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| 1 | Blood Pressure Associated with Arsenic Methylation and Arsenic Metabolism Caused by Chronic Exposure to Arsenic in Tube Well Water显示文摘Objective The effects of arsenic exposure from drinking water, arsenic metabolism, and arsenic methylation on blood pressure(BP) were observed in this study. Methods The BP and arsenic species of 560 participants were determined. Logistic regression analysis was applied to estimate the odds ratios of BP associated with arsenic metabolites and arsenic methylation capability. Results BP was positively associated with cumulative arsenic exposure(CAE). Subjects with abnormal diastolic blood pressure(DBP), systolic blood pressure(SBP), and pulse pressure(PP) usually had higher urinary i As(inorganic arsenic), MMA(monomethylated arsenic), DMA(dimethylated arsenic), and TAs(total arsenic) than subjects with normal DBP, SBP, and PP. The i As%, MMA%, and DMA% differed slightly between subjects with abnormal BP and those with normal BP. The PMI and SMI were slightly higher in subjects with abnormal PP than in those with normal PP. Conclusion Our findings suggest that higher CAE may elevate BP. Males may have a higher risk of abnormal DBP, whereas females have a higher risk of abnormal SBP and PP. Higher urinary i As may increase the risk of abnormal BP. Lower PMI may elevate the BP. However, higher SMI may increase the DBP and SBP, and lower SMI may elevate the PP. | WEI Bing Gan YE Bi Xiong YU Jiang Ping YANG Lin Sheng LI Hai Rong XIA Ya Juan WU Ke Gong | 2017 | Biomedical and Environmental Sciences2017，30，5： | 9 |
| 2 | Rh-incompatible hemolytic disease of the newborn in Hefei显示文摘BACKGROUND Anti-D antibody is not the common cause of Rh-isoimmunization in Chinese neonatal jaundice.Recent change in national population policy has followed by an increase in Rh-isoimmunization related hemolytic disease of the newborn(HDN).Unfortunately,regional status of Rh-HDN is unavailable.We hypothesize that Rh-HDN in our region is most commonly due to anti-E antibody.AIM To investigate the prevalence of hemolytic disease of the newborn due to Rhisoimmunization in Hefei City.METHODS Retrospective review of data obtained from Children’s Hospital of Anhui and Hefei Blood Center between January 2017 and June 2019.Status of minor blood group antibody was studied in the corresponding mothers.RESULTS Totally 4138 newborns with HDN admitted during the study period and 116(2.8%)received blood exchange transfusion(BET).Eighteen newborns(0.43%)with proven Rh-incompatible HDN were identified.All were not the first-born baby.Thirteen mothers were RhD(+)(72%)and five were RhD(-).The distribution of Rh-related antibodies in mothers was ten anti-E(55%),five anti-D(27%),and for one anti-C,anti-c,and anti-E/c(6%)each.Thirteen(72.2%)were qualified for BET,relative risk for BET was 28.9 as compared to other types of HDN,but only 10 received due to parenteral refusal.All(100%)RhD related HDN received BET which is not significantly different from RhE related HDN(81.8%).CONCLUSION As expected,all Rh-incompatible HDN newborns were not the first-born.Contrary to the Caucasian population,anti-D induced HDN is not the most common etiology.In our region,anti-E(11/18,61%)is the most common cause of Rh-HDN. | Shao-Hua Bi Liang-Liang Jiang Li-Ying Dai Hong Zheng Jian Zhang Li-Li Wang Chao Wang Qiao Jiang Yu Liu Yong-Li Zhang Juan Wang Chao Zhu Guang-Hui Liu Ru-Jeng Teng | 2019 | World Journal of Clinical Cases2019，7，20： | 7 |
| 3 | Integrin-interacting protein Kindlin-2 induces mammary tumors in transgenic mice显示文摘Kindlin-2, an integrin-interacting protein, regulates breast cancer progression. However, currently, no animal model to study the role of Kindlin-2 in the carcinogenesis of mammary gland is available. We established a Kindlin-2 transgenic mouse model using a mammary gland-specific promoter, mammary tumor virus(MMTV) long terminal repeat(LTR). Kindlin-2 was overexpressed in the epithelial cells of the transgenic mice. The mammary gland ductal trees were found to grow faster in MMTV-Kindlin-2 transgenic mice than in control mice during puberty. Kindlin-2 promoted mammary gland growth as indicated by more numerous duct branches and larger lumens, and more alveoli were formed in the mammary glands during pregnancy under Kindlin-2 overexpression. Importantly, mammary gland-specific expression of Kindlin-2 induced tumor formation at the age of 55 weeks on average. Additionally, the levels of estrogen receptor and progesterone receptor were decreased, whereas human epidermal growth factor receptor 2 and β-catenin were upregulated in the Kindlin-2-induced mammary tumors. These findings demonstrated that Kindlin-2 induces mammary tumor formation via activation of the Wnt signaling pathway. | Bing Li Xiaochun Chi Jiagui Song Yan Tang Juan Du Xiaokun He Xiaoran Sun Zhenwu Bi Yunling Wang Jun Zhan Hongquan Zhang | 2019 | Science China(Life Sciences)2019，62，2： | 6 |
| 4 | Bioremediation of Hexavalent Chromium Pollution by Sporosarcina saromensis M52 Isolated from Offshore Sediments in Xiamen, China显示文摘Objective Cr(VI)removal from industrial effluents and sediments has attracted the attention of environmental researchers.In the present study,we aimed to isolate bacteria for Cr(VI)bioremediation from sediment samples and to optimize parameters of biodegradation.Methods Strains with the ability to tolerate Cr(VI)were obtained by serial dilution and spread plate methods and characterized by morphology,16S r DNA identification,and phylogenetic analysis.Cr(VI)was determined using the 1,5-diphenylcarbazide method,and the optimum p H and temperature for degradation were studied using a multiple-factor mixed experimental design.Statistical analysis methods were used to analyze the results.Results Fifty-five strains were obtained,and one strain(Sporosarcina saromensis M52;patent application number:201410819443.3)having the ability to tolerate 500 mg Cr(VI)/L was selected to optimize the degradation conditions.M52 was found be able to efficiently remove 50-200 mg Cr(VI)/L in24 h,achieving the highest removal efficiency at p H 7.0-8.5 and 35°C.Moreover,M52 could completely degrade 100 mg Cr(VI)/L at p H 8.0 and 35°C in 24 h.The mechanism involved in the reduction of Cr(VI)was considered to be bioreduction rather than absorption.Conclusion The strong degradation ability of S.saromensis M52 and its advantageous functional characteristics support the potential use of this organism for bioremediation of heavy metal pollution. | ZHAO Ran WANG Bi CAI Qing Tao LI Xiao Xia LIU Min HU Dong GUO Dong Bei WANG Juan FAN Chun | 2016 | Biomedical and Environmental Sciences2016，29，2： | 4 |
| 5 | Association between Selenium in Soil and Diabetes in Chinese Residents Aged 35–74 Years:Results from the 2010 National Survey of Chronic Diseases and Behavioral Risk Factors Surveillance显示文摘Objective To explore the association between soil selenium levels and the risk of diabetes in Chinese adults aged 35–74 years.Methods Data for this study were derived from the China Chronic Diseases and Behavioral Risk Factors Surveillance 2010 survey.Selenium concentrations in soil were obtained from the Atlas of Soil Environmental Background Values in China.A two-level binary logistic regression model was used to determine the association between soil selenium concentrations and the risk of diabetes,with participants nested within districts/counties.Results A total of 69,332 participants aged 35–74 years,from 158 districts/counties were included in the analysis.Concentrations of selenium in soil varied greatly across the 158 districts/counties,with a median concentration of 0.219 mg/kg(IQR:0.185–0.248).The results showed that both Quartile 1(0.119–0.185 mg/kg)and Quartile 4(0.249–0.344 mg/kg)groups were positively associated with diabetes compared to a soil selenium concentration of 0.186–0.219 mg/kg(Quartile 2),crude odds ratios(ORs)(95%CI)were 1.227(1.003–1.502)and 1.280(1.048–1.563).The P values were 0.045 and 0.013,for Quartile 1 and Quartile 4 groups,respectively.After adjusting for all confounding factors of interest,the Quartile 1 group became non-significant,and the Quartile 4 group had an adjusted OR(95%CI)of 1.203(1.018–1.421)relative to the reference group(Quartile 2),the P values was 0.030.No significant results were seen for the Quartile 3 group(0.220–0.248 mg/kg)compared to the reference group.Conclusion Excessive selenium concentrations in soil could increase the risk of diabetes among Chinese adults aged 35–74 years. | WANG Qi Qi YU Shi Cheng XU Cheng Dong LIU Jian Jun LI Yuan Qiu ZHANG Man Hui LONG Xiao Juan LIU Yun Ning BI Yu Fang ZHAO Wen Hua YAO Hong Yan | 2020 | Biomedical and Environmental Sciences2020，33，4： | 3 |
| 6 | A selective voltammetric detection for dopamine using poly(gallic acid) film modified electrode显示文摘The electrochemistry behavior of dopamine was investigated by cyclic voltammetry and differential pulse voltammetry at a poly (gallic acid) film modified glassy carbon electrode.Two electrons and two protons participated in the diffusion-controlled electrocatalytic oxidation of dopamine with a diffusion coefficient of 2.186×10^(-5) cm^2/s.The interference of ascorbic acid with the determination of dopamine could be efficiently eliminated.This work provided a simple approach to selectively and sensitively... | Song, Wei Chen, Yu Xu, Juan Tian, Dan Bi | 2010 | Chinese Chemical Letters2010，21，3： | 3 |
| 7 | Clinical characteristics and one year outcomes in Chinese atrial fibrillation patients with stable coronary artery disease: a population-based study显示文摘然而, BackgroundAtrial 纤维性颤动(AF ) 和冠的动脉疾病(CAD ) 经常共存临床的特征和在有 AF 的中国病人的结果上的稳定的 CAD 的影响一直不好在到 2011 年 10 月的从 2008 年 11 月的中国的 20 所医院里的 understood.MethodsConsecutive AF 病人被注册。主要端点包括了 1 年的所有原因死亡,击,非中央的神经系统(non-CNS ) 栓塞,和 1947 个 AF 病人的主要 bleeding.ResultsA 总数被分析,谁 40.5% 有的稳定的 CAD。在 CAD 病人的吝啬的纸孔 2 分数比非 CAD 病人的显著地高(2.4 ±1.4 对 1.4 ±1.2, P <0.001 ) 。在后续时期期间, warfarin 使用在两个组是低的,与在与 CAD 病人相比的非 CAD 病人的相对更高的比例(22.3% 对 10.7% , P <0.001 ) 。与非 CAD 病人相比, CAD 病人有更高的一个年所有原因死亡(16.8% 对 12.9% , P = 0.017 ) 并且击的发生(9.0% 对 6.4% , P = 0.030 ) ,当 non-CNS 栓塞和主要流血率在二个组之间是可比较的时。在 multivariate 调整以后,稳定的 CAD 独立地与 1 年的所有原因死亡的增加的风险被联系(HR = 1.35, 95% CI:1.01 − 1 .80, P = 0.040 ) ,然而并非与击联系了(HR = 1.07, 95% CI:0.72-1.58, P = 0.736 ).ConclusionsStable CAD 在中国 AF 病人是流行的并且独立地与 1 年的所有原因的增加的风险被联系死亡。有稳定的 CAD 的中国 AF 病人收到了不适当的 antithrombotic 治疗和需要着急地被改善的 antithrombotic 治疗的这冷酷的地位。 | Ying BAI Jun ZHU Yan-Min YANG Yan LIANG Hui-Qiong TAN Juan WANG Bi HUANG Han ZHANG Xing-Hui SHAO | 2016 | Journal of Geriatric Cardiology2016，13，8： | 3 |
| 8 | Peripheral Artery Disease and Risk of Fibrosis Deterioration in Nonalcoholic Fatty Liver Disease:A Prospective Investigation显示文摘Objective Liver fibrosis is an important predictor of mortality in nonalcoholic fatty liver disease(NAFLD).Peripheral artery disease(PAD)and liver fibrosis share many common metabolic dysfunctions.We aimed to explore the association between PAD and risk of fibrosis deterioration in NAFLD patients.Methods The study recruited 1,610 NAFLD patients aged≥40 years from a well-defined community at baseline in 2010 and followed up between August 2014 and May 2015.Fibrosis deterioration was defined as the NAFLD fibrosis score(NFS)status increased to a higher category at the follow-up visit.PAD was defined as an ankle-brachial index of<0.90 or>1.40.Results During an average of 4.3 years’follow-up,618 patients progressed to a higher NFS category.PAD was associated with 92%increased risk of fibrosis deterioration[multivariable-adjusted odds ratio(OR):1.92,95%confidence interval(CI):1.24,2.98].When stratified by baseline NFS status,the OR for progression from low to intermediate or high NFS was 1.74(95%CI:1.02,3.00),and progression from intermediate to high NFS was 2.24(95%CI:1.05,4.80).There was a significant interaction between PAD and insulin resistance(IR)on fibrosis deterioration(P for interaction=0.03).As compared with non-PAD and non-IR,the coexistence of PAD and IR was associated with a 3.85-fold(95%CI:2.06,7.18)increased risk of fibrosis deterioration.Conclusion PAD is associated with an increased risk of fibrosis deterioration in NAFLD patients,especially in those with IR.The coexistence of PAD and IR may impose an interactive effect on the risk of fibrosis deterioration. | ZHU Wen DENG Chan Juan XUAN Li Ping DAI Hua Jie ZHAO Zhi Yun WANG Tian Ge LI Mian LU Jie Li XU Yu CHEN Yu Hong WANG Wei Qing BI Yu Fang XU Min | 2020 | Biomedical and Environmental Sciences2020，33，4： | 2 |
| 9 | Cloud Classification and Distribution of Cloud Types in Beijing Using Ka-Band Radar Data显示文摘A cloud clustering and classification algorithm is developed for a ground-based Ka-band radar system in the vertically pointing mode. Cloud profiles are grouped based on the combination of a time–height clustering method and the k-means clustering method. The cloud classification algorithm, developed using a fuzzy logic method, uses nine physical parameters to classify clouds into nine types: cirrostratus, cirrocumulus, altocumulus, altostratus, stratus, stratocumulus, nimbostratus,cumulus or cumulonimbus. The performance of the clustering and classification algorithm is presented by comparison with all-sky images taken from January to June 2014. Overall, 92% of the cloud profiles are clustered successfully and the agreement in classification between the radar system and the all-sky imager is 87%. The distribution of cloud types in Beijing from January 2014 to December 2017 is studied based on the clustering and classification algorithm. The statistics show that cirrostratus clouds have the highest occurrence frequency(24%) among the nine cloud types. High-level clouds have the maximum occurrence frequency and low-level clouds the minimum occurrence frequency. | Juan HUO Yongheng BI Daren Lü Shu DUAN | 2019 | Advances in Atmospheric Sciences2019，36，8： | 2 |
| 10 | S Phase Cell Percentage Normalized BrdU Incorporation Rate, a New Parameter for Determining S Arrest显示文摘In this study,a new parameter,S phase cell percentage(S fraction)normalized BrdU(SFN-BrdU)incorporation rate,was introduced to detect S arrest.The results showed a positive linear correlation between the BrdU incorporation rate and the S fraction in unperturbed 16HBE cells.Theoretical analysis indicated that only S | ZHAO Peng FU Juan Ling YAO Bi Yun JIA Yong Rui ZHOU Zong Can | 2014 | Biomedical and Environmental Sciences2014，27，3： | 2 |
| 11 | Coil-levitated hybrid generator for mechanical energy harvesting and wireless temperature and vibration monitoring显示文摘The development of wireless monitoring is currently restricted by the short lifetime of batteries,requiring frequent replacement.Utilization of abundant mechanical energy from the surrounding environment has attracted increasing attention in real-time monitoring.Herein,a coil-levitated hybrid generator was developed for the efficient harvesting of mechanical energy from mechanical motion.The novel coil-levitated structure adapted to the metal and magnetic environment.The output currents were systematically analyzed at different operation modes based on the unique combination of triboelectrification,electromagnetic induction,and piezoelectric effect.Under the excitation of vibration frequency and amplitude of 8 Hz and 5 mm respectively,the as-constructed triboelectric nanogenerator delivered a peak power density of 11.40 W/m3 at 10 MΩ.Meanwhile,the middle electromagnetic part and bottom piezoelectric generator provided peak power densities of 6.97 and 79.93 W/m2 at 10000Ω,respectively.More importantly,the battery charging experiment was verified,in which a 30 mA h Li-ion battery can be charged from 2.57 to 3.27 V in about 90 min.In sum,a self-powered temperature and vibration monitoring system was successfully developed based on hybrid generator,promising for realizing wireless monitoring of mechanical equipment without any external power supply. | XUE XiaoBin ZHANG ZengXing WU Bin HE ShanShan WANG Qiang ZHANG WenJun BI RuiYu CUI Juan ZHENG YongQiu XUE ChenYang | 2021 | Science China(Technological Sciences)2021，64，6： | 2 |
| 12 | Kinetic Characteristics of Neutralizing Antibody Responses Vary among Patients with COVID-19显示文摘Objective The coronavirus disease 2019(COVID-19) pandemic continues to present a major challenge to public health. Vaccine development requires an understanding of the kinetics of neutralizing antibody(NAb) responses to severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Methods In total, 605 serum samples from 125 COVID-19 patients(from January 1 to March 14, 2020)varying in age, sex, severity of symptoms, and presence of underlying diseases were collected, and antibody titers were measured using a micro-neutralization assay with wild-type SARS-CoV-2.Results NAbs were detectable approximately 10 days post-onset(dpo) of symptoms and peaked at approximately 20 dpo. The NAb levels were slightly higher in young males and severe cases, while no significant difference was observed for the other classifications. In follow-up cases, the NAb titer had increased or stabilized in 18 cases, whereas it had decreased in 26 cases, and in one case NAbs were undetectable at the end of our observation. Although a decreasing trend in NAb titer was observed in many cases, the NAb level was generally still protective.Conclusion We demonstrated that NAb levels vary among all categories of COVID-19 patients. Longterm studies are needed to determine the longevity and protective efficiency of NAbs induced by SARS-CoV-2. | LI Ling Hua TU Hong Wei LIANG Dan WEN Chun Yan LI An An LIN Wei Yin HU Ke Qi HONG Wen Shan LI Yue Ping SU Juan ZHAO San Tao LI Wei YUAN Run Yu ZHOU Ping Ping HU Feng Yu TANG Xiao Ping KE Chang Wen KE Bi Xia CAI Wei Ping | 2021 | Biomedical and Environmental Sciences2021，34，12： | 1 |
| 13 | Preparation of Multiwall Carbon Nanotubes-supported High Loading Platinum for Vehicular PEMFC Application显示文摘Multiwall carbon nanotube-supported Pt (Pt/MWNTs) catalysts with high dispersion and high loading of Pt were prepared by chemical reduction method and the loading of Pt got to 40 wt%. The average diameter of Pt nanoparticles on MWNTs was about 3.5 nm. When the hydrogen and air were used as reactant gases for PEMFC, Pt/MWNTs catalysts showed significantly higher performance than the Pt/XC-72 (carbon black) catalysts. | Bing ZHANG Li Juan CHEN Kai Yong GE Yah Chuan GUO Bi Xian PENG | 2005 | Chinese Chemical Letters2005，16，11： | 1 |
| 14 | Tumor markers in lung cancer:does the method of obtaining the Cut-off point and reference:populationinfluence diagnostic yield-显示文摘 | Teresa CP Isabel TZ Juan BI et a1 | 1999 | Clinical Biochemistry1999，32，： | 1 |
| 15 | Nitric oxide mediates abscisic acid induced thermotolerance in the calluses from two ecotypes of reed under heat stress显示文摘 | Lili Song Wei Ding Juan Shen Zhiguo Zhang Yurong Bi Lixin Zhang | 2008 | Plant Science2008，，6： | 1 |
| 16 | Effect of photoperiod on development and reproduction of Megacopta cribraria(Hemiptera:Plataspidae)显示文摘Megacopta cribraria (Hemiptera: Plataspidae) continually outbreaks due to suitable photoperiod in recent years. Effect of photoperiod on growth, development and reproduction of M. cribraria were assessed in this study. Results indicated that developmental duration, nutrient accumulation efficiency, and adult fecundity of M. cribraria were significantly different under 6 photoperiodical conditions. Developmental duration of nymph stage gradually tended to be shorter as day time increase. Body weights of 5th instar nymphs for 16 h and 4 h day time photoperiods were 5.2 mg and 4.6 mg, respectively. Moreover, longevity of adults tended to be longer as day time increase. However, for the short day photoperiod (4 L:20 D and 8 L:16 D), population showed no reproductive behaviors. Index of population trend increased with photoperiod extension and adults showed stronger reproductive capacity and longer longevity. This research identified the favorable photoperiodical conditions before outbreak. It may provided reference for ecological adaptability of M. cribraria, and contribute to the scientific basis for forecasting and controlling of M. cribraria. | Zhe Xu Juan Cui Rui Bi Wei Xu Shusen Shi Yu Gao | 2019 | Oil Crop Science2019，4，2： | 1 |
| 17 | Three Novel Avastroviruses Identified in Dead Wild Crows显示文摘Dear Editor,Astroviruses(AstVs)are non-enveloped,single-stranded RNA viruses with a diameter of approximately 35 nm(Madeley and Cosgrove 1975).The genomes of AstVs range in size from 6.8 to 7.9 kb(De Benedictis et al.2011),consisting of a 5'-untranslated region(UTR),three open reading frames(ORFs),a 3'-UTR,and a poly-adenylated(polyA)tail(Pantin-Jackwood et al.2006).In 1975,AstVs were first discovered in faeces of infants(Madeley and Cosgrove 1975).Until now,a variety of animal species,including cows,sheep,pigs,dogs,deer,rats,bats,chickens,ducks,turkeys,sea lions and seals have been reported to be infected with AstVs(Tzipori et al.1981;Cattoli et al.2007;Chu et al.2008,2010;Atkins et al.2009;Toffan et al.2009;Rivera et al.2010;Guix et al.2013;Kang et al.2012;Reuter et al.2012a,2012b;Li et al.2021).Currently,AstVs comprise two genera,Mamastrovirus(MAstV)and Avastrovirus(AAstV).Herein,we describe three novel AAstVs identified from dead crow tissues.To our knowledge,this is the first report for identification of AstVs in crows. | Chunge Zhang Yongchun Yang Tao Hu Hong Zhou Cheng Zhang Jian Cao Juan Li Peihan Wang Gary Wong Xiaodu Wang Houhui Song George FGao Weifeng Shi Yuhai Bi | 2021 | Virologica Sinica2021，36，6： | 1 |
| 18 | Research on solvent extraction process of coal for direct carbon fuel cells显示文摘 | Bi Wenyan Yang Hong Miao Juan | 2012 | Advanced Materials Research2012，，： | 1 |
| 19 | DEA-baesd production planning显示文摘 | DU Juan LIANG Liang CHEN Yao BI Gongbing | 2010 | Omega2010，38，： | 1 |
| 20 | A Novel Pilot-Scale Production of Gelatin Was Discovered and Established显示文摘The traditional method of gelatin mamtfacture has been existing for more than 130 years.Tnrough the continuous and sustainable improvement of the technological procedtae.s the traditional method is famous for its great ability to render the degreased bone chips into the photographic, pharmceutical and edible gelatins with high quality, | Peng Bi - xian Chen Li - Juan Wang Ying Shi Jing - jing Guo Yu - long Zheng TongLaboratory of Gelatin - Silver Halide Emulsion,Technical Institute of Chemistry and Physics, Chinese Academy of Sciences, 100101 .Beijing | 2002 | 明胶科学与技术2002，22，4： | 1 |
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