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| 1 | Contribution of additives Cu to its accumulation in pig feces: study in Beijing and Fuxin of China显示文摘猪粪肥的巨大的数量被集中的猪农场在中国生产,猪粪肥的 andthe 作文由于使用改变了大部分喂 additives.However ,关于准确 Cu (铜)的小 isknown 在 137 喂的 feces.One 和 142 烘便的 samplesfrom 作为在猪的沾染物喂的添加剂或礼品和 theresidues 喂 48 个猪农场在 1999 和 2005 在北京和 Fuxin 城市被收集, Cu 的 respectively.Theconcentrations 在 6.86-395 的范围。 | LI Yan-xia LI Wei WU Juan XU Li-chao SU Qiu-hong XIONG Xiong | 2007 | Journal of Environmental Sciences2007，19，5： | 38 |
| 2 | Apoptosis and Proinflammatory Cytokine Responses of Primary Mouse Microglia and Astrocytes Induced by Human H1N1 and Avian H5N1 Influenza Viruses显示文摘Patients with an influenza virus infection can be complicated by acute encephalopathy and encephalitis. To investigate the immune reactions involved in the neurocomplication,mouse microglia and astrocytes were isolated,infected with human H1N1 and avian H5N1 influenza viruses,and examined for their immune responses. We observed homogeneously distributed viral receptors,sialic acid (SA)-α2,3-Galactose (Gal) and SA-α2,6-Gal,on microglia and astrocytes. Both viruses were replicative and productive in microglia and astrocytes. Virus-induced apoptosis and cytopathy in infected cells were observed at 24 h post-infection (p.i.). Expression of IL-1β,IL-6 and TNF-α mRNA examined at 6 h and 24 h p.i. was up-regulated,and their expression levels were considerably higher in H5N1 infection. The amounts of secreted proinflammatory IL-1β,IL-6 and TNF-α at 6 h and 24 h p.i. were also induced,with greater induction by H5N1 infection. This study is the first demonstration that both human H1N1 and avian H5N1 influenza viruses can infect mouse microglia and astrocytes and induce apoptosis,cytopathy,and proinflammatory cytokine production in them in vitro. Our results suggest that the direct cellular damage and the consequences of immunopathological injury in the CNS contribute to the influenza viral pathogenesis. | Gefei Wang Juan Zhang Weizhong Li Yun Su Yuanli Gao Heng Zhang Guimei Lin Xiaoyang Jiao Kangsheng Li | 2008 | Cellular & Molecular Immunology2008，5，2： | 28 |
| 3 | Rhizospheric microbial communities are driven by Panax ginseng at different growth stages and biocontrol bacteria alleviates replanting mortality显示文摘The cultivation of Panax plants is hindered by replanting problems, which may be caused by plantdriven changes in the soil microbial community. Inoculation with microbial antagonists may efficiently alleviate replanting issues. Through high-throughput sequencing, this study revealed that bacterial diversity decreased,whereas fungal diversity increased, in the rhizosphere soils of adult ginseng plants at the root growth stage under different ages. Few microbial community, such as Luteolibacter, Cytophagaceae, Luteibacter, Sphingomonas,Sphingomonadaceae, and Zygomycota, were observed; the relative abundance of microorganisms, namely,Brevundimonas, Enterobacteriaceae, Pandoraea, Cantharellales, Dendryphion, Fusarium, and Chytridiomycota,increased in the soils of adult ginseng plants compared with those in the soils of 2-year-old seedlings. Bacillus subtilis 50-1, a microbial antagonist against the pathogenic Fusarium oxysporum, was isolated through a dual culture technique. These bacteria acted with a biocontrol efficacy of 67.8%. The ginseng death rate and Fusarium abundance decreased by 63.3% and 46.1%, respectively, after inoculation with B. subtilis 50-1. Data revealed that microecological degradation could result from ginseng-driven changes in rhizospheric microbial communities;these changes are associated with the different ages and developmental stages of ginseng plants. Biocontrol using microbial antagonists alleviated the replanting problem. | Linlin Dong Jiang Xu Lianjuan Zhang Ruiyang Cheng Guangfei Wei He Su Juan Yang Jun Qian Ran Xu Shilin Chen | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 27 |
| 4 | Different Effects of Homocysteine and Oxidized Low Density Lipoprotein on Methylation Status in the Promoter Region of the Estrogen Receptor α Gene显示文摘我们调查了人的效果半胱氨酸(Hcy ) 和在雌激素受体高山的倡导者区域的 DNA methylation 上的氧化低密度脂蛋白(ox-LDL ) 哈(ERalpha ) 基因,和它在动脉粥样硬化的致病的潜在的机制。人的有教养的光滑的肌肉房间(SMC ) 被 Hcy 和 ox-LDL 为时间的不同经期与不同集中对待。DNA methylation 地位是由嵌套的 methylation 特定的聚合酶链反应的 assayed,在 SMC 和泡沫房间形成积累了的类脂化合物被检验,油红 O 染色。SMC 的增长是由 the3-(4,5-dimethylthiazol-2-yl ) 的 assayed -2,5-diphenyltetrazolium 溴化物方法。结果证明 ox-LDLin 节制导致的集中(10-40 mg/L ) 在 SMCs.However 的 ERagene 的倡导者区域的 de novo methylation, ox-LDL 的高集中(50 mg/L ) ,导致了时代的 demethylation。 Hcytreatment 与 aconcentration 在时代基因的倡导者区域导致了 de novo methylation --并且对待时间依赖者举止,并且在 SMCproliferation.These 数据上支持效果的一个剂量依赖者显示为动脉粥样硬化的二个风险因素有在 SMCs.However 的时代基因的倡导者区域导致 de novo methylation 的功能, ox-LDL 的高集中( 50 mg/L )导致了 demethylation ,显示有不同力量力量的动脉粥样硬化的不同风险因素在时代基因的倡导者区域引起不同异常 methylation 模式。Hcy 的 atherogenic 机制可能包含 hypermethylationof 时代基因,在动脉粥样硬化患者损害导致 SMC 的增长。 | Yushan HUANG~1 Kejun PENG~2 Juan SU~1 Yuping HUANG~3 Yizhon XU~1 and Shuren WANG~1 ~1Department of Pathophysiology,West China School of Preclinic Medical Sciences & Forensic Medicine,Sichuan University,Chengdu 610041.China ~2Department of Laboratory Medicine,Chengdu Medical College,Chengdu 610500,China ~3Department of Biochemistry and Molecular Bilogy,Gannan Medical College,Ganzhou 341000,China | 2007 | Acta Biochimica et Biophysica Sinica2007，39，1： | 25 |
| 5 | Pharmacokinetics and pharmacodynamics of Da-Cheng-Qi decoction in the liver of rats with severe acute pancreatitis显示文摘AIM To explore the pharmacokinetics and pharmacodynamics of Da-Cheng-Qi decoction(DCQD) in the liver of rats with severe acute pancreatitis(SAP) based on an herbal recipe tissue pharmacology hypothesis.METHODS Healthy male Sprague-Dawley rats were randomly divided into a sham operation group(SOG); a model group(MG); and low-, median- and high-dose treatment groups(LDG, MDG, and HDG, respectively). Different dosages(6, 12 and 24 g/kg for the LDG, MDG, and HDG, respectively) of DCQD were administered to the rats with SAP. The tissue concentrations of aloeemodin, rhein, emodin, chrysophanol, honokiol, rheo chrysophanol, magnolol, hesperidin, naringenin and naringin in the liver of the treated rats were detected by high-performance liquid chromatography tandem mass spectrometry. Alanine transaminase(ALT) and aspartate transaminase(AST) in serum, inflammatory mediators in the liver and pathological scores were evaluated.RESULTS The major components of DCQD were detected in the liver, and their concentrations increased dosedependently. The high dose of DCQD showed a maximal effect in ameliorating the pathological damages, decreasing the pro-inflammatory mediators tumor necrosis factor-α and interleukin(IL)-6 and increasing anti-inflammatory mediators IL-4 and IL-10 in the liver. The pathological scores in the pancreas for the MG were significantly higher than those for the SOG(P < 0.05). DCQD could reduce the pathological scores in the pancreas and liver of the rats with SAP, especially in the HDG. Compared to the SOG, the ALT and AST levels in serum were higher in the MG(P < 0.05), while there was no statistical difference in the MG and HDG.CONCLUSION DCQD could alleviate liver damage by altering the inflammatory response in rats with SAP based on the liver distribution of its components. | Yu-Mei Zhang Hong-Yu Ren Xian-Lin Zhao Juan Li Jun-Yi Li Fu-Sheng Wu Hang Su Wen-Fu Tang | 2017 | World Journal of Gastroenterology2017，23，8： | 26 |
| 6 | Human ESC-derived expandable hepatic organoids enable therapeutic liver repopulation and pathophysiological modeling of alcoholic liver injury显示文摘We report the generation of human ESC-derived,expandable hepatic organoids(hEHOs)using our newly established method with wholly defined(serum-free,feeder free)media.The hEHOs stably maintain phenotypic features of bipotential liver stem/progenitor cells that can differentiate into functional hepatocytes or cholangiocytes.The hEHOs can expand for 20 passages enabling large scale expansion to cell numbers requisite for industry or clinical programs.The cells from hEHOs display remarkable repopulation capacity in injured livers of FRG mice following transplantation,and they differentiate in vivo into mature hepatocytes.If implanted into the epididymal fat pads of immune-deficient mice,they do not generate non-hepatic lineages and have no tendency to form teratomas.We further develop a derivative model by incorporating human fetal liver mesenchymal cells(hFLMCs)into the hEHOs,referred to as hFLMC/hEHO,which can model alcoholic liver disease-associated pathophysiologic changes,including oxidative stress generation,steatosis,inflammatory mediators release and fibrosis,under ethanol treatment.Our work demonstrates that the hEHOs have considerable potential to be a novel,ex vivo pathophysiological model for studying alcoholic liver disease as well as a promising cellular source for treating human liver diseases. | Shuyong Wang Xuan Wang Zuolong Tan Yuxin Su Juan Liu Mingyang Chang Fang Yan Jie Chen Tao Chen Chuanjiang Li Jie Hu Yunfang Wang | 2019 | Cell Research2019，29，12： | 20 |
| 7 | Immunogenicity noninferiority study of 2 doses and 3 doses of an Escherichia coli-produced HPV bivalent vaccine in girls vs.3 doses in young women显示文摘A new HPV-16/18 bivalent vaccine expressed by the Escherichia coli has been proven to be efficacious in adult women.A randomized,immunogenicity noninferiority study of this candidate vaccine was conducted in December 2015 in China.Girls aged 9–14 years were randomized to receive 2 doses at months 0 and 6(n=301)or 3 doses at months 0,1 and 6(n=304).Girls aged 15–17 years(n=149)and women aged 18–26 years(n=225)received 3 doses.The objectives included noninferiority analysis of the IgG geometric mean concentration(GMC)ratio(95%CI,lower bound>0.5)to HPV-16 and HPV-18 at month 7 in girls compared with women.In the per-protocol set,the GMC ratio of IgG was noninferior for girls aged 9–17 years receiving 3 doses compared with women(1.76(95%CI,1.56,1.99)for HPV-16 and 1.93(95%CI,1.69,2.21)for HPV-18)and noninferior for girls aged 9–14 years receiving 2 doses compared with women(1.45(95%CI,1.25,1.62)for HPV-16 and 1.17(95%CI,1.02,1.33)for HPV-18).Noninferiority was also demonstrated for neutralizing antibodies.The immunogenicity of the HPV vaccine in girls receiving 3 or 2 doses was noninferior compared with that in young adult women. | Yue-Mei Hu Meng Guo Chang-Gui Li Kai Chu Wen-Gang He Jing Zhang Jian-Xiang Gu Juan Li Hui Zhao Xiang-Hong Wu Bi-Zhen Lin Zhi-Jie Lin Xing-Mei Yao Ya-Fei Li Fei-Xue Wei Yue Huang Ying-Ying Su Feng-Cai Zhu Shou-Jie Huang Hui-Rong Pan Ting Wu Jun Zhang Ning-Shao Xia | 2020 | Science China(Life Sciences)2020，63，4： | 19 |
| 8 | Uric formaldehyde levels are negatively correlated with cognitive abilities in healthy older adults显示文摘Recent studies have shown that the abnormal accumulation of endogenous formaldehyde could be a critical factor in age-related cognitive decline. The aim of this study was to estimate the correlation between uric formaldehyde and general cognitive abilities in a community-based elderly population, and to measure the extent and direction in which the correlation varied with demographic characteristics. Using a double-blind design, formaldehyde in human urine was analyzed by high-performance liquid chromatography(n = 604), and general cognitive abilities were measured using the Montreal Cognitive Assessment(MoCA). Demographic characteristics, in terms of age, gender, residential region, and education were taken into consideration. We found that uric formaldehyde levels were inversely correlated with the MoCA score, and the concentration varied with demographic features: higher odds of a high formaldehyde level occurred among the less educated and those living in old urban or rural areas. In cytological experiments, the level of cellular formaldehyde released into the medium increased as SH-SY5Y and BV2 cells were incubated for three days. Formaldehyde in excess impairedthe processes of N2a cells and neurites of primary cultured rat hippocampal cells. However, removal of formaldehyde markedly rescued and regenerated the processes of N2a cells. These results demonstrated a negative correlation between the endogenous formaldehyde and general cognitive abilities. High formaldehyde levels could be a risk factor for cognitive impairment in older adults, and could be developed as a non-invasive marker for detection and monitoring of age-related cognitive impairment. | Jing Yu Tao Su Ting Zhou Yingge He Jing Lu Juan Li Rongqiao He | 2014 | Neuroscience Bulletin2014，30，2： | 14 |
| 9 | Aloe-emodin exerts cholesterol-lowering effects by inhibiting proprotein convertase subtilisin/kexin type 9 in hyperlipidemic rats显示文摘Hyperlipidemia(HPL)characterized by metabolic disorder of lipids and cholesterol is one of the important risk factors for cardiovascular diseases.Proprotein convertase subtilsin/kexin type 9(PCSK9)is a potent circulating regulator of LDL through its ability to induce degradation of the low-density lipoprotein cholesterol receptor(LDLR)in the lysosome of hepatocytes.Aloe-emodin(AE)is one of potentially bioactive components of Chinese traditionalmedicine Daming capsule.In this study we evaluated the HPL-lowering efficacy of AE in both in vivo and in vitro HPL models.High-fat diet-induced rats were treated with AE(100 mg/kg per day,ig)for 6 weeks.We found that AE administration significantly decreased the levels of total cholesterol(TC)and LDL in the serum and liver tissues.Moreover,AE administration ameliorated HPL-induced hepaticlipid aggregation.But AE administration did not significantly inhibit HMG-CoA reductase activity in the liver of HPL rats.A cellular model of HPL was established in human hepatoma(HepG2)cells treated with cholesterol(20 μg/mL)and 25-hydroxycholesterol(2 μg/mL),which exhibited markedly elevated cholesterol levels.The increased cholesterol levels could be reversed by subsequent treatment with AE(30 μM).In both the in vivo and in vitro HPL models,we revealed that AE selectively suppressed the stero-regulatory element-binding protein-2(SREBP-2)and hepatocyte nuclear factor(HNF)1α-mediated PCSK9 signaling,which in turn upregulated LDL receptor(LDLR)and promoted LDL uptake.This study demonstrates that AE reduces cholesterol content in HPL rats by inhibiting the hepatic PCSK9/LDLR pathway. | Zhen-li Su Peng-zhou Hang Juan Hu Yu-yang Zheng Han-qi Sun Jing Guo Ke-yu Liu Zhi-min Du | 2020 | Acta Pharmacologica Sinica2020，41，8： | 14 |
| 10 | The Effects of Demographic Features on Differences in Sensitivity between PCL-C and SCL-90 Scores in a Follow-up Study in Secondary School Students in the Wenchuan Earthquake Region显示文摘Objective To analyze the sensitivity of effect factors between the PCL‐C and the SCL‐90,to provide evidence for social psychological crisis screening and post‐trauma interventions.Methods We administered the PCL‐C and SCL‐90 to screen for PTSD and other psychological problems among students who survived the disaster and continued their school studies.The surveys were carried out 3,6,9,and 12 months after the earthquake.A bivariate 2‐level logistic model was used to explore the different levels of sensitivity among students.The factors influencing the relationships between PTSD and depression,and between PTSD and anxiety were examined.Results We analyzed data from 1 677 students,revealing that female students in higher grades were more likely to exhibit symptoms of depression,rather than PTSD,compared with the control group (males in lower grades),and the difference was significant (P<0.05).In contrast,ethnic minorities were more likely to exhibit PTSD symptoms compared to the others.In addition,female students were more likely to exhibit symptoms of anxiety than PTSD.Other effects that did not reach statistical significance were suggested to have a similar influence on PTSD,depression,and anxiety.Conclusion After a natural disaster,specific aspects of depression and anxiety should be examined,avoiding an overemphasis on PTSD in social psychological crisis interventions. | HOU Feng Su LI Ting LI Juan HU Xiao Qin LIU Zhi Yue YUAN Ping | 2011 | Biomedical and Environmental Sciences2011，24，6： | 11 |
| 11 | Activation of Mitochondrial orf355 Gene Expression by a Nuclear-Encoded DREB Transcription Factor Causes Cytoplasmic Male Sterility in Maize显示文摘Coordination between mitochondria and the nucleus is crucial for fertility determination in plants with cytoplasmic male sterility(CMS).Using yeast one-hybrid screening,we identified a transcription factor,ZmDREB1.7,that is highly expressed in sterile microspores at the large vacuole stage and activates the expression of mitochondria-encoded CMS gene orf355.Δpro,a weak allele of ZmDREB1.7 with the loss of a key unfolded protein response(UPR)motif in the promoter,partially restores male fertility of CMS-S maize.ZmDREB1.7 expression increases rapidly in response to antimycin A treatment,but this response is attenuated in theΔpro allele.Furthermore,we found that expression of orf355 in mitochondria activates mitochondrial retrograde signaling,which in turn induces ZmDREB1.7 expression.Taken together,these findings demonstrate that positive-feedback transcriptional regulation between a nuclear regulator and a mitochondrial CMS gene determines male sterility in maize,providing new insights into nucleus-mitochondria communication in plants. | Senlin Xiao Jie Zang Yuanrong Pei Jie Liu Juan Liu Wei Song Zi Shi Aiguo Su Jiuran Zhao Huabang Chen | 2020 | Molecular Plant2020，13，9： | 10 |
| 12 | A human circulating immune cell landscape in aging and COVID-19显示文摘Age-associated changes in immune cells have been linked to an increased risk for infection.However,a global and detailed characterization of the changes that human circulating immune cells undergo with age is lacking.Here,we combined scRNA-seq,mass cytometry and sCATAC-seq to compare immune cell types in peripheral blood collected from young and old subjects and patients with COVID-19.We found that the immune cell landscape was reprogrammed with age and was characterized by T cell polarization from naive and memory cells to effector,cytotoxic,exhausted and reg-ulatory cells,along with increased late natural killer cells,age-associated B cells,inflammatory monocytes and age-associated dendritic cells.In addition,the expression of genes,which were implicated in coron-avirus susceptibility,was upregulated in a cell subtype-specific manner with age.Notably,COVID-19 promoted age-induced immune cell polarization and gene expression related to inflammation and cellular senes-cence.Therefore,these findings suggest that a dysreg-ulated immune system and increased gene expression associated with SARS-CoV-2 susceptibility may at least partially account for COVID-19 vulnerability in the elderly. | Yingfeng Zheng Xiuxing Liu Wenqing Le Lihui Xie He Li Wen Wen Si Wang Shuai Ma Zhaohao Huang Jinguo Ye Wen Shi Yanxia Ye Zunpeng Liu Moshi Song Weiqi Zhang Jing-Dong J.Han Juan Carlos lzpisua Belmonte Chuanle Xiao Jing Qu Hongyang Wang Guang-Hui Liu Wenru Su | 2020 | Protein & Cell2020，11，10： | 10 |
| 13 | Pharmacokinetics and pharmacodynamics of Shengjiang decoction in rats with acute pancreatitis for protecting against multiple organ injury显示文摘AIM To explore the pharmacokinetics and pharmacodynamics of Shengjiang decoction(SJD) in rats with acute pancreatitis(AP) for protecting against multiple organ injury.METHODS An AP model was established by retrograde perfusion of 3.5% sodium taurocholate into the biliopancreatic duct, and a control group(CG) received 0.9% sodium chloride instead. Twelve male Sprague-Dawley rats were randomly divided into a CG treated with SJD(CG + SJD) and a model group treated with SJD(MG + SJD), both of which were orally administered with SJD(5 g/kg) 2 h after surgery. Blood samples were collected via the tail vein at 10, 20, and 40 min and 1, 2, 3, 4, 6, 8, and 12 h after a single dose of SJD to detect its main components using high-performance liquid chromatography-tandem mass spectrometry. The pharmacokinetic parameters were compared. In the pharmacodynamic experiment, 18 male SpragueDawley rats were randomly divided into a CG, an AP model group(MG), and an SJD treated AP group(SJDG). Serum amylase, lipase, and inflammatory cytokines were measured, and heart, lung, liver, spleen, pancreas, kidney, and intestine tissues were collected for pathological examination.RESULTS The MG + SJD displayed significantly shorter mean residence time(MRT) and higher clearance(CL) for emodin and aloe-emodin; significantly shorter time of maximum concentration and T1/2 and a lower area under curve(AUC) for aloe-emodin; a significantly higher AUC and lower CL for rhein; and longer MRT and lower CL for chrysophanol than the CG + SJD. In the pharmacodynamic experiment, the amylase, interleukin(IL)-6, IL-10, and tumor necrosis factor(TNF)-α levels in the MG were higher than those in the CG(P < 0.05). After the herbal decoction treatment, the SJDG had higher IL-10 and lower TNF-α levels than the MG(P < 0.05). The MG had the highest pathological scores, and the pathological scores of the lung, pancreas, kidney, and intestine in the SJDG were significantly lower than those in the MG(P < 0.05).CONCLUSION AP may have varying effects on the pharmacokinetics of the major SJD components in rats. SJD might alleviate pathological injuries of the lung, pancreas, kidney, and intestine in rats with AP via regulating pro-and antiinflammatory responses, which might guide the clinical application of SJD for AP treatment. | Lv Zhu Jun-Yi Li Yu-Mei Zhang Hong-Xin Kang Huan Chen Hang Su Juan Li Wen-Fu Tang | 2017 | World Journal of Gastroenterology2017，23，46： | 10 |
| 14 | An Abietane Diterpene and a Sterol from Fungus Phellinus igniarius显示文摘新 abietane diterpene12-hydroxy-7-oxo-5,8,11,13-tetraene-18,6-abietanolide 和新自然 sterolstigmasta-7,22-diene-3beta, 5alpha,6alpha-triol 从真菌 Phellinus igniarius.Their 结构的 fruiting 身体被孤立被分光镜的方法包括 2DNMR 技术阐明。 | Ying WANG Su Juan WANG Shun Yan MO Shuai LI Yong Chun YANG Jian Gong SHI | 2006 | Chinese Chemical Letters2006，17，4： | 10 |
| 15 | Portal hypertensive biliopathy: A single center experience and literature review显示文摘Portal hypertensive biliopathy (PHB) is characterized by anatomical and functional abnormalities of the intrahepatic, extrahepatic and pancreatic ducts, in patients with portal hypertension associated to extrahepatic portal vein obstruction and less frequently to cirrhosis. These morphological changes, consisting in dilatation and stenosis of the biliary tree, are due to extensive venous collaterals occurring in an attempt to decompress the portal venous blockage. It is usually asymptomatic until it progresses to more advanced stages with cholestasis, jaundice, biliary sludge, gallstones, cholangitis and finally biliary cirrhosis. Imaging mo-dalities of the biliary tree such as Doppler ultrasound, computed tomography, magnetic resonance cholangiopancreatography and endoscopic retrograde cholangiopancreatography are essential to establish the diagnosis and the need of therapeutical interventions. Once the diagnosis is established, treatment with ursodesoxycholic acid seems to be beneficial. Decompression of the biliary tree to dilate, remove stones or implant biliary prosthesis by endoscopic or surgical procedures (hepato-yeyunostomy) usually resolves the cholestatic picture and prevents septic complications. The ideal treatment is the decompression of the portal system, with transjugular intrahepatic porto-systemic shunt or a surgical porto-systemic shunt. Unfortunately, few patients will be candidates for these procedures due to the extension of the thrombotic process. The purpose of this paper is to report the first 3 cases of PHB seen in a Colombian center and to review the literature. | Vanessa Suárez Andrés Puerta Luisa Fernanda Santos Juan Manuel Pérez Adriana Varón Rafael Claudino Botero | 2013 | World Journal of Hepatology2013，5，3： | 10 |
| 16 | Genomic sequencing and analysis of the first imported Middle East Respiratory Syndrome Coronavirus(MERS CoV) in China显示文摘Dear Editors,Middle East Respiratory Syndrome(MERS)has spread to more than 23 countries since the first case of a MERS coronavirus(MERS Co V)infection was confirmed in Sep2012[1].Because MERS Co V has led to mortality as high as 40%,it has become one of the most important emerging pathogens threatening human health.Recently,the outbreak of MERS Co V,which resulted in 172 infections and | XIE Qian CAO YuJuan SU Juan WU XianBo WAN ChengSong KE ChangWen ZHAO Wei ZHANG Bao | 2015 | Science China(Life Sciences)2015，58，8： | 8 |
| 17 | Retrospective Study of Castleman's Disease:A Report of Fourteen Cases and Review of the Literature显示文摘OBJECTIVE To enhance the understanding of Castleman’s disease (CD), and to improve its diagnosis and management. METHODS Clinical features and related information on diagnosis and treatment of 14 cases of CD were retrospectively analyzed and the literature reviewed. RESULTS Based on the clinical classification, localized CD was found in 8 of the 14 cases. Both the results of lymph node biopsy and histopathology indicated they were a hyaline-vascular type. The multicentric type CD was detected in 6 cases, among which 4 were plasma cell type and 2 mixed type based on histopathologic examination. There were a variety of clinical situa-tions in the 14 cases, with a lack of specificity. They were previously misdiag-nosed as other diseases, and final diagnosis depended on a histopathologic examination. The 8 patients with localized CD underwent excision, without recurrence up to now. The 6 patients with multicentric-type CD were treated with glucocorticoids or combined chemotherapy, and all achieved remission. CONCLUSIONS CD has complicated clinical manifestations and is difficult to diagnose. Lymph node biopsy is important for early diagnosis. An optimal curative effect can be achieved with a suitable therapeutic option, based on histopathology and clinical classification. | Waiyi Zou Huixia Lan Chang Su Yunxian Chen Juan Li Shaokai Luo | 2007 | Chinese Journal of Clinical Oncology2007，4，3： | 8 |
| 18 | Widespread infection and diverse infection patterns of Wolbachia in Chinese aphids显示文摘Wolbachia 是感染大量节肢动物和丝虫的线虫的细胞内部的共生者。蚜虫从事与他们的 endosymbionts 的多样、复杂的关系。Wolbachia 的四超群(A, B, M 和 N ) 以前在蚜虫和超群 M 被检测, N 仅仅在蚜虫被发现。在这研究,我们在中国在蚜虫的自然人口检测了并且描述 Wolbachia 感染。三超群(A, B 和 M ) 在检验蚜虫种类被发现。超群 M 是优势的,而超群 A 和 B 仅仅在某些种类被检测。超群 N 没在这研究被发现。也就是,有在蚜虫的 Wolbachia 的四个感染模式有超群 M 的感染独自一个,有超群 A 和 M,有超群 B 和 M 的合作感染,和有超群 A, B 和 M 的合作感染的合作感染。仅仅有超群 M 的感染的模式是通用的并且在所有评估亚科被发现。仅仅二个亚科, Aphidinae 和 Lachninae,表明了介绍所有四个感染模式。三个模式在 Calaphidinae 被观察(M, A&M, B&M ) 并且 Eriosomatinae (M, B&M, A&B&M ) 。二个模式在 Anoeciinae 被观察(M, A&M ) 并且 Greenideinae (M, B&M ) ,并且一仅仅模式(M) 在 Aphidoidea 的留下的家庭或亚科被观察。这些结果显示在中国蚜虫的 Wolbachia 感染是普遍的。种系发生的分析建议超群 M 在中国在蚜虫的所有主人种类之中很快并且最近散布了的那 Wolbachia。为这传播和它的机制的原因在他们的蚜虫主人上与 Wolbachia 的可能的效果一起被讨论。 | Zhe Wang Xiao-Min Su Juan Wen Li-Yun Jiang Ge-Xia Qiao | 2014 | Insect Science2014，21，3： | 8 |
| 19 | Approximate Gaussian conjugacy: parametric recursive filtering under nonlinearity, multimodality, uncertainty, and constraint, and beyond显示文摘自上世纪60年代作为现代估计开山之作的卡尔曼滤波器(Kalman filter)的诞生,时间序列状态空间模型应用于各类动态估计问题吸引了大量的研究关注。特别是,寻求实现闭环马尔科夫-贝叶斯递归(比如,从一个高斯先验到一个高斯后验,本文称之为高斯共轭)的解析解成为一般时间序列滤波器设计的主流思路。其面临的主要挑战包括:系统的非线性、多模态(包括机动模型)、复杂不确定性(比如未知的系统输入,非高斯噪声等)和系统约束(包括循环随机变量)等。这些挑战不断触生新的理论、算法与滤波技术,以实现所期望的参数共轭递归。本文对最新研究进行分类、系统回顾,强调了一些容易被忽略的要点。着重介绍了高精观测非线性系统、高斯后验和机动多模态、以及复杂未知系统输入与约束,以弥补当前文献介绍的不足。同时,本文提出一些新的思考:一是一阶马尔科夫转移模型的替代模型,二是有关计算复杂度的滤波器评价。 | Tian-cheng LI Jin-ya SU Wei LIU Juan M.CORCHADO | 2017 | Frontiers of Information Technology & Electronic Engineering2017，18，12： | 8 |
| 20 | Consensus by Chinese Expert Panel on Chlamydia trachomatis-Resistant and Chlamydia trachomatis-Persistent Infection显示文摘 | Man-Li Qi Yuan-Li Guo Qian-Qiu Wang Xiang-Sheng Chen Jian-De Han Xiao-Hong Su Wen-Hui Lun Hao Cheng Jin-Hua Xu Hong-Qing Tian Li Che Zhi-Yuan Ya Wen-Li Feng Juan Jiang Ping-Yu Zhou Xian-Biao Zo Hong-Hui Xu Wei-Min Shi Jun Liu Lin Zhu Quan-Zhong Liu | 2017 | Chinese Medical Journal2017，，23： | 7 |
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