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| 1 | Should dopamine be the first line inotrope in the treatment of neonatal hypotension? Review of the evidence显示文摘AIM: To determine if dopamine is effective in treating neonatal hypotension and safe to use comparing to other inotropes. METHODS: This is a review of evidence on inotropic treatment of neonatal hypotension. Databases searched were MEDLINE and the Cochrane Library, a total of 134 studies were identified. Only studies with high quality evidence(level 1a and b and 2a) were included. After review, only eight studies were included in the final analysis. Pooled risk ratios derived for each outcome [Mantel-Haenzel(M-H) fixed effect] with CI, as reported in the Cochrane reviews were plotted in forest plot form. RESULTS: Eight articles met inclusion criteria, which all included treatment in preterm infants. Dopamine increased mean arterial blood pressure(BP)(n = 163; r = 0.88, 95%CI: 0.76 to 0.94) and systolic BP(n = 142; r = 0.81, 95%CI: 0.42 to 0.94) comparing to placebo. Dopamine has been shown overall to be statistically more effective in increasing BP than dobutamine(n = 251, r = 0.26, 95%CI: 0.20-0.32). However there were no differences in short term outcomes(periventricular leucomalacia, periventricular haemorrhage) and mortality between both drugs. There is no statistical evidence of dopamine being more effective than adrenaline or corticosteroids. There was no difference in morbidity and mortality outcomes when dopamine was compared to hydrocortisone(RR 1.81, 95%CI: 0.18 to 18.39) or adrenaline. CONCLUSION: In preterms, dopamine is the most studied drug, and we suggest it could be used as first line treatment in hypotension. | Sadaf I Bhayat Harsha MS Gowda Michael Eisenhut | 2016 | World Journal of Clinical Pediatrics2016，5，2： | 3 |
| 2 | Pediatric oral HIV research in the developing world 显示文摘 | Yengopal V Bhayat A Coogan M | 2011 | Adv Dent Res2011，23，1： | 1 |
| 3 | Pediatric oral HIV research in the developing world显示文摘 | Yengopal V Bhayat A Coogan M | 2011 | Adv Dent Res2011，23，1： | 1 |
| 4 | 维多株单抗在炎症性肠病手术患者中的应用:临床试验和上市后评估显示文摘背景:炎症性肠病(IBD)患者常需手术治疗,但其长期接受免疫治疗会增加术后并发症的风险。本研究从临床试验和上市后应用两个层面,调查接受维多株单抗(一种已被批准用于中重度IBD的肠道选择性抗体)治疗的炎症性肠病患者术后并发症的发生频率。方法:本研究基于GEMINI 1、GEMINI 2两项临床试验的安全性数据以及长期安全性研究数据进行析因分析,上述研究对象为接受结肠切除术或小肠切除术的IBD患者。同时,本研究也对维多株单抗全球安全性数据库进行上市后分析(截止日期:2016年5月19日)。使用Medical Dictionary for Regulatory Activities推荐术语对术后并发症相关的不良事件进行定义。结果:GEMINI 1和GEMINI 2研究共计纳入58例手术病例,维多株单抗治疗者和安慰剂对照者术后并发症发生率分别为5.9%(3/51)和14.3%(1/7)。在长期安全性研究中,2,243例病例中有157例(7%)接受了结肠或小肠切除手术,其中11例(7%)出现术后并发症。维多株单抗末次服药与手术的中位间隔时间,在GEMINI 1试验中为23天,在GEMINI 2试验中为20天,在长期安全性研究中为39-40天。上市后,基于46,978例维多株单抗服用者的分析显示,仅19例病例报道了术后并发症。结论:在临床试验中,结肠或小肠切除术后并发症并不常见,其在维多株单抗与安慰剂对照之间的差异甚微。在上市后分析中,术后并发症发生频率似乎非常低。 | Bo Shen Aimee Blake Karen Lasch Michael Smyth Fatima Bhayat | 2019 | Gastroenterology Report2019，7，5： | 1 |
| 5 | Correlating dental caries with oral bacteria and the buffering capacity of saliva in children in Madinah, Saudi Arabia显示文摘 | Bhayat A Ahmad MS Hifnawy T | 2013 | J Int Soc Prev Community Dent2013，3，1： | 1 |
| 6 | Predictive value of group I oral lesions for HIV infection显示文摘 | Bhayat A Yengopal V Rudolph M | 2010 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2010，109，5： | 1 |
| 7 | The impact of service-learning on two groups of South African dental students显示文摘 | Bhayat A Vergotine G Yengopal V | | 0，，11： | 1 |
| 8 | The incidence of and mortality from leukaemias in the UK:a general population-based study显示文摘 | Bhayat F Das-Gupta E Smith C | 2009 | BMC Cancer2009，9，： | 1 |
| 9 | Oral health status of 12-year-old male schoolchildren in Medina, Saudi Arabia 显示文摘 | Bhayat A Ahmad MS | 2014 | East Mediterr Health J2014，20，11： | 1 |
| 10 | Do more mature preterm babies with surgical necrotizing enterocolitis predominantly develop the colonic disease?显示文摘Background The primary aim was to scrutinize our hypothesis:“Do more mature preterm(MMP)babies with surgical necrotizing enterocolitis(NEC)predominantly develop the colonic disease and are different in their response and behaviour in comparison to exceedingly preterm(EP)babies?”Secondary outcomes were to define time taken in developing NEC,time from diagnosis to laparotomy,requirement of parenteral nutrition(PN),and ventilatory support.Methods We defined MMP babies as≥30 weeks of gestation and EP babies as≤29 weeks+6 days of gestation.Inclusion criteria were all babies<37 weeks with NEC requiring surgery(called surgical NEC group).Data were collected retrospectively and analyzed using QuickCalcs.Results Of the total,41%(97/234)of babies underwent laparotomy between 2010 and 2019.Totally,81%were EP and 19%were MMP babies.Pure colonic involvement was seen in 9%of EP babies in comparison to 56%in the MMP babies(p=0.0001).Involvement of only the small bowel was seen in two-thirds of EP babies in comparison to only one-third in MMP babies(p=0.01).EP cohort required PN for 82 days(median)in comparison to 17 days(median)in the MMP cohort(p=0.001).Ventilation requirement in the EP group versus the MMP group was 24 vs 9 days(median),respectively(p=0.0006).Conclusions MMP babies predominantly developed colonic disease,whereas EP babies predominantly developed small bowel disease.EP babies required a longer duration of PN and ventilation support.This study opens a new area of research to differentiate pathogenesis and maturation patterns of the small and large bowels in babies with NEC. | Chandrasen K Sinha Iona Ashworth Sarah Martin Sadaf Bhayat Anay Kulkarni | 2021 | World Journal of Pediatric Surgery2021，4，1： | 0 |
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