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| 1 | Treatment options in patients with metastatic gastric cancer:Current status and future perspectives显示文摘Despite advances in the treatment of gastric cancer,it remains the world’s second highest cause of cancer death.As gastric cancer is often diagnosed at an advanced stage,systemic chemotherapy is the mainstay of treatment for these patients.However,no standard palliative chemotherapy regimen has been accepted for patients with metastatic gastric cancer.Palliative chemotherapy including fluoropyrimidine,platin compounds,docetaxel and epirubicin prolongs survival,and improves a high quality of life to a greater extent than best supportive care.The number of clinical investigations associated with targeted agents has recently increased.Agents targeting the epidermal growth factor receptor 1 and human epidermal growth factor receptor 2(HER2)have been widely tested.Trastuzumab was the first target drug developed,and pivotal phaseⅢtrials showed improved survival when trastuzumab was integrated into cisplatin/fluoropyrimidine-based chemotherapy in patients with metastatic gastric cancer.Trastuzumab in combination with chemotherapy was thus approved to be a new standard of care for patients with HER2-positive advanced esophagogastric adenocarcinoma.Thus,the evaluation of HER2 status in all patients with metastatic gastroesophageal adenocarcinoma should be considered.Other agents targeting vascular endothelial growth factor,mammalian target of rapamycin,and other biological pathways have also been investigated in clinical trials,but showed little impact on the survival of patients.In this review,systemic chemotherapy and targeted therapies for metastatic gastric cancer in the first-and second-line setting are summarized in the light of recent advances. | Ahmet Bilici | 2014 | World Journal of Gastroenterology2014，20，14： | 23 |
| 2 | Assessment of the correlation between serum prolidase and alpha-fetoprotein levels in patients with hepatocellular carcinoma显示文摘AIM: To determine the predictive value of increased prolidase activity that reflects increased collagen turnover in patients with hepatocellular carcinoma(HCC).METHODS: Sixty-eight patients with HCC(mean age of 69.1 ± 10.1), 31 cirrhosis patients(mean age of59.3 ± 6.3) and 33 healthy volunteers(mean age of51.4 ± 12.6) were enrolled in this study. Univariate and multivariate analysis were used to evaluate the association of serum α-fetoprotein(AFP) values with HCC clinicopathological features, such as tumor size,number and presence of vascular and macrovascular invasion. The patients with HCC were divided into groups according to tumor size, number and presence of vascular invasion(diameters; ≤ 3 cm, 3-5 cmand ≥ 5 cm, number; 1, 2 and ≥ 3, macrovascular invasion; yes/no). Barcelona-clinic liver cancer(BCLC)criteria were used to stage HCC patients. Serum samples for measurement of prolidase and alphafetoprotein levels were kept at-80 ℃ until use.Prolidase levels were measured spectrophotometrically and AFP concentrations were determined by a chemiluminescence immunometric commercial diagnostic assay.RESULTS: In patients with HCC, prolidase and AFP values were evaluated according to tumor size, number,presence of macrovascular invasion and BCLC staging classification. Prolidase values were significantly higher in patients with HCC compared with controls(P <0.001). Prolidase levels were significantly associated with tumor size and number(P < 0.001, P = 0.002,respectively). Prolidase levels also differed in patients in terms of BCLC staging classification(P < 0.001).Furthermore the prolidase levels in HCC patients showed a significant difference compared with patients with cirrhosis(P < 0.001). In HCC patients grouped according to tumor size, number and BCLC staging classification, AFP values differed separately(P = 0.032,P = 0.038, P = 0.015, respectively). In patients with HCC, there was a significant correlation(r = 0.616; P< 0.001) between prolidase and AFP values in terms of tumor size, number and BCLC staging classification,whereas the presence of macrovascular invasion did not show a positive association with serum prolidase and AFP levels.CONCLUSION: Considering the levels of both serum prolidase and AFP could contribute to the early diagnosing of hepatocellular carcinoma. | Sevil Uygun Ilikhan Muammer Bilici Hatice Sahin Ayse Semra Demir Akca Murat Can Ibrahim Ilker Oz Berrak Guven M Cagatay Buyukuysal Yucel Ustundag | 2015 | World Journal of Gastroenterology2015，21，22： | 8 |
| 3 | Prognostic factors related with survival in patients with pancreatic adenocarcinoma显示文摘The prognosis in patients with pancreatic cancer is poor and this cancer is the fourth leading cause of cancer-related death worldwide. Although surgical resection is the only curative treatment of choice for pancreatic cancer, the majority of patients are diagnosed at an advanced stage, thus only 10%-15% of them are suitable for curative resection and the overall survival is less than 5%. Chemotherapy for metastatic disease is to palliate symptoms of patients and to improve survival. Therefore, prognostic factors are important and a correct definition of poor prognostic factors may help to guide more aggressive adjuvant or aggressive treatment protocols in patients with pancreatic cancer. This article reviews the prognostic factors affecting survival of patients with pancreatic cancer in the light of recent advances in the literature. | Ahmet Bilici | 2014 | World Journal of Gastroenterology2014，20，31： | 2 |
| 4 | 电阻点焊异质DP1000–QP1180钢板的组织和力学性能(英文)显示文摘研究了焊接参数对电阻点焊DP1000–QP1180异质接头组织和力学性能的影响。QP1180侧的热影响区宽度比DP1000侧的小。热影响区的宽度和压痕深度随着焊接电流增大和焊接时间的延长而增大。熔核尺寸随着焊接电流的增大而增大,但在低电流条件下,熔核尺寸随着焊接时间的延长而增大,在高电流条件下,熔核尺寸随着焊接时间的延长而减小。DP1000侧的硬度最低。在QP1180侧,热影响区中心硬度最高。随着焊接电流的增大,焊缝区硬度降低,拉伸剪切载荷增大。在较低的焊接电流下,焊接时间对拉伸剪切载荷没有影响。伸长率随焊接时间的延长而减小,而焊接电流与伸长率之间没有关系。强度较高的点焊接头具有较强的韧性断裂特性。 | Imren OZTURK YILMAZ Abdullah Yasin BILICI Hakan AYDIN | 2019 | Journal of Central South University2019，26，1： | 2 |
| 5 | Clinical value of FDG PET/CT in the diagnosis of suspected recurrent ovarian cancer:is there an impact of FDG PET/CT on patient management显示文摘 | Bilici A Ustaalioglu BB Seker M | 2010 | Eur J Nucl Med Mol Imaging2010，37，： | 1 |
| 6 | Determining predominating histologic component in malignant mixed m llerian tumors: is it worth it?显示文摘 | Ozguroglu M Bilici A Ilvan S | 2008 | Int J Gynecol Cancer2008，18，4： | 1 |
| 7 | Effect of mirtazapine on MNNG-induced gastric adenocarcinoma in rats显示文摘 | Bilici M Cayir K Tekin S B | 2012 | Asian Pac J Cancer Prev2012，13，10： | 1 |
| 8 | Circulating levels of IGF-I and IGFBP-3 in gastric cancer 显示文摘 | Ahinkaynak K Bilici M Bakan N | 2012 | Turkish Journal of Medical Sci- ences2012，42，9： | 1 |
| 9 | The effect ofradiotherapy on cardiac function 显示文摘 | Dogan SM Bilici HM Bakkal H | 2012 | Coron Artery Dis2012，23，3： | 1 |
| 10 | Prognostic Significance of Perineural Invasion in Patients with Gastric Cancer Who Underwent Curative Resection显示文摘 | Ahmet Bilici MD Mesut Seker MD Bala Basak Oven Ustaalioglu MD Umut Kefeli MD Emre Yildirim MD Dilek Yavuzer MD Fatih Muhammed Aydin MD Taflan Salepci MD Mustafa Oncel MD FASCRS(Int) Mahmut Gumus MD | 2010 | Annals of Surgical Oncology2010，，8： | 1 |
| 11 | The changing of ser-um vitamin B12 and homocysteine levels after gastrectomyin patients with gastric cancer : do they associate withclinicopathological factors 显示文摘 | Bilici A Sonkaya A Ercan S | 2015 | Tumour Biol2015，36，2： | 1 |
| 12 | Prognostic significance of perineural invasion in patients with gastric cancer who underwent cur- ative resection显示文摘 | Bilici A Seker M Ustaalioglu BBO | 2010 | Ann Surg Onco12010，17，8： | 1 |
| 13 | Development of a thulium (Tm : YAP) laser system for brain tissue ablation 显示文摘 | BILICI T MUTLU S KALAYCIOGLU H | 2011 | Lasers in Medical Science2011，26，5： | 1 |
| 14 | Comparison of dartos flap and dartos flap plus spongioplasty to prevent the formation of fis- tulae in the Snodgrass technique显示文摘 | Bilici S Sekmenli T Gunes M | 2011 | Int Urol Nephrol2011，43，4： | 1 |
| 15 | Diameters of the common bile duct in adults and postcholecystectomy patients: A study with 64-slice CT显示文摘 | Senem Senturk Tugba Cezlan Miroglu Aslan Bilici Hatice Gumus Rojbin Ceylan Tekin Faysal Ekici Güven Tekbas | 2010 | European Journal of Radiology2010，，： | 1 |
| 16 | Effect of mirtazapine on MNNG-in- duced gastric adenocarcinoma in rats 显示文摘 | Bilici M Cayir K Tekin SB | 2012 | Asian Pac J Cancer Prev2012，13，10： | 1 |
| 17 | Modified docetaxel and cisplatin in combination with capecitabine (DCX) as a first-line treatment in HER2-negative advanced gastric cancer显示文摘 | Bilici A Selcukbiricik F Demir N | 2014 | Asian PacJ Cancer Prev2014，15，20： | 1 |
| 18 | Prognostic significance of perineural invasion in patients with gastric cancer who underwent curative resection显示文摘 | Bilici A Seker M Ustaalioglu BB | 2010 | Ann Surg Oncol2010，17，8： | 1 |
| 19 | Steroid responsiveness of children with idiopathic nephrotic syndrome in south- eastern region of Turkey显示文摘 | DAVUTOGLU M ECE A BILICI M | 2007 | Ren Fail2007，29，7： | 1 |
| 20 | The optimization of welding parameters for friction stir spot welding of high density polyethylene sheets 显示文摘 | Mustafa Kemal Bilici Memduh Kurtulmus | 2011 | Materials and Desigh2011，32，： | 1 |
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