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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | 阵发性心房颤动患者心房不应期的离散度研究显示文摘 目的研究表明心房颤动(简称房颤)患者心房不应期(AERP)离散度较无房颤患者显著增加,但临床获得多部位心房不应期存在一定难度.单相动作电位记录发现,房颤时心房肌被近乎连续的快速的冲动所激动,基于这一发现,房颤时的颤动间期(AFI)可用来评价AERP.但既往研究中的记录位点的数目、记录长短,所用参数均存在较大差异.本研究采用左、右两房多部位记录,分析多个AFI参数的离散度来评价阵发性房颤患者AERP的离散度.…… | 李真 杨延宗 Eva Hertervig Jonas Carlson Camilla Johansson S Bertil Olsson Shiwen Yuan | 2004 | 中国心脏起搏与心电生理杂志2004，，z1： | 1 |
| 3 | Association of a lack of psychosocical resourse and the risk of giving birth to maall for gestational age infants: a stress hypothesis显示文摘 | ELISABETH D K BERTIL S H PEROLOF O | 2000 | BJ of Obstetrics and Gynaecology2000，107，1： | 1 |
| 4 | Oral direct thrombin inhibitor AZD0837 for the prevention of stroke and systemic embolism in patients with nonvalvular atrialfi brillation:A Phase Ⅱ study of AZD0837in patients who are appropriate for but unable or unwilling to take vitamin K antagonist t显示文摘 | Lip Gregory Y H Rasmussen L H Bertil O S | | 0，，02： | 1 |
| 5 | N-Terminal Pro-Brain Natriuretic Peptide and Other Risk Markers for the Separate Prediction of Mortality and Subsequent Myocardial Infarction in Patients With Unstable Coronary Artery Disease: A Global Utilization of Strategies To Open occluded arteries (显示文摘 | Stefan K James Bertil Lindahl Agneta Siegbahn Mats Stridsberg Per Venge Paul Armstrong Elliot S Barnathan Robert Califf Eric J Topol Maarten L Simoons Lars Wallentin | 2003 | Circulation2003，，3： | 1 |
| 6 | On oblique contact of creeping solids 显示文摘 | Joachim Bertil S | 2002 | Journal of the Mechanics and Physics of Solid2002，50，10： | 1 |
| 7 | Adhesive joints for structural timber/glass applications:Experimental testing and evaluation methods显示文摘 | Louise B Erik S Bertil E | 2012 | International Journal of Adhesion&Adhesives2012，35，： | 1 |
| 8 | CUDASW + + : optimizing smith- waterman sequence database searches for cuda-enabled graphics processing units显示文摘 | Liu Y Douglas M Bertil S | 2009 | BMC Research Notes2009，2，1： | 1 |
| 9 | Ultrasound enhanced thrombolysis in experiment retinal vein occlusion in the rabit显示文摘 | Jǒregn L Jonas C S Bertil O | 1998 | Br J Ophthalmol1998，82，12： | 1 |
| 10 | Stent implantation,but not pathogen burden,is associated with plasma C-reactive protein and interleukin-6 levels after percutaneous coronary intervention in patients with stable angina pectoris显示文摘 | S vane Bertil MD Jens MD | 2005 | Am Heart J2005，149，5： | 1 |
| 11 | Streaming algorithms for bio logical sequence alignment on GPUs 显示文摘 | Liu W G Bertil S Gerrit V | 2007 | IEEE Trans on Paral- lel and Distrib Systems2007，18，9： | 1 |
| 12 | Biokinetics and radiation doses for carbon-14 urea in adults and children undergoing the Helicobacter pylori breath test显示文摘 | Sigrid Leide-Svegborn Kristina Stenstr?m Mikael Olofsson S?ren Mattsson Lars-Erik Nilsson Bertil Nosslin Kinga Pau Lennart Johansson Bengt Erlandsson Ragnar Hellborg G?ran Skog | 1999 | European Journal of Nuclear Medicine1999，，6： | 1 |
| 13 | Biokinetics and radiation doses for carbon-14 urea in adults and children undergoing the Helicobacter pylori breath test显示文摘 | Sigrid Leide-Svegborn Kristina Stenstr?m Mikael Olofsson S?ren Mattsson Lars-Erik Nilsson Bertil Nosslin Kinga Pau Lennart Johansson Bengt Erlandsson Ragnar Hellborg G?ran Skog | 1999 | European Journal of Nuclear Medicine1999，，6： | 1 |
| 14 | CUDA-BLASTP: Accelera- ting BLASTP on CUDA-Enabled Graphics Hardware 显示文摘 | Weiguo L Bertil S Wolfgang M W | 2011 | IEEE/ACM Transations on Computational Biology And Bioin- formatics2011，8，6： | 1 |
| 15 | N-Terminal Pro-Brain Natriuretic Peptide and Other Risk Markers for the Separate Prediction of Mortality and Subsequent Myocardial Infarction in Patients With Unstable Coronary Artery Disease: A Global Utilization of Strategies To Open occluded arteries (显示文摘 | Stefan K James Bertil Lindahl Agneta Siegbahn Mats Stridsberg Per Venge Paul Armstrong Elliot S Barnathan Robert Califf Eric J Topol Maarten L Simoons Lars Wallentin | 2003 | Circulation2003，，3： | 1 |
| 16 | Using recon? gurable hardware to accelerate multiple sequence alignment with ClustalW 显示文摘 | Tim O Bertil S Darran N | 2005 | Bioinformaties2005，21，6： | 1 |
| 17 | Stent implantation,but not pathogen burden, is associated with plasma C-reactive protein and interleukin-6 levels after percutaneous coronary intervention in patients with stable angina pectoris显示文摘 | Nawsad S Bertil S Jens MD | 2005 | Am Heart J2005，149，5： | 1 |
| 18 | High performance pro- tein sequence database scanning on the Cell Broadband Engine 显示文摘 | Adrianto W Bertil S Huiliang Zh | 2009 | Scientific Programming2009，17，12： | 1 |
| 19 | Multi-threaded vectorized dis- tance matrix computation on the CELL/BE and x86/SSE2 ar- chitecture 显示文摘 | Adrianto W Chee K K Bertil S | 2010 | Bioinformatics2010，26，10： | 1 |
| 20 | Recording of Monophasic Action Potentials in Swine Using a Modified-tip Platinum Ablation Catheter and Electroanatomical Mapping System(摘要 )显示文摘Objective:In this study, the feasibility to evaluate the global myocardial activation and repolarization sequence using the electroanatomical mapping system and MAP recording technique via the modified platinum catheter was explored in swine. Methods:Ten healthy pigs (50-55 kg) were anaesthetized with pentobarbital and catamine, intubated and ventilated. Four vascular accesses were obtained. A modified small tip ablation catheter (Navi-Star, Biosense Webster), the end surface of tip electrode was 0.81 mm 2 and 1 mm in diameter, was used for MAP recording. The MAP electrograms were recorded between the tip (exploring electrode) and the ring electrode proximal to the tip (indifferent electrode). The catheter was intentionally positioned perpendicular to endocardium with slight contact pressure to allow MAP recording with a satisfactory amplitude and morphology. All MAP recordings were performed during sinus rhythm.Results:The MAP recordings were obtained from both right atrium and left ventricle in 9 pigs, while the right ventricle was mapped during the same procedure in 2. The MAP electrograms were recorded from both right and left atrium via a patent foramen ovale in 1 pig. Totally, the right atrium was mapped in all the 10 pigs, right ventricle in 2, left atrium in 1 and left ventricle in 9. The MAP electrograms were recorded from 733 sites of right atrium, 179 of right ventricle, 63 of left atrium and 517 of left ventricle. There were 62% of right and 54% left atrial MAPamp satisfied the earlier defined criteria of acceptable MAP, i.e., the MAPamp ≥ 3 mV in atrium, while 32% of right and 38% of left ventricular MAPamp were ≥ 10 mV. The mean MAPamp was 5.7±3.1 mV in right atrium, 12.4±2.5 mV in right ventricle, 4.5±1.9 mV in left atrium and 13.8±4 mV in left ventricle. The local activation was more distinctly and easily defined using MAP recordings with the computer-assisted manual determination, so were the end-of-repolarization points. The global activation and repolarization sequence and MAP duration distribution were constructed in all the pigs both in atrium and in ventricle. The activation sequence both in atrium and ventricle could be determined in all pigs three-dimensionally. In the right atrium two preferential inter-nodal conductions were evident, along the crista terminalis and atrial septum from the sinus node area down to the atrioventricular node. Two main connections, Bachman’s bundle and coronary sinus region, constitute the electrophysiologic pathways for right to left atria activation during sinus rhythm. The earliest ventricular activation was located at the high left ventricular septum and followed by radial activation sequence in both ventricles. The posterior base segments of left and right ventricle were activated latest. In the 4 pigs whose chest was opened after sacrifice, no visual detectable injury or bleeding was found in the endocardium and valvular structure. No perforation and no epicardial effusion were observed either.Conclusion: MAP electrograms recorded using the modified platinum catheter were associated with a stable baseline and higher amplitude. MAP recording in difficult areas in all the four chambers of the swine heart was facilitated by the modification of the tip electrode. The construction of the global myocardial activation and repolarization sequence is feasible using the electroanatomical mapping system and MAP recording technique via the modified catheter. The ability to combine MAP recording and spatial information provides a unique tool for both research and clinical electrophysiology. | SHAO Wenliu SHIA Wenyuan Ole Kongstad S Bertil Olsson Department of Cardiology, First Affiliated Hospital of Dalian Medical University. University Hospital, Lund, Sweden | 2002 | 海南医学2002，13，12： | 1 |
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