that this material refers to ferrorigid materials with high coercive fields,stable dielectric properties in a wide temperature range,practically no Curie temperature hysteresis,as well as low controllability of the dielectric constant and deformation characteristics by constant bias electric fields.The revealed correlation between dielectric,deformation characteristics and dielectric hysteresis allows us to consider this material as promising for devices operating in power modes:piezotransformers,highly loaded ultrasonic devices,piezoelectric motors,etc. | Konstantin Andryushin Inna Andryushina Hizir Sadykov Alexandr Nagaenko Larisa Reznichenko | 2020 | Journal of Advanced Dielectrics2020，10，1： | 0 |
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