|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | Next-Generation Stool DNA Test Accurately Detects Colorectal Cancer and Large Adenomas显示文摘 | David A. Ahlquist Hongzhi Zou Michael Domanico Douglas W. Mahoney Tracy C. Yab William R. Taylor Malinda L. Butz Stephen N. Thibodeau Linda Rabeneck Lawrence F. Paszat Kenneth W. Kinzler Bert Vogelstein Niels Chr. Bjerregaard S?ren Laurberg Henrik Toft S? | 2012 | Gastroenterology2012，，2： | 7 |
| 3 | Surgical stress and cytoskeletal changes in lens epithelial cells following manual and femtosecond laser-assisted capsulotomy显示文摘AIM:To study the effect of mechanical stress on the cytoskeleton in lens epithelial cells following conventional phacoemulsification surgery(CPS)and femtosecond laserassisted cataract surgery(FLACS).METHODS:The cytoskeleton of the epithelial cells of the anterior lens capsules(ALC)removed by CPS and FLACS was examined by immunohistochemistry.Expression of the intermediate filament,glial fibrillary acidic protein(GFAP),and glutamine synthetase(GS)immunoreactivity were detected.In order to map the actin network of cells,fluorescently labeled phalloidin was used.The samples were examined using confocal laser scanning microscopy.RESULTS:GFAP expression was visible in a larger number of the epithelial cells after CPS compared to FLACS.In CPS sample’s epithelial cells,GFAP immunoreactivity indicated robust morphological change.Regarding the actin filaments,the presence of tubular elements connecting epithelial cells,regular actin pattern and marked cortical network after CPS were found.Following FLACS,the actin cytoskeleton of the epithelial cells remained densely structured,and the tubular elements were undetectable,however,the above-mentioned regular actin pattern and the marked cortical network were visible.CONCLUSION:The conventional removal of the ALC induces more robust changes of the cytoskeleton of the lens epithelial cells. | ANDrea Krisztina Sükosd Krisztina Szabadfi Edina Szabó-Meleg Beáta Gáspár Pavel Stodulka Gyorgy SétálóJr Róbert Gábriel Miklós Nyitrai Zsolt Biró Hajnalka Abrahám | 2020 | International Journal of Ophthalmology(English edition)2020，13，6： | 2 |
| 4 | Computational models for sandwich panels and shells显示文摘 | Noor A K Burton W S Bert C W | 1996 | Applied Mechanics Reviews1996，4，3： | 1 |
| 5 | Hydrostatic pressure and cellular respiration:are the values observed post-decompression representative of the reality under pressure?显示文摘 | Theron M Sébert P | 2003 | Mitochondrion2003，3，2： | 1 |
| 6 | Ultrasound biomicroscopy in chronic ocular hypotony:its impact on diagnosis and management显示文摘 | Sigrid R Peter S Bert E Karl BS Gunter K | 2002 | Retina2002，22，5： | 1 |
| 7 | Polyamines, indolamines, and catecholamines in gills and haemolymph of the euryhaline crab, Eriocheir sinensis. Effects of high pressure and salinity显示文摘 | A. Péqueux P. Le Bras C. Cann-Moisan J. Caroff P. Sébert | 2002 | Crustaceana (-)2002，，3： | 1 |
| 8 | Physical and bioticdrivers of plant distribution across estuarine salinity gradients显示文摘 | Crain C M Silliman B R Bertness S L | 2004 | Ecology2004，85，： | 1 |
| 9 | Regional Activation of the Cancer Genome by Long-Range Epigenetie Remodeling显示文摘 | BERT S A ROBINSON M D STRBENAC D | 2012 | Cancer Cell2012，23，1： | 1 |
| 10 | Role of life style and aging on the longitudinal change in cardiorespiratory fitness显示文摘 | ACLS ANDREW S JACKSON XUEMEI SUI JAMES R HE BERT | 2009 | Arch Int Ern Med2009，169，19： | 1 |
| 11 | Heme oxygenase-1 expression inhibits dendritic cell maturation and proinflammatory function but conserves IL 10 expression显示文摘 | Chauveau C Remy S Royer P J Hill M Tanguy Royer S Hu- bert F X | 2005 | Blood2005，106，： | 1 |
| 12 | The miR - 15/107 group of microRNA genes: evolutionary biology, cellular functions, and roles in human diseases显示文摘 | FINNERTY J R WANG W X HI'BERT S S | 2010 | J Mol Biol2010，402，3： | 1 |
| 13 | Expression of Smads during in vitro transdifferentiation of hepatic stellate cells to myofibroblasts显示文摘 | Steven D Maike S Bert D | 2001 | Biochemical and Biophysical Research Communications2001，283，3： | 1 |
| 14 | 显示文摘 | Miclau M He' bert S Retoux R | 2005 | J Solid State Chem2005，178，： | 1 |
| 15 | Population structure of the Spanish sardine Sardinella auriia:natural morphological variation in a genetically homogenous population显示文摘 | KINSEY S T ORSOY T BERT T M | 1994 | Marine Biology1994，118，： | 1 |
| 16 | Neurodegeneration in newborn rats following propofol and sevoflurane anesthesia 显示文摘 | Bercker S Bert B Bittigau P | 2009 | Neurotox Res2009，16，2： | 1 |
| 17 | Stable isotopic evidence for climate and basin evolu- tion of the Late Cretaceous Songliao basin, China 显示文摘 | Chamberlain C P Wan X Q Graham S A Carroll A R Doeb- bert A C Sageman B B Blisniuk P Kent-Corson M L Wang Z Wang C S | 2013 | Palaeo- geogr Palaeoclimatol Palaeoecol2013，385，： | 1 |
| 18 | Plant zona- tion in low-latitude salt marshes disentangling the roles of flooding, salinity and competition 显示文摘 | PENNINGS S C GRANT M B BERTNESS M D | 2006 | Journal of Ecology2006，93，159： | 1 |
| 19 | A novel cell culture model for studying differentiation and apoptosis in the mouse mammary gland显示文摘 | Katrina E G Bert B Rachel S C | 2000 | Breast Cancer Res2000，2，3： | 1 |
| 20 | Airgap analysis of floating structures:first-and second-order transfer functions from system identification显示文摘 | Bert S Steven R W | | 0，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员