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| 1 | 精氨酸酶I在HCV转染肝癌细胞增殖中的作用显示文摘目的:研究丙型肝炎病毒(hepatitis C virus,HCV)基因组转染的肝癌细胞中精氨酸酶Ⅰ的表达及其意义,探究其在HCV-肝细胞肝癌(HCC)发病中的作用。方法:以转染HCV基因组的人肝癌细胞系(Huh7)为研究对象,采用蛋白印迹技术研究HCV基因组转染对细胞内精氨酸酶Ⅰ表达的影响;运用小干扰RNA(siRNA)技术抑制细胞精氨酸酶Ⅰ表达,并探讨其对细胞生长的影响及作用机制。结果:精氨酸酶Ⅰ在HCV阳性肝癌细胞系(Huh7-HCV)中的表达上调,且与对照细胞相比,Huh7-HCV细胞的精氨酸酶Ⅰ含量升高4.3倍。运用siRNA抑制细胞精氨酸酶Ⅰ表达,可明显抑制细胞生长并导致其死亡,且可使细胞周期发生明显改变。结论:精氨酸酶Ⅰ在HCV阳性肝细胞Huh7中表达上调,可能对促进Huh7-HCV细胞生长具重要意义。 | 曹文俊 Bill Sun 连兆瑞 Marcy Clayton Mark Feitelson 樊绮诗 | 2007 | 诊断学理论与实践2007，6，4： | 3 |
| 2 | Political connections and the process of going public: Evidence from China显示文摘 | Bill B. Francis Iftekhar Hasan Xian Sun | 2009 | Journal of International Money and Finance2009，，4： | 2 |
| 3 | Putative roles of hepatitis B x antigen in the pathogenesis of chronic liver disease显示文摘 | Mark A. Feitelson Helena M.G.P.V. Reis N. Lale Tufan Bill Sun Jingbo Pan Zhaorui Lian | 2008 | Cancer Letters2008，，1： | 1 |
| 4 | HCV感染相关的肝细胞性肝癌中精氨酸酶Ⅱ的表达显示文摘目的通过对丙型肝炎病毒-原发性肝细胞肝癌(HCV-HCC)组织及细胞中精氨酸酶Ⅱ(Arg-Ⅱ)的表达进行分析,并以RNA干扰技术阻断其在细胞内的表达,初步研究Arg-Ⅱ表达在HCV-HCC发病中的意义。方法首先以基因转染技术分别将HCV基因组和对照质粒导入HuH7细胞中,以逆转录-实时荧光PCR检测HCV基因组的转录并作细胞生长曲线测定,以Western blotting技术研究HCV基因组转染对细胞内Arg-Ⅱ表达的影响,以免疫组化技术分析HCV-HCC组织中Arg-Ⅱ的表达水平,运用RNA干扰技术对Arg-Ⅱ作初步的功能分析。结果以基因转染技术分别将HCV基因组和对照质粒导入HuH7,成功建立了HuH7-HCV和HuH7-vector两个细胞系,逆转录-实时荧光PCR检测表明HuH7-HCV细胞的HCV转录水平为0.5~5拷贝/细胞。Western blotting结果显示,与对照细胞相比,HuH-7-HCV细胞的Arg-Ⅱ含量升高3.9倍。免疫组化技术分析HCV-HCC组织标本中Arg-Ⅱ的表达,结果呈强阳性,而对照标本中基本不表达。采用RNA干扰方法阻断HuH7-HCV细胞的Arg-Ⅱ表达,发现细胞增殖被明显抑制。结论Arg-Ⅱ在HCV阳性肝细胞系中及HCV-HCC组织中异常表达并可能参与HCV-HCC的发病机制。 | 曹文俊 Bill Sun 徐锋 连兆瑞 Marcy Clayton Mark Feitelson 樊绮诗 | 2007 | 上海交通大学学报(医学版)2007，27，8： | 1 |
| 5 | Emergency department use among patients from residential aged care facilities under a Hospital in the Nursing Home scheme in public hospitals in Queensland Australia显示文摘BACKGROUND: Hospital emergency department(ED) use by patients from residential aged care facilities(RACFs) is not always appropriate, and this calls for interventions to avoid some unnecessary uses. This study aims to compare patterns of ED use by RACF patients with and without a Hospital in the Nursing Home(Hi NH) program.METHODS: RACF patients presenting to EDs of a hospital with and a hospital without this program during pre- and post-intervention periods were included. Data on patient demographics and ED presentation characteristics were obtained from the Emergency Department Information System database, and were analysed by descriptive and comparative statistics.RESULTS: In both hospitals, most RACF residents presenting to EDs were aged between 75–94 years, female, triaged at scale 3 to 5, and transferred on weekdays and during working hours. Almost half of them were subsequently admitted to hospitals. In accordance with the ICD-10-AM diagnostic coding system, diagnoses that consistently ranked among the top three reasons for visiting the two hospitals before and after intervention included Chapter XIX: injury and poisoning and Chapter X: respiratory diseases. Associated with the intervention, significant decreases in the numbers of presentations per 1 000 RACF beds were identified among patients diagnosed with Chapter XI: digestive diseases [rate ratio(95%CI): 0.09(0.04, 0.22); P<0.0001] and Chapter XXI: factors influencing health status and contact with health services [rate ratio(95%CI): 0.22(0.07, 0.66); P=0.007].CONCLUSION: The Hi NH program may reduce the incidence of RACF residents visiting EDs for diagnoses of Chapter XI and Chapter XXI. | Bill Lukin Li-jun Fan Jing-zhou Zhao Jian-dong Sun Kaeleen Dingle Rhonda Purtill Sam Tapp Xiang-yu Hou | 2016 | World Journal of Emergency Medicine2016，7，3： | 1 |
| 6 | Political connections and the process of going public: Evidence from China显示文摘 | Bill B. Francis Iftekhar Hasan Xian Sun | 2009 | Journal of International Money and Finance2009，，4： | 1 |
| 7 | A dynamic study on ecological disas- ter, government regulation, and renewable resources 显示文摘 | NIE P Y SUN P Bill Z ea tl | 2014 | The Ameri- can Journal of Economics and Sociology2014，73，2： | 1 |
| 8 | Electrophysiological and behavioral responses of turnip moth males,Agrotis segetum to fluorinated pheromone analogs显示文摘 | Wu Wenqi Marie Bengtsson Bill S. Hansson Tommy Liljefors Christer L?fstedt Glenn D. Prestwich Wei-Chuan Sun Mats Svensson | 1993 | Journal of Chemical Ecology1993，，1： | 1 |
| 9 | Characterization of the distinct orthotopic bone- forming activity of14 BMPs using recombinant adenovirumediated gene d elivery显示文摘 | Kang Q Sun bill Chang It | 2004 | GeneThel2004，11，13： | 1 |
| 10 | Trust,politics and post-IPO performance:SOEs vs.the private sector显示文摘This paper empirically investigates the role of social trust in the long-term performance of the initial public offerings(IPOs)in China,controlling for the formal institutional environment.We find that privately owned or smaller IPO firms experience signifi-cantly better post-IPO performance when they are incorporated in regions with more social trust.The state-owned and bigger IPO firms,on the other hand,experience better long-term post-IPO performance when they are incorporated in regions with stronger formal institutions(e.g.court enforcement and contract holding).Political pluralism turns out to benefit all IPOs in the long term.In addition,our evidence shows that stronger social trust substitutes for the quality of court enforcement but complements the role of contract holding.These results are robust after controlling for alternative definitions of ownership,outliers,non-linear effects of institutions,and the potential endogeneity of institutions in the model. | Bill Francis Iftekhar Hasan Xian Sun Mingming Zhou | 2022 | Economic and Political Studies2022，10，3： | 0 |
| 11 | 新西兰的十大热门行业显示文摘近年来,越来越多的中国移民进入新西兰。他们大都集中在奥克兰、惠灵顿和基督城等大城市。如何在新西兰找到合适的工作是新移民最为关心的问题。应当说,在新西兰的商业机会还是不少。如:中医诊所;利用新西兰的白松制造筷子,然后出口至日本及韩国;种植鲜花供应日本插花艺术之需;捕捉海产供应中国或日本市场;设立贸易公司;加工木材; | Bill Sun | 2002 | 成才与就业2002，，11： | 0 |
| 12 | Long-term transit timing monitoring and homogenous study of WASP-32显示文摘We report new photometric observations of the transiting exoplanetary system WASP-32 made by using CCD cameras at Yunnan Observatories and Ho Koon Nature Education cum Astronomical Centre, China from 2010 to 2012. Following our usual procedure, the observed data are corrected for systematic errors according to the coarse decorrelation and SYSREM algorithms so as to enhance the signal of the transit events. Combined with radial velocity data presented in the literature, our newly observed data and earlier photometric data in the literature are simultaneously analyzed to derive the physical parameters describing the system by employing the Markov chain Monte Carlo technique. The derived parameters are consistent with the result published in the original paper about WASP-32b, but the uncertainties of the new parameters are smaller than those in the original paper. Moreover, our modeling result supports a circular orbit for WASP-32b. Through the analysis of all available mid-transit times, we have refined the orbital period of WASP-32b; no evident transit timing variation is found in these transit events. | Lei-Lei Sun Sheng-Hong Gu Xiao-Bin Wang Andrew Collier Cameron Dong-Tao Cao Yi-Bo Wang Yue Xiang Ho-Keung Hui Chi-Tai Kwok Bill Yeung Kam-Cheung Leung | 2015 | Research in Astronomy and Astrophysics2015，15，1： | 0 |
| 13 | Multiphysics extension to physically based analyses of pipes with emphasis on frost actions显示文摘Pipes,especially buried pipes,in cold regions generally experience a rash of failures during cold weather snaps.However,the existing heuristic models are unable to explain the basic processes involving frost actions.This is because the frost action is not a direct load but one that causes variations in pipe-soil interactions resulting from the coupled thermo-hydro-mechanical process in soils.This paper developed and implemented a holistic multiphysics simulation model for freezing soils and extended it to the analysis of pipe-soil systems.The theoretical framework was implemented to analyze both static and dynamic responses of buried pipes subjected to frost actions.The multiphysics simulations reproduced phenomena commonly observed during frost actions,e.g.,ice fringe advancement and an increase in the internal stress of pipes.The influences of important design factors,i.e.,buried depth and overburden pressure,on pipe responses were simulated.A fatigue cracking criterion was utilized to predict the crack initialization under the joint effects of frost and dynamic traffic loads.The frost effects were found to have detrimental effects for accelerating fatigue crack initialization in pipes. | Zhen LIU Xiong (Bill) YU Jun-liang TAO Ye SUN | 2012 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2012，13，11： | 0 |
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